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Mol. Life Sci."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cancer cells must adapt to harsh microenvironmental conditions such as nutrient deprivation, hypoxia and immune pressure to sustain their high proliferative potential. One adaptive mechanism involves the formation of stress granules (SGs), which promote cell survival under stress. Interestingly, melanoma cells appear to tolerate such stressors, including hypoxia and chemotherapeutic agents, with minimal dependence on SG formation. In this study, we identify heat shock protein 70 (HSP70) as a key mediator of stress resistance in melanoma cells and the participation of the kinase CK2 in this process. We demonstrate that melanoma cells express high endogenous levels of HSP70, which preserves protein homeostasis and inhibits apoptosis under both environmental and drug-induced stress. Silencing of HSP70 led to increased SG formation and sensitized melanoma cells to apoptosis, particularly in response to the BRAF inhibitor Vemurafenib. These findings suggest that HSP70 plays a central role in melanoma cell survival by compensating for the need for SGs and promoting resistance to therapeutic stress.<\/jats:p>","DOI":"10.1007\/s00018-025-05939-8","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T07:32:03Z","timestamp":1761636723000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In long-lasting cellular stress phases of melanoma cells, stress granules are dissolved by HSP70"],"prefix":"10.1007","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3772-477X","authenticated-orcid":false,"given":"Sebastian","family":"Staebler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Pieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Perl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Stieglitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aranya","family":"Thongmao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8147-394X","authenticated-orcid":false,"given":"Anja Katrin","family":"Bosserhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4490-7387","authenticated-orcid":false,"given":"Silke","family":"Kuphal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"issue":"5","key":"5939_CR1","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1515\/hsz-2018-0327","volume":"400","author":"E Obrador","year":"2019","unstructured":"Obrador E, Liu-Smith F, Dellinger RW, Salvador R, Meyskens FL, Estrela JM (2019) Oxidative stress and antioxidants in the pathophysiology of malignant melanoma. 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The use of human tissue material had been approved by the local ethics committee of the University of Regensburg (application number 09\/11 and 03\/151).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"366"}}