{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:11:58Z","timestamp":1792681918300,"version":"4.5.0"},"reference-count":223,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["11P4G24N"],"award-info":[{"award-number":["11P4G24N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0A9625FWO"],"award-info":[{"award-number":["G0A9625FWO"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-025-06053-5","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T08:37:15Z","timestamp":1772095035000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Role of mitochondria in neuronal function and survival in the enteric and central nervous systems"],"prefix":"10.1007","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7831-0003","authenticated-orcid":false,"given":"Irem","family":"Kural","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4188-7771","authenticated-orcid":false,"given":"Lobke Marie","family":"M Mombeek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8945-0395","authenticated-orcid":false,"suffix":"III","given":"David M.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"6053_CR1","unstructured":"Thau LRV, Singh P, Anatomy Central Nervous System. [Updated 2022 Oct 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK542179\/"},{"issue":"3","key":"6053_CR2","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1152\/physrev.1997.77.3.731","volume":"77","author":"DF Rolfe","year":"1997","unstructured":"Rolfe DF, Brown GC (1997) Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev 77(3):731\u2013758","journal-title":"Physiol Rev"},{"issue":"6","key":"6053_CR3","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.3945\/ajcn.2010.29885","volume":"92","author":"W ZiMian","year":"2010","unstructured":"ZiMian W, Zhiliang Y, Anja B-W, Junyi Z, Britta S, Wiebke L et al (2010) Specific metabolic rates of major organs and tissues across adulthood: evaluation by mechanistic model of resting energy expenditure1234. Am J Clin Nutr 92(6):1369\u20131377","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"6053_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017514","volume":"6","author":"S Herculano-Houzel","year":"2011","unstructured":"Herculano-Houzel S (2011) Scaling of brain metabolism with a fixed energy budget per neuron: implications for neuronal activity, plasticity and evolution. PLoS One 6(3):e17514","journal-title":"PLoS One"},{"issue":"5","key":"6053_CR5","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/nrgastro.2012.32","volume":"9","author":"JB Furness","year":"2012","unstructured":"Furness JB (2012) The enteric nervous system and neurogastroenterology. Nat Rev Gastroenterol Hepatol 9(5):286\u2013294","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"6053_CR6","doi-asserted-by":"publisher","first-page":"8024171","DOI":"10.1155\/2020\/8024171","volume":"2020","author":"MA Fleming 2nd","year":"2020","unstructured":"Fleming MA 2nd, Ehsan L, Moore SR, Levin DE (2020) The enteric nervous system and its emerging role as a therapeutic target. Gastroenterol Res Pract 2020:8024171","journal-title":"Gastroenterol Res Pract"},{"issue":"36","key":"6053_CR7","doi-asserted-by":"publisher","first-page":"13010","DOI":"10.1073\/pnas.1323099111","volume":"111","author":"CW Kuzawa","year":"2014","unstructured":"Kuzawa CW, Chugani HT, Grossman LI, Lipovich L, Muzik O, Hof PR et al (2014) Metabolic costs and evolutionary implications of human brain development. Proc Natl Acad Sci U S A 111(36):13010\u20135","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7113","key":"6053_CR8","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nature05292","volume":"443","author":"MT Lin","year":"2006","unstructured":"Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443(7113):787\u2013795","journal-title":"Nature"},{"issue":"5","key":"6053_CR9","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1111\/jnc.16032","volume":"168","author":"CD Rae","year":"2024","unstructured":"Rae CD, Baur JA, Borges K, Dienel G, D\u00edaz-Garc\u00eda CM, Douglass SR et al (2024) Brain energy metabolism: a roadmap for future research. J Neurochem 168(5):910\u201354","journal-title":"J Neurochem"},{"issue":"26","key":"6053_CR10","doi-asserted-by":"publisher","first-page":"7035","DOI":"10.1523\/JNEUROSCI.1012-06.2006","volume":"26","author":"DT Chang","year":"2006","unstructured":"Chang DT, Honick AS, Reynolds IJ (2006) Mitochondrial trafficking to synapses in cultured primary cortical neurons. J Neurosci 26(26):7035\u20137045","journal-title":"J Neurosci"},{"issue":"7","key":"6053_CR11","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1038\/s42255-025-01321-x","volume":"7","author":"M Kumar","year":"2025","unstructured":"Kumar M, Wu Y, Knapp J, Pontius CL, Park D, Witte RE et al (2025) Triglycerides are an important fuel reserve for synapse function in the brain. Nat Metabolism 7(7):1392\u20131403","journal-title":"Nat Metabolism"},{"issue":"4","key":"6053_CR12","doi-asserted-by":"publisher","first-page":"112335","DOI":"10.1016\/j.celrep.2023.112335","volume":"42","author":"L Huihui","year":"2023","unstructured":"Huihui L, Caroline G, Yoshitaka JS, Misha Z, Lydia M, Lauren S et al (2023) Neurons require glucose uptake and Glycolysis in vivo. Cell Rep 42(4):112335","journal-title":"Cell Rep"},{"issue":"4","key":"6053_CR13","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2022.12.032","volume":"186","author":"DM Wilson 3rd","year":"2023","unstructured":"Wilson DM 3rd, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I (2023) Hallmarks of neurodegenerative diseases. Cell 186(4):693\u2013714","journal-title":"Cell"},{"key":"6053_CR14","doi-asserted-by":"crossref","unstructured":"Fame RM, Shannon ML, Chau KF, Head JP, Lehtinen MK (2019) A concerted metabolic shift in early forebrain alters the CSF proteome and depends on MYC downregulation for mitochondrial maturation. Development. ;146(20)","DOI":"10.1242\/dev.182857"},{"key":"6053_CR15","doi-asserted-by":"publisher","first-page":"1212375","DOI":"10.3389\/fcell.2023.1212375","volume":"11","author":"D Sakai","year":"2023","unstructured":"Sakai D, Murakami Y, Shigeta D, Tomosugi M, Sakata-Haga H, Hatta T et al (2023) Glycolytic activity is required for the onset of neural plate folding during neural tube closure in mouse embryos. Front Cell Dev Biol 11:1212375","journal-title":"Front Cell Dev Biol"},{"key":"6053_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceb.2017.11.003","volume":"49","author":"M Khacho","year":"2017","unstructured":"Khacho M, Slack RS (2017) Mitochondrial activity in the regulation of stem cell self-renewal and differentiation. Curr Opin Cell Biol 49:1\u20138","journal-title":"Curr Opin Cell Biol"},{"key":"6053_CR17","doi-asserted-by":"crossref","unstructured":"Zheng X, Boyer L, Jin M, Mertens J, Kim Y, Ma L et al (2016) Metabolic reprogramming during neuronal differentiation from aerobic Glycolysis to neuronal oxidative phosphorylation. Elife. ;5","DOI":"10.7554\/eLife.13374"},{"issue":"1","key":"6053_CR18","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.cell.2007.11.024","volume":"132","author":"JS Kang","year":"2008","unstructured":"Kang JS, Tian JH, Pan PY, Zald P, Li C, Deng C et al (2008) Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitation. Cell 132(1):137\u201348","journal-title":"Cell"},{"issue":"1","key":"6053_CR19","doi-asserted-by":"publisher","first-page":"5008","DOI":"10.1038\/s41467-018-07416-2","volume":"9","author":"TL Lewis Jr","year":"2018","unstructured":"Lewis TL Jr., Kwon SK, Lee A, Shaw R, Polleux F (2018) MFF-dependent mitochondrial fission regulates presynaptic release and axon branching by limiting axonal mitochondria size. Nat Commun 9(1):5008","journal-title":"Nat Commun"},{"issue":"11","key":"6053_CR20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027727","volume":"6","author":"A Viader","year":"2011","unstructured":"Viader A, Wright-Jin EC, Vohra BPS, Heuckeroth RO, Milbrandt J (2011) Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction. PLoS One 6(11):e27727","journal-title":"PLoS One"},{"issue":"7","key":"6053_CR21","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1038\/nn.3132","volume":"15","author":"S Hallermann","year":"2012","unstructured":"Hallermann S, de Kock CP, Stuart GJ, Kole MH (2012) State and location dependence of action potential metabolic cost in cortical pyramidal neurons. Nat Neurosci 15(7):1007\u201314","journal-title":"Nat Neurosci"},{"key":"6053_CR22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3389\/fnsyn.2010.00139","volume":"2","author":"M Vos","year":"2010","unstructured":"Vos M, Lauwers E, Verstreken P (2010) Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease. Front Synaptic Neurosci 2:139","journal-title":"Front Synaptic Neurosci"},{"issue":"2","key":"6053_CR23","first-page":"F315","volume":"274","author":"W Lieberthal","year":"1998","unstructured":"Lieberthal W, Menza SA, Levine JS (1998) Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells. Am J Physiol 274(2):F315\u2013F327","journal-title":"Am J Physiol"},{"issue":"52","key":"6053_CR24","doi-asserted-by":"publisher","first-page":"52ra73","DOI":"10.1126\/scitranslmed.3001059","volume":"2","author":"B Zheng","year":"2010","unstructured":"Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML et al (2010) PGC-1\u03b1, a potential therapeutic target for early intervention in parkinson\u2019s disease. Sci Transl Med 2(52):52ra73","journal-title":"Sci Transl Med"},{"issue":"1","key":"6053_CR25","doi-asserted-by":"publisher","first-page":"C8","DOI":"10.1152\/ajpcell.00232.2006","volume":"292","author":"MS Parihar","year":"2007","unstructured":"Parihar MS, Brewer GJ (2007) Mitoenergetic failure in alzheimer disease. Am J Physiol Cell Physiol 292(1):C8\u201323","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"6053_CR26","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1172\/JCI45691","volume":"121","author":"F Mochel","year":"2011","unstructured":"Mochel F, Haller RG (2011) Energy deficit in huntington disease: why it matters. J Clin Invest 121(2):493\u2013499","journal-title":"J Clin Invest"},{"issue":"4","key":"6053_CR27","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.mito.2013.03.008","volume":"13","author":"A Bobba","year":"2013","unstructured":"Bobba A, Amadoro G, Valenti D, Corsetti V, Lassandro R, Atlante A (2013) Mitochondrial respiratory chain complexes I and IV are impaired by \u03b2-amyloid via direct interaction and through complex I-dependent ROS production, respectively. Mitochondrion 13(4):298\u2013311","journal-title":"Mitochondrion"},{"issue":"3","key":"6053_CR28","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1002\/mds.26513","volume":"31","author":"AP Gatt","year":"2016","unstructured":"Gatt AP, Duncan OF, Attems J, Francis PT, Ballard CG, Bateman JM (2016) Dementia in parkinson\u2019s disease is associated with enhanced mitochondrial complex I deficiency. Mov Disord 31(3):352\u2013359","journal-title":"Mov Disord"},{"issue":"6","key":"6053_CR29","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1111\/j.1471-4159.1985.tb07192.x","volume":"44","author":"WA Brennan Jr.","year":"1985","unstructured":"Brennan WA Jr., Bird ED, Aprille JR (1985) Regional mitochondrial respiratory activity in Huntington\u2019s disease brain. J Neurochem 44(6):1948\u201350","journal-title":"J Neurochem"},{"issue":"5","key":"6053_CR30","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1002\/ana.410410514","volume":"41","author":"SE Browne","year":"1997","unstructured":"Browne SE, Bowling AC, Macgarvey U, Baik MJ, Berger SC, Muquit MMK et al (1997) Oxidative damage and metabolic dysfunction in Huntington\u2019s disease: selective vulnerability of the basal ganglia. Ann Neurol 41(5):646\u201353","journal-title":"Ann Neurol"},{"issue":"2","key":"6053_CR31","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0022-510X(85)90112-1","volume":"67","author":"J Butterworth","year":"1985","unstructured":"Butterworth J, Yates CM, Reynolds GP (1985) Distribution of phosphate-activated glutaminase, succinic dehydrogenase, pyruvate dehydrogenase and \u03b3-glutamyl transpeptidase in post-mortem brain from huntington\u2019s disease and agonal cases. J Neurol Sci 67(2):161\u2013171","journal-title":"J Neurol Sci"},{"issue":"4","key":"6053_CR32","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1016\/j.neuron.2014.07.001","volume":"83","author":"G Le Masson","year":"2014","unstructured":"Le Masson G, Przedborski S, Abbott LF (2014) A computational model of motor neuron degeneration. Neuron 83(4):975\u201388","journal-title":"Neuron"},{"issue":"5","key":"6053_CR33","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1093\/brain\/awab056","volume":"144","author":"E Bonora","year":"2021","unstructured":"Bonora E, Chakrabarty S, Kellaris G, Tsutsumi M, Bianco F, Bergamini C et al (2021) Biallelic variants in LIG3 cause a novel mitochondrial neurogastrointestinal encephalomyopathy. Brain 144(5):1451\u20131466","journal-title":"Brain"},{"key":"6053_CR34","doi-asserted-by":"crossref","unstructured":"Desmet AS, Cirillo C, Tack J, Vandenberghe W, Vanden Berghe P (2017) Live calcium and mitochondrial imaging in the enteric nervous system of Parkinson patients and controls. Elife. ;6","DOI":"10.7554\/eLife.26850"},{"issue":"3","key":"6053_CR35","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1152\/physrev.00026.2013","volume":"94","author":"DB Zorov","year":"2014","unstructured":"Zorov DB, Juhaszova M, Sollott SJ (2014) Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release. Physiol Rev 94(3):909\u2013950","journal-title":"Physiol Rev"},{"issue":"1","key":"6053_CR36","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.abb.2004.07.036","volume":"434","author":"H Kamata","year":"2005","unstructured":"Kamata H, Oka S-i, Shibukawa Y, Kakuta J, Hirata H (2005) Redox regulation of nerve growth factor-induced neuronal differentiation of PC12 cells through modulation of the nerve growth factor receptor, TrkA. Arch Biochem Biophys 434(1):16\u201325","journal-title":"Arch Biochem Biophys"},{"issue":"5","key":"6053_CR37","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.cellsig.2010.01.007","volume":"22","author":"M Nitti","year":"2010","unstructured":"Nitti M, Furfaro AL, Cevasco C, Traverso N, Marinari UM, Pronzato MA et al (2010) PKC delta and NADPH oxidase in retinoic acid-induced neuroblastoma cell differentiation. Cell Signal 22(5):828\u2013835","journal-title":"Cell Signal"},{"issue":"2","key":"6053_CR38","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.jmb.2007.04.056","volume":"370","author":"I Lassing","year":"2007","unstructured":"Lassing I, Schmitzberger F, Bj\u00f6rnstedt M, Holmgren A, Nordlund P, Schutt CE et al (2007) Molecular and structural basis for redox regulation of \u03b2-Actin. J Mol Biol 370(2):331\u201348","journal-title":"J Mol Biol"},{"issue":"32","key":"6053_CR39","doi-asserted-by":"publisher","first-page":"22983","DOI":"10.1074\/jbc.M603040200","volume":"281","author":"T Fiaschi","year":"2006","unstructured":"Fiaschi T, Cozzi G, Raugei G, Formigli L, Ramponi G, Chiarugi P (2006) Redox regulation of \u03b2-Actin during integrin-mediated cell adhesion*. J Biol Chem 281(32):22983\u201391","journal-title":"J Biol Chem"},{"key":"6053_CR40","doi-asserted-by":"crossref","unstructured":"Oswald MC, Brooks PS, Zwart MF, Mukherjee A, West RJ, Giachello CN et al (2018) Reactive oxygen species regulate activity-dependent neuronal plasticity in drosophila. Elife. ;7","DOI":"10.7554\/eLife.39393"},{"key":"6053_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2013.02.011","volume":"60","author":"SI Liochev","year":"2013","unstructured":"Liochev SI (2013) Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med 60:1\u20134","journal-title":"Free Radic Biol Med"},{"key":"6053_CR42","doi-asserted-by":"crossref","unstructured":"Lee KH, Cha M, Lee BH (2020) Neuroprotective effect of antioxidants in the brain. Int J Mol Sci. ;21(19)","DOI":"10.3390\/ijms21197152"},{"issue":"1","key":"6053_CR43","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.mito.2006.11.026","volume":"7","author":"HP Indo","year":"2007","unstructured":"Indo HP, Davidson M, Yen H-C, Suenaga S, Tomita K, Nishii T et al (2007) Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage. Mitochondrion 7(1):106\u2013118","journal-title":"Mitochondrion"},{"issue":"22","key":"6053_CR44","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1089\/scd.2020.0103","volume":"29","author":"L Zhang","year":"2020","unstructured":"Zhang L, Xu M, Ren Q, Liu G, Meng S, Xiahou K et al (2020) Human induced pluripotent stem Cell-Derived neural cells from alzheimer\u2019s disease patients exhibited different susceptibility to oxidative stress. Stem Cells Dev 29(22):1444\u20131456","journal-title":"Stem Cells Dev"},{"issue":"342","key":"6053_CR45","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf3634","volume":"8","author":"R Di Maio","year":"2016","unstructured":"Di Maio R, Barrett PJ, Hoffman EK, Barrett CW, Zharikov A, Borah A et al (2016) \u03b1-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson\u2019s disease. Sci Transl Med 8(342):342ra78","journal-title":"Sci Transl Med"},{"issue":"3","key":"6053_CR46","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/S0304-3940(02)00016-2","volume":"320","author":"E Junn","year":"2002","unstructured":"Junn E, Mouradian MM (2002) Human alpha-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine. Neurosci Lett 320(3):146\u2013150","journal-title":"Neurosci Lett"},{"issue":"1","key":"6053_CR47","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jcmgh.2015.08.007","volume":"2","author":"IA Brown","year":"2016","unstructured":"Brown IA, McClain JL, Watson RE, Patel BA, Gulbransen BD (2016) Enteric glia mediate neuron death in colitis through purinergic pathways that require connexin-43 and nitric oxide. Cell Mol Gastroenterol Hepatol 2(1):77\u201391","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"5","key":"6053_CR48","doi-asserted-by":"publisher","first-page":"G893","DOI":"10.1152\/ajpgi.2000.279.5.G893","volume":"279","author":"S Wada-Takahashi","year":"2000","unstructured":"Wada-Takahashi S, Tamura K (2000) Actions of reactive oxygen species on AH\/type 2 myenteric neurons in Guinea pig distal colon. Am J Physiol Gastrointest Liver Physiol 279(5):G893\u2013902","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"15","key":"6053_CR49","doi-asserted-by":"publisher","first-page":"3725","DOI":"10.1113\/jphysiol.2013.254136","volume":"591","author":"JA Roberts","year":"2013","unstructured":"Roberts JA, Durnin L, Sharkey KA, Mutafova-Yambolieva VN, Mawe GM (2013) Oxidative stress disrupts purinergic neuromuscular transmission in the inflamed colon. J Physiol 591(15):3725\u20133737","journal-title":"J Physiol"},{"issue":"16","key":"6053_CR50","doi-asserted-by":"publisher","first-page":"6962","DOI":"10.1523\/JNEUROSCI.22-16-06962.2002","volume":"22","author":"P Vanden Berghe","year":"2002","unstructured":"Vanden Berghe P, Kenyon JL, Smith TK (2002) Mitochondrial Ca2\u2009+\u2009uptake regulates the excitability of myenteric neurons. J Neurosci 22(16):6962\u20136971","journal-title":"J Neurosci"},{"key":"6053_CR51","doi-asserted-by":"crossref","unstructured":"Stavely R, Sahakian L, Filippone RT, Stojanovska V, Bornstein JC, Sakkal S et al (2022) Oxidative Stress-Induced HMGB1 translocation in myenteric neurons contributes to neuropathy in colitis. Biomolecules. ;12(12)","DOI":"10.3390\/biom12121831"},{"issue":"24","key":"6053_CR52","doi-asserted-by":"publisher","first-page":"3502","DOI":"10.1111\/bph.13646","volume":"173","author":"RM McQuade","year":"2016","unstructured":"McQuade RM, Carbone SE, Stojanovska V, Rahman A, Gwynne RM, Robinson AM et al (2016) Role of oxidative stress in oxaliplatin-induced enteric neuropathy and colonic dysmotility in mice. Br J Pharmacol 173(24):3502\u20133521","journal-title":"Br J Pharmacol"},{"key":"6053_CR53","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3389\/fphar.2012.00061","volume":"3","author":"EM Kawamoto","year":"2012","unstructured":"Kawamoto EM, Vivar C, Camandola S (2012) Physiology and pathology of calcium signaling in the brain. Front Pharmacol 3:61","journal-title":"Front Pharmacol"},{"key":"6053_CR54","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jprot.2012.12.018","volume":"79","author":"CN Poston","year":"2013","unstructured":"Poston CN, Krishnan SC, Bazemore-Walker CR (2013) In-depth proteomic analysis of mammalian mitochondria-associated membranes (MAM). J Proteom 79:219\u2013230","journal-title":"J Proteom"},{"issue":"11","key":"6053_CR55","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/s41580-018-0052-8","volume":"19","author":"C Giorgi","year":"2018","unstructured":"Giorgi C, Marchi S, Pinton P (2018) The machineries, regulation and cellular functions of mitochondrial calcium. Nat Rev Mol Cell Biol 19(11):713\u2013730","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7360","key":"6053_CR56","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/nature10234","volume":"476","author":"JM Baughman","year":"2011","unstructured":"Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y et al (2011) Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature 476(7360):341\u2013345","journal-title":"Nature"},{"issue":"7360","key":"6053_CR57","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nature10230","volume":"476","author":"D De Stefani","year":"2011","unstructured":"De Stefani D, Raffaello A, Teardo E, Szab\u00f2 I, Rizzuto R (2011) A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter. Nature 476(7360):336\u201340","journal-title":"Nature"},{"issue":"1","key":"6053_CR58","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/s42003-021-02114-0","volume":"4","author":"A Stavsky","year":"2021","unstructured":"Stavsky A, Stoler O, Kostic M, Katoshevsky T, Assali EA, Savic I et al (2021) Aberrant activity of mitochondrial NCLX is linked to impaired synaptic transmission and is associated with mental retardation. Commun Biol 4(1):666","journal-title":"Commun Biol"},{"issue":"1","key":"6053_CR59","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/s42003-022-03848-1","volume":"5","author":"CJ Groten","year":"2022","unstructured":"Groten CJ, MacVicar BA (2022) Mitochondrial Ca(2+) uptake by the MCU facilitates pyramidal neuron excitability and metabolism during action potential firing. Commun Biol 5(1):900","journal-title":"Commun Biol"},{"key":"6053_CR60","doi-asserted-by":"crossref","unstructured":"Matuz-Mares D, Gonz\u00e1lez-Andrade M, Araiza-Villanueva MG, Vilchis-Landeros MM, V\u00e1zquez-Meza H (2022) Mitochondrial calcium: effects of its imbalance in disease. Antioxid (Basel). ;11(5)","DOI":"10.3390\/antiox11050801"},{"issue":"1","key":"6053_CR61","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16074-2","volume":"11","author":"M Calvo-Rodriguez","year":"2020","unstructured":"Calvo-Rodriguez M, Hou SS, Snyder AC, Kharitonova EK, Russ AN, Das S et al (2020) Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer\u2019s disease. Nat Commun 11(1):2146","journal-title":"Nat Commun"},{"issue":"3","key":"6053_CR62","doi-asserted-by":"publisher","first-page":"G330","DOI":"10.1152\/ajpgi.00224.2023","volume":"326","author":"G Delfino","year":"2024","unstructured":"Delfino G, Briand JB, Oullier T, Nienkemper L, Greig J, V\u00e9ziers J et al (2024) Characterization of mitochondria-associated ER membranes in the enteric nervous system under physiological and pathological conditions. Am J Physiol Gastrointest Liver Physiol 326(3):G330\u2013G43","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"2","key":"6053_CR63","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/0003-9861(79)90373-4","volume":"195","author":"DR Hunter","year":"1979","unstructured":"Hunter DR, Haworth RA (1979) The Ca2+-induced membrane transition in mitochondria: III. transitional Ca2\u2009+\u2009release. Arch Biochem Biophys 195(2):468\u2013477","journal-title":"Arch Biochem Biophys"},{"issue":"2","key":"6053_CR64","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/0003-9861(79)90372-2","volume":"195","author":"RA Haworth","year":"1979","unstructured":"Haworth RA, Hunter DR (1979) The Ca2+-induced membrane transition in mitochondria: II. nature of the Ca2\u2009+\u2009trigger site. Arch Biochem Biophys 195(2):460\u2013467","journal-title":"Arch Biochem Biophys"},{"issue":"2","key":"6053_CR65","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/0003-9861(79)90371-0","volume":"195","author":"DR Hunter","year":"1979","unstructured":"Hunter DR, Haworth RA (1979) The Ca2+-induced membrane transition in mitochondria: i. the protective mechanisms. Arch Biochem Biophys 195(2):453\u2013459","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"6053_CR66","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60177-1","volume":"10","author":"B Wacquier","year":"2020","unstructured":"Wacquier B, Combettes L, Dupont G (2020) Dual dynamics of mitochondrial permeability transition pore opening. Sci Rep 10(1):3924","journal-title":"Sci Rep"},{"key":"6053_CR67","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1146\/annurev.biochem.73.011303.073706","volume":"73","author":"X Jiang","year":"2004","unstructured":"Jiang X, Wang X (2004) Cytochrome C-mediated apoptosis. Annu Rev Biochem 73:87\u2013106","journal-title":"Annu Rev Biochem"},{"key":"6053_CR68","doi-asserted-by":"crossref","unstructured":"Andreone BJ, Larhammar M, Lewcock JW (2020) Cell death and neurodegeneration. Cold Spring Harb Perspect Biol. ;12(2)","DOI":"10.1101\/cshperspect.a036434"},{"issue":"8","key":"6053_CR69","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1111\/bph.12416","volume":"171","author":"AA Fatokun","year":"2014","unstructured":"Fatokun AA, Dawson VL, Dawson TM (2014) Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities. Br J Pharmacol 171(8):2000\u20132016","journal-title":"Br J Pharmacol"},{"key":"6053_CR70","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.jare.2024.04.031","volume":"70","author":"J Zhang","year":"2025","unstructured":"Zhang J, Hu X, Geng Y, Xiang L, Wu Y, Li Y et al (2025) Exploring the role of parthanatos in CNS injury: molecular insights and therapeutic approaches. J Adv Res 70:271\u2013286","journal-title":"J Adv Res"},{"issue":"7","key":"6053_CR71","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/j.bpj.2014.07.074","volume":"107","author":"J Kim","year":"2014","unstructured":"Kim J, Yang Y, Song SS, Na JH, Oh KJ, Jeong C et al (2014) Beta-amyloid oligomers activate apoptotic BAK pore for cytochrome c release. Biophys J 107(7):1601\u20131608","journal-title":"Biophys J"},{"issue":"12","key":"6053_CR72","doi-asserted-by":"publisher","first-page":"109729","DOI":"10.1016\/j.celrep.2021.109729","volume":"36","author":"Y-C Hung","year":"2021","unstructured":"Hung Y-C, Huang K-L, Chen P-L, Li J-L, Lu SH-A, Chang J-C et al (2021) UQCRC1 engages cytochrome c for neuronal apoptotic cell death. Cell Rep 36(12):109729","journal-title":"Cell Rep"},{"issue":"1","key":"6053_CR73","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1136\/gut.2005.073197","volume":"55","author":"G Bassotti","year":"2006","unstructured":"Bassotti G, Villanacci V, Maurer CA, Fisogni S, Di Fabio F, Cadei M et al (2006) The role of glial cells and apoptosis of enteric neurones in the neuropathology of intractable slow transit constipation. Gut 55(1):41\u201346","journal-title":"Gut"},{"issue":"12","key":"6053_CR74","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13457","volume":"30","author":"W Fan","year":"2018","unstructured":"Fan W, Fei G, Li X, Wang X, Hu C, Xin H et al (2018) Sera with anti-enteric neuronal antibodies from patients with irritable bowel syndrome promote apoptosis in myenteric neurons of guinea pigs and human SH-Sy5Y cells. Neurogastroenterol Motil 30(12):e13457","journal-title":"Neurogastroenterol Motil"},{"issue":"4","key":"6053_CR75","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.crohns.2009.06.004","volume":"3","author":"G Bassotti","year":"2009","unstructured":"Bassotti G, Villanacci V, Nascimbeni R, Cadei M, Fisogni S, Antonelli E et al (2009) Enteric neuroglial apoptosis in inflammatory bowel diseases. J Crohn\u2019s Colitis 3(4):264\u2013270","journal-title":"J Crohn\u2019s Colitis"},{"key":"6053_CR76","doi-asserted-by":"crossref","unstructured":"Maragkakis M, Malla S, Hatzoglou M, Trifunovic A, Glick AB, Finkel T et al (2023) Biology of stress responses in aging. Aging Biol. ;1","DOI":"10.59368\/agingbio.20230001"},{"key":"6053_CR77","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2023.1158198","volume":"11","author":"P Chaudhary","year":"2023","unstructured":"Chaudhary P, Janmeda P, Docea AO, Yeskaliyeva B, Abdull Razis AF, Modu B et al (2023) Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases. Front Chem 11:1158198","journal-title":"Front Chem"},{"key":"6053_CR78","doi-asserted-by":"crossref","unstructured":"Chen TH, Wang HC, Chang CJ, Lee SY (2024) Mitochondrial glutathione in cellular redox homeostasis and disease manifestation. Int J Mol Sci. ;25(2)","DOI":"10.3390\/ijms25021314"},{"issue":"10","key":"6053_CR79","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","volume":"97","author":"K Jomova","year":"2023","unstructured":"Jomova K, Raptova R, Alomar SY, Alwasel SH, Nepovimova E, Kuca K et al (2023) Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging. Arch Toxicol 97(10):2499\u2013574","journal-title":"Arch Toxicol"},{"issue":"1","key":"6053_CR80","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-03891-8","volume":"12","author":"M Berdy\u0144ski","year":"2022","unstructured":"Berdy\u0144ski M, Miszta P, Safranow K, Andersen PM, Morita M, Filipek S et al (2022) SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity. Sci Rep 12(1):103","journal-title":"Sci Rep"},{"key":"6053_CR81","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.freeradbiomed.2014.02.019","volume":"70","author":"E Miquel","year":"2014","unstructured":"Miquel E, Cassina A, Mart\u00ednez-Palma L, Souza JM, Bolatto C, Rodr\u00edguez-Bottero S et al (2014) Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis. Free Radic Biol Med 70:204\u201313","journal-title":"Free Radic Biol Med"},{"key":"6053_CR82","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.freeradbiomed.2019.11.021","volume":"146","author":"BR Pinho","year":"2020","unstructured":"Pinho BR, Duarte AI, Canas PM, Moreira PI, Murphy MP, Oliveira JMA (2020) The interplay between redox signalling and proteostasis in neurodegeneration: in vivo effects of a mitochondria-targeted antioxidant in Huntington\u2019s disease mice. Free Radic Biol Med 146:372\u2013382","journal-title":"Free Radic Biol Med"},{"key":"6053_CR83","doi-asserted-by":"crossref","unstructured":"Xun Z, Rivera-S\u00e1nchez S, Ayala-Pe\u00f1a S, Lim J, Budworth H, Skoda Erin M, et al. Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington\u2019s Disease. Cell Reports. 2012;2(5):1137\u201342","DOI":"10.1016\/j.celrep.2012.10.001"},{"key":"6053_CR84","doi-asserted-by":"publisher","first-page":"102759","DOI":"10.1016\/j.autneu.2020.102759","volume":"230","author":"CC Sehaber-Sierakowski","year":"2021","unstructured":"Sehaber-Sierakowski CC, Vieira-Frez FC, Hermes-Uliana C, Martins HA, Bossolani GDP, Lima MM et al (2021) Protective effects of quercetin-loaded microcapsules on the enteric nervous system of diabetic rats. Auton Neurosci 230:102759","journal-title":"Auton Neurosci"},{"key":"6053_CR85","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2025.103814","volume":"146","author":"DE King","year":"2025","unstructured":"King DE, Copeland WC (2025) DNA repair pathways in the mitochondria. DNA Repair 146:103814","journal-title":"DNA Repair"},{"key":"6053_CR86","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.984245","volume":"10","author":"M Akbari","year":"2022","unstructured":"Akbari M, Nilsen HL, Montaldo NP (2022) Dynamic features of human mitochondrial DNA maintenance and transcription. Front Cell Dev Biol 10:984245. https:\/\/doi.org\/10.3389\/fcell.2022.984245","journal-title":"Front Cell Dev Biol"},{"issue":"8","key":"6053_CR87","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1002\/jcb.25103","volume":"116","author":"A Prakash","year":"2015","unstructured":"Prakash A, Doubli\u00e9 S (2015) Base excision repair in the mitochondria. J Cell Biochem 116(8):1490\u20131499","journal-title":"J Cell Biochem"},{"key":"6053_CR88","doi-asserted-by":"publisher","first-page":"A1","DOI":"10.1016\/j.dnarep.2017.11.002","volume":"60","author":"BA Kaufman","year":"2017","unstructured":"Kaufman BA, Van Houten B (2017) POLB: a new role of DNA polymerase beta in mitochondrial base excision repair. DNA Repair (Amst) 60:A1-a5","journal-title":"DNA Repair (Amst)"},{"issue":"16","key":"6053_CR89","doi-asserted-by":"publisher","first-page":"5545","DOI":"10.1093\/nar\/gkm605","volume":"35","author":"L Weissman","year":"2007","unstructured":"Weissman L, Jo D-G, S\u00f8rensen MM, de Souza-Pinto NC, Markesbery WR, Mattson MP et al (2007) Defective DNA base excision repair in brain from individuals with alzheimer\u2019s disease and amnestic mild cognitive impairment. Nucleic Acids Res 35(16):5545\u20135555","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"6053_CR90","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.neurobiolaging.2005.06.002","volume":"27","author":"SZ Imam","year":"2006","unstructured":"Imam SZ, Karahalil B, Hogue BA, Souza-Pinto NC, Bohr VA (2006) Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol Aging 27(8):1129\u201336","journal-title":"Neurobiol Aging"},{"issue":"14","key":"6053_CR91","doi-asserted-by":"publisher","first-page":"4660","DOI":"10.1093\/nar\/gki759","volume":"33","author":"JF Harrison","year":"2005","unstructured":"Harrison JF, Hollensworth SB, Spitz DR, Copeland WC, Wilson GL, LeDoux SP (2005) Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance. Nucleic Acids Res 33(14):4660\u20134671","journal-title":"Nucleic Acids Res"},{"key":"6053_CR92","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.669379","volume":"9","author":"Z Rong","year":"2021","unstructured":"Rong Z, Tu P, Xu P, Sun Y, Yu F, Tu N et al (2021) The mitochondrial response to DNA damage. Front Cell Dev Biol 9:669379","journal-title":"Front Cell Dev Biol"},{"key":"6053_CR93","doi-asserted-by":"crossref","unstructured":"Al Ojaimi M, Salah A, El-Hattab AW (2022) Mitochondrial fission and fusion: molecular Mechanisms, biological Functions, and related disorders. Membr (Basel). ;12(9)","DOI":"10.3390\/membranes12090893"},{"issue":"2","key":"6053_CR94","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1083\/jcb.200211046","volume":"160","author":"H Chen","year":"2003","unstructured":"Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE, Chan DC (2003) Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 160(2):189\u2013200","journal-title":"J Cell Biol"},{"issue":"8","key":"6053_CR95","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1038\/90976","volume":"7","author":"K Nakada","year":"2001","unstructured":"Nakada K, Inoue K, Ono T, Isobe K, Ogura A, Goto YI et al (2001) Inter-mitochondrial complementation: mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA. Nat Med 7(8):934\u201340","journal-title":"Nat Med"},{"issue":"3","key":"6053_CR96","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/90116","volume":"28","author":"T Ono","year":"2001","unstructured":"Ono T, Isobe K, Nakada K, Hayashi JI (2001) Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria. Nat Genet 28(3):272\u2013275","journal-title":"Nat Genet"},{"issue":"13","key":"6053_CR97","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1007\/s00018-015-1863-9","volume":"72","author":"L Yang","year":"2015","unstructured":"Yang L, Long Q, Liu J, Tang H, Li Y, Bao F et al (2015) Mitochondrial fusion provides an \u201cinitial metabolic complementation\u201d controlled by mtDNA. Cell Mol Life Sci 72(13):2585\u201398","journal-title":"Cell Mol Life Sci"},{"issue":"9","key":"6053_CR98","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/nrg3966","volume":"16","author":"JB Stewart","year":"2015","unstructured":"Stewart JB, Chinnery PF (2015) The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease. Nat Rev Genet 16(9):530\u2013542","journal-title":"Nat Rev Genet"},{"issue":"5","key":"6053_CR99","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1091\/mbc.e12-10-0721","volume":"24","author":"OC Los\u00f3n","year":"2013","unstructured":"Los\u00f3n OC, Song Z, Chen H, Chan DC (2013) Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol Biol Cell 24(5):659\u2013667","journal-title":"Mol Biol Cell"},{"issue":"9","key":"6053_CR100","first-page":"1171","volume":"72","author":"DB Zorov","year":"2017","unstructured":"Zorov DB, Popkov VA, Zorova LD, Vorobjev IA, Pevzner IB, Silachev DN et al (2017) Mitochondrial aging: is there a mitochondrial clock? J Gerontol Biol Sci Med Sci 72(9):1171\u20131179","journal-title":"J Gerontol Biol Sci Med Sci"},{"issue":"25","key":"6053_CR101","doi-asserted-by":"publisher","first-page":"10190","DOI":"10.1073\/pnas.1107402108","volume":"108","author":"AS Rambold","year":"2011","unstructured":"Rambold AS, Kostelecky B, Elia N, Lippincott-Schwartz J (2011) Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation. Proc Natl Acad Sci U S A 108(25):10190\u201310195","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"6053_CR102","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1093\/brain\/awm298","volume":"131","author":"P Amati-Bonneau","year":"2008","unstructured":"Amati-Bonneau P, Valentino ML, Reynier P, Gallardo ME, Bornstein B, Boissi\u00e8re A et al (2008) OPA1 mutations induce mitochondrial DNA instability and optic atrophy \u2018plus\u2019 phenotypes. Brain 131(2):338\u201351","journal-title":"Brain"},{"issue":"20","key":"6053_CR103","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1212\/WNL.0b013e31821a441e","volume":"76","author":"SM Feely","year":"2011","unstructured":"Feely SM, Laura M, Siskind CE, Sottile S, Davis M, Gibbons VS et al (2011) MFN2 mutations cause severe phenotypes in most patients with CMT2A. Neurology 76(20):1690\u20136","journal-title":"Neurology"},{"issue":"10","key":"6053_CR104","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1242\/jcs.118844","volume":"126","author":"M Cagalinec","year":"2013","unstructured":"Cagalinec M, Safiulina D, Liiv M, Liiv J, Choubey V, Wareski P et al (2013) Principles of the mitochondrial fusion and fission cycle in neurons. J Cell Sci 126(10):2187\u201397","journal-title":"J Cell Sci"},{"issue":"1","key":"6053_CR105","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1053\/j.gastro.2024.08.009","volume":"168","author":"C Diquigiovanni","year":"2025","unstructured":"Diquigiovanni C, Rizzardi N, Cataldi-Stagetti E, Gozzellino L, Isidori F, Valenti F et al (2025) Glutamine supplementation as a novel metabolic therapeutic strategy for LIG3-Dependent chronic intestinal Pseudo-Obstruction. Gastroenterology 168(1):68\u201383","journal-title":"Gastroenterology"},{"issue":"4","key":"6053_CR106","doi-asserted-by":"publisher","first-page":"R170","DOI":"10.1016\/j.cub.2018.01.004","volume":"28","author":"S Pickles","year":"2018","unstructured":"Pickles S, Vigi\u00e9 P, Youle RJ (2018) Mitophagy and quality control mechanisms in mitochondrial maintenance. Curr Biol 28(4):R170\u2013r85","journal-title":"Curr Biol"},{"issue":"1","key":"6053_CR107","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-024-00409-w","volume":"13","author":"N Song","year":"2024","unstructured":"Song N, Mei S, Wang X, Hu G, Lu M (2024) Focusing on mitochondria in the brain: from biology to therapeutics. Transl Neurodegener 13(1):23","journal-title":"Transl Neurodegener"},{"issue":"5","key":"6053_CR108","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1083\/jcb.200809125","volume":"183","author":"D Narendra","year":"2008","unstructured":"Narendra D, Tanaka A, Suen DF, Youle RJ (2008) Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183(5):795\u2013803","journal-title":"J Cell Biol"},{"issue":"2","key":"6053_CR109","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1083\/jcb.200910140","volume":"189","author":"N Matsuda","year":"2010","unstructured":"Matsuda N, Sato S, Shiba K, Okatsu K, Saisho K, Gautier CA et al (2010) PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol 189(2):211\u201321","journal-title":"J Cell Biol"},{"issue":"2","key":"6053_CR110","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","volume":"85","author":"AM Pickrell","year":"2015","unstructured":"Pickrell AM, Youle RJ (2015) The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease. Neuron 85(2):257\u2013273","journal-title":"Neuron"},{"issue":"4","key":"6053_CR111","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1080\/15548627.2016.1151580","volume":"12","author":"M Chen","year":"2016","unstructured":"Chen M, Chen Z, Wang Y, Tan Z, Zhu C, Li Y et al (2016) Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy. Autophagy 12(4):689\u2013702","journal-title":"Autophagy"},{"issue":"1\u20132","key":"6053_CR112","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.cell.2016.11.042","volume":"168","author":"Y Wei","year":"2017","unstructured":"Wei Y, Chiang WC, Sumpter R Jr., Mishra P, Levine B (2017) Prohibitin 2 is an inner mitochondrial membrane mitophagy receptor. Cell 168(1\u20132):224\u201338.e10","journal-title":"Cell"},{"issue":"10","key":"6053_CR113","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1080\/15548627.2015.1085136","volume":"11","author":"AH Chourasia","year":"2015","unstructured":"Chourasia AH, Macleod KF (2015) Tumor suppressor functions of BNIP3 and mitophagy. Autophagy 11(10):1937\u20131938","journal-title":"Autophagy"},{"issue":"2","key":"6053_CR114","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/sj.emboj.7601963","volume":"27","author":"G Twig","year":"2008","unstructured":"Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G et al (2008) Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. Embo J 27(2):433\u2013446","journal-title":"Embo J"},{"issue":"16","key":"6053_CR115","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1093\/hmg\/ddr235","volume":"20","author":"W Yu","year":"2011","unstructured":"Yu W, Sun Y, Guo S, Lu B (2011) The PINK1\/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons. Hum Mol Genet 20(16):3227\u20133240","journal-title":"Hum Mol Genet"},{"issue":"3","key":"6053_CR116","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41593-018-0332-9","volume":"22","author":"EF Fang","year":"2019","unstructured":"Fang EF, Hou Y, Palikaras K, Adriaanse BA, Kerr JS, Yang B et al (2019) Mitophagy inhibits amyloid-\u03b2 and tau pathology and reverses cognitive deficits in models of Alzheimer\u2019s disease. Nat Neurosci 22(3):401\u201312","journal-title":"Nat Neurosci"},{"issue":"35","key":"6053_CR117","doi-asserted-by":"publisher","first-page":"5574","DOI":"10.2174\/1381612820666140305224906","volume":"20","author":"M Uittenbogaard","year":"2014","unstructured":"Uittenbogaard M, Chiaramello A (2014) Mitochondrial biogenesis: a therapeutic target for neurodevelopmental disorders and neurodegenerative diseases. Curr Pharm Des 20(35):5574\u20135593","journal-title":"Curr Pharm Des"},{"key":"6053_CR118","doi-asserted-by":"crossref","unstructured":"Abu Shelbayeh O, Arroum T, Morris S, Busch KB (2023) PGC-1\u03b1 is a master regulator of mitochondrial lifecycle and ROS stress response. Antioxid (Basel). ;12(5)","DOI":"10.3390\/antiox12051075"},{"key":"6053_CR119","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2238","volume":"3","author":"A Cheng","year":"2012","unstructured":"Cheng A, Wan R, Yang JL, Kamimura N, Son TG, Ouyang X et al (2012) Involvement of PGC-1\u03b1 in the formation and maintenance of neuronal dendritic spines. Nat Commun 3:1250","journal-title":"Nat Commun"},{"issue":"6","key":"6053_CR120","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1016\/j.celrep.2013.11.022","volume":"5","author":"M Spillane","year":"2013","unstructured":"Spillane M, Ketschek A, Merianda TT, Twiss JL, Gallo G (2013) Mitochondria coordinate sites of axon branching through localized intra-axonal protein synthesis. Cell Rep 5(6):1564\u20131575","journal-title":"Cell Rep"},{"issue":"3","key":"6053_CR121","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/j.1471-4159.2011.07581.x","volume":"120","author":"B Sheng","year":"2012","unstructured":"Sheng B, Wang X, Su B, Lee HG, Casadesus G, Perry G et al (2012) Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in alzheimer\u2019s disease. J Neurochem 120(3):419\u2013429","journal-title":"J Neurochem"},{"issue":"1","key":"6053_CR122","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3233\/JPD-2012-11074","volume":"2","author":"RR Thomas","year":"2012","unstructured":"Thomas RR, Keeney PM, Bennett JP (2012) Impaired complex-I mitochondrial biogenesis in Parkinson disease frontal cortex. J Parkinsons Dis 2(1):67\u201376","journal-title":"J Parkinsons Dis"},{"issue":"7","key":"6053_CR123","first-page":"e70259","volume":"6","author":"Y Liu","year":"2025","unstructured":"Liu Y, Mao Z-H, Huang J, Wang H, Zhang X, Zhou X et al (2025) Mitochondria-Associated Endoplasmic Reticulum Membr Hum Health Dis MedComm 6(7):e70259","journal-title":"Mitochondria-Associated Endoplasmic Reticulum Membr Hum Health Dis MedComm"},{"key":"6053_CR124","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4578809","volume":"2021","author":"Y Luan","year":"2021","unstructured":"Luan Y, Luan Y, Yuan RX, Feng Q, Chen X, Yang Y (2021) Structure and function of mitochondria-associated endoplasmic reticulum membranes (MAMs) and their role in cardiovascular diseases. Oxid Med Cell Longev 2021:4578809","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"6053_CR125","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14417","volume":"21","author":"JC Zellmer","year":"2025","unstructured":"Zellmer JC, Tarantino MB, Kim M, Lomoio S, Maesako M, Hajn\u00f3czky G et al (2025) Stabilization of mitochondria-associated endoplasmic reticulum membranes regulates A\u03b2 generation in a three-dimensional neural model of Alzheimer\u2019s disease. Alzheimers Dement 21(2):e14417","journal-title":"Alzheimers Dement"},{"issue":"21","key":"6053_CR126","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.1038\/emboj.2012.202","volume":"31","author":"E Area-Gomez","year":"2012","unstructured":"Area-Gomez E, Del Carmen Lara Castillo M, Tambini MD, Guardia-Laguarta C, de Groof AJ, Madra M et al (2012) Upregulated function of mitochondria-associated ER membranes in alzheimer disease. Embo J 31(21):4106\u20134123","journal-title":"Embo J"},{"issue":"1","key":"6053_CR127","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1523\/JNEUROSCI.2507-13.2014","volume":"34","author":"C Guardia-Laguarta","year":"2014","unstructured":"Guardia-Laguarta C, Area-Gomez E, R\u00fcb C, Liu Y, Magran\u00e9 J, Becker D et al (2014) \u03b1-Synuclein is localized to mitochondria-associated ER membranes. J Neurosci 34(1):249\u2013259","journal-title":"J Neurosci"},{"issue":"3","key":"6053_CR128","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1159\/000446586","volume":"7","author":"DM Niyazov","year":"2016","unstructured":"Niyazov DM, Kahler SG, Frye RE (2016) Primary mitochondrial disease and secondary mitochondrial dysfunction: importance of distinction for diagnosis and treatment. Mol Syndromol 7(3):122\u2013137","journal-title":"Mol Syndromol"},{"key":"6053_CR129","first-page":"1","volume":"4","author":"BE Bax","year":"2020","unstructured":"Bax BE (2020) Mitochondrial neurogastrointestinal encephalomyopathy: approaches to diagnosis and treatment. J Transl Genet Genom 4:1\u201316","journal-title":"J Transl Genet Genom"},{"key":"6053_CR130","doi-asserted-by":"crossref","unstructured":"Pizzamiglio C, Hanna MG, Pitceathly RDS (2024) Chapter 4 - Primary mitochondrial diseases. In: Lynch DS, Houlden H (eds) Handbook of clinical neurology, vol 204. Elsevier, pp 53\u201376","DOI":"10.1016\/B978-0-323-99209-1.00004-1"},{"issue":"1","key":"6053_CR131","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2023.168276","volume":"436","author":"A Sallmyr","year":"2024","unstructured":"Sallmyr A, Bhandari SK, Naila T, Tomkinson AE (2024) Mammalian DNA ligases; roles in maintaining genome integrity. J Mol Biol 436(1):168276","journal-title":"J Mol Biol"},{"issue":"7337","key":"6053_CR132","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/nature09794","volume":"471","author":"D Simsek","year":"2011","unstructured":"Simsek D, Furda A, Gao Y, Artus J, Brunet E, Hadjantonakis AK et al (2011) Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature 471(7337):245\u2013248","journal-title":"Nature"},{"issue":"8","key":"6053_CR133","doi-asserted-by":"publisher","first-page":"e14860","DOI":"10.1111\/nmo.14860","volume":"37","author":"LMM Mombeek","year":"2025","unstructured":"Mombeek LMM, Boesmans W, Wilson DM 3 (2025) Genomic stress in diseases stemming from defects in the second brain. Neurogastroenterol Motil 37(8):e14860","journal-title":"Neurogastroenterol Motil"},{"key":"6053_CR134","doi-asserted-by":"publisher","first-page":"s1","DOI":"10.4081\/ejh.2021.3289","volume":"65","author":"F Bianco","year":"2021","unstructured":"Bianco F, Lattanzio G, Lorenzini L, Diquigiovanni C, Mazzoni M, Clavenzani P et al (2021) Novel understanding on genetic mechanisms of enteric neuropathies leading to severe gut dysmotility. Eur J Histochem 65:s1","journal-title":"Eur J Histochem"},{"issue":"12","key":"6053_CR135","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","volume":"30","author":"RB Postuma","year":"2015","unstructured":"Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W et al (2015) MDS clinical diagnostic criteria for parkinson\u2019s disease. Mov Disord 30(12):1591\u20131601","journal-title":"Mov Disord"},{"issue":"1","key":"6053_CR136","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47867-4","volume":"15","author":"IH Fl\u00f8nes","year":"2024","unstructured":"Fl\u00f8nes IH, Toker L, Sandnes DA, Castelli M, Mostafavi S, Lura N et al (2024) Mitochondrial complex I deficiency stratifies idiopathic Parkinson\u2019s disease. Nat Commun 15(1):3631","journal-title":"Nat Commun"},{"issue":"1","key":"6053_CR137","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/S0169-328X(98)00259-9","volume":"63","author":"DJ Eve","year":"1998","unstructured":"Eve DJ, Nisbet AP, Kingsbury AE, Hewson EL, Daniel SE, Lees AJ et al (1998) Basal ganglia neuronal nitric oxide synthase mRNA expression in Parkinson\u2019s disease. Mol Brain Res 63(1):62\u201371","journal-title":"Mol Brain Res"},{"issue":"2","key":"6053_CR138","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/0306-4522(95)00578-1","volume":"72","author":"S Hunot","year":"1996","unstructured":"Hunot S, Boissi\u00e8re F, Faucheux B, Brugg B, Mouatt-Prigent A, Agid Y et al (1996) Nitric oxide synthase and neuronal vulnerability in parkinson\u2019s disease. Neuroscience 72(2):355\u2013363","journal-title":"Neuroscience"},{"issue":"3","key":"6053_CR139","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.ajhg.2016.01.014","volume":"98","author":"S Lesage","year":"2016","unstructured":"Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A et al (2016) Loss of VPS13C function in Autosomal-Recessive parkinsonism causes mitochondrial dysfunction and increases PINK1\/Parkin-Dependent mitophagy. Am J Hum Genet 98(3):500\u2013513","journal-title":"Am J Hum Genet"},{"issue":"Pt 4","key":"6053_CR140","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1093\/brain\/awq051","volume":"133","author":"L Samaranch","year":"2010","unstructured":"Samaranch L, Lorenzo-Betancor O, Arbelo JM, Ferrer I, Lorenzo E, Irigoyen J et al (2010) PINK1-linked parkinsonism is associated with lewy body pathology. Brain 133(Pt 4):1128\u20131142","journal-title":"Brain"},{"issue":"3","key":"6053_CR141","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/ana.20587","volume":"58","author":"PP Pramstaller","year":"2005","unstructured":"Pramstaller PP, Schlossmacher MG, Jacques TS, Scaravilli F, Eskelson C, Pepivani I et al (2005) Lewy body Parkinson\u2019s disease in a large pedigree with 77 Parkin mutation carriers. Ann Neurol 58(3):411\u201322","journal-title":"Ann Neurol"},{"issue":"Pt 6","key":"6053_CR142","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1093\/brain\/aww080","volume":"139","author":"R Taipa","year":"2016","unstructured":"Taipa R, Pereira C, Reis I, Alonso I, Bastos-Lima A, Melo-Pires M et al (2016) DJ-1 linked parkinsonism (PARK7) is associated with lewy body pathology. Brain 139(Pt 6):1680\u20131687","journal-title":"Brain"},{"issue":"41","key":"6053_CR143","doi-asserted-by":"publisher","first-page":"10510","DOI":"10.1523\/JNEUROSCI.1659-16.2016","volume":"36","author":"MH Ludtmann","year":"2016","unstructured":"Ludtmann MH, Angelova PR, Ninkina NN, Gandhi S, Buchman VL, Abramov AY (2016) Monomeric alpha-synuclein exerts a physiological role on brain ATP synthase. J Neurosci 36(41):10510\u201310521","journal-title":"J Neurosci"},{"issue":"22","key":"6053_CR144","doi-asserted-by":"publisher","first-page":"10190","DOI":"10.1128\/MCB.25.22.10190-10201.2005","volume":"25","author":"CE Ellis","year":"2005","unstructured":"Ellis CE, Murphy EJ, Mitchell DC, Golovko MY, Scaglia F, Barcel\u00f3-Coblijn GC et al (2005) Mitochondrial lipid abnormality and electron transport chain impairment in mice lacking alpha-synuclein. Mol Cell Biol 25(22):10190\u201310201","journal-title":"Mol Cell Biol"},{"key":"6053_CR145","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.abb.2018.04.018","volume":"651","author":"JH Mart\u00ednez","year":"2018","unstructured":"Mart\u00ednez JH, Fuentes F, Vanasco V, Alvarez S, Alaimo A, Cassina A et al (2018) Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment. Arch Biochem Biophys 651:1\u201312","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"6053_CR146","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00401-017-1704-z","volume":"134","author":"S Paillusson","year":"2017","unstructured":"Paillusson S, Gomez-Suaga P, Stoica R, Little D, Gissen P, Devine MJ et al (2017) \u03b1-Synuclein binds to the ER-mitochondria tethering protein VAPB to disrupt Ca(2+) homeostasis and mitochondrial ATP production. Acta Neuropathol 134(1):129\u201349","journal-title":"Acta Neuropathol"},{"issue":"11","key":"6053_CR147","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1002\/jnr.24952","volume":"99","author":"AG Erustes","year":"2021","unstructured":"Erustes AG, D\u2019Eletto M, Guarache GC, Ureshino RP, Bincoletto C, da Silva Pereira GJ et al (2021) Overexpression of \u03b1-synuclein inhibits mitochondrial Ca(2+) trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75-IP3R interaction. J Neurosci Res 99(11):2932\u201347","journal-title":"J Neurosci Res"},{"issue":"38","key":"6053_CR148","doi-asserted-by":"publisher","first-page":"14503","DOI":"10.1073\/pnas.0803998105","volume":"105","author":"H Deng","year":"2008","unstructured":"Deng H, Dodson MW, Huang H, Guo M (2008) The parkinson\u2019s disease genes pink1 and parkin promote mitochondrial fission and\/or inhibit fusion in drosophila. Proc Natl Acad Sci U S A 105(38):14503\u201314508","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"15","key":"6053_CR149","doi-asserted-by":"publisher","first-page":"11740","DOI":"10.1074\/jbc.M109.066662","volume":"285","author":"M Cui","year":"2010","unstructured":"Cui M, Tang X, Christian WV, Yoon Y, Tieu K (2010) Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. J Biol Chem 285(15):11740\u201311752","journal-title":"J Biol Chem"},{"issue":"1","key":"6053_CR150","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/s41392-022-00933-z","volume":"7","author":"Q Gao","year":"2022","unstructured":"Gao Q, Tian R, Han H, Slone J, Wang C, Ke X et al (2022) PINK1-mediated Drp1(S616) phosphorylation modulates synaptic development and plasticity via promoting mitochondrial fission. Signal Transduct Target Ther 7(1):103","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"6053_CR151","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1111\/jnc.13845","volume":"139","author":"AG Corbill\u00e9","year":"2016","unstructured":"Corbill\u00e9 AG, Neunlist M, Derkinderen P (2016) Cross-linking for the analysis of \u03b1-synuclein in the enteric nervous system. J Neurochem 139(5):839\u2013847","journal-title":"J Neurochem"},{"issue":"1","key":"6053_CR152","doi-asserted-by":"publisher","first-page":"33117","DOI":"10.1038\/srep33117","volume":"6","author":"AS Baumuratov","year":"2016","unstructured":"Baumuratov AS, Antony PMA, Ostaszewski M, He F, Salamanca L, Antunes L et al (2016) Enteric neurons from parkinson\u2019s disease patients display ex vivo aberrations in mitochondrial structure. Sci Rep 6(1):33117","journal-title":"Sci Rep"},{"issue":"9","key":"6053_CR153","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nrd3505","volume":"10","author":"E Karran","year":"2011","unstructured":"Karran E, Mercken M, Strooper BD (2011) The amyloid cascade hypothesis for alzheimer\u2019s disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov 10(9):698\u2013712","journal-title":"Nat Rev Drug Discov"},{"key":"6053_CR154","doi-asserted-by":"crossref","unstructured":"Kametani F, Hasegawa M (2018) Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer\u2019s Disease. Front NeuroSci. ;Volume 12\u20132018","DOI":"10.3389\/fnins.2018.00025"},{"key":"6053_CR155","doi-asserted-by":"crossref","unstructured":"Boccardi V, Comanducci C, Baroni M, Mecocci P (2017) Of energy and entropy: the ineluctable impact of aging in old age dementia. Int J Mol Sci. ;18(12)","DOI":"10.3390\/ijms18122672"},{"issue":"Suppl 2Suppl 2","key":"6053_CR156","doi-asserted-by":"publisher","first-page":"S265","DOI":"10.3233\/JAD-2010-100339","volume":"20","author":"RH Swerdlow","year":"2010","unstructured":"Swerdlow RH, Burns JM, Khan SM (2010) The alzheimer\u2019s disease mitochondrial cascade hypothesis. J Alzheimers Dis 20(Suppl 2Suppl 2):S265\u2013S279","journal-title":"J Alzheimers Dis"},{"key":"6053_CR157","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1206688","volume":"17","author":"D Jia","year":"2023","unstructured":"Jia D, Wang F, Yu H (2023) Systemic alterations of tricarboxylic acid cycle enzymes in Alzheimer\u2019s disease. Front Neurosci 17:1206688","journal-title":"Front Neurosci"},{"issue":"2","key":"6053_CR158","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3233\/JAD-141890","volume":"44","author":"C Zhang","year":"2015","unstructured":"Zhang C, Rissman RA, Feng J (2015) Characterization of ATP alternations in an alzheimer\u2019s disease Transgenic mouse model. J Alzheimers Dis 44(2):375\u2013378","journal-title":"J Alzheimers Dis"},{"key":"6053_CR159","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jns.2004.11.040","volume":"229\u2013230","author":"A Aliyev","year":"2005","unstructured":"Aliyev A, Chen SG, Seyidova D, Smith MA, Perry G, de la Torre J et al (2005) Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of alzheimer\u2019s disease. J Neurol Sci 229\u2013230:285\u2013292","journal-title":"J Neurol Sci"},{"issue":"1","key":"6053_CR160","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/j.1749-6632.2002.tb04798.x","volume":"977","author":"G Aliev","year":"2002","unstructured":"Aliev G, Seyidova D, Neal ML, Shi J, Lamb BT, Siedlak SL et al (2002) Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice. Ann N Y Acad Sci 977(1):45\u201364","journal-title":"Ann N Y Acad Sci"},{"issue":"9","key":"6053_CR161","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.2174\/092986706776360978","volume":"13","author":"P Zafrilla","year":"2006","unstructured":"Zafrilla P, Mulero J, Xandri JM, Santo E, Caravaca G, Morillas JM (2006) Oxidative stress in alzheimer patients in different stages of the disease. Curr Med Chem 13(9):1075\u20131083","journal-title":"Curr Med Chem"},{"key":"6053_CR162","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105781","volume":"171","author":"BR Troutwine","year":"2022","unstructured":"Troutwine BR, Strope TA, Franczak E, Lysaker CR, Hamid L, Mansel C et al (2022) Mitochondrial function and A\u03b2 in Alzheimer\u2019s disease postmortem brain. Neurobiol Dis 171:105781","journal-title":"Neurobiol Dis"},{"issue":"2","key":"6053_CR163","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1111\/j.1471-4159.1992.tb09439.x","volume":"59","author":"SJ Kish","year":"1992","unstructured":"Kish SJ, Bergeron C, Rajput A, Dozic S, Mastrogiacomo F, Chang LJ et al (1992) Brain cytochrome oxidase in alzheimer\u2019s disease. J Neurochem 59(2):776\u2013779","journal-title":"J Neurochem"},{"issue":"6","key":"6053_CR164","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1046\/j.1471-4159.1994.63062179.x","volume":"63","author":"EM Mutisya","year":"1994","unstructured":"Mutisya EM, Bowling AC, Beal MF (1994) Cortical cytochrome oxidase activity is reduced in Alzheimer\u2019s disease. J Neurochem 63(6):2179\u20132184","journal-title":"J Neurochem"},{"issue":"8926","key":"6053_CR165","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0140-6736(94)92871-1","volume":"344","author":"S Minoshima","year":"1994","unstructured":"Minoshima S, Foster NL, Kuhl DE (1994) Posterior cingulate cortex in Alzheimer\u2019s disease. Lancet 344(8926):895","journal-title":"Lancet"},{"issue":"1","key":"6053_CR166","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/ana.410420114","volume":"42","author":"S Minoshima","year":"1997","unstructured":"Minoshima S, Giordani B, Berent S, Frey KA, Foster NL, Kuhl DE (1997) Metabolic reduction in the posterior cingulate cortex in very early Alzheimer\u2019s disease. Ann Neurol 42(1):85\u201394","journal-title":"Ann Neurol"},{"issue":"1","key":"6053_CR167","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.nbd.2011.09.001","volume":"45","author":"L Devi","year":"2012","unstructured":"Devi L, Ohno M (2012) Mitochondrial dysfunction and accumulation of the \u03b2-secretase-cleaved C-terminal fragment of APP in Alzheimer\u2019s disease transgenic mice. Neurobiol Dis 45(1):417\u2013424","journal-title":"Neurobiol Dis"},{"issue":"1","key":"6053_CR168","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00401-020-02234-7","volume":"141","author":"L Vaillant-Beuchot","year":"2021","unstructured":"Vaillant-Beuchot L, Mary A, Pardossi-Piquard R, Bourgeois A, Lauritzen I, Eysert F et al (2021) Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in alzheimer\u2019s disease models and human brains. Acta Neuropathol 141(1):39\u201365","journal-title":"Acta Neuropathol"},{"issue":"5","key":"6053_CR169","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.15016","volume":"37","author":"KR Tasn\u00e1dy","year":"2025","unstructured":"Tasn\u00e1dy KR, Jehoul R, de Rav\u00e9 MG, Gijbels MJ, Br\u00f4ne B, Dewachter I et al (2025) Gastrointestinal dysfunction and low-grade inflammation associate with enteric neuronal amyloid-\u03b2 in a model for amyloid pathology. Neurogastroenterol Motil 37(5):e15016","journal-title":"Neurogastroenterol Motil"},{"issue":"12","key":"6053_CR170","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00018-023-04948-9","volume":"80","author":"G Liu","year":"2023","unstructured":"Liu G, Yu Q, Zhu H, Tan B, Yu H, Li X et al (2023) Amyloid-\u03b2 mediates intestinal dysfunction and enteric neurons loss in alzheimer\u2019s disease Transgenic mouse. Cell Mol Life Sci 80(12):351","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"6053_CR171","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s41419-017-0215-0","volume":"9","author":"E Area-Gomez","year":"2018","unstructured":"Area-Gomez E, de Groof A, Bonilla E, Montesinos J, Tanji K, Boldogh I et al (2018) A key role for MAM in mediating mitochondrial dysfunction in alzheimer disease. Cell Death Dis 9(3):335","journal-title":"Cell Death Dis"},{"issue":"14","key":"6053_CR172","doi-asserted-by":"publisher","first-page":"17356","DOI":"10.18632\/oncotarget.7861","volume":"7","author":"Y Hu","year":"2016","unstructured":"Hu Y, Li XC, Wang ZH, Luo Y, Zhang X, Liu XP et al (2016) <article-title update=\"added\"> Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin. Oncotarget 7(14):17356\u201368","journal-title":"Oncotarget"},{"issue":"47","key":"6053_CR173","doi-asserted-by":"publisher","first-page":"20057","DOI":"10.1073\/pnas.0905529106","volume":"106","author":"V Rhein","year":"2009","unstructured":"Rhein V, Song X, Wiesner A, Ittner LM, Baysang G, Meier F et al (2009) Amyloid-beta and Tau synergistically impair the oxidative phosphorylation system in triple Transgenic alzheimer\u2019s disease mice. Proc Natl Acad Sci U S A 106(47):20057\u201320062","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6053_CR174","doi-asserted-by":"crossref","unstructured":"Fi\u0161ar Z, Hroudov\u00e1 J (2025) Functional analysis of direct in vitro effect of phosphorylated Tau on mitochondrial respiration and hydrogen peroxide production. Biomolecules. ;15(4)","DOI":"10.3390\/biom15040495"},{"issue":"8","key":"6053_CR175","doi-asserted-by":"publisher","first-page":"e57499","DOI":"10.15252\/embr.202357499","volume":"24","author":"L Szabo","year":"2023","unstructured":"Szabo L, Cummins N, Paganetti P, Odermatt A, Papassotiropoulos A, Karch C et al (2023) ER\u2010mitochondria contacts and cholesterol metabolism are disrupted by disease\u2010associated Tau protein. EMBO Rep 24(8):e57499","journal-title":"EMBO Rep"},{"issue":"4","key":"6053_CR176","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.neuron.2012.06.026","volume":"75","author":"B DuBoff","year":"2012","unstructured":"DuBoff B, G\u00f6tz J, Feany MB (2012) Tau promotes neurodegeneration via DRP1 mislocalization in vivo. Neuron 75(4):618\u2013632","journal-title":"Neuron"},{"issue":"4","key":"6053_CR177","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.3233\/JAD-210095","volume":"81","author":"F Du","year":"2021","unstructured":"Du F, Yu Q, Yan SS (2021) PINK1 activation attenuates impaired neuronal-like differentiation and synaptogenesis and mitochondrial dysfunction in alzheimer\u2019s disease trans-mitochondrial cybrid cells. J Alzheimers Dis 81(4):1749\u20131761","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"6053_CR178","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/nn.3721","volume":"17","author":"H Yano","year":"2014","unstructured":"Yano H, Baranov SV, Baranova OV, Kim J, Pan Y, Yablonska S et al (2014) Inhibition of mitochondrial protein import by mutant huntingtin. Nat Neurosci 17(6):822\u201331","journal-title":"Nat Neurosci"},{"issue":"33","key":"6053_CR179","doi-asserted-by":"publisher","first-page":"16593","DOI":"10.1073\/pnas.1904101116","volume":"116","author":"S Yablonska","year":"2019","unstructured":"Yablonska S, Ganesan V, Ferrando LM, Kim J, Pyzel A, Baranova OV et al (2019) Mutant Huntingtin disrupts mitochondrial proteostasis by interacting with TIM23. Proc Natl Acad Sci U S A 116(33):16593\u201316602","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6053_CR180","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102424","volume":"56","author":"C Lopes","year":"2022","unstructured":"Lopes C, Ferreira IL, Maranga C, Beatriz M, Mota SI, Sereno J et al (2022) Mitochondrial and redox modifications in early stages of Huntington\u2019s disease. Redox Biol 56:102424","journal-title":"Redox Biol"},{"issue":"19","key":"6053_CR181","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.1093\/hmg\/ddt242","volume":"22","author":"M Damiano","year":"2013","unstructured":"Damiano M, Diguet E, Malgorn C, D\u2019Aurelio M, Galvan L, Petit F et al (2013) A role of mitochondrial complex II defects in genetic models of huntington\u2019s disease expressing N-terminal fragments of mutant Huntingtin. Hum Mol Genet 22(19):3869\u20133882","journal-title":"Hum Mol Genet"},{"issue":"1","key":"6053_CR182","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/mds.870010110","volume":"1","author":"KL Leenders","year":"1986","unstructured":"Leenders KL, Frackowiak RS, Quinn N, Marsden CD (1986) Brain energy metabolism and dopaminergic function in Huntington\u2019s disease measured in vivo using positron emission tomography. Mov Disord 1(1):69\u201377","journal-title":"Mov Disord"},{"issue":"5","key":"6053_CR183","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/ana.410120504","volume":"12","author":"DE Kuhl","year":"1982","unstructured":"Kuhl DE, Phelps ME, Markham CH, Metter EJ, Riege WH, Winter J (1982) Cerebral metabolism and atrophy in Huntington\u2019s disease determined by 18FDG and computed tomographic scan. Ann Neurol 12(5):425\u2013434","journal-title":"Ann Neurol"},{"issue":"Suppl","key":"6053_CR184","doi-asserted-by":"publisher","first-page":"S119","DOI":"10.1002\/ana.410150723","volume":"15","author":"DE Kuhl","year":"1984","unstructured":"Kuhl DE, Metter EJ, Riege WH, Markham CH (1984) Patterns of cerebral glucose utilization in Parkinson\u2019s disease and Huntington\u2019s disease. Ann Neurol 15(Suppl):S119\u2013S125","journal-title":"Ann Neurol"},{"issue":"6","key":"6053_CR185","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1002\/ana.410230603","volume":"23","author":"S Berent","year":"1988","unstructured":"Berent S, Giordani B, Lehtinen S, Markel D, Penney JB, Buchtel HA et al (1988) Positron emission tomographic scan investigations of huntington\u2019s disease: cerebral metabolic correlates of cognitive function. Ann Neurol 23(6):541\u2013546","journal-title":"Ann Neurol"},{"issue":"1","key":"6053_CR186","doi-asserted-by":"publisher","first-page":"e16172","DOI":"10.1371\/journal.pone.0016172","volume":"6","author":"G Ellrichmann","year":"2011","unstructured":"Ellrichmann G, Petrasch-Parwez E, Lee DH, Reick C, Arning L, Saft C et al (2011) Efficacy of fumaric acid esters in the R6\/2 and YAC128 models of huntington\u2019s disease. PLoS ONE 6(1):e16172","journal-title":"PLoS ONE"},{"key":"6053_CR187","doi-asserted-by":"crossref","unstructured":"Tucci P, Lattanzi R, Severini C, Saso L (2022) Nrf2 Pathway in Huntington\u2019s Disease (HD): What Is Its Role? Int J Mol Sci. ;23(23)","DOI":"10.3390\/ijms232315272"},{"key":"6053_CR188","doi-asserted-by":"crossref","unstructured":"D\u2019Egidio F, Qosja E, Ammannito F, Topi S, d\u2019Angelo M, Cimini A et al (2025) Antioxidant and Anti-Inflammatory Defenses in Huntington\u2019s Disease: Roles of NRF2 and PGC-1\u03b1, and Therapeutic Strategies. Life (Basel). ;15(4)","DOI":"10.3390\/life15040577"},{"issue":"13","key":"6053_CR189","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.1523\/JNEUROSCI.0848-17.2018","volume":"38","author":"LJ McMeekin","year":"2018","unstructured":"McMeekin LJ, Li Y, Fox SN, Rowe GC, Crossman DK, Day JJ et al (2018) Cell-Specific deletion of PGC-1\u03b1 from medium spiny neurons causes transcriptional alterations and Age-Related motor impairment. J Neurosci 38(13):3273\u20133286","journal-title":"J Neurosci"},{"issue":"7","key":"6053_CR190","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1093\/hmg\/ddr024","volume":"20","author":"U Shirendeb","year":"2011","unstructured":"Shirendeb U, Reddy AP, Manczak M, Calkins MJ, Mao P, Tagle DA et al (2011) Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington\u2019s disease: implications for selective neuronal damage. Hum Mol Genet 20(7):1438\u201355","journal-title":"Hum Mol Genet"},{"issue":"1\u20132","key":"6053_CR191","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.bbrc.2012.10.107","volume":"429","author":"M Suzuki","year":"2012","unstructured":"Suzuki M, Nagai Y, Wada K, Koike T (2012) Calcium leak through ryanodine receptor is involved in neuronal death induced by mutant Huntingtin. Biochem Biophys Res Commun 429(1\u20132):18\u201323","journal-title":"Biochem Biophys Res Commun"},{"key":"6053_CR192","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.611735","volume":"8","author":"M Czeredys","year":"2020","unstructured":"Czeredys M (2020) Dysregulation of neuronal calcium signaling via store-operated channels in Huntington\u2019s Disease. Front Cell Dev Biol 8:611735","journal-title":"Front Cell Dev Biol"},{"issue":"2","key":"6053_CR193","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0896-6273(03)00366-0","volume":"39","author":"TS Tang","year":"2003","unstructured":"Tang TS, Tu H, Chan EY, Maximov A, Wang Z, Wellington CL et al (2003) Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1. Neuron 39(2):227\u2013239","journal-title":"Neuron"},{"issue":"2","key":"6053_CR194","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s13311-021-01022-9","volume":"18","author":"L Naia","year":"2021","unstructured":"Naia L, Ly P, Mota SI, Lopes C, Maranga C, Coelho P et al (2021) The Sigma-1 receptor mediates Pridopidine rescue of mitochondrial function in huntington disease models. Neurotherapeutics 18(2):1017\u20131038","journal-title":"Neurotherapeutics"},{"key":"6053_CR195","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.parkreldis.2016.10.017","volume":"34","author":"S Sciacca","year":"2017","unstructured":"Sciacca S, Favellato M, Madonna M, Metro D, Marano M, Squitieri F (2017) Early enteric neuron dysfunction in mouse and human Huntington disease. Parkinsonism Relat Disord 34:73\u20134","journal-title":"Parkinsonism Relat Disord"},{"key":"6053_CR196","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/cells11132049","volume":"11","author":"J Zhao","year":"2022","unstructured":"Zhao J, Wang X, Huo Z, Chen Y, Liu J, Zhao Z et al (2022) The impact of mitochondrial dysfunction in amyotrophic lateral sclerosis. Cells 11:13","journal-title":"Cells"},{"key":"6053_CR197","doi-asserted-by":"crossref","unstructured":"Hartopp N, Lau DHW, Martin-Guerrero SM, Markovinovic A, M\u00f3rotz GM, Greig J et al (2022) Disruption of the VAPB-PTPIP51 ER-mitochondria tethering proteins in post-mortem human amyotrophic lateral sclerosis. Front Cell Dev Biology. ;Volume 10\u20132022","DOI":"10.3389\/fcell.2022.950767"},{"issue":"5","key":"6053_CR198","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/00005072-198409000-00002","volume":"43","author":"A Hirano","year":"1984","unstructured":"Hirano A, Nakano I, Kurland LT, Mulder DW, Holley PW, Saccomanno G (1984) Fine structural study of neurofibrillary changes in a family with amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 43(5):471\u2013480","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"6053_CR199","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1212\/WNL.47.2.535","volume":"47","author":"S Sasaki","year":"1996","unstructured":"Sasaki S, Iwata M (1996) Impairment of fast axonal transport in the proximal axons of anterior horn neurons in amyotrophic lateral sclerosis. Neurology 47(2):535\u2013540","journal-title":"Neurology"},{"issue":"2","key":"6053_CR200","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1002\/ana.410390210","volume":"39","author":"L Sikl\u00f3s","year":"1996","unstructured":"Sikl\u00f3s L, Engelhardt J, Harati Y, Smith RG, Jo\u00f3 F, Appel SH (1996) Ultrastructural evidence for altered calcium in motor nerve terminals in amyotropic lateral sclerosis. Ann Neurol 39(2):203\u2013216","journal-title":"Ann Neurol"},{"issue":"Pt 7","key":"6053_CR201","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1093\/brain\/123.7.1339","volume":"123","author":"S Vielhaber","year":"2000","unstructured":"Vielhaber S, Kunz D, Winkler K, Wiedemann FR, Kirches E, Feistner H et al (2000) Mitochondrial DNA abnormalities in skeletal muscle of patients with sporadic amyotrophic lateral sclerosis. Brain 123(Pt 7):1339\u20131348","journal-title":"Brain"},{"issue":"1","key":"6053_CR202","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0022-510X(98)00008-2","volume":"156","author":"FR Wiedemann","year":"1998","unstructured":"Wiedemann FR, Winkler K, Kuznetsov AV, Bartels C, Vielhaber S, Feistner H et al (1998) Impairment of mitochondrial function in skeletal muscle of patients with amyotrophic lateral sclerosis. J Neurol Sci 156(1):65\u201372","journal-title":"J Neurol Sci"},{"issue":"4","key":"6053_CR203","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1046\/j.0022-3042.2001.00731.x","volume":"80","author":"FR Wiedemann","year":"2002","unstructured":"Wiedemann FR, Manfredi G, Mawrin C, Beal MF, Schon EA (2002) Mitochondrial DNA and respiratory chain function in spinal cords of ALS patients. J Neurochem 80(4):616\u2013625","journal-title":"J Neurochem"},{"issue":"10","key":"6053_CR204","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1212\/WNL.62.10.1758","volume":"62","author":"EP Simpson","year":"2004","unstructured":"Simpson EP, Henry YK, Henkel JS, Smith RG, Appel SH (2004) Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden. Neurology 62(10):1758\u20131765","journal-title":"Neurology"},{"key":"6053_CR205","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3389\/fncel.2015.00336","volume":"9","author":"F Tafuri","year":"2015","unstructured":"Tafuri F, Ronchi D, Magri F, Comi GP, Corti S (2015) SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis. Front Cell Neurosci 9:336","journal-title":"Front Cell Neurosci"},{"issue":"23","key":"6053_CR206","doi-asserted-by":"publisher","first-page":"4706","DOI":"10.1093\/hmg\/ddt319","volume":"22","author":"W Wang","year":"2013","unstructured":"Wang W, Li L, Lin WL, Dickson DW, Petrucelli L, Zhang T et al (2013) The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons. Hum Mol Genet 22(23):4706\u20134719","journal-title":"Hum Mol Genet"},{"issue":"2","key":"6053_CR207","doi-asserted-by":"publisher","first-page":"e13549","DOI":"10.1111\/acel.13549","volume":"21","author":"P Gomez-Suaga","year":"2022","unstructured":"Gomez-Suaga P, M\u00f3rotz GM, Markovinovic A, Mart\u00edn-Guerrero SM, Preza E, Arias N et al (2022) Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia. Aging Cell 21(2):e13549","journal-title":"Aging Cell"},{"key":"6053_CR208","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22158194","author":"I M\u00e9ndez-L\u00f3pez","year":"2021","unstructured":"M\u00e9ndez-L\u00f3pez I, Sancho-Bielsa FJ, Engel T, Garc\u00eda AG, Pad\u00edn JF (2021) Progressive mitochondrial SOD1(G93A) accumulation causes severe structural, metabolic and functional aberrations through OPA1 down-regulation in a mouse model of amyotrophic lateral sclerosis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms22158194","journal-title":"Int J Mol Sci"},{"key":"6053_CR209","doi-asserted-by":"crossref","unstructured":"Joshi AU, Saw NL, Vogel H, Cunnigham AD, Shamloo M, Mochly-Rosen D (2018) Inhibition of Drp1\/Fis1 interaction slows progression of amyotrophic lateral sclerosis. EMBO Mol Med. ;10(3)","DOI":"10.15252\/emmm.201708166"},{"issue":"11","key":"6053_CR210","doi-asserted-by":"publisher","first-page":"4657","DOI":"10.1523\/JNEUROSCI.1119-12.2013","volume":"33","author":"PA Parone","year":"2013","unstructured":"Parone PA, Da Cruz S, Han JS, McAlonis-Downes M, Vetto AP, Lee SK et al (2013) Enhancing mitochondrial calcium buffering capacity reduces aggregation of misfolded SOD1 and motor neuron cell death without extending survival in mouse models of inherited amyotrophic lateral sclerosis. J Neurosci 33(11):4657\u20134671","journal-title":"J Neurosci"},{"key":"6053_CR211","doi-asserted-by":"crossref","unstructured":"Belosludtseva NV, Matveeva LA, Belosludtsev KN (2023) Mitochondrial dyshomeostasis as an early hallmark and a therapeutic target in amyotrophic lateral sclerosis. Int J Mol Sci. ;24(23)","DOI":"10.3390\/ijms242316833"},{"key":"6053_CR212","doi-asserted-by":"crossref","unstructured":"Simone R, Balendra R, Moens TG, Preza E, Wilson KM, Heslegrave A, et al. G\u2010quadruplex\u2010binding small molecules ameliorate\u2009<\u2009i\u2009>\u2009C9orf72 FTD\/ALS pathology\u2009<\u2009i\u2009>\u2009in\u00a0vitro\u2009and<\u2009i\u2009>\u2009in\u00a0vivo. EMBO Molecular Medicine. 2018;10(1):22\u201331\u2013.","DOI":"10.15252\/emmm.201707850"},{"issue":"5","key":"6053_CR213","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1016\/j.neuron.2014.07.041","volume":"83","author":"Z Su","year":"2014","unstructured":"Su Z, Zhang Y, Gendron Tania F, Bauer Peter O, Chew J, Yang W-Y et al (2014) Discovery of a biomarker and lead small molecules to target r(GGGGCC)-Associated defects in c9FTD\/ALS. Neuron 83(5):1043\u20131050","journal-title":"Neuron"},{"issue":"1","key":"6053_CR214","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1996848","volume":"13","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Ogbu D, Garrett S, Xia Y, Sun J (2021) Aberrant enteric neuromuscular system and dysbiosis in amyotrophic lateral sclerosis. Gut Microbes 13(1):1996848","journal-title":"Gut Microbes"},{"issue":"11","key":"6053_CR215","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1093\/brain\/awr245","volume":"134","author":"C Garone","year":"2011","unstructured":"Garone C, Tadesse S, Hirano M (2011) Clinical and genetic spectrum of mitochondrial neurogastrointestinal encephalomyopathy. Brain 134(11):3326\u20133332","journal-title":"Brain"},{"issue":"S1","key":"6053_CR216","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/jnc.13691","volume":"139","author":"S Sveinbjornsdottir","year":"2016","unstructured":"Sveinbjornsdottir S (2016) The clinical symptoms of Parkinson\u2019s disease. J Neurochem 139(S1):318\u2013324","journal-title":"J Neurochem"},{"key":"6053_CR217","doi-asserted-by":"crossref","unstructured":"Andrade-Guerrero J, Mart\u00ednez-Orozco H, Villegas-Rojas MM, Santiago-Balmaseda A, Delgado-Minjares KM, P\u00e9rez-Segura I et al (2024) Alzheimer\u2019s Disease: Understanding Motor Impairments. Brain Sci. ;14(11)","DOI":"10.3390\/brainsci14111054"},{"issue":"1","key":"6053_CR218","first-page":"7517379","volume":"2021","author":"W Zhang","year":"2021","unstructured":"Zhang W, Zhang X, Zhang Y, Wu H, Liu Q, Zhou X et al (2021) Analysis of changes of intestinal flora in elderly patients with alzheimer\u2019s disease and liver cancer and its correlation with abnormal Gastrointestinal motility. J Oncol 2021(1):7517379","journal-title":"J Oncol"},{"issue":"6","key":"6053_CR219","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1007\/s00415-019-09263-7","volume":"266","author":"T Aldaz","year":"2019","unstructured":"Aldaz T, Nigro P, S\u00e1nchez-G\u00f3mez A, Painous C, Planellas L, Santacruz P et al (2019) Non-motor symptoms in Huntington\u2019s disease: a comparative study with Parkinson\u2019s disease. J Neurol 266(6):1340\u201350","journal-title":"J Neurol"},{"issue":"1","key":"6053_CR220","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1750-1172-5-40","volume":"5","author":"RAC Roos","year":"2010","unstructured":"Roos RAC (2010) Huntington\u2019s disease: a clinical review. Orphanet J Rare Dis 5(1):40","journal-title":"Orphanet J Rare Dis"},{"issue":"5","key":"6053_CR221","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S1474-4422(21)00465-8","volume":"21","author":"SA Goutman","year":"2022","unstructured":"Goutman SA, Hardiman O, Al-Chalabi A, Chi\u00f3 A, Savelieff MG, Kiernan MC et al (2022) Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis. Lancet Neurol 21(5):480\u2013493","journal-title":"Lancet Neurol"},{"issue":"7\u20138","key":"6053_CR222","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1080\/21678421.2023.2220748","volume":"24","author":"A Shojaie","year":"2023","unstructured":"Shojaie A, Rota S, Al Khleifat A, Ray Chaudhuri K, Al-Chalabi A (2023) Non-motor symptoms in amyotrophic lateral sclerosis: lessons from Parkinson\u2019s disease. Amyotroph Lateral Scler Frontotemporal Degener 24(7\u20138):562\u2013571","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"1","key":"6053_CR223","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1080\/146608299300079484","volume":"1","author":"CFAKRLRWM-FDPM Toepfer","year":"2000","unstructured":"Toepfer CFAKRLRWM-FDPM (2000) Gastrointestinal dysfunction in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disorders 1(1):15\u201319","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disorders"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-025-06053-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-025-06053-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-025-06053-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T18:55:01Z","timestamp":1781636101000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-025-06053-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":223,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6053"],"URL":"https:\/\/doi.org\/10.1007\/s00018-025-06053-5","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"29 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors confirm they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"129"}}