{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:51:51Z","timestamp":1793224311659,"version":"4.5.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402977"],"award-info":[{"award-number":["32402977"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U23A20243"],"award-info":[{"award-number":["U23A20243"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32402972"],"award-info":[{"award-number":["32402972"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172820"],"award-info":[{"award-number":["32172820"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009620","name":"Science and Technology Department of Gansu Province","doi-asserted-by":"publisher","award":["24JRRA021"],"award-info":[{"award-number":["24JRRA021"]}],"id":[{"id":"10.13039\/501100009620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-026-06146-9","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T01:05:43Z","timestamp":1771981543000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Enolase 1 suppresses influenza A virus replication by blocking the nuclear import of the viral ribonucleoprotein complex"],"prefix":"10.1007","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9784-3636","authenticated-orcid":false,"given":"Xingtian","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3748-948X","authenticated-orcid":false,"given":"Qiyun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9176-3809","authenticated-orcid":false,"given":"Shuai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"6146_CR1","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/s41579-023-00945-8","volume":"21","author":"AX Han","year":"2023","unstructured":"Han AX, de Jong SPJ, Russell CA (2023) Co-evolution of immunity and seasonal influenza viruses. Nat Rev Microbiol 21:805\u2013817. https:\/\/doi.org\/10.1038\/s41579-023-00945-8","journal-title":"Nat Rev Microbiol"},{"key":"6146_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41572-018-0002-y","volume":"4","author":"F Krammer","year":"2018","unstructured":"Krammer F, Smith GJD, Fouchier RAM et al (2018) Influenza Nat Reviews Disease Primers 4:3. https:\/\/doi.org\/10.1038\/s41572-018-0002-y","journal-title":"Influenza Nat Reviews Disease Primers"},{"key":"6146_CR3","unstructured":"WHO (2025) Avian influenza weekly update. World Health Organization"},{"key":"6146_CR4","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1038\/s41586-024-08254-7","volume":"636","author":"C Gu","year":"2024","unstructured":"Gu C, Maemura T, Guan L et al (2024) A human isolate of bovine H5N1 is transmissible and lethal in animal models. Nature 636:711\u2013718. https:\/\/doi.org\/10.1038\/s41586-024-08254-7","journal-title":"Nature"},{"key":"6146_CR5","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.chom.2018.08.006","volume":"24","author":"J Shi","year":"2018","unstructured":"Shi J, Deng G, Ma S et al (2018) Rapid Evolution of H7N9 Highly Pathogenic Viruses that Emerged in China in 2017. Cell Host Microbe 24:558\u2013568. https:\/\/doi.org\/10.1016\/j.chom.2018.08.006","journal-title":"Cell Host Microbe"},{"key":"6146_CR6","doi-asserted-by":"publisher","first-page":"e824","DOI":"10.1016\/S2666-5247(22)00192-6","volume":"3","author":"R Yang","year":"2022","unstructured":"Yang R, Sun H, Gao F et al (2022) Human infection of avian influenza A H3N8 virus and the viral origins: a descriptive study. Lancet Microbe 3:e824\u2013e834. https:\/\/doi.org\/10.1016\/S2666-5247(22)00192-6","journal-title":"Lancet Microbe"},{"key":"6146_CR7","doi-asserted-by":"publisher","first-page":"2143282","DOI":"10.1080\/22221751.2022.2143282","volume":"12","author":"J Yang","year":"2023","unstructured":"Yang J, Yan J, Zhang C et al (2023) Genetic, biological and epidemiological study on a cluster of H9N2 avian influenza virus infections among chickens, a pet cat, and humans at a backyard farm in Guangxi, China. Emerg microbes infections 12:2143282. https:\/\/doi.org\/10.1080\/22221751.2022.2143282","journal-title":"Emerg microbes infections"},{"key":"6146_CR8","doi-asserted-by":"publisher","first-page":"e0236324","DOI":"10.1128\/mbio.02363-24","volume":"16","author":"X Wang","year":"2025","unstructured":"Wang X, Yu H, Ma Y et al (2025) The novel H10N3 avian influenza virus acquired airborne transmission among chickens: an increasing threat to public health. mBio 16:e0236324. https:\/\/doi.org\/10.1128\/mbio.02363-24","journal-title":"mBio"},{"key":"6146_CR9","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1128\/jvi.02175-15","volume":"90","author":"S Yamayoshi","year":"2015","unstructured":"Yamayoshi S, Watanabe M, Goto H et al (2015) Identification of a Novel Viral Protein Expressed from the PB2 Segment of Influenza A Virus. J Virol 90:444\u2013456. https:\/\/doi.org\/10.1128\/jvi.02175-15","journal-title":"J Virol"},{"key":"6146_CR10","doi-asserted-by":"publisher","first-page":"eadq7597","DOI":"10.1126\/science.adq7597","volume":"388","author":"R Peng","year":"2025","unstructured":"Peng R, Xu X, Nepal B et al (2025) Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis. Science 388:eadq7597. https:\/\/doi.org\/10.1126\/science.adq7597","journal-title":"Science"},{"key":"6146_CR11","doi-asserted-by":"publisher","unstructured":"Deng T, Zhang L, Shi Y et al (2025) In transition: how influenza virus switches from transcription to genome replication. Ann Rev Virol. https:\/\/doi.org\/10.1146\/annurev-virology-092623-095030","DOI":"10.1146\/annurev-virology-092623-095030"},{"key":"6146_CR12","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nrmicro.2016.87","volume":"14","author":"AJ Te Velthuis","year":"2016","unstructured":"Te Velthuis AJ, Fodor E (2016) Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis. Nat Rev Microbiol 14:479\u2013493. https:\/\/doi.org\/10.1038\/nrmicro.2016.87","journal-title":"Nat Rev Microbiol"},{"key":"6146_CR13","doi-asserted-by":"publisher","unstructured":"Long JS, Mistry B, Haslam SM et al (2019) Host and viral determinants of influenza A virus species specificity. Nat Rev Microbiol 17. https:\/\/doi.org\/10.1038\/s41579-018-0115-z","DOI":"10.1038\/s41579-018-0115-z"},{"key":"6146_CR14","doi-asserted-by":"publisher","first-page":"3966","DOI":"10.1128\/jvi.03137-15","volume":"90","author":"J Zhang","year":"2016","unstructured":"Zhang J, Huang F, Tan L et al (2016) Host Protein Moloney Leukemia Virus 10 (MOV10) Acts as a Restriction Factor of Influenza A Virus by Inhibiting the Nuclear Import of the Viral Nucleoprotein. J Virol 90:3966\u20133980. https:\/\/doi.org\/10.1128\/jvi.03137-15","journal-title":"J Virol"},{"key":"6146_CR15","doi-asserted-by":"publisher","first-page":"e1006851","DOI":"10.1371\/journal.ppat.1006851","volume":"14","author":"W Luo","year":"2018","unstructured":"Luo W, Zhang J, Liang L et al (2018) Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication. PLoS Pathog 14:e1006851. https:\/\/doi.org\/10.1371\/journal.ppat.1006851","journal-title":"PLoS Pathog"},{"key":"6146_CR16","doi-asserted-by":"publisher","first-page":"e01391","DOI":"10.1128\/jvi.01391-20","volume":"95","author":"Q Gao","year":"2021","unstructured":"Gao Q, Yang C, Ren C et al (2021) Eukaryotic translation elongation factor 1 delta inhibits the nuclear Import of the nucleoprotein and PA-PB1 heterodimer of influenza A virus. J Virol 95:e01391\u2013e01320. https:\/\/doi.org\/10.1128\/jvi.01391-20","journal-title":"J Virol"},{"key":"6146_CR17","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1038\/s41423-022-00906-w","volume":"19","author":"X Wang","year":"2022","unstructured":"Wang X, Jiang L, Wang G et al (2022) Influenza A virus use of BinCARD1 to facilitate the binding of viral NP to importin \u03b17 is counteracted by TBK1-p62 axis-mediated autophagy. Cell Mol Immunol 19:1168\u20131184. https:\/\/doi.org\/10.1038\/s41423-022-00906-w","journal-title":"Cell Mol Immunol"},{"key":"6146_CR18","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1038\/s41589-023-01391-6","volume":"19","author":"L Sun","year":"2023","unstructured":"Sun L, Suo C, Zhang T et al (2023) ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism. Nat Chem Biol 19:1492\u20131503. https:\/\/doi.org\/10.1038\/s41589-023-01391-6","journal-title":"Nat Chem Biol"},{"key":"6146_CR19","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.omto.2021.12.026","volume":"24","author":"CK Huang","year":"2022","unstructured":"Huang CK, Sun Y, Lv L et al (2022) ENO1 and cancer. Mol Ther Oncolytics 24:288\u2013298. https:\/\/doi.org\/10.1016\/j.omto.2021.12.026","journal-title":"Mol Ther Oncolytics"},{"key":"6146_CR20","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12977-020-00539-9","volume":"17","author":"N Kishimoto","year":"2020","unstructured":"Kishimoto N, Yamamoto K, Iga N et al (2020) Alpha-enolase in viral target cells suppresses the human immunodeficiency virus type 1 integration. Retrovirology 17:31. https:\/\/doi.org\/10.1186\/s12977-020-00539-9","journal-title":"Retrovirology"},{"key":"6146_CR21","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12929-022-00794-2","volume":"29","author":"YW Cheng","year":"2022","unstructured":"Cheng YW, Chuang YC, Huang SW et al (2022) An auto-antibody identified from phenotypic directed screening platform shows host immunity against EV-A71 infection. J Biomed Sci 29:10. https:\/\/doi.org\/10.1186\/s12929-022-00794-2","journal-title":"J Biomed Sci"},{"key":"6146_CR22","doi-asserted-by":"publisher","unstructured":"Zhang B, Xu S, Liu M et al The nucleoprotein of influenza A virus inhibits the innate immune response by inducing mitophagy. Autophagy 20231\u201320218. https:\/\/doi.org\/10.1080\/15548627.2022.2162798","DOI":"10.1080\/15548627.2022.2162798"},{"key":"6146_CR23","doi-asserted-by":"publisher","first-page":"e01640","DOI":"10.1128\/jvi.01640-20","volume":"94","author":"Y Wei","year":"2020","unstructured":"Wei Y, Zeng Y, Zhang X et al (2020) The Nucleoprotein of H7N9 Influenza Virus Positively Regulates TRAF3-Mediated Innate Signaling and Attenuates Viral Virulence in Mice. J Virol 94:e01640\u2013e01620. https:\/\/doi.org\/10.1128\/jvi.01640-20","journal-title":"J Virol"},{"key":"6146_CR24","doi-asserted-by":"publisher","first-page":"2902","DOI":"10.1016\/j.devcel.2021.09.015","volume":"56","author":"W Bian","year":"2021","unstructured":"Bian W, Tang M, Jiang H et al (2021) Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation. Dev Cell 56:2902\u20132919e8. https:\/\/doi.org\/10.1016\/j.devcel.2021.09.015","journal-title":"Dev Cell"},{"key":"6146_CR25","doi-asserted-by":"publisher","first-page":"e1010446","DOI":"10.1371\/journal.ppat.1010446","volume":"18","author":"G Wang","year":"2022","unstructured":"Wang G, Zhao Y, Zhou Y et al (2022) PIAS1-mediated SUMOylation of influenza A virus PB2 restricts viral replication and virulence. PLoS Pathog 18:e1010446. https:\/\/doi.org\/10.1371\/journal.ppat.1010446","journal-title":"PLoS Pathog"},{"key":"6146_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jviromet.2010.12.014","volume":"173","author":"E Kawakami","year":"2010","unstructured":"Kawakami E, Watanabe T, Fujii K et al (2010) Strand-specific real-time RT-PCR for distinguishing influenza vRNA, cRNA, and mRNA. J Virol Methods 173:1\u20136. https:\/\/doi.org\/10.1016\/j.jviromet.2010.12.014","journal-title":"J Virol Methods"},{"key":"6146_CR27","doi-asserted-by":"publisher","first-page":"e1010299","DOI":"10.1371\/journal.ppat.1010299","volume":"18","author":"S Xu","year":"2022","unstructured":"Xu S, Han L, Wei Y et al (2022) MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS. PLoS Pathog 18:e1010299. https:\/\/doi.org\/10.1371\/journal.ppat.1010299","journal-title":"PLoS Pathog"},{"key":"6146_CR28","doi-asserted-by":"publisher","first-page":"e2411554122","DOI":"10.1073\/pnas.2411554122","volume":"122","author":"Q Wang","year":"2025","unstructured":"Wang Q, Xu S, Shen W et al (2025) N6-methyladnosine of vRNA facilitates influenza A virus replication by promoting the interaction of vRNA with polymerase proteins. Proc Natl Acad Sci USA 122:e2411554122. https:\/\/doi.org\/10.1073\/pnas.2411554122","journal-title":"Proc Natl Acad Sci USA"},{"key":"6146_CR29","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1126\/science.1238327","volume":"341","author":"RE Moellering","year":"2013","unstructured":"Moellering RE, Cravatt BF (2013) Functional lysine modification by an intrinsically reactive primary glycolytic metabolite. Science 341:549\u2013553. https:\/\/doi.org\/10.1126\/science.1238327","journal-title":"Science"},{"key":"6146_CR30","doi-asserted-by":"publisher","first-page":"7337","DOI":"10.1128\/jvi.02474-09","volume":"84","author":"WH Chan","year":"2010","unstructured":"Chan WH, Ng AK, Robb NC et al (2010) Functional analysis of the influenza virus H5N1 nucleoprotein tail loop reveals amino acids that are crucial for oligomerization and ribonucleoprotein activities. J Virol 84:7337\u20137345. https:\/\/doi.org\/10.1128\/jvi.02474-09","journal-title":"J Virol"},{"key":"6146_CR31","doi-asserted-by":"publisher","unstructured":"Zhao L, Liu Q, Huang J et al (2022) TREX (transcription\/export)-NP complex exerts a dual effect on regulating polymerase activity and replication of influenza A virus. PLoS Path cited. https:\/\/doi.org\/10.1371\/journal.ppat.1010835","DOI":"10.1371\/journal.ppat.1010835"},{"key":"6146_CR32","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a038398","author":"E Fodor","year":"2019","unstructured":"Fodor E, Te Velthuis AJW (2019) Structure and Function of the Influenza Virus Transcription and Replication Machinery. Cold Spring Harb Perspect Med. https:\/\/doi.org\/10.1101\/cshperspect.a038398","journal-title":"Cold Spring Harb Perspect Med"},{"key":"6146_CR33","doi-asserted-by":"publisher","first-page":"3638","DOI":"10.1096\/fj.08-112110","volume":"22","author":"AK Ng","year":"2008","unstructured":"Ng AK, Zhang H, Tan K et al (2008) Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. Faseb j 22:3638\u20133647. https:\/\/doi.org\/10.1096\/fj.08-112110","journal-title":"Faseb j"},{"key":"6146_CR34","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1126\/science.1228172","volume":"338","author":"R Arranz","year":"2012","unstructured":"Arranz R, Coloma R, Chichon FJ et al (2012) The structure of native influenza virion ribonucleoproteins. Science 338:1634\u20131637. https:\/\/doi.org\/10.1126\/science.1228172","journal-title":"Science"},{"key":"6146_CR35","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1038\/s41594-023-01043-2","volume":"30","author":"H Li","year":"2023","unstructured":"Li H, Wu Y, Li M et al (2023) An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles. Nat Struct Mol Biol 30:1183\u20131192. https:\/\/doi.org\/10.1038\/s41594-023-01043-2","journal-title":"Nat Struct Mol Biol"},{"key":"6146_CR36","doi-asserted-by":"publisher","first-page":"9690","DOI":"10.1128\/jvi.71.12.9690-9700.1997","volume":"71","author":"G Neumann","year":"1997","unstructured":"Neumann G, Castrucci MR, Kawaoka Y (1997) Nuclear import and export of influenza virus nucleoprotein. J Virol 71:9690\u20139700","journal-title":"J Virol"},{"key":"6146_CR37","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/ncomms1158","volume":"2","author":"G Gabriel","year":"2011","unstructured":"Gabriel G, Klingel K, Otte A et al (2011) Differential use of importin-alpha isoforms governs cell tropism and host adaptation of influenza virus. Nat Commun 2:156. https:\/\/doi.org\/10.1038\/ncomms1158","journal-title":"Nat Commun"},{"key":"6146_CR38","doi-asserted-by":"publisher","unstructured":"Miyake Y, Ishii K, Honda A (2017) Influenza Virus Infection Induces Host Pyruvate Kinase M Which Interacts with Viral RNA-Dependent RNA Polymerase. Front Microbiol 8. https:\/\/doi.org\/10.3389\/fmicb.2017.00162","DOI":"10.3389\/fmicb.2017.00162"},{"key":"6146_CR39","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s43018-021-00299-1","volume":"3","author":"T Zhang","year":"2022","unstructured":"Zhang T, Sun L, Hao Y et al (2022) ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1. Nat Cancer 3:75\u201389. https:\/\/doi.org\/10.1038\/s43018-021-00299-1","journal-title":"Nat Cancer"},{"key":"6146_CR40","doi-asserted-by":"publisher","first-page":"e0004022","DOI":"10.1128\/cmr.00040-22","volume":"36","author":"R Kumari","year":"2023","unstructured":"Kumari R, Sharma SD, Kumar A et al (2023) Antiviral Approaches against Influenza Virus. Clin Microbiol Rev 36:e0004022. https:\/\/doi.org\/10.1128\/cmr.00040-22","journal-title":"Clin Microbiol Rev"},{"key":"6146_CR41","doi-asserted-by":"publisher","first-page":"6030","DOI":"10.1038\/s41467-023-41442-z","volume":"14","author":"KM Haas","year":"2023","unstructured":"Haas KM, McGregor MJ, Bouhaddou M et al (2023) Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets. Nat Commun 14:6030. https:\/\/doi.org\/10.1038\/s41467-023-41442-z","journal-title":"Nat Commun"},{"key":"6146_CR42","doi-asserted-by":"publisher","first-page":"e2203088","DOI":"10.1002\/advs.202203088","volume":"9","author":"QC Li","year":"2022","unstructured":"Li QC, Jiang ZM, Ren SN et al (2022) SRSF5-mediated alternative splicing of M gene is essential for influenza A virus replication: a host-directed target against influenza virus. Adv Sci 9:e2203088. https:\/\/doi.org\/10.1002\/advs.202203088","journal-title":"Adv Sci"},{"key":"6146_CR43","doi-asserted-by":"publisher","first-page":"101129","DOI":"10.1016\/j.redox.2019.101129","volume":"22","author":"N Chamberlain","year":"2019","unstructured":"Chamberlain N, Korwin-Mihavics BR, Nakada EM et al (2019) Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics. Redox Biol 22:101129. https:\/\/doi.org\/10.1016\/j.redox.2019.101129","journal-title":"Redox Biol"},{"key":"6146_CR44","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1038\/nature05379","volume":"444","author":"Q Ye","year":"2006","unstructured":"Ye Q, Krug RM, Tao YJ (2006) The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA. Nature 444:1078\u20131082. https:\/\/doi.org\/10.1038\/nature05379","journal-title":"Nature"},{"key":"6146_CR45","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1038\/s41467-017-01112-3","volume":"8","author":"S Giese","year":"2017","unstructured":"Giese S, Ciminski K, Bolte H et al (2017) Role of influenza A virus NP acetylation on viral growth and replication. Nat Commun 8:1259. https:\/\/doi.org\/10.1038\/s41467-017-01112-3","journal-title":"Nat Commun"},{"key":"6146_CR46","doi-asserted-by":"publisher","unstructured":"Ren C, Chen T, Zhang S et al (2023) PLK3 facilitates replication of swine influenza virus by phosphorylating viral NP protein. Emerg microbes infections 12. https:\/\/doi.org\/10.1080\/22221751.2023.2275606","DOI":"10.1080\/22221751.2023.2275606"},{"key":"6146_CR47","doi-asserted-by":"publisher","unstructured":"Patil G, Zhao M, Song K et al (2018) TRIM41-mediated ubiquitination of nucleoprotein limits influenza A virus infection. J Virol 92. https:\/\/doi.org\/10.1128\/jvi.00905-18","DOI":"10.1128\/jvi.00905-18"},{"key":"6146_CR48","doi-asserted-by":"publisher","first-page":"102160","DOI":"10.1016\/j.isci.2021.102160","volume":"24","author":"X Wang","year":"2021","unstructured":"Wang X, Lin L, Zhong Y et al (2021) Cellular hnRNPAB binding to viral nucleoprotein inhibits flu virus replication by blocking nuclear export of viral mRNA. iScience 24:102160. https:\/\/doi.org\/10.1016\/j.isci.2021.102160","journal-title":"iScience"},{"key":"6146_CR49","doi-asserted-by":"publisher","first-page":"100079","DOI":"10.1016\/j.cellin.2023.100079","volume":"2","author":"L Jiang","year":"2023","unstructured":"Jiang L, Chen H, Li C (2023) Advances in deciphering the interactions between viral proteins of influenza A virus and host cellular proteins. Cell Insight 2:100079. https:\/\/doi.org\/10.1016\/j.cellin.2023.100079","journal-title":"Cell Insight"},{"key":"6146_CR50","doi-asserted-by":"publisher","first-page":"2387910","DOI":"10.1080\/22221751.2024.2387910","volume":"13","author":"L Cao","year":"2024","unstructured":"Cao L, She Z, Zhao Y et al (2024) Inhibition of RAN attenuates influenza a virus replication and nucleoprotein nuclear export. Emerg microbes infections 13:2387910. https:\/\/doi.org\/10.1080\/22221751.2024.2387910","journal-title":"Emerg microbes infections"},{"key":"6146_CR51","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01042-18","author":"C Yang","year":"2018","unstructured":"Yang C, Liu X, Gao Q et al (2018) The nucleolar protein LYAR facilitates ribonucleoprotein assembly of influenza A virus. J Virol. https:\/\/doi.org\/10.1128\/jvi.01042-18","journal-title":"J Virol"},{"key":"6146_CR52","doi-asserted-by":"publisher","first-page":"e1012110","DOI":"10.1371\/journal.ppat.1012110","volume":"20","author":"Y Zhou","year":"2024","unstructured":"Zhou Y, Li T, Zhang Y et al (2024) BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly. PLoS Pathog 20:e1012110. https:\/\/doi.org\/10.1371\/journal.ppat.1012110","journal-title":"PLoS Pathog"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-026-06146-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06146-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06146-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T11:22:21Z","timestamp":1772450541000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-026-06146-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6146"],"URL":"https:\/\/doi.org\/10.1007\/s00018-026-06146-9","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"30 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors consent to submit and publish this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No potential conflict of interest was reported by the author(s).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"127"}}