{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:35:07Z","timestamp":1766576107666,"version":"3.48.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["RS-2023-KH143762"],"award-info":[{"award-number":["RS-2023-KH143762"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2022-NR067329"],"award-info":[{"award-number":["RS-2022-NR067329"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-025-05930-3","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:34:08Z","timestamp":1766576048000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Newly-engineered angiopoietin-1 as a cell-priming agent for CVD"],"prefix":"10.1007","volume":"83","author":[{"given":"Jeehoon","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Ju","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HyunJu","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaewon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ju","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2779-4037","authenticated-orcid":false,"given":"Hyun-Jai","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"5930_CR1","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1016\/j.jacc.2024.02.056","volume":"83","author":"FGP Welt","year":"2024","unstructured":"Welt FGP, Batchelor W, Spears JR, Penna C, Pagliaro P, Ibanez B, Drakos SG, Dangas G, Kapur NK (2024) Reperfusion Injury in Patients With Acute Myocardial Infarction: JACC Scientific Statement. J Am Coll Cardiol 83:2196\u20132213. https:\/\/doi.org\/10.1016\/j.jacc.2024.02.056","journal-title":"J Am Coll Cardiol"},{"key":"5930_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2023.12.009","volume":"188","author":"W Yan","year":"2024","unstructured":"Yan W, Xia Y, Zhao H, Xu X, Ma X, Tao L (2024) Stem cell-based therapy in cardiac repair after myocardial infarction: promise, challenges, and future directions. J Mol Cell Cardiol 188:1\u201314. https:\/\/doi.org\/10.1016\/j.yjmcc.2023.12.009","journal-title":"J Mol Cell Cardiol"},{"key":"5930_CR3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1161\/CIRCULATIONAHA.105.001107","volume":"114","author":"HJ Kang","year":"2006","unstructured":"Kang HJ, Lee HY, Na SH, Chang SA, Park KW, Kim HK, Kim SY, Chang HJ, Lee W, Kang WJ et al (2006) Differential effect of intracoronary infusion of mobilized peripheral blood stem cells by granulocyte colony-stimulating factor on left ventricular function and remodeling in patients with acute myocardial infarction versus old myocardial infarction: the MAGIC cell-3-DES randomized, controlled trial. Circulation 114:145\u2013151. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.105.001107","journal-title":"Circulation"},{"key":"5930_CR4","doi-asserted-by":"publisher","first-page":"3062","DOI":"10.1093\/eurheartj\/ehs231","volume":"33","author":"HJ Kang","year":"2012","unstructured":"Kang HJ, Kim MK, Lee HY, Park KW, Lee W, Cho YS, Koo BK, Choi DJ, Park YB, Kim HS (2012) Five-year results of intracoronary infusion of the mobilized peripheral blood stem cells by granulocyte colony-stimulating factor in patients with myocardial infarction. Eur Heart J 33:3062\u20133069. https:\/\/doi.org\/10.1093\/eurheartj\/ehs231","journal-title":"Eur Heart J"},{"key":"5930_CR5","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2016.00046","volume":"3","author":"J Kang","year":"2016","unstructured":"Kang J, Kim TW, Hur J, Kim HS (2016) Strategy to prime the host and cells to augment therapeutic efficacy of progenitor cells for patients with myocardial infarction. Front Cardiovasc Med 3:46. https:\/\/doi.org\/10.3389\/fcvm.2016.00046","journal-title":"Front Cardiovasc Med"},{"key":"5930_CR6","first-page":"1295","volume":"47","author":"WJ Kang","year":"2006","unstructured":"Kang WJ, Kang HJ, Kim HS, Chung JK, Lee MC, Lee DS (2006) Tissue distribution of 18F-FDG-labeled peripheral hematopoietic stem cells after intracoronary administration in patients with myocardial infarction. J Nucl Med 47:1295\u20131301","journal-title":"J Nucl Med"},{"key":"5930_CR7","doi-asserted-by":"publisher","first-page":"12323","DOI":"10.1038\/s41598-018-30513-7","volume":"8","author":"SW Youn","year":"2018","unstructured":"Youn SW, Lee HC, Lee SW, Lee J, Jang H, Lee EJ, Kim HS (2018) COMP-angiopoietin-1 accelerates muscle regeneration through N-cadherin activation. Sci Rep 8:12323. https:\/\/doi.org\/10.1038\/s41598-018-30513-7","journal-title":"Sci Rep"},{"key":"5930_CR8","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.canlet.2012.08.018","volume":"328","author":"E Fagiani","year":"2013","unstructured":"Fagiani E, Christofori G (2013) Angiopoietins in angiogenesis. Cancer Lett 328:18\u201326. https:\/\/doi.org\/10.1016\/j.canlet.2012.08.018","journal-title":"Cancer Lett"},{"key":"5930_CR9","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1161\/01.res.83.3.233","volume":"83","author":"T Asahara","year":"1998","unstructured":"Asahara T, Chen D, Takahashi T, Fujikawa K, Kearney M, Magner M, Yancopoulos GD, Isner JM (1998) Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. Circ Res 83:233\u2013240. https:\/\/doi.org\/10.1161\/01.res.83.3.233","journal-title":"Circ Res"},{"key":"5930_CR10","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1002\/jnr.22274","volume":"88","author":"HY Shin","year":"2010","unstructured":"Shin HY, Lee YJ, Kim HJ, Park CK, Kim JH, Wang KC, Kim DG, Koh GY, Paek SH (2010) Protective role of COMP-Ang1 in ischemic rat brain. J Neurosci Res 88:1052\u20131063. https:\/\/doi.org\/10.1002\/jnr.22274","journal-title":"J Neurosci Res"},{"key":"5930_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/biom13010062","author":"H Ma","year":"2022","unstructured":"Ma H, Qiu Q, Tan D, Chen Q, Liu Y, Chen B, Wang M (2022) The cancer-associated fibroblasts-related gene COMP is a novel predictor for prognosis and immunotherapy efficacy and is correlated with M2 macrophage infiltration in colon cancer. Biomolecules. https:\/\/doi.org\/10.3390\/biom13010062","journal-title":"Biomolecules"},{"key":"5930_CR12","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.bone.2009.09.019","volume":"46","author":"BC Jeong","year":"2010","unstructured":"Jeong BC, Kim HJ, Bae IH, Lee KN, Lee KY, Oh WM, Kim SH, Kang IC, Lee SE, Koh GY et al (2010) COMP-Ang1, a chimeric form of Angiopoietin 1, enhances BMP2-induced osteoblast differentiation and bone formation. Bone 46:479\u2013486. https:\/\/doi.org\/10.1016\/j.bone.2009.09.019","journal-title":"Bone"},{"key":"5930_CR13","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1161\/CIRCULATIONAHA.109.856815","volume":"120","author":"MS Kim","year":"2009","unstructured":"Kim MS, Lee CS, Hur J, Cho HJ, Jun SI, Kim TY, Lee SW, Suh JW, Park KW, Lee HY et al (2009) Priming with angiopoietin-1 augments the vasculogenic potential of the peripheral blood stem cells mobilized with granulocyte colony-stimulating factor through a novel Tie2\/Ets-1 pathway. Circulation 120:2240\u20132250. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.856815","journal-title":"Circulation"},{"key":"5930_CR14","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1006\/jmbi.1996.0137","volume":"256","author":"K Beck","year":"1996","unstructured":"Beck K, Gambee JE, Bohan CA, Bachinger HP (1996) The c-terminal domain of cartilage matrix protein assembles into a triple-stranded alpha-helical coiled-coil structure. J Mol Biol 256:909\u2013923. https:\/\/doi.org\/10.1006\/jmbi.1996.0137","journal-title":"J Mol Biol"},{"key":"5930_CR15","doi-asserted-by":"publisher","first-page":"5547","DOI":"10.1073\/pnas.0307574101","volume":"101","author":"CH Cho","year":"2004","unstructured":"Cho CH, Kammerer RA, Lee HJ, Steinmetz MO, Ryu YS, Lee SH, Yasunaga K, Kim KT, Kim I, Choi HH, Kim W (2004) COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity. Proc Natl Acad Sci U S A 101:5547\u20135552. https:\/\/doi.org\/10.1073\/pnas.0307574101","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5930_CR16","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/s41392-022-01134-4","volume":"7","author":"DM Hoang","year":"2022","unstructured":"Hoang DM, Pham PT, Bach TQ, Ngo ATL, Nguyen QT, Phan TTK, Nguyen GH, Le PTT, Hoang VT, Forsyth NR et al (2022) Stem cell-based therapy for human diseases. Signal Transduct Target Ther 7:272. https:\/\/doi.org\/10.1038\/s41392-022-01134-4","journal-title":"Signal Transduct Target Ther"},{"key":"5930_CR17","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/0042-6822(79)90358-1","volume":"97","author":"GM Air","year":"1979","unstructured":"Air GM (1979) Nucleotide sequence coding for the \u201csignal peptide\u201d and N terminus of the hemagglutinin from an asian (H2N2) strain of influenza virus. Virology 97:468\u2013472. https:\/\/doi.org\/10.1016\/0042-6822(79)90358-1","journal-title":"Virology"},{"key":"5930_CR18","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1182\/blood-2010-12-323907","volume":"118","author":"HJ Joo","year":"2011","unstructured":"Joo HJ, Kim H, Park SW, Cho HJ, Kim HS, Lim DS, Chung HM, Kim I, Han YM, Koh GY (2011) Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells. Blood 118:2094\u20132104. https:\/\/doi.org\/10.1182\/blood-2010-12-323907","journal-title":"Blood"},{"key":"5930_CR19","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jmb.2006.05.063","volume":"361","author":"J Liu","year":"2006","unstructured":"Liu J, Zheng Q, Deng Y, Kallenbach NR, Lu M (2006) Conformational transition between four and five-stranded phenylalanine zippers determined by a local packing interaction. J Mol Biol 361:168\u2013179. https:\/\/doi.org\/10.1016\/j.jmb.2006.05.063","journal-title":"J Mol Biol"},{"key":"5930_CR20","doi-asserted-by":"publisher","first-page":"17027","DOI":"10.1073\/pnas.0403069101","volume":"101","author":"K Kuhnel","year":"2004","unstructured":"Kuhnel K, Jarchau T, Wolf E, Schlichting I, Walter U, Wittinghofer A, Strelkov SV (2004) The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proc Natl Acad Sci U S A 101:17027\u201317032. https:\/\/doi.org\/10.1073\/pnas.0403069101","journal-title":"Proc Natl Acad Sci U S A"},{"key":"5930_CR21","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.026943","volume":"12","author":"R Liga","year":"2023","unstructured":"Liga R, Colli A, Taggart DP, Boden WE, De Caterina R (2023) Myocardial revascularization in patients with ischemic cardiomyopathy: for whom and how. J Am Heart Assoc 12:e026943. https:\/\/doi.org\/10.1161\/JAHA.122.026943","journal-title":"J Am Heart Assoc"},{"key":"5930_CR22","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1093\/eurheartj\/ehv592","volume":"37","author":"F Montecucco","year":"2016","unstructured":"Montecucco F, Carbone F, Schindler TH (2016) Pathophysiology of ST-segment elevation myocardial infarction: novel mechanisms and treatments. Eur Heart J 37:1268\u20131283. https:\/\/doi.org\/10.1093\/eurheartj\/ehv592","journal-title":"Eur Heart J"},{"key":"5930_CR23","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nrm3043","volume":"12","author":"C Jopling","year":"2011","unstructured":"Jopling C, Boue S, Izpisua Belmonte JC (2011) Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat Rev Mol Cell Biol 12:79\u201389. https:\/\/doi.org\/10.1038\/nrm3043","journal-title":"Nat Rev Mol Cell Biol"},{"key":"5930_CR24","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/S0140-6736(04)15689-4","volume":"363","author":"HJ Kang","year":"2004","unstructured":"Kang HJ, Kim HS, Zhang SY, Park KW, Cho HJ, Koo BK, Kim YJ, Soo Lee D, Sohn DW, Han KS et al (2004) Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clinical trial. Lancet 363:751\u2013756. https:\/\/doi.org\/10.1016\/S0140-6736(04)15689-4","journal-title":"Lancet"},{"key":"5930_CR25","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1038\/s41435-021-00145-5","volume":"22","author":"I Mikocziova","year":"2021","unstructured":"Mikocziova I, Greiff V, Sollid LM (2021) Immunoglobulin germline gene variation and its impact on human disease. Genes Immun 22:205\u2013217. https:\/\/doi.org\/10.1038\/s41435-021-00145-5","journal-title":"Genes Immun"},{"key":"5930_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116878","volume":"10","author":"R Haryadi","year":"2015","unstructured":"Haryadi R, Ho S, Kok YJ, Pu HX, Zheng L, Pereira NA, Li B, Bi X, Goh LT, Yang Y, Song Z (2015) Optimization of heavy chain and light chain signal peptides for high level expression of therapeutic antibodies in CHO cells. PLoS ONE 10:e0116878. https:\/\/doi.org\/10.1371\/journal.pone.0116878","journal-title":"PLoS ONE"},{"key":"5930_CR27","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1093\/abbs\/gmq117","volume":"43","author":"B Wen","year":"2011","unstructured":"Wen B, Deng Y, Guan J, Yan W, Wang Y, Tan W, Gao J (2011) Signal peptide replacements enhance expression and secretion of hepatitis C virus envelope glycoproteins. Acta Biochim Biophys Sin (Shanghai) 43:96\u2013102. https:\/\/doi.org\/10.1093\/abbs\/gmq117","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"5930_CR28","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.bbrc.2009.11.167","volume":"391","author":"M Futatsumori-Sugai","year":"2010","unstructured":"Futatsumori-Sugai M, Tsumoto K (2010) Signal peptide design for improving recombinant protein secretion in the baculovirus expression vector system. Biochem Biophys Res Commun 391:931\u2013935. https:\/\/doi.org\/10.1016\/j.bbrc.2009.11.167","journal-title":"Biochem Biophys Res Commun"},{"key":"5930_CR29","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/s1525-0016(03)00034-0","volume":"7","author":"N Arsic","year":"2003","unstructured":"Arsic N, Zentilin L, Zacchigna S, Santoro D, Stanta G, Salvi A, Sinagra G, Giacca M (2003) Induction of functional neovascularization by combined VEGF and angiopoietin-1 gene transfer using AAV vectors. Mol Ther 7:450\u2013459. https:\/\/doi.org\/10.1016\/s1525-0016(03)00034-0","journal-title":"Mol Ther"},{"key":"5930_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-12-33","volume":"12","author":"HJ Kang","year":"2011","unstructured":"Kang HJ, Kim MK, Kim MG, Choi DJ, Yoon JH, Park YB, Kim HS (2011) A multicenter, prospective, randomized, controlled trial evaluating the safety and efficacy of intracoronary cell infusion mobilized with granulocyte colony-stimulating factor and darbepoetin after acute myocardial infarction: study design and rationale of the \u201cMAGIC cell-5-combination cytokine trial.\u201d Trials 12:33. https:\/\/doi.org\/10.1186\/1745-6215-12-33","journal-title":"Trials"},{"key":"5930_CR31","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/1755-5922.12194","volume":"34","author":"J Kang","year":"2016","unstructured":"Kang J, Hur J, Kang JA, Lee HS, Jung H, Choi JI, Lee H, Kim YS, Ahn Y, Kim HS (2016) Priming mobilized peripheral blood mononuclear cells with the \u201cactivated platelet supernatant\u201d enhances the efficacy of cell therapy for myocardial infarction of rats. Cardiovasc Ther 34:245\u2013253. https:\/\/doi.org\/10.1111\/1755-5922.12194","journal-title":"Cardiovasc Ther"},{"key":"5930_CR32","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.yjmcc.2014.06.019","volume":"75","author":"J Kang","year":"2014","unstructured":"Kang J, Hur J, Kang JA, Yun JY, Choi JI, Ko SB, Lee CS, Lee J, Han JK, Kim HK, Kim HS (2014) Activated platelet supernatant can augment the angiogenic potential of human peripheral blood stem cells mobilized from bone marrow by G-CSF. J Mol Cell Cardiol 75:64\u201375. https:\/\/doi.org\/10.1016\/j.yjmcc.2014.06.019","journal-title":"J Mol Cell Cardiol"},{"key":"5930_CR33","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.jcyt.2013.03.005","volume":"15","author":"L Barkholt","year":"2013","unstructured":"Barkholt L, Flory E, Jekerle V, Lucas-Samuel S, Ahnert P, Bisset L, Buscher D, Fibbe W, Foussat A, Kwa M et al (2013) Risk of tumorigenicity in mesenchymal stromal cell-based therapies\u2013bridging scientific observations and regulatory viewpoints. Cytotherapy 15:753\u2013759. https:\/\/doi.org\/10.1016\/j.jcyt.2013.03.005","journal-title":"Cytotherapy"},{"key":"5930_CR34","doi-asserted-by":"publisher","first-page":"16","DOI":"10.5455\/medarh.2021.75.16-22","volume":"75","author":"D Hermansyah","year":"2021","unstructured":"Hermansyah D, Putra A, Muhar AM, Wirastuti K, Dirja BT (2021) Mesenchymal Stem Cells Suppress TGF-beta Release to Decrease alpha-SMA Expression in Ameliorating CCl4-Induced Liver Fibrosis. Med Arch 75:16\u201322. https:\/\/doi.org\/10.5455\/medarh.2021.75.16-22","journal-title":"Med Arch"},{"key":"5930_CR35","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1002\/bit.24776","volume":"110","author":"L Kober","year":"2013","unstructured":"Kober L, Zehe C, Bode J (2013) Optimized signal peptides for the development of high expressing CHO cell lines. Biotechnol Bioeng 110:1164\u20131173. https:\/\/doi.org\/10.1002\/bit.24776","journal-title":"Biotechnol Bioeng"},{"key":"5930_CR36","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1097\/ICO.0b013e31819839c6","volume":"28","author":"D Kook","year":"2009","unstructured":"Kook D, Derhartunian V, Bug R, Kohnen T (2009) Top-hat shaped corneal trephination for penetrating keratoplasty using the femtosecond laser: a histomorphological study. Cornea 28:795\u2013800. https:\/\/doi.org\/10.1097\/ICO.0b013e31819839c6","journal-title":"Cornea"},{"key":"5930_CR37","doi-asserted-by":"publisher","first-page":"R22","DOI":"10.1186\/gb-2011-12-3-r22","volume":"12","author":"A Roberts","year":"2011","unstructured":"Roberts A, Trapnell C, Donaghey J, Rinn JL, Pachter L (2011) Improving RNA-Seq expression estimates by correcting for fragment bias. Genome Biol 12:R22. https:\/\/doi.org\/10.1186\/gb-2011-12-3-r22","journal-title":"Genome Biol"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-025-05930-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-025-05930-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-025-05930-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:34:09Z","timestamp":1766576049000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-025-05930-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5930"],"URL":"https:\/\/doi.org\/10.1007\/s00018-025-05930-3","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]},"assertion":[{"value":"15 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 December 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interests"}}],"article-number":"2"}}