{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:15:01Z","timestamp":1792782901344,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the National Key R&D Program of China","award":["2023YFC0871200"],"award-info":[{"award-number":["2023YFC0871200"]}]},{"name":"the National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention","award":["33054"],"award-info":[{"award-number":["33054"]}],"id":[{"id":"https:\/\/ror.org\/04wktzw65","id-type":"ROR","asserted-by":"crossref"}]},{"name":"the National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention","award":["29172"],"award-info":[{"award-number":["29172"]}],"id":[{"id":"https:\/\/ror.org\/04wktzw65","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-025-05910-7","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T13:59:57Z","timestamp":1762437597000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["B.uniformis IM01-derived IAA alleviates asthma via AhR\/NLRP3 pathways in mice"],"prefix":"10.1007","volume":"82","author":[{"given":"Yujia","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jielan","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqiong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-2600","authenticated-orcid":false,"given":"Zhihong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"5910_CR1","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.jaip.2014.09.004","volume":"2","author":"M Schatz","year":"2014","unstructured":"Schatz M, Rosenwasser L (2014) The allergic asthma phenotype. J Allergy Clin Immunol Pract 2:645\u2013648 .quiz 649","journal-title":"J Allergy Clin Immunol Pract"},{"key":"5910_CR2","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1056\/NEJMra1800345","volume":"381","author":"SC Christiansen","year":"2019","unstructured":"Christiansen SC, Zuraw BL (2019) Treatment of hypertension in patients with asthma. N Engl J Med 381:1046\u20131057","journal-title":"N Engl J Med"},{"key":"5910_CR3","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.immuni.2020.01.007","volume":"52","author":"W Barcik","year":"2020","unstructured":"Barcik W, Boutin RCT, Sokolowska M, Finlay BB (2020) The role of lung and gut microbiota in the pathology of asthma. Immunity 52:241\u2013255","journal-title":"Immunity"},{"key":"5910_CR4","doi-asserted-by":"publisher","first-page":"2003393","DOI":"10.1183\/13993003.03393-2020","volume":"58","author":"WW Busse","year":"2021","unstructured":"Busse WW, Kraft M, Rabe KF, Deniz Y, Rowe PJ, Ruddy M, Castro M (2021) Understanding the key issues in the treatment of uncontrolled persistent asthma with type 2 inflammation. Eur Respir J 58:2003393","journal-title":"Eur Respir J"},{"key":"5910_CR5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1056\/NEJMra2032506","volume":"386","author":"GG Brusselle","year":"2022","unstructured":"Brusselle GG, Koppelman GH (2022) Biologic therapies for severe asthma. N Engl J Med 386:157\u2013171","journal-title":"N Engl J Med"},{"key":"5910_CR6","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1126\/science.1195568","volume":"330","author":"YK Lee","year":"2010","unstructured":"Lee YK, Mazmanian SK (2010) Has the microbiota played a critical role in the evolution of the adaptive immune system? Science 330:1768\u20131773","journal-title":"Science"},{"key":"5910_CR7","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1111\/all.15606","volume":"78","author":"B Alashkar Alhamwe","year":"2023","unstructured":"Alashkar Alhamwe B, Gao Z, Alhamdan F, Harb H, Pichene M, Garnier A, El Andari J et al (2023) Intranasal administration of Acinetobacter lwoffii in a murine model of asthma induces IL-6-mediated protection associated with cecal microbiota changes. Allergy 78:1245\u20131257","journal-title":"Allergy"},{"key":"5910_CR8","doi-asserted-by":"crossref","unstructured":"Lee-Sarwar KA, Chen YC, Chen YY, Kozyrskyj AL, Mandhane PJ, Turvey SE, Subbarao P, Bisgaard H et al (2023) The maternal prenatal and offspring early-life gut Microbiome of childhood asthma phenotypes. Allergy 418\u2013428","DOI":"10.1111\/all.15516"},{"key":"5910_CR9","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/j.jaci.2023.07.024","volume":"152","author":"M Mahdavinia","year":"2023","unstructured":"Mahdavinia M, Fyolek JP, Jiang J, Thivalapill N, Bilaver LA, Warren C, Fox S, Nimmagadda SR et al (2023) Gut Microbiome is associated with asthma and race in children with food allergy. J Allergy Clin Immunol 152:1541\u20131549","journal-title":"J Allergy Clin Immunol"},{"key":"5910_CR10","doi-asserted-by":"publisher","first-page":"620943","DOI":"10.3389\/fimmu.2021.620943","volume":"12","author":"W Pang","year":"2021","unstructured":"Pang W, Jiang Y, Li A, Zhang J, Chen M, Hu L, Li Z, Wang D (2021) Bacteroides thetaiotaomicron ameliorates experimental allergic airway inflammation via activation of ICOS\u2009+\u2009Tregs and inhibition of Th2 response. Front Immunol 12:620943","journal-title":"Front Immunol"},{"key":"5910_CR11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fcimb.2018.00013","volume":"8","author":"J Gao","year":"2018","unstructured":"Gao J, Xu K, Liu H, Liu G, Bai M, Peng C, Li T, Yin Y (2018) Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism. Front Cell Infect Microbiol 8:13","journal-title":"Front Cell Infect Microbiol"},{"issue":"10","key":"5910_CR12","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1080\/10408398.2019.1598334","volume":"60","author":"M Sun","year":"2020","unstructured":"Sun M, Ma N, He T, Johnston LJ, Ma X (2020) Tryptophan (Trp) modulates gut homeostasis via Aryl hydrocarbon receptor (AhR). Crit Rev Food Sci Nutr 60(10):1760\u20131768","journal-title":"Crit Rev Food Sci Nutr"},{"key":"5910_CR13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1186\/s12974-019-1572-7","volume":"16","author":"WC Chen","year":"2019","unstructured":"Chen WC, Chang LH, Huang SS, Huang YJ, Chih CL, Kuo HC, Lee YH, Lee IH (2019) Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain. J Neuroinflammation 16:187","journal-title":"J Neuroinflammation"},{"key":"5910_CR14","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1111\/bpa.12908","volume":"30","author":"O Mossad","year":"2020","unstructured":"Mossad O, Erny D (2020) The microbiota-microglia axis in central nervous system disorders. Brain Pathol 30:1159\u20131177","journal-title":"Brain Pathol"},{"key":"5910_CR15","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/s41577-019-0125-8","volume":"19","author":"V Rothhammer","year":"2019","unstructured":"Rothhammer V, Quintana FJ (2019) The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease. Nat Rev Immunol 19:184\u2013197","journal-title":"Nat Rev Immunol"},{"key":"5910_CR16","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.brainresbull.2021.08.013","volume":"176","author":"Y Zhou","year":"2021","unstructured":"Zhou Y, Zhao WJ, Quan W, Qiao CM, Cui C, Hong H, Shi Y, Niu GY, Zhao LP, Shen YQ (2021) Dynamic changes of activated AHR in microglia and astrocytes in the substantia nigra-striatum system in an MPTP-induced parkinson\u2019s disease mouse model. Brain Res Bull 176:174\u2013183","journal-title":"Brain Res Bull"},{"key":"5910_CR17","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.freeradbiomed.2024.08.009","volume":"224","author":"L Li","year":"2024","unstructured":"Li L, Xu Z, Ni H, Meng Y, Xu Y, Xu H, Zheng Y, Zhang Y, Xue G, Shang Y (2024) Hydrogen-rich water alleviates asthma airway inflammation by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation. Free Radic Biol Med 224:50\u201361","journal-title":"Free Radic Biol Med"},{"key":"5910_CR18","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.3390\/foods13091336","volume":"13","author":"H Wang","year":"2024","unstructured":"Wang H, He Y, Dang D, Zhao Y, Zhao J, Lu W (2024) Gut microbiota-derived tryptophan metabolites alleviate allergic asthma inflammation in Ovalbumin-induced mice. Foods 13:1336","journal-title":"Foods"},{"key":"5910_CR19","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.bbi.2022.08.003","volume":"106","author":"J Sun","year":"2022","unstructured":"Sun J, Zhang Y, Kong Y, Ye T, Yu Q, Kumaran Satyanarayanan S, Su KP, Liu J (2022) Microbiota-derived metabolite indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP\/PS1 mice. Brain Behav Immun 106:76\u201388","journal-title":"Brain Behav Immun"},{"key":"5910_CR20","doi-asserted-by":"publisher","first-page":"8810","DOI":"10.1039\/D4FO01079E","volume":"15","author":"H Wang","year":"2024","unstructured":"Wang H, He Y, Dang D, Feng L, Huang L, Zhao J, Lu S, Lu W (2024) Bifidobacterium animalis subsp. lactis CCFM1274 relieved allergic asthma symptoms by modifying intestinal tryptophan metabolism in mice. Food Funct 15:8810\u20138822","journal-title":"Food Funct"},{"key":"5910_CR21","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s40168-024-01896-9","volume":"12","author":"S Zhang","year":"2024","unstructured":"Zhang S, Nie Q, Sun Y, Zuo S, Chen C, Li S, Yang J, Hu J, Zhou X, Yu Y, Huang P, Lian L, Xie M, Nie S (2024) Bacteroides uniformis degrades \u03b2-glucan to promote Lactobacillus johnsonii improving indole-3-lactic acid levels in alleviating colitis. Microbiome 12:177","journal-title":"Microbiome"},{"key":"5910_CR22","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1038\/s41401-021-00781-7","volume":"43","author":"YY Li","year":"2022","unstructured":"Li YY, Wang XJ, Su YL, Wang Q, Huang SW, Pan ZF, Chen YP, Liang JJ, Zhang ML, Xie XQ, Wu ZY, Chen JY, Zhou L, Luo X (2022) Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR\/IL-22 pathway in ILC3s. Acta Pharmacol Sin 43:1495\u20131507","journal-title":"Acta Pharmacol Sin"},{"key":"5910_CR23","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1080\/19490976.2020.1766345","volume":"11","author":"I Spacova","year":"2020","unstructured":"Spacova I, Van Beeck W, Seys S, Devos F, Vanoirbeek J, Vanderleyden J, Ceuppens J, Petrova M, Lebeer S (2020) Lactobacillus rhamnosus probiotic prevents airway function deterioration and promotes gut microbiome resilience in a murine asthma model. Gut Microbes 11:1729\u20131744","journal-title":"Gut Microbes"},{"key":"5910_CR24","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228797","volume":"21","author":"O Poulain-Godefroy","year":"2020","unstructured":"Poulain-Godefroy O, Bout\u00e9 M, Carrard J, Alvarez-Simon D, Tsicopoulos A, de Nadai P (2020) The aryl hydrocarbon receptor in asthma: friend or foe?? Int J Mol Sci 21:8797","journal-title":"Int J Mol Sci"},{"key":"5910_CR25","doi-asserted-by":"publisher","first-page":"15300","DOI":"10.1096\/fj.202001529R","volume":"34","author":"YD Chang","year":"2020","unstructured":"Chang YD, Li CH, Tsai CH, Cheng YW, Kang JJ, Lee CC (2020) Aryl hydrocarbon receptor deficiency enhanced airway inflammation and remodeling in a murine chronic asthma model. FASEB J 34:15300\u201315313","journal-title":"FASEB J"},{"key":"5910_CR26","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1093\/toxsci\/kfx215","volume":"161","author":"AK Ehrlich","year":"2018","unstructured":"Ehrlich AK, Pennington JM, Bisson WH, Kolluri SK, Kerkvliet NI (2018) Tcdd, Ficz, and other high affinity Ahr ligands dose-dependently determine the fate of CD4\u2009+\u2009t cell differentiation. Toxicol Sci 161:310\u2013320","journal-title":"Toxicol Sci"},{"key":"5910_CR27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.immuni.2017.12.012","volume":"48","author":"C Guti\u00e9rrez-V\u00e1zquez","year":"2018","unstructured":"Guti\u00e9rrez-V\u00e1zquez C, Quintana FJ (2018) Regulation of the immune response by the aryl hydrocarbon receptor. Immunity 48:19\u201333","journal-title":"Immunity"},{"key":"5910_CR28","doi-asserted-by":"publisher","first-page":"155850","DOI":"10.1016\/j.phymed.2024.155850","volume":"132","author":"Z Yang","year":"2024","unstructured":"Yang Z, Li X, Wei L, Bao L, Hu H, Liu L, Tan W, Tong X, Huang F (2024) Involucrasin B suppresses airway inflammation in obese asthma by inhibiting the TLR4-NF-\u03baB-NLRP3 pathway. Phytomedicine 132:155850","journal-title":"Phytomedicine"},{"key":"5910_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2024.106923","volume":"270","author":"Y Tang","year":"2024","unstructured":"Tang Y, Zhao Y, Guan Y, Xue L, Guo J, Zhao T, Guan Y, Tong S, Che C (2024) Silencing TRIM8 alleviates allergic asthma and suppressing Th2 differentiation through inhibiting NF-\u03baB\/NLRP3 signaling pathway. Immunol Lett 270:106923","journal-title":"Immunol Lett"},{"key":"5910_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2020.102292","volume":"30","author":"S Roy","year":"2020","unstructured":"Roy S, Manna K, Jha T, Saha KD (2020) Chrysin-loaded PLGA attenuates OVA-induced allergic asthma by modulating TLR\/NF-\u03baB\/NLRP3 axis. Nanomedicine 30:102292","journal-title":"Nanomedicine"},{"key":"5910_CR31","doi-asserted-by":"publisher","first-page":"21000","DOI":"10.1021\/acs.jafc.4c04933","volume":"72","author":"C Wang","year":"2024","unstructured":"Wang C, Xu Q, Wei C, Hu Q, Xiao Y, Jin Y (2024) Kynurenine attenuates ulcerative colitis mediated by the aryl hydrocarbon receptor. J Agric Food Chem 72:21000\u201321012","journal-title":"J Agric Food Chem"},{"key":"5910_CR32","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/mi.2016.47","volume":"10","author":"SM Coomes","year":"2017","unstructured":"Coomes SM, Kannan Y, Pelly VS, Entwistle LJ, Guidi R, Perez-Lloret J, Nikolov N, M\u00fcller W, Wilson MS (2017) CD4+ Th2 cells are directly regulated by IL-10 during allergic airway inflammation. Mucosal Immunol 10:150\u2013161","journal-title":"Mucosal Immunol"},{"key":"5910_CR33","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/ni.1915","volume":"11","author":"R Gandhi","year":"2010","unstructured":"Gandhi R, Kumar D, Burns EJ, Nadeau M, Dake B, Laroni A, Kozoriz D, Weiner HL, Quintana FJ (2010) Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol 11:846\u2013853","journal-title":"Nat Immunol"},{"key":"5910_CR34","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/nature06880","volume":"453","author":"FJ Quintana","year":"2008","unstructured":"Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL (2008) Control of T(reg) and T(H)17 cell differentiation by the Aryl hydrocarbon receptor. Nature 453:65\u201371","journal-title":"Nature"},{"key":"5910_CR35","doi-asserted-by":"publisher","first-page":"156013","DOI":"10.1016\/j.phymed.2024.156013","volume":"135","author":"HC Chuang","year":"2024","unstructured":"Chuang HC, Chuang KJ, Cheng PC, Hsieh CL, Fan YY, Lee YL (2024) Indirubin induces tolerogenic dendritic cells via Aryl hydrocarbon receptor activation and ameliorates allergic asthma in a murine model by expanding Foxp3-expressing regulatory T cells. Phytomedicine 135:156013","journal-title":"Phytomedicine"},{"key":"5910_CR36","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2044723","volume":"14","author":"Z Fang","year":"2022","unstructured":"Fang Z, Pan T, Li L, Wang H, Zhu J, Zhang H, Zhao J, Chen W, Lu W (2022) Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis. Gut Microbes 14:2044723","journal-title":"Gut Microbes"},{"key":"5910_CR37","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s40168-024-01750-y","volume":"12","author":"G Wang","year":"2024","unstructured":"Wang G, Fan Y, Zhang G, Cai S, Ma Y, Yang L, Wang Y, Yu H, Qiao S, Zeng X (2024) Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding. Microbiome 12:59","journal-title":"Microbiome"},{"key":"5910_CR38","doi-asserted-by":"publisher","first-page":"e0152724","DOI":"10.1371\/journal.pone.0152724","volume":"11","author":"Q Zhang","year":"2016","unstructured":"Zhang Q, Cox M, Liang Z, Brinkmann F, Cardenas PA, Duff R, Bhavsar P, Cookson W, Moffatt M, Chung KF (2016) Airway microbiota in severe asthma and relationship to asthma severity and phenotypes. PLoS ONE 11:e0152724","journal-title":"PLoS ONE"},{"key":"5910_CR39","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.jaci.2012.11.013","volume":"131","author":"PR Marri","year":"2013","unstructured":"Marri PR, Stern DA, Wright AL, Billheimer D, Martinez FD (2013) Asthma-associated differences in microbial composition of induced sputum. J Allergy Clin Immunol 131:346\u2013352","journal-title":"J Allergy Clin Immunol"},{"key":"5910_CR40","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008578","volume":"5","author":"M Hilty","year":"2010","unstructured":"Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, Davies J, Ervine A, Poulter L, Pachter L, Moffatt MF, Cookson WO (2010) Disordered microbial communities in asthmatic airways. PLoS ONE 5:e8578","journal-title":"PLoS ONE"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-025-05910-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-025-05910-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-025-05910-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T13:59:58Z","timestamp":1762437598000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-025-05910-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,6]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["5910"],"URL":"https:\/\/doi.org\/10.1007\/s00018-025-05910-7","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,6]]},"assertion":[{"value":"21 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have declared that no competing interests exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"388"}}