{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:35:46Z","timestamp":1790019346041,"version":"4.0.1"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:00:00Z","timestamp":1770422400000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972048"],"award-info":[{"award-number":["81972048"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901247"],"award-info":[{"award-number":["81901247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Changzhou Sci&Tech Program","award":["CJ20245003"],"award-info":[{"award-number":["CJ20245003"]}]},{"name":"Changzhou Longcheng Talent Program for Youth Scientific Researchers","award":["2025 No.25"],"award-info":[{"award-number":["2025 No.25"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-026-06082-8","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:54:26Z","timestamp":1770058466000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["PPARa-FSP1 axis modulates lipid peroxidation-induced neuronal ferroptosis to promote functional recovery in mouse model of traumatic spinal cord injury"],"prefix":"10.1007","volume":"83","author":[{"given":"Yu","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenge","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baizhen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haining","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5345-4108","authenticated-orcid":false,"given":"Jinbo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"6082_CR1","doi-asserted-by":"publisher","first-page":"17018","DOI":"10.1038\/nrdp.2017.18","volume":"3","author":"CS Ahuja","year":"2017","unstructured":"Ahuja CS et al (2017) Traumatic spinal cord injury. Nat Rev Dis Primers 3:17018","journal-title":"Nat Rev Dis Primers"},{"issue":"12","key":"6082_CR2","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1038\/s41593-022-01196-1","volume":"25","author":"MA Anderson","year":"2022","unstructured":"Anderson MA et al (2022) Natural and targeted circuit reorganization after spinal cord injury. Nat Neurosci 25(12):1584\u20131596","journal-title":"Nat Neurosci"},{"issue":"9304","key":"6082_CR3","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0140-6736(02)07603-1","volume":"359","author":"JW McDonald","year":"2002","unstructured":"McDonald JW, Sadowsky C (2002) Spinal-cord injury. Lancet 359(9304):417\u2013425","journal-title":"Lancet"},{"issue":"4","key":"6082_CR4","doi-asserted-by":"publisher","first-page":"384","DOI":"10.4065\/71.4.384","volume":"71","author":"PP Atkinson","year":"1996","unstructured":"Atkinson PP, Atkinson JL (1996) Spinal shock. Mayo Clin Proc 71(4):384\u2013389","journal-title":"Mayo Clin Proc"},{"issue":"7","key":"6082_CR5","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/sj.sc.3101483","volume":"41","author":"ON Hausmann","year":"2003","unstructured":"Hausmann ON (2003) Post-traumatic inflammation following spinal cord injury. Spinal Cord 41(7):369\u2013378","journal-title":"Spinal Cord"},{"issue":"1","key":"6082_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41392-023-01477-6","volume":"8","author":"X Hu","year":"2023","unstructured":"Hu X et al (2023) Spinal cord injury: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther 8(1):245","journal-title":"Signal Transduct Target Ther"},{"issue":"10","key":"6082_CR7","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.1093\/brain\/awab250","volume":"144","author":"J Van Broeckhoven","year":"2021","unstructured":"Van Broeckhoven J et al (2021) Macrophage phagocytosis after spinal cord injury: when friends become foes. Brain 144(10):2933\u20132945","journal-title":"Brain"},{"issue":"9","key":"6082_CR8","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1093\/procel\/pwad003","volume":"14","author":"T Tian","year":"2023","unstructured":"Tian T, Zhang S, Yang M (2023) Recent progress and challenges in the treatment of spinal cord injury. Protein Cell 14(9):635\u2013652","journal-title":"Protein Cell"},{"issue":"5","key":"6082_CR9","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060\u20131072","journal-title":"Cell"},{"issue":"6","key":"6082_CR10","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","volume":"25","author":"SJ Dixon","year":"2024","unstructured":"Dixon SJ, Olzmann JA (2024) The cell biology of ferroptosis. Nat Rev Mol Cell Biol 25(6):424\u2013442","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"6082_CR11","first-page":"1188","volume":"181","author":"K Hadian","year":"2020","unstructured":"Hadian K, Stockwell BR (2020) SnapShot: Ferroptosis Cell 181(5):1188\u20131188e1","journal-title":"SnapShot: Ferroptosis Cell"},{"key":"6082_CR12","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.freeradbiomed.2022.12.002","volume":"194","author":"Y Cheng","year":"2023","unstructured":"Cheng Y et al (2023) TrkB agonist N-acetyl serotonin promotes functional recovery after traumatic brain injury by suppressing ferroptosis via the PI3K\/Akt\/Nrf2\/Ferritin H pathway. Free Radic Biol Med 194:184\u2013198","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"6082_CR13","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.4103\/1673-5374.389362","volume":"19","author":"L Feng","year":"2024","unstructured":"Feng L et al (2024) Ferroptosis mechanism and alzheimer\u2019s disease. Neural Regen Res 19(8):1741\u20131750","journal-title":"Neural Regen Res"},{"issue":"2","key":"6082_CR14","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1002\/nep3.46","volume":"2","author":"JY Magdaleno Roman","year":"2024","unstructured":"Magdaleno Roman JY, Chapa C, Gonz\u00e1lez (2024) Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection. Neuroprotection 2(2):137\u2013150","journal-title":"Neuroprotection"},{"issue":"6","key":"6082_CR15","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/s41418-021-00910-z","volume":"29","author":"T Wang","year":"2022","unstructured":"Wang T et al (2022) Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis. Cell Death Differ 29(6):1187\u20131198","journal-title":"Cell Death Differ"},{"issue":"1","key":"6082_CR16","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s00401-024-02758-2","volume":"147","author":"F Ryan","year":"2024","unstructured":"Ryan F et al (2024) Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury. Acta Neuropathol 147(1):106","journal-title":"Acta Neuropathol"},{"key":"6082_CR17","doi-asserted-by":"publisher","first-page":"102871","DOI":"10.1016\/j.redox.2023.102871","volume":"67","author":"S Yao","year":"2023","unstructured":"Yao S et al (2023) Mesenchymal stem cell attenuates spinal cord injury by inhibiting mitochondrial quality control-associated neuronal ferroptosis. Redox Biol 67:102871","journal-title":"Redox Biol"},{"issue":"3","key":"6082_CR18","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","volume":"62","author":"M Pawlak","year":"2015","unstructured":"Pawlak M, Lefebvre P, Staels B (2015) Molecular mechanism of PPARalpha action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. J Hepatol 62(3):720\u2013733","journal-title":"J Hepatol"},{"key":"6082_CR19","doi-asserted-by":"publisher","first-page":"106786","DOI":"10.1016\/j.phrs.2023.106786","volume":"192","author":"YY Qiu","year":"2023","unstructured":"Qiu YY et al (2023) Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Pharmacol Res 192:106786","journal-title":"Pharmacol Res"},{"issue":"5","key":"6082_CR20","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1210\/er.2018-00064","volume":"39","author":"N Bougarne","year":"2018","unstructured":"Bougarne N et al (2018) Molecular actions of PPARalpha in lipid metabolism and inflammation. Endocr Rev 39(5):760\u2013802","journal-title":"Endocr Rev"},{"issue":"22","key":"6082_CR21","doi-asserted-by":"publisher","first-page":"24640","DOI":"10.18632\/aging.203699","volume":"13","author":"H Zhang","year":"2021","unstructured":"Zhang H et al (2021) PPARalpha agonist relieves spinal cord injury in rats by activating Nrf2\/HO-1 via the Raf-1\/MEK\/ERK pathway. Aging 13(22):24640\u201324654","journal-title":"Aging"},{"issue":"4","key":"6082_CR22","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1073\/pnas.90.4.1440","volume":"90","author":"KL Gearing","year":"1993","unstructured":"Gearing KL et al (1993) Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor. Proc Natl Acad Sci U S A 90(4):1440\u20131444","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"6082_CR23","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/S0969-2126(01)00634-7","volume":"9","author":"P Cronet","year":"2001","unstructured":"Cronet P et al (2001) Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family. Structure 9(8):699\u2013706","journal-title":"Structure"},{"issue":"41","key":"6082_CR24","doi-asserted-by":"publisher","first-page":"23975","DOI":"10.1074\/jbc.270.41.23975","volume":"270","author":"K Yu","year":"1995","unstructured":"Yu K et al (1995) Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem 270(41):23975\u201323983","journal-title":"J Biol Chem"},{"issue":"8","key":"6082_CR25","doi-asserted-by":"publisher","first-page":"e52280","DOI":"10.15252\/embr.202052280","volume":"23","author":"G Xing","year":"2022","unstructured":"Xing G et al (2022) PPARalpha alleviates iron overload-induced ferroptosis in mouse liver. EMBO Rep 23(8):e52280","journal-title":"EMBO Rep"},{"issue":"1","key":"6082_CR26","doi-asserted-by":"publisher","first-page":"6908","DOI":"10.1038\/s41467-023-42702-8","volume":"14","author":"J Tschuck","year":"2023","unstructured":"Tschuck J et al (2023) Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis. Nat Commun 14(1):6908","journal-title":"Nat Commun"},{"issue":"28","key":"6082_CR27","doi-asserted-by":"publisher","first-page":"25617","DOI":"10.1074\/jbc.M202285200","volume":"277","author":"M Wu","year":"2002","unstructured":"Wu M et al (2002) AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J Biol Chem 277(28):25617\u201325623","journal-title":"J Biol Chem"},{"issue":"7784","key":"6082_CR28","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","volume":"575","author":"S Doll","year":"2019","unstructured":"Doll S et al (2019) FSP1 is a glutathione-independent ferroptosis suppressor. Nature 575(7784):693\u2013698","journal-title":"Nature"},{"issue":"10","key":"6082_CR29","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1016\/j.cell.2025.03.019","volume":"188","author":"JS Yang","year":"2025","unstructured":"Yang JS et al (2025) ALDH7A1 protects against ferroptosis by generating membrane NADH and regulating FSP1. Cell 188(10):2569\u20132585e20","journal-title":"Cell"},{"issue":"7\u20138","key":"6082_CR30","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1101\/gad.334219.119","volume":"34","author":"D Venkatesh","year":"2020","unstructured":"Venkatesh D et al (2020) MDM2 and MDMX promote ferroptosis by PPARalpha-mediated lipid remodeling. Genes Dev 34(7\u20138):526\u2013543","journal-title":"Genes Dev"},{"issue":"7784","key":"6082_CR31","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","volume":"575","author":"K Bersuker","year":"2019","unstructured":"Bersuker K et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575(7784):688\u2013692","journal-title":"Nature"},{"issue":"9","key":"6082_CR32","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.7150\/thno.49054","volume":"11","author":"H Liu","year":"2021","unstructured":"Liu H et al (2021) SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-kappaB signaling. Theranostics 11(9):4187\u20134206","journal-title":"Theranostics"},{"issue":"29","key":"6082_CR33","doi-asserted-by":"publisher","first-page":"22067","DOI":"10.1074\/jbc.M109.085118","volume":"285","author":"VR Narala","year":"2010","unstructured":"Narala VR et al (2010) Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-alpha agonist. J Biol Chem 285(29):22067\u201322074","journal-title":"J Biol Chem"},{"key":"6082_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2025.05.002","author":"W Chen","year":"2025","unstructured":"Chen W et al (2025) Mitochondrial protease AFG3L2 inhibits ferroptosis of intestinal epithelial cells through PPARA\/GPX4 signaling pathway to improve experimental enteritis. Am J Pathol. https:\/\/doi.org\/10.1016\/j.ajpath.2025.05.002","journal-title":"Am J Pathol"},{"key":"6082_CR35","doi-asserted-by":"publisher","first-page":"116227","DOI":"10.1016\/j.jep.2023.116227","volume":"307","author":"J Dong","year":"2023","unstructured":"Dong J et al (2023) Verbenalin attenuates hepatic damage and mitochondrial dysfunction in alcohol-associated steatohepatitis by regulating MDMX\/PPARalpha-mediated ferroptosis. J Ethnopharmacol 307:116227","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"6082_CR36","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1053\/j.gastro.2022.09.027","volume":"164","author":"H Li","year":"2023","unstructured":"Li H et al (2023) Hepatocyte adenosine kinase promotes excessive fat deposition and liver inflammation. Gastroenterology 164(1):134\u2013146","journal-title":"Gastroenterology"},{"issue":"1","key":"6082_CR37","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/hep.32105","volume":"75","author":"S Fan","year":"2022","unstructured":"Fan S et al (2022) YAP-TEAD mediates PPAR alpha-induced hepatomegaly and liver regeneration in mice. Hepatology 75(1):74\u201388","journal-title":"Hepatology"},{"issue":"2","key":"6082_CR38","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1007\/s12035-023-03589-0","volume":"61","author":"N Wang","year":"2024","unstructured":"Wang N et al (2024) Gemfibrozil alleviates cognitive impairment by inhibiting ferroptosis of astrocytes via restoring the iron metabolism and promoting antioxidant capacity in type 2 diabetes. Mol Neurobiol 61(2):1187\u20131201","journal-title":"Mol Neurobiol"},{"key":"6082_CR39","doi-asserted-by":"publisher","first-page":"103130","DOI":"10.1016\/j.ebiom.2020.103130","volume":"62","author":"Y Wada","year":"2020","unstructured":"Wada Y et al (2020) Peroxisome proliferator-activated receptor alpha as a novel therapeutic target for schizophrenia. EBioMedicine 62:103130","journal-title":"EBioMedicine"},{"issue":"4","key":"6082_CR40","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22(4):266\u2013282","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"6082_CR41","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41556-021-00824-5","volume":"24","author":"J Rodencal","year":"2022","unstructured":"Rodencal J, Dixon SJ (2022) Positive feedback amplifies ferroptosis. Nat Cell Biol 24(1):4\u20135","journal-title":"Nat Cell Biol"},{"issue":"1","key":"6082_CR42","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41556-021-00818-3","volume":"24","author":"HL Zhang","year":"2022","unstructured":"Zhang HL et al (2022) PKCbetaII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis. Nat Cell Biol 24(1):88\u201398","journal-title":"Nat Cell Biol"},{"issue":"1","key":"6082_CR43","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41589-021-00915-2","volume":"18","author":"H Liu","year":"2022","unstructured":"Liu H et al (2022) Characterization of a patient-derived variant of GPX4 for precision therapy. Nat Chem Biol 18(1):91\u2013100","journal-title":"Nat Chem Biol"},{"issue":"18","key":"6082_CR44","doi-asserted-by":"publisher","first-page":"3356","DOI":"10.1016\/j.cell.2022.07.025","volume":"185","author":"H Kalkavan","year":"2022","unstructured":"Kalkavan H et al (2022) Sublethal cytochrome c release generates drug-tolerant persister cells. Cell 185(18):3356\u20133374e22","journal-title":"Cell"},{"issue":"11","key":"6082_CR45","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1016\/j.chembiol.2019.09.007","volume":"26","author":"R Shah","year":"2019","unstructured":"Shah R et al (2019) Beyond DPPH: use of Fluorescence-Enabled inhibited autoxidation to predict oxidative cell death rescue. Cell Chem Biol 26(11):1594\u20131607e7","journal-title":"Cell Chem Biol"},{"key":"6082_CR46","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.semcdb.2020.07.017","volume":"112","author":"JA Lee","year":"2021","unstructured":"Lee JA et al (2021) Lipid metabolism in astrocytic structure and function. Semin Cell Dev Biol 112:123\u2013136","journal-title":"Semin Cell Dev Biol"},{"issue":"9","key":"6082_CR47","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.tem.2019.07.018","volume":"30","author":"S Mukherjee","year":"2019","unstructured":"Mukherjee S, Suresh SN (2019) Neuron-astrocyte liaison to maintain lipid metabolism of brain. Trends Endocrinol Metab 30(9):573\u2013575","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"6082_CR48","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1186\/s12951-023-02110-y","volume":"21","author":"P Gao","year":"2023","unstructured":"Gao P et al (2023) Pericyte-derived Exosomal miR-210 improves mitochondrial function and inhibits lipid peroxidation in vascular endothelial cells after traumatic spinal cord injury by activating JAK1\/STAT3 signaling pathway. J Nanobiotechnol 21(1):452","journal-title":"J Nanobiotechnol"},{"key":"6082_CR49","doi-asserted-by":"publisher","first-page":"108633","DOI":"10.1016\/j.jnutbio.2021.108633","volume":"95","author":"Z Yang","year":"2021","unstructured":"Yang Z et al (2021) The transcription factors CREBH, PPARa, and FOXO1 as critical hepatic mediators of diet-induced metabolic dysregulation. J Nutr Biochem 95:108633","journal-title":"J Nutr Biochem"},{"issue":"6","key":"6082_CR50","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.cmet.2024.04.015","volume":"36","author":"S Gallage","year":"2024","unstructured":"Gallage S et al (2024) A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARalpha and PCK1. Cell Metab 36(6):1371\u20131393e7","journal-title":"Cell Metab"},{"key":"6082_CR51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249577","author":"DV Chistyakov","year":"2020","unstructured":"Chistyakov DV et al (2020) Comparison of PPAR ligands as modulators of resolution of inflammation, via their influence on cytokines and oxylipins release in astrocytes. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21249577","journal-title":"Int J Mol Sci"},{"key":"6082_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062420","author":"M de Ceglia","year":"2025","unstructured":"de Ceglia M et al (2025) A combined GLP-1\/PPARa\/CB1-based therapy to restore the central and peripheral metabolic dysregulation induced by a high-fructose high-fat diet. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms26062420","journal-title":"Int J Mol Sci"},{"key":"6082_CR53","doi-asserted-by":"publisher","first-page":"154726","DOI":"10.1016\/j.phymed.2023.154726","volume":"113","author":"Q Li","year":"2023","unstructured":"Li Q et al (2023) Pectolinarigenin ameliorates acetaminophen-induced acute liver injury via attenuating oxidative stress and inflammatory response in Nrf2 and PPARa dependent manners. Phytomedicine 113:154726","journal-title":"Phytomedicine"},{"key":"6082_CR54","doi-asserted-by":"publisher","first-page":"27618","DOI":"10.1038\/srep27618","volume":"6","author":"A Warden","year":"2016","unstructured":"Warden A et al (2016) Localization of PPAR isotypes in the adult mouse and human brain. Sci Rep 6:27618","journal-title":"Sci Rep"},{"issue":"1","key":"6082_CR55","doi-asserted-by":"publisher","first-page":"5847","DOI":"10.1038\/s41467-020-19554-7","volume":"11","author":"CN Brocker","year":"2020","unstructured":"Brocker CN et al (2020) Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting. Nat Commun 11(1):5847","journal-title":"Nat Commun"},{"issue":"1","key":"6082_CR56","doi-asserted-by":"publisher","first-page":"7965","DOI":"10.1038\/s41467-022-35707-2","volume":"13","author":"Z Lin","year":"2022","unstructured":"Lin Z et al (2022) The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis. Nat Commun 13(1):7965","journal-title":"Nat Commun"},{"key":"6082_CR57","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68457","author":"O Avraham","year":"2021","unstructured":"Avraham O et al (2021) Profiling sensory neuron microenvironment after peripheral and central axon injury reveals key pathways for neural repair. Elife. https:\/\/doi.org\/10.7554\/eLife.68457","journal-title":"Elife"}],"updated-by":[{"DOI":"10.1007\/s00018-026-06160-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000}}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-026-06082-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06082-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06082-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T06:02:55Z","timestamp":1775109775000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-026-06082-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6082"],"URL":"https:\/\/doi.org\/10.1007\/s00018-026-06082-8","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]},"assertion":[{"value":"10 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2026","order":7,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":8,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised due to tagging of the co-corresponding author Zhiwen Song. Now, it has been updated.","order":9,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2026","order":10,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":11,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":12,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s00018-026-06160-x","URL":"https:\/\/doi.org\/10.1007\/s00018-026-06160-x","order":13,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures were in accordance with the guidelines of animal research of Science and technology department of China, and have been approved by the ethic committee of animal research in Soochow University. Efforts were made to minimize animal discomfort and limit the number of animals used in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"94"}}