{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T20:06:29Z","timestamp":1793995589174,"version":"4.8.0"},"reference-count":186,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T00:00:00Z","timestamp":1752883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFA1305600"],"award-info":[{"award-number":["2022YFA1305600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2023YFC2413804"],"award-info":[{"award-number":["2023YFC2413804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470584 and 82000561"],"award-info":[{"award-number":["82470584 and 82000561"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270614, 81974078 and 81570530"],"award-info":[{"award-number":["82270614, 81974078 and 81570530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170678"],"award-info":[{"award-number":["82170678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science foundation of union hospital","award":["2021xhyn005"],"award-info":[{"award-number":["2021xhyn005"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-025-05815-5","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T08:40:31Z","timestamp":1752914431000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ferroptosis and gut microbiota: A new horizon in alcohol-associated liver disease management"],"prefix":"10.1007","volume":"82","author":[{"given":"Yue","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5349-8429","authenticated-orcid":false,"given":"Huikuan","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,19]]},"reference":[{"issue":"1","key":"5815_CR1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/s41575-022-00688-6","volume":"20","author":"DQ Huang","year":"2023","unstructured":"Huang DQ et al (2023) Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors. Nat Rev Gastroenterol Hepatol 20(1):37\u201349","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"1","key":"5815_CR2","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1186\/s12876-022-02430-7","volume":"22","author":"N Alkhouri","year":"2022","unstructured":"Alkhouri N et al (2022) The prevalence of alcoholic and nonalcoholic fatty liver disease in adolescents and young adults in the united states: analysis of the NHANES database. BMC Gastroenterol 22(1):366","journal-title":"BMC Gastroenterol"},{"issue":"1","key":"5815_CR3","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/hep.30866","volume":"71","author":"DW Crabb","year":"2020","unstructured":"Crabb DW et al (2020) Diagnosis and treatment of Alcohol-Associated liver diseases: 2019 practice guidance from the American association for the study of liver diseases. Hepatology 71(1):306\u2013333","journal-title":"Hepatology"},{"issue":"3","key":"5815_CR4","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/apt.18101","volume":"60","author":"P Danpanichkul","year":"2024","unstructured":"Danpanichkul P et al (2024) Global epidemiology of alcohol-associated liver disease in adolescents and young adults. Aliment Pharmacol Ther 60(3):378\u2013388","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"5815_CR5","doi-asserted-by":"publisher","first-page":"101020","DOI":"10.1016\/j.jhepr.2024.101020","volume":"6","author":"P Danpanichkul","year":"2024","unstructured":"Danpanichkul P et al (2024) Global and regional burden of alcohol-associated liver disease and alcohol use disorder in the elderly. JHEP Rep 6(4):101020","journal-title":"JHEP Rep"},{"key":"5815_CR6","doi-asserted-by":"crossref","unstructured":"Aberg F et al (2024) Alcohol-associated liver disease-Global epidemiology. Hepatol 80(6):1307\u20131322","DOI":"10.1097\/HEP.0000000000000899"},{"issue":"3","key":"5815_CR7","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1001\/jamainternmed.2018.6536","volume":"179","author":"BP Lee","year":"2019","unstructured":"Lee BP et al (2019) National trends and Long-term outcomes of liver transplant for Alcohol-Associated liver disease in the united States. JAMA Intern Med 179(3):340\u2013348","journal-title":"JAMA Intern Med"},{"issue":"3","key":"5815_CR8","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.mcna.2022.12.005","volume":"107","author":"P Penninti","year":"2023","unstructured":"Penninti P, Adekunle AD, Singal AK (2023) Alcoholic hepatitis: the rising epidemic. Med Clin North Am 107(3):533\u2013554","journal-title":"Med Clin North Am"},{"issue":"4","key":"5815_CR9","doi-asserted-by":"publisher","first-page":"618","DOI":"10.3350\/cmh.2020.0142","volume":"26","author":"T Miyata","year":"2020","unstructured":"Miyata T, Nagy LE (2020) Programmed cell death in alcohol-associated liver disease. Clin Mol Hepatol 26(4):618\u2013625","journal-title":"Clin Mol Hepatol"},{"key":"5815_CR10","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1146\/annurev-pathmechdis-031521-030435","volume":"18","author":"X Wu","year":"2023","unstructured":"Wu X et al (2023) Recent advances in Understanding of pathogenesis of Alcohol-Associated liver disease. Annu Rev Pathol 18:411\u2013438","journal-title":"Annu Rev Pathol"},{"key":"5815_CR11","doi-asserted-by":"crossref","unstructured":"Chen M, Zhong W, Xu W (2023) Alcohol and the mechanisms of liver disease. J Gastroenterol Hepatol 38(8):1233\u20131240","DOI":"10.1111\/jgh.16282"},{"issue":"19","key":"5815_CR12","first-page":"9296","volume":"27","author":"JQ Bo","year":"2023","unstructured":"Bo JQ et al (2023) Advancements in ferroptosis research and therapeutic strategies for alcoholic liver disease: a narrative review. Eur Rev Med Pharmacol Sci 27(19):9296\u20139308","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"5815_CR13","doi-asserted-by":"crossref","unstructured":"Hyun J et al (2021) Pathophysiological aspects of alcohol metabolism in the liver. Int J Mol Sci 22(11):5717","DOI":"10.3390\/ijms22115717"},{"issue":"40","key":"5815_CR14","doi-asserted-by":"publisher","first-page":"14652","DOI":"10.3748\/wjg.v20.i40.14652","volume":"20","author":"A Rocco","year":"2014","unstructured":"Rocco A et al (2014) Alcoholic disease: liver and beyond. World J Gastroenterol 20(40):14652\u201314659","journal-title":"World J Gastroenterol"},{"key":"5815_CR15","doi-asserted-by":"publisher","first-page":"1194343","DOI":"10.3389\/fphar.2023.1194343","volume":"14","author":"JF Shi","year":"2023","unstructured":"Shi JF et al (2023) Targeting ferroptosis, a novel programmed cell death, for the potential of alcohol-related liver disease therapy. Front Pharmacol 14:1194343","journal-title":"Front Pharmacol"},{"issue":"1","key":"5815_CR16","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/s41420-023-01608-6","volume":"9","author":"J Luo","year":"2023","unstructured":"Luo J et al (2023) Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation. Cell Death Discov 9(1):311","journal-title":"Cell Death Discov"},{"key":"5815_CR17","doi-asserted-by":"crossref","unstructured":"Wu Z et al (2024) Ferroptosis in liver disease: natural active compounds and therapeutic implications. Antioxid (Basel) 13(3):352","DOI":"10.3390\/antiox13030352"},{"key":"5815_CR18","doi-asserted-by":"publisher","first-page":"1258062","DOI":"10.3389\/fphar.2023.1258062","volume":"14","author":"L Zhu","year":"2023","unstructured":"Zhu L et al (2023) Gut microbiota in alcohol-related liver disease: pathophysiology and gut-brain cross talk. Front Pharmacol 14:1258062","journal-title":"Front Pharmacol"},{"issue":"11","key":"5815_CR19","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/s41579-023-00904-3","volume":"21","author":"CL Hsu","year":"2023","unstructured":"Hsu CL, Schnabl B (2023) The gut-liver axis and gut microbiota in health and liver disease. Nat Rev Microbiol 21(11):719\u2013733","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"5815_CR20","doi-asserted-by":"publisher","first-page":"2393272","DOI":"10.1080\/19490976.2024.2393272","volume":"16","author":"K Sosnowski","year":"2024","unstructured":"Sosnowski K, Przybylkowski A (2024) Ethanol-induced changes to the gut Microbiome compromise the intestinal homeostasis: a review. Gut Microbes 16(1):2393272","journal-title":"Gut Microbes"},{"issue":"2","key":"5815_CR21","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.chom.2020.07.007","volume":"28","author":"S Lang","year":"2020","unstructured":"Lang S, Schnabl B (2020) Microbiota and fatty liver Disease-the known, the unknown, and the future. Cell Host Microbe 28(2):233\u2013244","journal-title":"Cell Host Microbe"},{"issue":"4","key":"5815_CR22","doi-asserted-by":"publisher","first-page":"595","DOI":"10.3350\/cmh.2020.0086","volume":"26","author":"BG Mendes","year":"2020","unstructured":"Mendes BG, Schnabl B (2020) From intestinal dysbiosis to alcohol-associated liver disease. Clin Mol Hepatol 26(4):595\u2013605","journal-title":"Clin Mol Hepatol"},{"issue":"1","key":"5815_CR23","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/0016-5085(95)90027-6","volume":"108","author":"Y Adachi","year":"1995","unstructured":"Adachi Y et al (1995) Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 108(1):218\u2013224","journal-title":"Gastroenterology"},{"issue":"8","key":"5815_CR24","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1136\/gutjnl-2018-317232","volume":"68","author":"T Hendrikx","year":"2019","unstructured":"Hendrikx T et al (2019) Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice. Gut 68(8):1504\u20131515","journal-title":"Gut"},{"issue":"11","key":"5815_CR25","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/s41574-022-00721-3","volume":"18","author":"J Mayneris-Perxachs","year":"2022","unstructured":"Mayneris-Perxachs J, Moreno-Navarrete JM, Fernandez-Real JM (2022) The role of iron in host-microbiota crosstalk and its effects on systemic glucose metabolism. Nat Rev Endocrinol 18(11):683\u2013698","journal-title":"Nat Rev Endocrinol"},{"key":"5815_CR26","doi-asserted-by":"publisher","first-page":"127667","DOI":"10.1016\/j.micres.2024.127667","volume":"282","author":"Y Yan","year":"2024","unstructured":"Yan Y et al (2024) Crosstalk between intestinal flora and human iron metabolism: the role in metabolic syndrome-related comorbidities and its potential clinical application. Microbiol Res 282:127667","journal-title":"Microbiol Res"},{"issue":"5","key":"5815_CR27","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1136\/gutjnl-2014-307720","volume":"64","author":"T Jaeggi","year":"2015","unstructured":"Jaeggi T et al (2015) Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants. Gut 64(5):731\u2013742","journal-title":"Gut"},{"issue":"1","key":"5815_CR28","doi-asserted-by":"publisher","first-page":"2221978","DOI":"10.1080\/19490976.2023.2221978","volume":"15","author":"C Liu","year":"2023","unstructured":"Liu C et al (2023) Dietary iron modulates gut microbiota and induces SLPI secretion to promote colorectal tumorigenesis. Gut Microbes 15(1):2221978","journal-title":"Gut Microbes"},{"key":"5815_CR29","doi-asserted-by":"crossref","unstructured":"Puga AM et al (2022) Iron supplementation at the crossroads of nutrition and gut microbiota: the state of the Art. Nutrients 14(9):1926","DOI":"10.3390\/nu14091926"},{"key":"5815_CR30","doi-asserted-by":"publisher","first-page":"167043","DOI":"10.1016\/j.scitotenv.2023.167043","volume":"905","author":"K Gu","year":"2023","unstructured":"Gu K et al (2023) Iron overload induces colitis by modulating ferroptosis and interfering gut microbiota in mice. Sci Total Environ 905:167043","journal-title":"Sci Total Environ"},{"issue":"11","key":"5815_CR31","doi-asserted-by":"publisher","first-page":"100307","DOI":"10.1016\/j.advnut.2024.100307","volume":"15","author":"S Liu","year":"2024","unstructured":"Liu S et al (2024) The role of Iron in intestinal mucus: perspectives from both the host and gut microbiota. Adv Nutr 15(11):100307","journal-title":"Adv Nutr"},{"issue":"9","key":"5815_CR32","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1007\/s11427-022-2302-5","volume":"66","author":"L Xiao","year":"2023","unstructured":"Xiao L et al (2023) Gut microbiota bridges the iron homeostasis and host health. Sci China Life Sci 66(9):1952\u20131975","journal-title":"Sci China Life Sci"},{"key":"5815_CR33","doi-asserted-by":"crossref","unstructured":"Gozzelino R, Arosio P (2016) Iron homeostasis in health and disease. Int J Mol Sci 17(1):130","DOI":"10.3390\/ijms17010130"},{"issue":"7","key":"5815_CR34","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1080\/15216540500149904","volume":"57","author":"TM Steele","year":"2005","unstructured":"Steele TM, Frazer DM, Anderson GJ (2005) Systemic regulation of intestinal iron absorption. IUBMB Life 57(7):499\u2013503","journal-title":"IUBMB Life"},{"issue":"2","key":"5815_CR35","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1182\/blood-2007-12-077388","volume":"112","author":"NC Andrews","year":"2008","unstructured":"Andrews NC (2008) Forging a field: the golden age of iron biology. Blood 112(2):219\u2013230","journal-title":"Blood"},{"issue":"4","key":"5815_CR36","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s00018-022-04239-9","volume":"79","author":"LX Li","year":"2022","unstructured":"Li LX et al (2022) Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets. Cell Mol Life Sci 79(4):201","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"5815_CR37","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/j.1478-3231.2005.01004.x","volume":"25","author":"SC Eng","year":"2005","unstructured":"Eng SC et al (2005) Hepatic iron overload in alcoholic end-stage liver disease is associated with iron deposition in other organs in the absence of HFE-1 hemochromatosis. Liver Int 25(3):513\u2013517","journal-title":"Liver Int"},{"issue":"7","key":"5815_CR38","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.3324\/haematol.2012.072314","volume":"98","author":"H Nam","year":"2013","unstructured":"Nam H et al (2013) ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders. Haematologica 98(7):1049\u20131057","journal-title":"Haematologica"},{"issue":"7","key":"5815_CR39","doi-asserted-by":"publisher","first-page":"e1004039","DOI":"10.1371\/journal.pmed.1004039","volume":"19","author":"A Topiwala","year":"2022","unstructured":"Topiwala A et al (2022) Associations between moderate alcohol consumption, brain iron, and cognition in UK biobank participants: observational and Mendelian randomization analyses. PLoS Med 19(7):e1004039","journal-title":"PLoS Med"},{"key":"5815_CR40","doi-asserted-by":"publisher","first-page":"115728","DOI":"10.1016\/j.biopha.2023.115728","volume":"168","author":"Y Liu","year":"2023","unstructured":"Liu Y et al (2023) Excess iron intake induced liver injury: the role of gut-liver axis and therapeutic potential. Biomed Pharmacother 168:115728","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"5815_CR41","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060\u20131072","journal-title":"Cell"},{"issue":"3","key":"5815_CR42","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S1535-6108(03)00050-3","volume":"3","author":"S Dolma","year":"2003","unstructured":"Dolma S et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3(3):285\u2013296","journal-title":"Cancer Cell"},{"issue":"1","key":"5815_CR43","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","volume":"9","author":"Q Ru","year":"2024","unstructured":"Ru Q et al (2024) Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects. Signal Transduct Target Ther 9(1):271","journal-title":"Signal Transduct Target Ther"},{"key":"5815_CR44","doi-asserted-by":"crossref","unstructured":"Rochette L et al (2022) Lipid peroxidation and iron metabolism: two corner stones in the homeostasis control of ferroptosis. Int J Mol Sci 24(1):449","DOI":"10.3390\/ijms24010449"},{"issue":"1","key":"5815_CR45","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","volume":"8","author":"S Sun","year":"2023","unstructured":"Sun S et al (2023) Targeting ferroptosis opens new avenues for the development of novel therapeutics. Signal Transduct Target Ther 8(1):372","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"5815_CR46","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","volume":"29","author":"J Chen","year":"2022","unstructured":"Chen J et al (2022) The multifaceted role of ferroptosis in liver disease. Cell Death Differ 29(3):467\u2013480","journal-title":"Cell Death Differ"},{"issue":"10","key":"5815_CR47","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/j.ajpath.2022.08.010","volume":"193","author":"N Ali","year":"2023","unstructured":"Ali N, Ferrao K, Mehta KJ (2023) Liver Iron loading in Alcohol-Associated liver disease. Am J Pathol 193(10):1427\u20131439","journal-title":"Am J Pathol"},{"key":"5815_CR48","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/978-3-319-09614-8_6","volume":"815","author":"S Mueller","year":"2015","unstructured":"Mueller S, Rausch V (2015) The role of iron in alcohol-mediated hepatocarcinogenesis. Adv Exp Med Biol 815:89\u2013112","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"5815_CR49","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1053\/j.gastro.2004.01.020","volume":"126","author":"GN Ioannou","year":"2004","unstructured":"Ioannou GN et al (2004) The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia. Gastroenterology 126(5):1293\u20131301","journal-title":"Gastroenterology"},{"issue":"3","key":"5815_CR50","doi-asserted-by":"publisher","first-page":"398","DOI":"10.14309\/ajg.0000000000000492","volume":"115","author":"SR Atkinson","year":"2020","unstructured":"Atkinson SR et al (2020) Serum transferrin is an independent predictor of mortality in severe alcoholic hepatitis. Am J Gastroenterol 115(3):398\u2013405","journal-title":"Am J Gastroenterol"},{"issue":"Pt 6","key":"5815_CR51","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1177\/000456329503200602","volume":"32","author":"C Ford","year":"1995","unstructured":"Ford C, Wells FE, Rogers JN (1995) Assessment of iron status in association with excess alcohol consumption. Ann Clin Biochem 32(Pt 6):527\u2013531","journal-title":"Ann Clin Biochem"},{"issue":"7","key":"5815_CR52","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1111\/j.1530-0277.2001.tb02314.x","volume":"25","author":"JB Whitfield","year":"2001","unstructured":"Whitfield JB et al (2001) Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers. Alcohol Clin Exp Res 25(7):1037\u20131045","journal-title":"Alcohol Clin Exp Res"},{"issue":"2","key":"5815_CR53","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1136\/gut.46.2.277","volume":"46","author":"N Ganne-Carrie","year":"2000","unstructured":"Ganne-Carrie N et al (2000) Liver iron is predictive of death in alcoholic cirrhosis: a multivariate study of 229 consecutive patients with alcoholic and\/or hepatitis C virus cirrhosis: a prospective follow up study. Gut 46(2):277\u2013282","journal-title":"Gut"},{"issue":"1","key":"5815_CR54","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1053\/j.gastro.2007.10.038","volume":"134","author":"P Nahon","year":"2008","unstructured":"Nahon P et al (2008) Liver iron, HFE gene mutations, and hepatocellular carcinoma occurrence in patients with cirrhosis. Gastroenterology 134(1):102\u2013110","journal-title":"Gastroenterology"},{"issue":"12","key":"5815_CR55","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1007\/s00109-022-02254-8","volume":"100","author":"K Ferrao","year":"2022","unstructured":"Ferrao K, Ali N, Mehta KJ (2022) Iron and iron-related proteins in alcohol consumers: cellular and clinical aspects. J Mol Med (Berl) 100(12):1673\u20131689","journal-title":"J Mol Med (Berl)"},{"issue":"2","key":"5815_CR56","doi-asserted-by":"publisher","first-page":"793","DOI":"10.3390\/biom5020793","volume":"5","author":"DD Harrison-Findik","year":"2015","unstructured":"Harrison-Findik DD, Lu S (2015) The effect of alcohol and hydrogen peroxide on liver Hepcidin gene expression in mice lacking antioxidant enzymes, glutathione peroxidase-1 or catalase. Biomolecules 5(2):793\u2013807","journal-title":"Biomolecules"},{"issue":"6","key":"5815_CR57","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1002\/hep.21895","volume":"46","author":"DD Harrison-Findik","year":"2007","unstructured":"Harrison-Findik DD et al (2007) Iron-mediated regulation of liver Hepcidin expression in rats and mice is abolished by alcohol. Hepatology 46(6):1979\u20131985","journal-title":"Hepatology"},{"issue":"8 Suppl","key":"5815_CR58","doi-asserted-by":"publisher","first-page":"26S","DOI":"10.1111\/j.1530-0277.2002.tb02698.x","volume":"26","author":"Y Suzuki","year":"2002","unstructured":"Suzuki Y et al (2002) Up-regulation of transferrin receptor expression in hepatocytes by habitual alcohol drinking is implicated in hepatic iron overload in alcoholic liver disease. Alcohol Clin Exp Res 26(8 Suppl):26S\u201331S","journal-title":"Alcohol Clin Exp Res"},{"issue":"8 Suppl Proceed","key":"5815_CR59","doi-asserted-by":"publisher","first-page":"98S","DOI":"10.1111\/j.1530-0277.2004.tb03225.x","volume":"28","author":"M Suzuki","year":"2004","unstructured":"Suzuki M et al (2004) Induction of transferrin receptor by ethanol in rat primary hepatocyte culture. Alcohol Clin Exp Res 28(8 Suppl Proceedings):98S\u2013105S","journal-title":"Alcohol Clin Exp Res"},{"issue":"8","key":"5815_CR60","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1111\/j.1530-0277.1996.tb01134.x","volume":"20","author":"LG Valerio Jr","year":"1996","unstructured":"Valerio LG Jr., Parks T, Petersen DR (1996) Alcohol mediates increases in hepatic and serum nonheme iron stores in a rat model for alcohol-induced liver injury. Alcohol Clin Exp Res 20(8):1352\u20131361","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"5815_CR61","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1002\/hep.25746","volume":"56","author":"Z Zhang","year":"2012","unstructured":"Zhang Z et al (2012) Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice. Hepatology 56(3):961\u2013971","journal-title":"Hepatology"},{"issue":"2","key":"5815_CR62","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0741-8329(03)00126-5","volume":"30","author":"A Pietrangelo","year":"2003","unstructured":"Pietrangelo A (2003) Iron-induced oxidant stress in alcoholic liver fibrogenesis. Alcohol 30(2):121\u2013129","journal-title":"Alcohol"},{"issue":"1","key":"5815_CR63","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s12185-008-0120-5","volume":"88","author":"Y Kohgo","year":"2008","unstructured":"Kohgo Y et al (2008) Body iron metabolism and pathophysiology of iron overload. Int J Hematol 88(1):7\u201315","journal-title":"Int J Hematol"},{"issue":"8","key":"5815_CR64","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/j.cmet.2022.07.006","volume":"34","author":"H Gao","year":"2022","unstructured":"Gao H et al (2022) Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Cell Metab 34(8):1201\u20131213.e5","journal-title":"Cell Metab"},{"issue":"3","key":"5815_CR65","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00535-016-1237-6","volume":"52","author":"T Hasebe","year":"2017","unstructured":"Hasebe T et al (2017) Bone morphogenetic protein-binding endothelial regulator of liver sinusoidal endothelial cells induces iron overload in a fatty liver mouse model. J Gastroenterol 52(3):341\u2013351","journal-title":"J Gastroenterol"},{"issue":"4","key":"5815_CR66","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1182\/blood-2016-07-729822","volume":"129","author":"PS Koch","year":"2017","unstructured":"Koch PS et al (2017) Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis. Blood 129(4):415\u2013419","journal-title":"Blood"},{"issue":"3","key":"5815_CR67","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1182\/blood.2022016987","volume":"141","author":"E Charlebois","year":"2023","unstructured":"Charlebois E et al (2023) Liver sinusoidal endothelial cells induce BMP6 expression in response to non-transferrin-bound iron. Blood 141(3):271\u2013284","journal-title":"Blood"},{"key":"5815_CR68","doi-asserted-by":"publisher","first-page":"102559","DOI":"10.1016\/j.redox.2022.102559","volume":"59","author":"Y Li","year":"2023","unstructured":"Li Y et al (2023) RAGE promotes dysregulation of iron and lipid metabolism in alcoholic liver disease. Redox Biol 59:102559","journal-title":"Redox Biol"},{"key":"5815_CR69","doi-asserted-by":"publisher","first-page":"152584","DOI":"10.1016\/j.tox.2020.152584","volume":"445","author":"J Liu","year":"2020","unstructured":"Liu J et al (2020) Oxidative stress-dependent frataxin Inhibition mediated alcoholic hepatocytotoxicity through ferroptosis. Toxicology 445:152584","journal-title":"Toxicology"},{"issue":"4","key":"5815_CR70","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1080\/10715762.2023.2232941","volume":"57","author":"G Guo","year":"2023","unstructured":"Guo G et al (2023) Dissecting the potential role of ferroptosis in liver diseases: an updated review. Free Radic Res 57(4):282\u2013293","journal-title":"Free Radic Res"},{"issue":"Pt 2","key":"5815_CR71","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.freeradbiomed.2022.10.322","volume":"193","author":"Y You","year":"2022","unstructured":"You Y et al (2022) FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease. Free Radic Biol Med 193(Pt 2):808\u2013819","journal-title":"Free Radic Biol Med"},{"issue":"21","key":"5815_CR72","doi-asserted-by":"publisher","first-page":"3931","DOI":"10.1016\/j.molcel.2023.09.025","volume":"83","author":"S Cui","year":"2023","unstructured":"Cui S et al (2023) Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases. Mol Cell 83(21):3931\u20133939.e5","journal-title":"Mol Cell"},{"key":"5815_CR73","doi-asserted-by":"publisher","first-page":"105388","DOI":"10.1016\/j.tiv.2022.105388","volume":"82","author":"XY Song","year":"2022","unstructured":"Song XY et al (2022) Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines. Toxicol Vitro 82:105388","journal-title":"Toxicol Vitro"},{"issue":"7","key":"5815_CR74","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/j.cmet.2024.05.003","volume":"36","author":"P Horn","year":"2024","unstructured":"Horn P, Tacke F (2024) Metabolic reprogramming in liver fibrosis. Cell Metab 36(7):1439\u20131455","journal-title":"Cell Metab"},{"issue":"8","key":"5815_CR75","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/j.cmet.2024.05.008","volume":"36","author":"J Zhang","year":"2024","unstructured":"Zhang J et al (2024) Reactive oxygen species regulation by NCF1 governs ferroptosis susceptibility of Kupffer cells to MASH. Cell Metab 36(8):1745\u20131763.e6","journal-title":"Cell Metab"},{"issue":"1","key":"5815_CR76","doi-asserted-by":"publisher","first-page":"19805","DOI":"10.1038\/s41598-022-23858-7","volume":"12","author":"IC Hirako","year":"2022","unstructured":"Hirako IC et al (2022) Uptake of plasmodium Chabaudi hemozoin drives Kupffer cell death and fuels superinfections. Sci Rep 12(1):19805","journal-title":"Sci Rep"},{"issue":"9","key":"5815_CR77","doi-asserted-by":"publisher","first-page":"3983","DOI":"10.1016\/j.apsb.2024.05.007","volume":"14","author":"R Li","year":"2024","unstructured":"Li R et al (2024) Heme Oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke. Acta Pharm Sin B 14(9):3983\u20134000","journal-title":"Acta Pharm Sin B"},{"key":"5815_CR78","doi-asserted-by":"publisher","first-page":"1071844","DOI":"10.3389\/fphar.2022.1071844","volume":"13","author":"L Li","year":"2022","unstructured":"Li L, Zhu Z (2022) Pharmacological modulation of ferroptosis as a therapeutic target for liver fibrosis. Front Pharmacol 13:1071844","journal-title":"Front Pharmacol"},{"key":"5815_CR79","doi-asserted-by":"publisher","first-page":"155289","DOI":"10.1016\/j.phymed.2023.155289","volume":"124","author":"Y Hu","year":"2024","unstructured":"Hu Y et al (2024) Ginsenoside Rg3 promotes hepatic stellate cell ferroptosis by epigenetically regulating ACSL4 to suppress liver fibrosis progression. Phytomedicine 124:155289","journal-title":"Phytomedicine"},{"issue":"1","key":"5815_CR80","doi-asserted-by":"publisher","first-page":"20220781","DOI":"10.1515\/biol-2022-0781","volume":"18","author":"Z Cheng","year":"2023","unstructured":"Cheng Z et al (2023) Sarcoma protein kinase Inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis. Open Life Sci 18(1):20220781","journal-title":"Open Life Sci"},{"issue":"3","key":"5815_CR81","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00535-023-02068-6","volume":"59","author":"J Wang","year":"2024","unstructured":"Wang J et al (2024) CircDCBLD2 alleviates liver fibrosis by regulating ferroptosis via facilitating STUB1-mediated PARK7 ubiquitination degradation. J Gastroenterol 59(3):229\u2013249","journal-title":"J Gastroenterol"},{"issue":"9","key":"5815_CR82","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/s41418-024-01322-5","volume":"31","author":"Y Deng","year":"2024","unstructured":"Deng Y et al (2024) MafG\/MYH9-LCN2 axis promotes liver fibrosis through inhibiting ferroptosis of hepatic stellate cells. Cell Death Differ 31(9):1127\u20131139","journal-title":"Cell Death Differ"},{"issue":"4","key":"5815_CR83","doi-asserted-by":"publisher","first-page":"167748","DOI":"10.1016\/j.bbadis.2025.167748","volume":"1871","author":"W Li","year":"2025","unstructured":"Li W et al (2025) Hepatic microRNA-320 restrains ferroptosis to mitigate acute-on-chronic alcohol-induced liver injury. Biochim Biophys Acta Mol Basis Dis 1871(4):167748","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"8","key":"5815_CR84","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1111\/liv.15936","volume":"44","author":"C Yang","year":"2024","unstructured":"Yang C et al (2024) Loss of GCN5L1 exacerbates damage in alcoholic liver disease through ferroptosis activation. Liver Int 44(8):1924\u20131936","journal-title":"Liver Int"},{"key":"5815_CR85","doi-asserted-by":"publisher","first-page":"117715","DOI":"10.1016\/j.biopha.2024.117715","volume":"181","author":"M Khazaei","year":"2024","unstructured":"Khazaei M, Ardeshir RA (2024) Protective effects of sulfated polysaccharides from Enteromorpha intestinalis on oxidative stress, liver iron overload and ferroptosis in Zebra fish exposed to ethanol. Biomed Pharmacother 181:117715","journal-title":"Biomed Pharmacother"},{"issue":"8","key":"5815_CR86","doi-asserted-by":"publisher","first-page":"5316","DOI":"10.3168\/jds.2023-24490","volume":"107","author":"S Guan","year":"2024","unstructured":"Guan S et al (2024) Preventive effects of lactoferrin on acute alcohol-induced liver injury via iron chelation and regulation of iron metabolism. J Dairy Sci 107(8):5316\u20135329","journal-title":"J Dairy Sci"},{"key":"5815_CR87","doi-asserted-by":"publisher","first-page":"113402","DOI":"10.1016\/j.biopha.2022.113402","volume":"153","author":"M Xue","year":"2022","unstructured":"Xue M et al (2022) Protective effect of fucoidan against iron overload and ferroptosis-induced liver injury in rats exposed to alcohol. Biomed Pharmacother 153:113402","journal-title":"Biomed Pharmacother"},{"key":"5815_CR88","doi-asserted-by":"crossref","unstructured":"Chen F et al (2025) Selenomethionine alleviates Alcohol-Induced liver injury by inhibiting ferroptosis. Dig Dis Sci 70(5):1779\u20131787","DOI":"10.1007\/s10620-025-08960-w"},{"key":"5815_CR89","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.molimm.2025.02.012","volume":"181","author":"W Xue","year":"2025","unstructured":"Xue W et al (2025) Caveolin-1 protects against liver injury and lipid accumulation in alcoholic fatty liver via ferroptosis resistance. Mol Immunol 181:53\u201365","journal-title":"Mol Immunol"},{"key":"5815_CR90","doi-asserted-by":"crossref","unstructured":"Zhang Q et al (2024) Reducing Oxidative Stress-Mediated Alcoholic Liver Injury by Multiplexed RNAi of Cyp2e1, Cyp4a10, and Cyp4a14. Biomedicines 12(7):1505","DOI":"10.3390\/biomedicines12071505"},{"key":"5815_CR91","doi-asserted-by":"publisher","first-page":"103274","DOI":"10.1016\/j.redox.2024.103274","volume":"75","author":"Y Zhou","year":"2024","unstructured":"Zhou Y et al (2024) Inhibition of ethanol-induced eNAMPT secretion attenuates liver ferroptosis through BAT-Liver communication. Redox Biol 75:103274","journal-title":"Redox Biol"},{"issue":"7","key":"5815_CR92","first-page":"6147","volume":"16","author":"X Zhou","year":"2024","unstructured":"Zhou X, Wang J, Zhou S (2024) Poria cocos polysaccharides improve alcoholic liver disease by interfering with ferroptosis through NRF2 regulation. Aging 16(7):6147\u20136162","journal-title":"Aging"},{"issue":"1","key":"5815_CR93","doi-asserted-by":"publisher","first-page":"e202412031","DOI":"10.1002\/anie.202412031","volume":"64","author":"D Jiang","year":"2025","unstructured":"Jiang D, Yang B, Shi J (2025) Antioxidative therapy of alcoholic liver injury by amorphous Two-Dimensional Cobalt hydroxide nanocatalyst. Angew Chem Int Ed Engl 64(1):e202412031","journal-title":"Angew Chem Int Ed Engl"},{"issue":"29","key":"5815_CR94","doi-asserted-by":"publisher","first-page":"16323","DOI":"10.1021\/acs.jafc.4c02912","volume":"72","author":"Y Zhang","year":"2024","unstructured":"Zhang Y et al (2024) The flavonoid glycoside from Abrus cantoniensis hance alleviates alcoholic liver injury by inhibiting ferroptosis in an AMPK-Dependent manner. J Agric Food Chem 72(29):16323\u201316333","journal-title":"J Agric Food Chem"},{"key":"5815_CR95","doi-asserted-by":"publisher","first-page":"4907","DOI":"10.2147\/IJN.S462602","volume":"19","author":"W Zhang","year":"2024","unstructured":"Zhang W et al (2024) Preparation of Pueraria lobata Root-Derived Exosome-Like nanovesicles and evaluation of their effects on mitigating alcoholic intoxication and promoting alcohol metabolism in mice. Int J Nanomed 19:4907\u20134921","journal-title":"Int J Nanomed"},{"issue":"7","key":"5815_CR96","doi-asserted-by":"publisher","first-page":"e2300343","DOI":"10.1002\/mnfr.202300343","volume":"68","author":"H Lin","year":"2024","unstructured":"Lin H et al (2024) Ethanol-Induced hepatic ferroptosis is mediated by PERK-Dependent MAMs formation: preventive role of Quercetin. Mol Nutr Food Res 68(7):e2300343","journal-title":"Mol Nutr Food Res"},{"key":"5815_CR97","doi-asserted-by":"publisher","first-page":"116227","DOI":"10.1016\/j.jep.2023.116227","volume":"307","author":"J Dong","year":"2023","unstructured":"Dong J et al (2023) Verbenalin attenuates hepatic damage and mitochondrial dysfunction in alcohol-associated steatohepatitis by regulating MDMX\/PPARalpha-mediated ferroptosis. J Ethnopharmacol 307:116227","journal-title":"J Ethnopharmacol"},{"issue":"40","key":"5815_CR98","doi-asserted-by":"publisher","first-page":"12953","DOI":"10.1021\/acs.jafc.2c04337","volume":"70","author":"Y Zhao","year":"2022","unstructured":"Zhao Y et al (2022) Melatonin prevents against Ethanol-Induced liver injury by mitigating ferroptosis via targeting brain and muscle ARNT-like 1 in mice liver and HepG2 cells. J Agric Food Chem 70(40):12953\u201312967","journal-title":"J Agric Food Chem"},{"issue":"3","key":"5815_CR99","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1053\/j.gastro.2020.04.077","volume":"159","author":"DM Chopyk","year":"2020","unstructured":"Chopyk DM, Grakoui A (2020) Contribution of the intestinal Microbiome and gut barrier to hepatic disorders. Gastroenterology 159(3):849\u2013863","journal-title":"Gastroenterology"},{"issue":"15","key":"5815_CR100","doi-asserted-by":"publisher","first-page":"6877","DOI":"10.1002\/jsfa.12049","volume":"102","author":"W Zhao","year":"2022","unstructured":"Zhao W et al (2022) Probiotic-fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota. J Sci Food Agric 102(15):6877\u20136888","journal-title":"J Sci Food Agric"},{"issue":"1","key":"5815_CR101","doi-asserted-by":"publisher","first-page":"4630","DOI":"10.1038\/s41467-022-31973-2","volume":"13","author":"C Martino","year":"2022","unstructured":"Martino C et al (2022) Acetate reprograms gut microbiota during alcohol consumption. Nat Commun 13(1):4630","journal-title":"Nat Commun"},{"key":"5815_CR102","doi-asserted-by":"crossref","unstructured":"Jew MH, Hsu CL (2023) Alcohol, the gut microbiome, and liver disease. J Gastroenterol Hepatol 38(8):1205\u20131210","DOI":"10.1111\/jgh.16199"},{"issue":"10","key":"5815_CR103","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1111\/apt.13164","volume":"41","author":"G Vassallo","year":"2015","unstructured":"Vassallo G et al (2015) Review article: alcohol and gut microbiota - the possible role of gut microbiota modulation in the treatment of alcoholic liver disease. Aliment Pharmacol Ther 41(10):917\u2013927","journal-title":"Aliment Pharmacol Ther"},{"key":"5815_CR104","doi-asserted-by":"publisher","first-page":"840164","DOI":"10.3389\/fcimb.2022.840164","volume":"12","author":"AW Day","year":"2022","unstructured":"Day AW, Kumamoto CA (2022) Gut Microbiome dysbiosis in alcoholism: consequences for health and recovery. Front Cell Infect Microbiol 12:840164","journal-title":"Front Cell Infect Microbiol"},{"issue":"4","key":"5815_CR105","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/s41575-018-0099-1","volume":"16","author":"JS Bajaj","year":"2019","unstructured":"Bajaj JS (2019) Alcohol, liver disease and the gut microbiota. Nat Rev Gastroenterol Hepatol 16(4):235\u2013246","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"5815_CR106","doi-asserted-by":"crossref","unstructured":"Dukic M et al (2023) Alcohol, inflammation, and microbiota in alcoholic liver disease. Int J Mol Sci 24(4):3735","DOI":"10.3390\/ijms24043735"},{"key":"5815_CR107","doi-asserted-by":"publisher","first-page":"1159148","DOI":"10.3389\/fendo.2023.1159148","volume":"14","author":"L Zhang","year":"2023","unstructured":"Zhang L et al (2023) Investigating causal associations among gut microbiota, metabolites, and liver diseases: a Mendelian randomization study. Front Endocrinol (Lausanne) 14:1159148","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"5815_CR108","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s12602-022-10005-x","volume":"15","author":"H Liu","year":"2023","unstructured":"Liu H et al (2023) Compound probiotic ameliorates acute alcoholic liver disease in mice by modulating gut microbiota and maintaining intestinal barrier. Probiotics Antimicrob Proteins 15(1):185\u2013201","journal-title":"Probiotics Antimicrob Proteins"},{"key":"5815_CR109","doi-asserted-by":"crossref","unstructured":"Xu T et al (2022) Hawk tea flavonoids as natural hepatoprotective agents alleviate acute liver damage by reshaping the intestinal microbiota and modulating the Nrf2 and NF-kappaB signaling pathways. Nutrients 14(17):3662","DOI":"10.3390\/nu14173662"},{"key":"5815_CR110","doi-asserted-by":"publisher","first-page":"111888","DOI":"10.1016\/j.nut.2022.111888","volume":"106","author":"RU Thoen","year":"2023","unstructured":"Thoen RU et al (2023) Alcoholic liver disease and intestinal microbiota in an experimental model: biochemical, inflammatory, and histologic parameters. Nutrition 106:111888","journal-title":"Nutrition"},{"issue":"6","key":"5815_CR111","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1080\/19490976.2019.1580097","volume":"10","author":"ST Bjorkhaug","year":"2019","unstructured":"Bjorkhaug ST et al (2019) Characterization of gut microbiota composition and functions in patients with chronic alcohol overconsumption. Gut Microbes 10(6):663\u2013675","journal-title":"Gut Microbes"},{"key":"5815_CR112","doi-asserted-by":"crossref","unstructured":"Litwinowicz K, Gamian A (2023) Microbiome alterations in alcohol use disorder and alcoholic liver disease. Int J Mol Sci 24(3):2461","DOI":"10.3390\/ijms24032461"},{"issue":"1","key":"5815_CR113","doi-asserted-by":"publisher","first-page":"1785251","DOI":"10.1080\/19490976.2020.1785251","volume":"12","author":"S Lang","year":"2020","unstructured":"Lang S et al (2020) Changes in the fecal bacterial microbiota associated with disease severity in alcoholic hepatitis patients. Gut Microbes 12(1):1785251","journal-title":"Gut Microbes"},{"issue":"5","key":"5815_CR114","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1136\/gutjnl-2016-313432","volume":"67","author":"C Grander","year":"2018","unstructured":"Grander C et al (2018) Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease. Gut 67(5):891\u2013901","journal-title":"Gut"},{"issue":"20","key":"5815_CR115","doi-asserted-by":"publisher","first-page":"10053","DOI":"10.1039\/D1FO01693H","volume":"12","author":"W Nie","year":"2021","unstructured":"Nie W et al (2021) Oligopeptides from Jinhua Ham prevent alcohol-induced liver damage by regulating intestinal homeostasis and oxidative stress in mice. Food Funct 12(20):10053\u201310070","journal-title":"Food Funct"},{"issue":"3","key":"5815_CR116","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jhep.2019.09.029","volume":"72","author":"H Chu","year":"2020","unstructured":"Chu H et al (2020) The Candida albicans exotoxin Candidalysin promotes alcohol-associated liver disease. J Hepatol 72(3):391\u2013400","journal-title":"J Hepatol"},{"issue":"6","key":"5815_CR117","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1002\/hep.31459","volume":"72","author":"L Jiang","year":"2020","unstructured":"Jiang L et al (2020) Intestinal Virome in patients with alcoholic hepatitis. Hepatology 72(6):2182\u20132196","journal-title":"Hepatology"},{"key":"5815_CR118","doi-asserted-by":"publisher","first-page":"1018557","DOI":"10.3389\/fendo.2022.1018557","volume":"13","author":"J Liu","year":"2022","unstructured":"Liu J et al (2022) Seabuckthorn polysaccharide combined with astragalus polysaccharide ameliorate alcoholic fatty liver by regulating intestinal flora. Front Endocrinol (Lausanne) 13:1018557","journal-title":"Front Endocrinol (Lausanne)"},{"key":"5815_CR119","doi-asserted-by":"publisher","first-page":"1068825","DOI":"10.3389\/fmicb.2022.1068825","volume":"13","author":"X Wang","year":"2022","unstructured":"Wang X et al (2022) Alterations and correlations of gut microbiota, fecal, and serum metabolome characteristics in a rat model of alcohol use disorder. Front Microbiol 13:1068825","journal-title":"Front Microbiol"},{"key":"5815_CR120","doi-asserted-by":"publisher","first-page":"1053718","DOI":"10.3389\/fnut.2022.1053718","volume":"9","author":"L Xu","year":"2022","unstructured":"Xu L et al (2022) Oenothein B ameliorates hepatic injury in alcoholic liver disease mice by improving oxidative stress and inflammation and modulating the gut microbiota. Front Nutr 9:1053718","journal-title":"Front Nutr"},{"issue":"18","key":"5815_CR121","doi-asserted-by":"publisher","first-page":"9391","DOI":"10.1039\/D2FO01547A","volume":"13","author":"Y Du","year":"2022","unstructured":"Du Y et al (2022) Fu brick tea alleviates alcoholic liver injury by modulating the gut microbiota-liver axis and inhibiting the hepatic TLR4\/NF-kappaB signaling pathway. Food Funct 13(18):9391\u20139406","journal-title":"Food Funct"},{"key":"5815_CR122","doi-asserted-by":"publisher","first-page":"100546","DOI":"10.1016\/j.crfs.2023.100546","volume":"7","author":"KY Lin","year":"2023","unstructured":"Lin KY et al (2023) Caulerpa lentillifera improves ethanol-induced liver injury and modulates the gut microbiota in rats. Curr Res Food Sci 7:100546","journal-title":"Curr Res Food Sci"},{"issue":"12","key":"5815_CR123","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1089\/jmf.2022.K.0056","volume":"25","author":"MH Do","year":"2022","unstructured":"Do MH et al (2022) Morinda citrifolia extract prevents alcoholic fatty liver disease by improving gut health. J Med Food 25(12):1102\u20131111","journal-title":"J Med Food"},{"issue":"3","key":"5815_CR124","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1002\/hep.27489","volume":"61","author":"P Chen","year":"2015","unstructured":"Chen P et al (2015) Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice. Hepatology 61(3):883\u2013894","journal-title":"Hepatology"},{"key":"5815_CR125","doi-asserted-by":"crossref","unstructured":"Helsley RN et al (2022) Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice. Elife 11:e76554","DOI":"10.7554\/eLife.76554.sa2"},{"issue":"5","key":"5815_CR126","doi-asserted-by":"publisher","first-page":"101123","DOI":"10.1016\/j.aohep.2023.101123","volume":"28","author":"L Abenavoli","year":"2023","unstructured":"Abenavoli L, Scarpellini E (2023) Gut dysbiosis in alcoholic liver disease: wonderful dilemma? Ann Hepatol 28(5):101123","journal-title":"Ann Hepatol"},{"key":"5815_CR127","doi-asserted-by":"crossref","unstructured":"Hyun JY et al (2022) Microbiome-Based metabolic therapeutic approaches in alcoholic liver disease. Int J Mol Sci 23(15):8749","DOI":"10.3390\/ijms23158749"},{"key":"5815_CR128","doi-asserted-by":"publisher","first-page":"120760","DOI":"10.1016\/j.lfs.2022.120760","volume":"305","author":"N Zafari","year":"2022","unstructured":"Zafari N et al (2022) Role of gut bacterial and non-bacterial microbiota in alcohol-associated liver disease: molecular mechanisms, biomarkers, and therapeutic prospective. Life Sci 305:120760","journal-title":"Life Sci"},{"key":"5815_CR129","doi-asserted-by":"crossref","unstructured":"Gao H et al (2024) Cell-to-cell and organ-to-organ crosstalk in the pathogenesis of alcohol-associated liver disease. eGastroenterology 2(4):e100104","DOI":"10.1136\/egastro-2024-100104"},{"issue":"1","key":"5815_CR130","doi-asserted-by":"publisher","first-page":"1984122","DOI":"10.1080\/19490976.2021.1984122","volume":"13","author":"W Gao","year":"2021","unstructured":"Gao W et al (2021) Gut non-bacterial microbiota contributing to alcohol-associated liver disease. Gut Microbes 13(1):1984122","journal-title":"Gut Microbes"},{"issue":"3","key":"5815_CR131","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.chom.2023.02.001","volume":"31","author":"S Zeng","year":"2023","unstructured":"Zeng S et al (2023) Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease. Cell Host Microbe 31(3):389\u2013404.e7","journal-title":"Cell Host Microbe"},{"issue":"7783","key":"5815_CR132","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/s41586-019-1742-x","volume":"575","author":"Y Duan","year":"2019","unstructured":"Duan Y et al (2019) Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature 575(7783):505\u2013511","journal-title":"Nature"},{"issue":"5","key":"5815_CR133","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1002\/hep.31496","volume":"73","author":"JS Bajaj","year":"2021","unstructured":"Bajaj JS et al (2021) A randomized clinical trial of fecal microbiota transplant for alcohol use disorder. Hepatology 73(5):1688\u20131700","journal-title":"Hepatology"},{"issue":"1","key":"5815_CR134","doi-asserted-by":"publisher","first-page":"6198","DOI":"10.1038\/s41467-022-34054-6","volume":"13","author":"JT Wolstenholme","year":"2022","unstructured":"Wolstenholme JT et al (2022) Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice. Nat Commun 13(1):6198","journal-title":"Nat Commun"},{"issue":"1","key":"5815_CR135","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1007\/s12072-022-10438-0","volume":"17","author":"A Pande","year":"2023","unstructured":"Pande A et al (2023) Fecal microbiota transplantation compared with prednisolone in severe alcoholic hepatitis patients: a randomized trial. Hepatol Int 17(1):249\u2013261","journal-title":"Hepatol Int"},{"issue":"4","key":"5815_CR136","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.cgh.2016.10.029","volume":"15","author":"CA Philips","year":"2017","unstructured":"Philips CA et al (2017) Healthy donor fecal microbiota transplantation in Steroid-Ineligible severe alcoholic hepatitis: A pilot study. Clin Gastroenterol Hepatol 15(4):600\u2013602","journal-title":"Clin Gastroenterol Hepatol"},{"key":"5815_CR137","doi-asserted-by":"publisher","first-page":"175096","DOI":"10.1016\/j.ejphar.2022.175096","volume":"928","author":"H Zhu","year":"2022","unstructured":"Zhu H et al (2022) Ameliorative effects of chlorogenic acid on alcoholic liver injury in mice via gut microbiota informatics. Eur J Pharmacol 928:175096","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"5815_CR138","doi-asserted-by":"publisher","first-page":"2281014","DOI":"10.1080\/19490976.2023.2281014","volume":"15","author":"JA Eom","year":"2023","unstructured":"Eom JA et al (2023) Gut-microbiota prompt activation of natural killer cell on alcoholic liver disease. Gut Microbes 15(2):2281014","journal-title":"Gut Microbes"},{"issue":"18","key":"5815_CR139","doi-asserted-by":"publisher","first-page":"e0083421","DOI":"10.1128\/AEM.00834-21","volume":"87","author":"F Yang","year":"2021","unstructured":"Yang F et al (2021) Integrated analyses of the gut microbiota, intestinal permeability, and serum metabolome phenotype in rats with alcohol withdrawal syndrome. Appl Environ Microbiol 87(18):e0083421","journal-title":"Appl Environ Microbiol"},{"key":"5815_CR140","doi-asserted-by":"publisher","first-page":"109061","DOI":"10.1016\/j.jnutbio.2022.109061","volume":"107","author":"P Guo","year":"2022","unstructured":"Guo P et al (2022) Antarctic Krill oil ameliorates liver injury in rats exposed to alcohol by regulating bile acids metabolism and gut microbiota. J Nutr Biochem 107:109061","journal-title":"J Nutr Biochem"},{"issue":"5","key":"5815_CR141","doi-asserted-by":"publisher","first-page":"e63388","DOI":"10.1371\/journal.pone.0063388","volume":"8","author":"H Endo","year":"2013","unstructured":"Endo H et al (2013) Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis. PLoS ONE 8(5):e63388","journal-title":"PLoS ONE"},{"issue":"10","key":"5815_CR142","doi-asserted-by":"publisher","first-page":"e14372","DOI":"10.1111\/jfbc.14372","volume":"46","author":"X Li","year":"2022","unstructured":"Li X et al (2022) The effect of Lactobacillus rhamnosus B10 on alcoholic liver injury and intestinal microbiota in alcohol-induced mice model. J Food Biochem 46(10):e14372","journal-title":"J Food Biochem"},{"key":"5815_CR143","doi-asserted-by":"crossref","unstructured":"Patel D et al (2022) Synbiotic Intervention Ameliorates Oxidative Stress and Gut Permeability in an In Vitro and In Vivo Model of Ethanol-Induced Intestinal Dysbiosis. Biomedicines 10(12):3285","DOI":"10.3390\/biomedicines10123285"},{"issue":"4","key":"5815_CR144","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1002\/hep.32608","volume":"77","author":"M Jiang","year":"2023","unstructured":"Jiang M et al (2023) Probiotic-derived nanoparticles inhibit ALD through intestinal miR194 suppression and subsequent FXR activation. Hepatology 77(4):1164\u20131180","journal-title":"Hepatology"},{"issue":"1","key":"5815_CR145","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13578-023-00974-z","volume":"13","author":"L Chen","year":"2023","unstructured":"Chen L et al (2023) Modulating phenylalanine metabolism by L. acidophilus alleviates alcohol-related liver disease through enhancing intestinal barrier function. Cell Biosci 13(1):24","journal-title":"Cell Biosci"},{"key":"5815_CR146","doi-asserted-by":"publisher","first-page":"153487","DOI":"10.1016\/j.tox.2023.153487","volume":"488","author":"S Wang","year":"2023","unstructured":"Wang S et al (2023) Bacillus subtilis pretreatment alleviates ethanol-induced acute liver injury by regulating the Gut-liver axis in mice. Toxicology 488:153487","journal-title":"Toxicology"},{"issue":"20","key":"5815_CR147","doi-asserted-by":"publisher","first-page":"10281","DOI":"10.1039\/D1FO01117K","volume":"12","author":"X Yan","year":"2021","unstructured":"Yan X et al (2021) Gut dysbiosis correction contributes to the hepatoprotective effects of Thymus quinquecostatus Celak extract against alcohol through the gut-liver axis. Food Funct 12(20):10281\u201310290","journal-title":"Food Funct"},{"key":"5815_CR148","doi-asserted-by":"crossref","unstructured":"Zhang J et al (2023) Alleviation of alcoholic fatty liver by Dendrobium officinale flower extracts due to regulation of gut microbiota and Short-Chain fatty acids in mice exposed to chronic alcohol. Foods 12(7):1428","DOI":"10.3390\/foods12071428"},{"issue":"1","key":"5815_CR149","doi-asserted-by":"publisher","first-page":"2216942","DOI":"10.1080\/07853890.2023.2216942","volume":"55","author":"S Wu","year":"2023","unstructured":"Wu S et al (2023) Astragaloside IV ameliorate acute alcohol-induced liver injury in mice via modulating gut microbiota and regulating NLRP3\/caspase-1 signaling pathway. Ann Med 55(1):2216942","journal-title":"Ann Med"},{"issue":"5","key":"5815_CR150","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1111\/liv.15207","volume":"42","author":"C Jimenez","year":"2022","unstructured":"Jimenez C et al (2022) Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: A pilot study (RIFA-AH). Liver Int 42(5):1109\u20131120","journal-title":"Liver Int"},{"issue":"1","key":"5815_CR151","doi-asserted-by":"publisher","first-page":"101571","DOI":"10.1016\/j.aohep.2024.101571","volume":"30","author":"X Wang","year":"2024","unstructured":"Wang X et al (2024) Efficacy of prophylactic antibiotics in the adjuvant treatment of alcohol-related liver disease (ALD): A systematic review and meta-analysisProphylactic antibiotics in ALD. Ann Hepatol 30(1):101571","journal-title":"Ann Hepatol"},{"key":"5815_CR152","doi-asserted-by":"publisher","first-page":"985141","DOI":"10.3389\/fmed.2022.985141","volume":"9","author":"Y Daou","year":"2022","unstructured":"Daou Y et al (2022) Host and microbiota derived extracellular vesicles: crucial players in iron homeostasis. Front Med (Lausanne) 9:985141","journal-title":"Front Med (Lausanne)"},{"issue":"S1","key":"5815_CR153","doi-asserted-by":"publisher","first-page":"24","DOI":"10.33594\/000000620","volume":"57","author":"E Delesderrier","year":"2023","unstructured":"Delesderrier E et al (2023) Can Iron and polyunsaturated fatty acid supplementation induce ferroptosis?? Cell Physiol Biochem 57(S1):24\u201341","journal-title":"Cell Physiol Biochem"},{"issue":"12","key":"5815_CR154","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1080\/10408398.2019.1630599","volume":"60","author":"X Qi","year":"2020","unstructured":"Qi X et al (2020) Mechanism and intervention measures of iron side effects on the intestine. Crit Rev Food Sci Nutr 60(12):2113\u20132125","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"29","key":"5815_CR155","doi-asserted-by":"publisher","first-page":"10714","DOI":"10.1080\/10408398.2023.2227888","volume":"64","author":"DK Dje Kouadio","year":"2024","unstructured":"Dje Kouadio DK et al (2024) Bacteria from the gut influence the host micronutrient status. Crit Rev Food Sci Nutr 64(29):10714\u201310729","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"5815_CR156","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/s41522-019-0097-2","volume":"5","author":"F La Carpia","year":"2019","unstructured":"La Carpia F et al (2019) Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron. NPJ Biofilms Microbiomes 5(1):26","journal-title":"NPJ Biofilms Microbiomes"},{"key":"5815_CR157","doi-asserted-by":"crossref","unstructured":"Bao H et al (2024) Mechanism of Iron ion homeostasis in intestinal immunity and gut microbiota remodeling. Int J Mol Sci 25(2):727","DOI":"10.3390\/ijms25020727"},{"issue":"1","key":"5815_CR158","doi-asserted-by":"publisher","first-page":"2361660","DOI":"10.1080\/19490976.2024.2361660","volume":"16","author":"ML Noordine","year":"2024","unstructured":"Noordine ML et al (2024) The microbiota and the host organism switch between Cooperation and competition based on dietary iron levels. Gut Microbes 16(1):2361660","journal-title":"Gut Microbes"},{"issue":"9","key":"5815_CR159","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1007\/s11427-022-2409-0","volume":"66","author":"Z Dong","year":"2023","unstructured":"Dong Z et al (2023) Role of iron in host-microbiota interaction and its effects on intestinal mucosal growth and immune plasticity in a piglet model. Sci China Life Sci 66(9):2086\u20132098","journal-title":"Sci China Life Sci"},{"issue":"2","key":"5815_CR160","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1007\/s12011-019-1658-1","volume":"192","author":"K Skrypnik","year":"2019","unstructured":"Skrypnik K et al (2019) The effect of multispecies probiotic supplementation on Iron status in rats. Biol Trace Elem Res 192(2):234\u2013243","journal-title":"Biol Trace Elem Res"},{"issue":"8","key":"5815_CR161","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1017\/S000711451500241X","volume":"114","author":"M Hoppe","year":"2015","unstructured":"Hoppe M et al (2015) Probiotic strain Lactobacillus plantarum 299v increases iron absorption from an iron-supplemented fruit drink: a double-isotope cross-over single-blind study in women of reproductive age. Br J Nutr 114(8):1195\u20131202","journal-title":"Br J Nutr"},{"issue":"1","key":"5815_CR162","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.cmet.2019.10.005","volume":"31","author":"NK Das","year":"2020","unstructured":"Das NK et al (2020) Microbial metabolite signaling is required for systemic Iron homeostasis. Cell Metab 31(1):115\u2013130e6","journal-title":"Cell Metab"},{"issue":"2","key":"5815_CR163","doi-asserted-by":"publisher","first-page":"108158","DOI":"10.1016\/j.jbc.2025.108158","volume":"301","author":"AK Sewell","year":"2025","unstructured":"Sewell AK et al (2025) Enterobactin carries iron into Caenorhabditis elegans and mammalian intestinal cells by a mechanism independent of divalent metal transporter DMT1. J Biol Chem 301(2):108158","journal-title":"J Biol Chem"},{"issue":"1","key":"5815_CR164","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.apsb.2024.10.010","volume":"15","author":"A Zhuge","year":"2025","unstructured":"Zhuge A et al (2025) Akkermansia muciniphila-derived acetate activates the hepatic AMPK\/SIRT1\/PGC-1alpha axis to alleviate ferroptosis in metabolic-associated fatty liver disease. Acta Pharm Sin B 15(1):151\u2013167","journal-title":"Acta Pharm Sin B"},{"issue":"Pt 1","key":"5815_CR165","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.freeradbiomed.2022.10.270","volume":"193","author":"S Liu","year":"2022","unstructured":"Liu S et al (2022) The gut microbiota metabolite glycochenodeoxycholate activates TFR-ACSL4-mediated ferroptosis to promote the development of environmental toxin-linked MAFLD. Free Radic Biol Med 193(Pt 1):213\u2013226","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"5815_CR166","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1177\/10815589231204058","volume":"72","author":"G Bu","year":"2024","unstructured":"Bu G et al (2024) Bifidobacterium bifidum BGN4 fractions ameliorate palmitic acid-induced hepatocyte ferroptosis by inhibiting SREBP1-CYP2E1 pathway. J Investig Med 72(1):67\u201379","journal-title":"J Investig Med"},{"issue":"10","key":"5815_CR167","doi-asserted-by":"publisher","first-page":"2687","DOI":"10.1007\/s00210-023-02492-8","volume":"396","author":"J Xu","year":"2023","unstructured":"Xu J et al (2023) Urolithin C reveals anti-NAFLD potential via AMPK-ferroptosis axis and modulating gut microbiota. Naunyn Schmiedebergs Arch Pharmacol 396(10):2687\u20132699","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"33","key":"5815_CR168","doi-asserted-by":"publisher","first-page":"20800","DOI":"10.1021\/acsomega.0c01689","volume":"5","author":"K Ning","year":"2020","unstructured":"Ning K et al (2020) Epigallocatechin gallate protects mice against Methionine-Choline-Deficient-Diet-Induced nonalcoholic steatohepatitis by improving gut microbiota to attenuate hepatic injury and regulate metabolism. ACS Omega 5(33):20800\u201320809","journal-title":"ACS Omega"},{"issue":"5","key":"5815_CR169","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1016\/j.apsb.2024.02.017","volume":"14","author":"J Fu","year":"2024","unstructured":"Fu J et al (2024) A combined nanotherapeutic approach targeting farnesoid X receptor, ferroptosis, and fibrosis for nonalcoholic steatohepatitis treatment. Acta Pharm Sin B 14(5):2228\u20132246","journal-title":"Acta Pharm Sin B"},{"key":"5815_CR170","doi-asserted-by":"publisher","first-page":"119571","DOI":"10.1016\/j.jep.2025.119571","volume":"345","author":"S Gao","year":"2025","unstructured":"Gao S et al (2025) Total Sanghuangporus vaninii extract inhibits hepatocyte ferroptosis and intestinal microbiota disturbance to attenuate liver fibrosis in mice. J Ethnopharmacol 345:119571","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"5815_CR171","doi-asserted-by":"publisher","first-page":"2410474","DOI":"10.1080\/19490976.2024.2410474","volume":"16","author":"H Yu","year":"2024","unstructured":"Yu H et al (2024) Synergistic activity of Enterococcus Faecium-induced ferroptosis via expansion of IFN-gamma(+)CD8(+) T cell population in advanced hepatocellular carcinoma treated with Sorafenib. Gut Microbes 16(1):2410474","journal-title":"Gut Microbes"},{"issue":"Pt 2","key":"5815_CR172","doi-asserted-by":"publisher","first-page":"140460","DOI":"10.1016\/j.foodchem.2024.140460","volume":"460","author":"Y Chen","year":"2024","unstructured":"Chen Y et al (2024) Hepatoprotective potential of four fruit extracts rich in different structural flavonoids against alcohol-induced liver injury via gut microbiota-liver axis. Food Chem 460(Pt 2):140460","journal-title":"Food Chem"},{"issue":"38","key":"5815_CR173","doi-asserted-by":"publisher","first-page":"21181","DOI":"10.1021\/acs.jafc.4c04762","volume":"72","author":"L Zhou","year":"2024","unstructured":"Zhou L et al (2024) Ursolic acid ameliorates alcoholic liver injury through attenuating oxidative Stress-Mediated ferroptosis and modulating gut microbiota. J Agric Food Chem 72(38):21181\u201321192","journal-title":"J Agric Food Chem"},{"issue":"3","key":"5815_CR174","doi-asserted-by":"publisher","first-page":"105250","DOI":"10.1016\/j.micinf.2023.105250","volume":"26","author":"C Yao","year":"2024","unstructured":"Yao C et al (2024) Porphyromonas gingivalis as a promotor in the development of the alcoholic liver disease via ferroptosis. Microbes Infect 26(3):105250","journal-title":"Microbes Infect"},{"key":"5815_CR175","doi-asserted-by":"crossref","unstructured":"Wang F et al (2024) Gut microbiota-derived gamma-aminobutyric acid from Metformin treatment reduces hepatic ischemia\/reperfusion injury through inhibiting ferroptosis. Elife 12:RP89045","DOI":"10.7554\/eLife.89045"},{"issue":"1","key":"5815_CR176","doi-asserted-by":"publisher","first-page":"2460543","DOI":"10.1080\/19490976.2025.2460543","volume":"17","author":"S Deng","year":"2025","unstructured":"Deng S et al (2025) Lachnospiraceae-bacterium alleviates ischemia-reperfusion injury in steatotic donor liver by inhibiting ferroptosis via the Foxo3-Alox15 signaling pathway. Gut Microbes 17(1):2460543","journal-title":"Gut Microbes"},{"key":"5815_CR177","doi-asserted-by":"publisher","first-page":"413","DOI":"10.2217\/fmb-2023-0133","volume":"19","author":"M Yuan","year":"2024","unstructured":"Yuan M et al (2024) Ferrostatin-1 improves prognosis and regulates gut microbiota of steatotic liver transplantation recipients in rats. Future Microbiol 19:413\u2013429","journal-title":"Future Microbiol"},{"issue":"5","key":"5815_CR178","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.chom.2023.04.002","volume":"31","author":"Y Zeng","year":"2023","unstructured":"Zeng Y et al (2023) Liberation of Daidzein by gut microbial beta-galactosidase suppresses acetaminophen-induced hepatotoxicity in mice. Cell Host Microbe 31(5):766\u2013780.e7","journal-title":"Cell Host Microbe"},{"issue":"1","key":"5815_CR179","doi-asserted-by":"publisher","first-page":"113591","DOI":"10.1016\/j.celrep.2023.113591","volume":"43","author":"CJ Yang","year":"2024","unstructured":"Yang CJ et al (2024) Oral fecal transplantation enriches Lachnospiraceae and butyrate to mitigate acute liver injury. Cell Rep 43(1):113591","journal-title":"Cell Rep"},{"key":"5815_CR180","doi-asserted-by":"crossref","unstructured":"Huang S et al (2023) Total flavonoids of rhizoma drynariae mitigates aflatoxin B1-Induced liver toxicity in chickens via Microbiota-Gut-Liver Axis interaction mechanisms. Antioxid (Basel) 12(4):819","DOI":"10.3390\/antiox12040819"},{"issue":"16","key":"5815_CR181","doi-asserted-by":"publisher","first-page":"7692","DOI":"10.1039\/D3FO01684F","volume":"14","author":"W Huang","year":"2023","unstructured":"Huang W et al (2023) Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota. Food Funct 14(16):7692\u20137704","journal-title":"Food Funct"},{"issue":"1","key":"5815_CR182","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/s41420-024-02168-z","volume":"10","author":"HL Xu","year":"2024","unstructured":"Xu HL et al (2024) Targeting cell death in NAFLD: mechanisms and targeted therapies. Cell Death Discov 10(1):399","journal-title":"Cell Death Discov"},{"issue":"1\u20132","key":"5815_CR183","doi-asserted-by":"publisher","first-page":"105040","DOI":"10.1016\/j.micinf.2022.105040","volume":"25","author":"C Yao","year":"2023","unstructured":"Yao C et al (2023) Porphyromonas gingivalis is a risk factor for the development of nonalcoholic fatty liver disease via ferroptosis. Microbes Infect 25(1\u20132):105040","journal-title":"Microbes Infect"},{"key":"5815_CR184","doi-asserted-by":"publisher","first-page":"127704","DOI":"10.1016\/j.micres.2024.127704","volume":"283","author":"H Mo","year":"2024","unstructured":"Mo H et al (2024) Ferrous sulphate triggers ferroptosis in Candida albicans and cures vulvovaginal candidiasis in a mouse model. Microbiol Res 283:127704","journal-title":"Microbiol Res"},{"key":"5815_CR185","doi-asserted-by":"publisher","first-page":"103954","DOI":"10.1016\/j.fgb.2024.103954","volume":"176","author":"H Miao","year":"2025","unstructured":"Miao H et al (2025) PPZ1-TORC1 pathway mediates ferroptosis and antifungal resistance in Candida albicans. Fungal Genet Biol 176:103954","journal-title":"Fungal Genet Biol"},{"key":"5815_CR186","doi-asserted-by":"publisher","first-page":"106884","DOI":"10.1016\/j.ultsonch.2024.106884","volume":"106","author":"J Sun","year":"2024","unstructured":"Sun J et al (2024) Ferrous sulfate combined with ultrasound emulsified cinnamaldehyde nanoemulsion to cause ferroptosis in Escherichia coli O157:H7. Ultrason Sonochem 106:106884","journal-title":"Ultrason Sonochem"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-025-05815-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-025-05815-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-025-05815-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T16:40:18Z","timestamp":1757263218000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-025-05815-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,19]]},"references-count":186,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5815"],"URL":"https:\/\/doi.org\/10.1007\/s00018-025-05815-5","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,19]]},"assertion":[{"value":"22 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have approved the manuscript and agree with submission to Cellular and Molecular Life Sciences.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"282"}}