{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:38:44Z","timestamp":1774384724824,"version":"3.50.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974329"],"award-info":[{"award-number":["81974329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Program of Guangzhou","award":["2023A04J1829"],"award-info":[{"award-number":["2023A04J1829"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-026-06170-9","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T01:25:55Z","timestamp":1773192355000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dexras1 plays a crucial role in glucocorticoid-induced osteonecrosis of the femoral head by mediating imbalance between osteogenesis and adipogenesis"],"prefix":"10.1007","volume":"83","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhou","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0338-375X","authenticated-orcid":false,"given":"Haixia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"issue":"8","key":"6170_CR1","doi-asserted-by":"publisher","first-page":"590","DOI":"10.5312\/wjo.v6.i8.590","volume":"6","author":"J Moya-Angeler","year":"2015","unstructured":"Moya-Angeler J, Gianakos AL, Villa JC, Ni A, Lane JM (2015) Current concepts on osteonecrosis of the femoral head. World J Orthop 6(8):590\u2013601","journal-title":"World J Orthop"},{"key":"6170_CR2","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.jot.2019.12.004","volume":"21","author":"D Zhao","year":"2020","unstructured":"Zhao D, Zhang F, Wang B, Liu B, Li L, Kim SY, Goodman SB, Hernigou P, Cui Q, Lineaweaver WC, Xu J, Drescher WR, Qin L (2020) Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version). J Orthop Translat 21:100\u2013110","journal-title":"J Orthop Translat"},{"issue":"6","key":"6170_CR3","doi-asserted-by":"publisher","first-page":"667","DOI":"10.3390\/biom14060667","volume":"14","author":"J Zhang","year":"2024","unstructured":"Zhang J, Cao J, Liu Y, Zhao H (2024) Advances in the Pathogenesis of Steroid-Associated Osteonecrosis of the Femoral Head. Biomolecules 14(6):667","journal-title":"Biomolecules"},{"issue":"1","key":"6170_CR4","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.mce.2010.04.005","volume":"335","author":"AE Coutinho","year":"2011","unstructured":"Coutinho AE, Chapman KE (2011) The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol 335(1):2\u201313","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"6170_CR5","doi-asserted-by":"publisher","first-page":"2416070","DOI":"10.1080\/07853890.2024.2416070","volume":"56","author":"L Li","year":"2024","unstructured":"Li L, Zhao S, Leng Z, Chen S, Shi Y, Shi L, Li J, Mao K, Tang H, Meng B, Wang Y, Shang G, Liu H (2024) Pathological mechanisms and related markers of steroid-induced osteonecrosis of the femoral head. Ann Med 56(1):2416070","journal-title":"Ann Med"},{"issue":"5","key":"6170_CR6","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1007\/s00264-018-4011-y","volume":"43","author":"W Fu","year":"2019","unstructured":"Fu W, Liu B, Wang B, Zhao D (2019) Early diagnosis and treatment of steroid-induced osteonecrosis of the femoral head. Int Orthop 43(5):1083\u20131087","journal-title":"Int Orthop"},{"key":"6170_CR7","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.gene.2018.05.091","volume":"671","author":"A Wang","year":"2018","unstructured":"Wang A, Ren M, Wang J (2018) The pathogenesis of steroid-induced osteonecrosis of the femoral head: A systematic review of the literature. Gene 671:103\u2013109","journal-title":"Gene"},{"issue":"1","key":"6170_CR8","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1007\/s00018-024-05443-5","volume":"81","author":"N Yang","year":"2024","unstructured":"Yang N, Li M, Li X, Wu L, Wang W, Xu Y, Wang Z, Zhu C, Geng D (2024) MAGL blockade alleviates steroid-induced femoral head osteonecrosis by reprogramming BMSC fate in rat. Cell Mol Life Sci 81(1):418","journal-title":"Cell Mol Life Sci"},{"key":"6170_CR9","doi-asserted-by":"publisher","first-page":"RP92469","DOI":"10.7554\/eLife.92469.3","volume":"12","author":"C Xia","year":"2024","unstructured":"Xia C, Xu H, Fang L, Chen J, Yuan W, Fu D, Wang X, He B, Xiao L, Wu C, Tong P, Chen D, Wang P, Jin H (2024) beta-catenin inhibition disrupts the homeostasis of osteogenic\/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of the femoral head. Elife 12:RP92469","journal-title":"Elife"},{"issue":"1","key":"6170_CR10","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1186\/s13287-019-1498-0","volume":"10","author":"L Han","year":"2019","unstructured":"Han L, Wang B, Wang R, Gong S, Chen G, Xu W (2019) The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor. Stem Cell Res Ther 10(1):377","journal-title":"Stem Cell Res Ther"},{"issue":"7","key":"6170_CR11","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1007\/s00264-012-1497-6","volume":"36","author":"HY Erken","year":"2012","unstructured":"Erken HY, Ofluoglu O, Aktas M, Topal C, Yildiz M (2012) Effect of pentoxifylline on histopathological changes in steroid-induced osteonecrosis of femoral head: experimental study in chicken. Int Orthop 36(7):1523\u20131528","journal-title":"Int Orthop"},{"issue":"7","key":"6170_CR12","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/stmcls\/sxad038","volume":"41","author":"Y Chen","year":"2023","unstructured":"Chen Y, Tang B, Jiang W, Sun M, Zhang H, Tao Y, Wang H, Xiang D, Bai H, Guo M, Zhao P, Yan W, Huang X, Chen T, Lian C, Zhang J (2023) miR\u2013486\u20135p Attenuates Steroid-Induced Adipogenesis and Osteonecrosis of the Femoral Head Via TBX2\/P21 Axis. Stem Cells 41(7):711\u2013723","journal-title":"Stem Cells"},{"issue":"6","key":"6170_CR13","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1074\/jbc.273.6.3129","volume":"273","author":"RJ Kemppainen","year":"1998","unstructured":"Kemppainen RJ, Behrend EN (1998) Dexamethasone rapidly induces a novel ras superfamily member-related gene in AtT\u201320 cells. J Biol Chem 273(6):3129\u20133131","journal-title":"J Biol Chem"},{"issue":"16","key":"6170_CR14","doi-asserted-by":"publisher","first-page":"1711","DOI":"10.1056\/NEJMra050541","volume":"353","author":"T Rhen","year":"2005","unstructured":"Rhen T, Cidlowski JA (2005) Antiinflammatory action of glucocorticoids\u2013new mechanisms for old drugs. N Engl J Med 353(16):1711\u20131723","journal-title":"N Engl J Med"},{"issue":"51","key":"6170_CR15","doi-asserted-by":"publisher","first-page":"20575","DOI":"10.1073\/pnas.1320454110","volume":"110","author":"JY Cha","year":"2013","unstructured":"Cha JY, Kim HJ, Yu JH, Xu J, Kim D, Paul BD, Choi H, Kim S, Lee YJ, Ho GP, Rao F, Snyder SH, Kim JW (2013) Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity. Proc Natl Acad Sci U S A 110(51):20575\u201320580","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6170_CR16","doi-asserted-by":"publisher","first-page":"154250","DOI":"10.1016\/j.metabol.2020.154250","volume":"108","author":"JW Seok","year":"2020","unstructured":"Seok JW, Kim D, Yoon BK, Lee Y, Kim HJ, Hwang N, Fang S, Kim HJ, Kim JW (2020) Dexras1 plays a pivotal role in maintaining the equilibrium between adipogenesis and osteogenesis. Metabolism 108:154250","journal-title":"Metabolism"},{"key":"6170_CR17","doi-asserted-by":"publisher","first-page":"28648","DOI":"10.1038\/srep28648","volume":"6","author":"HJ Kim","year":"2016","unstructured":"Kim HJ, Cha JY, Seok JW, Choi Y, Yoon BK, Choi H, Yu JH, Song SJ, Kim A, Lee H, Kim D, Han JY, Kim JW (2016) Dexras1 links glucocorticoids to insulin-like growth factor\u20131 signaling in adipogenesis. Sci Rep 6:28648","journal-title":"Sci Rep"},{"issue":"7","key":"6170_CR18","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1007\/s00264-018-3830-1","volume":"42","author":"SB Goodman","year":"2018","unstructured":"Goodman SB (2018) The biological basis for concentrated iliac crest aspirate to enhance core decompression in the treatment of osteonecrosis. Int Orthop 42(7):1705\u20131709","journal-title":"Int Orthop"},{"issue":"3","key":"6170_CR19","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/s00264-020-04790-9","volume":"45","author":"O Andronic","year":"2021","unstructured":"Andronic O, Weiss O, Shoman H, Kriechling P, Khanduja V (2021) What are the outcomes of core decompression without augmentation in patients with nontraumatic osteonecrosis of the femoral head? Int Orthop 45(3):605\u2013613","journal-title":"Int Orthop"},{"issue":"1","key":"6170_CR20","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41413-022-00196-y","volume":"10","author":"N Kong","year":"2022","unstructured":"Kong N, Yang H, Tian R, Liu G, Li Y, Guan H, Wei Q, Du X, Lei Y, Li Z, Cao R, Zhao Y, Wang X, Wang K, Yang P (2022) An injectable self-adaptive polymer as a drug carrier for the treatment of nontraumatic early-stage osteonecrosis of the femoral head. Bone Res 10(1):28","journal-title":"Bone Res"},{"key":"6170_CR21","first-page":"678","volume":"59","author":"Y Chen","year":"2026","unstructured":"Chen Y, He W, Ling S, Zhou Y, Chen J, Du Y, Mo R, Cui W (2026) Boosting ribosomal translation via ionizable lipid-hydrogel microplexes for localized mRNA therapy. Bioact Mater 59:678\u2013696","journal-title":"Bioact Mater"},{"issue":"1","key":"6170_CR22","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00198-014-2809-z","volume":"26","author":"ZB Sun","year":"2015","unstructured":"Sun ZB, Wang JW, Xiao H, Zhang QS, Kan WS, Mo FB, Hu S, Ye SN (2015) Icariin may benefit the mesenchymal stem cells of patients with steroid-associated osteonecrosis by ABCB1-promoter demethylation: a preliminary study. Osteoporos Int 26(1):187\u2013197","journal-title":"Osteoporos Int"},{"issue":"1","key":"6170_CR23","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1186\/s12891-020-03225-1","volume":"21","author":"H Yu","year":"2020","unstructured":"Yu H, Liu P, Zuo W, Sun X, Liu H, Lu F, Guo W, Zhang Q (2020) Decreased angiogenic and increased apoptotic activities of bone microvascular endothelial cells in patients with glucocorticoid-induced osteonecrosis of the femoral head. BMC Musculoskelet Disord 21(1):277","journal-title":"BMC Musculoskelet Disord"},{"issue":"3","key":"6170_CR24","doi-asserted-by":"publisher","first-page":"345","DOI":"10.17219\/acem\/112602","volume":"29","author":"Y Lu","year":"2020","unstructured":"Lu Y, Yu Q, Guo W, Hao Y, Sun W, Cheng L (2020) Effect of glucocorticoids on the function of microvascular endothelial cells in the human femoral head bone. Adv Clin Exp Med 29(3):345\u2013353","journal-title":"Adv Clin Exp Med"},{"key":"6170_CR25","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.freeradbiomed.2021.07.016","volume":"176","author":"L Chen","year":"2021","unstructured":"Chen L, Wang BZ, Xie J, Zhang RY, Jin C, Chen WK, Fang KH, Hong CX, Xu TH, Huang CB, Yang L, Weng SJ (2021) Therapeutic effect of SIRT3 on glucocorticoid-induced osteonecrosis of the femoral head via intracellular oxidative suppression. Free Radic Biol Med 176:228\u2013240","journal-title":"Free Radic Biol Med"},{"key":"6170_CR26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1471-2474-15-239","volume":"15","author":"DA Zhou","year":"2014","unstructured":"Zhou DA, Zheng HX, Wang CW, Shi D, Li JJ (2014) Influence of glucocorticoids on the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells. BMC Musculoskelet Disord 15:23\u201329","journal-title":"BMC Musculoskelet Disord"},{"key":"6170_CR27","doi-asserted-by":"publisher","first-page":"148575","DOI":"10.1016\/j.gene.2024.148575","volume":"923","author":"F Liu","year":"2024","unstructured":"Liu F, Wang X, Xu J, Lu Y, Bai Y, Lv J (2024) Preliminary study on the mechanism by which exosomes derived from human exfoliated deciduous teeth improve the proliferation and osteogenic inhibitory effect of glucocorticoid-induced BMSCs. Gene 923:148575","journal-title":"Gene"},{"issue":"1","key":"6170_CR28","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41413-023-00259-8","volume":"11","author":"F Zhang","year":"2023","unstructured":"Zhang F, Wei L, Wang L, Wang T, Xie Z, Luo H, Li F, Zhang J, Dong W, Liu G, Kang Q, Zhu X, Peng W (2023) FAR591 promotes the pathogenesis and progression of SONFH by regulating Fos expression to mediate the apoptosis of bone microvascular endothelial cells. Bone Res 11(1):27","journal-title":"Bone Res"},{"issue":"Suppl 2","key":"6170_CR29","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1186\/ar4686","volume":"16","author":"MC van der Goes","year":"2014","unstructured":"van der Goes MC, Jacobs JW, Bijlsma JW (2014) The value of glucocorticoid co-therapy in different rheumatic diseases\u2013positive and adverse effects. Arthritis Res Ther 16(Suppl 2):S2","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"6170_CR30","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1177\/1535370213519215","volume":"239","author":"Y Jiang","year":"2014","unstructured":"Jiang Y, Zhang Y, Zhang H, Zhu B, Li P, Lu C, Xu Y, Chen W, Lin N (2014) Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPARgamma expression and activating Wnt signaling pathway. Exp Biol Med (Maywood) 239(3):347\u2013355","journal-title":"Exp Biol Med (Maywood)"},{"key":"6170_CR31","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.biopha.2018.05.051","volume":"105","author":"H Hu","year":"2018","unstructured":"Hu H, Li Z, Lu M, Yun X, Li W, Liu C, Guo A (2018) Osteoactivin inhibits dexamethasone-induced osteoporosis through up-regulating integrin \u03b21 and activate ERK pathway. Biomed Pharmacother 105:66\u201372","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"6170_CR32","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1186\/s13018-025-05697-0","volume":"20","author":"W Ji","year":"2025","unstructured":"Ji W, Gong G, Liu Y, Liu Y, Zhang J, Li Q (2025) Icariin promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by activating PI3K-AKT-UTX\/EZH2 signaling in steroid-induced femoral head osteonecrosis. J Orthop Surg Res 20(1):290","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"6170_CR33","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/jcmm.16103","volume":"25","author":"X Zhao","year":"2021","unstructured":"Zhao X, Alqwbani M, Luo Y, Chen C, Wei AG, Li Y, Wang D, Tian Q, Kang M (2021) Glucocorticoids decreased Cx43 expression in osteonecrosis of femoral head: The effect on proliferation and osteogenic differentiation of rat BMSCs. J Cell Mol Med 25(1):484\u2013498","journal-title":"J Cell Mol Med"},{"key":"6170_CR34","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.omtn.2022.02.017","volume":"28","author":"X Feng","year":"2022","unstructured":"Feng X, Xiang Q, Jia J, Guo T, Liao Z, Yang S, Cai X, Liu X (2022) CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR\u201325\u20133p binding to SMAD7. Mol Ther Nucleic Acids 28:99\u2013113","journal-title":"Mol Ther Nucleic Acids"},{"issue":"11","key":"6170_CR35","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1038\/s12276-022-00875-0","volume":"54","author":"F Zhang","year":"2022","unstructured":"Zhang F, Peng W, Wang T, Zhang J, Dong W, Wang C, Xie Z, Luo H, Liu G (2022) Lnc Tmem235 promotes repair of early steroid-induced osteonecrosis of the femoral head by inhibiting hypoxia-induced apoptosis of BMSCs. Exp Mol Med 54(11):1991\u20132006","journal-title":"Exp Mol Med"},{"issue":"10","key":"6170_CR36","doi-asserted-by":"publisher","first-page":"e30195","DOI":"10.1016\/j.heliyon.2024.e30195","volume":"10","author":"Z Xie","year":"2024","unstructured":"Xie Z, Luo H, Wang T, Wang L, Zhang J, Dong W, Liu G, Li F, Kang Q, Zhu X, Zhang F, Peng W (2024) METTL3 inhibits BMSC apoptosis and facilitates osteonecrosis repair via an m6A-IGF2BP2-dependent mechanism. Heliyon 10(10):e30195","journal-title":"Heliyon"},{"issue":"1","key":"6170_CR37","doi-asserted-by":"publisher","first-page":"11664","DOI":"10.1038\/s41598-019-48087-3","volume":"9","author":"RS Khan","year":"2019","unstructured":"Khan RS, Baumann B, Dine K, Song Y, Dunaief JL, Kim SF, Shindler KS (2019) Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis. Sci Rep 9(1):11664","journal-title":"Sci Rep"},{"issue":"4","key":"6170_CR38","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s11064-007-9516-5","volume":"33","author":"G Attarzadeh-Yazdi","year":"2008","unstructured":"Attarzadeh-Yazdi G, Shipston MJ, Antoni FA (2008) Dex-ras1 and serum- and glucocorticoid-inducible protein kinase 1: regulation of expression by dexamethasone in HEK293 cells. Neurochem Res 33(4):609\u2013613","journal-title":"Neurochem Res"},{"issue":"5","key":"6170_CR39","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1080\/10253890.2021.1907340","volume":"24","author":"CD Foradori","year":"2021","unstructured":"Foradori CD, Mackay L, Huang CJ, Kemppainen RJ (2021) Expression of Rasd1 in mouse endocrine pituitary cells and its response to dexamethasone. Stress 24(5):659\u2013666","journal-title":"Stress"},{"key":"6170_CR40","doi-asserted-by":"publisher","first-page":"12171","DOI":"10.2147\/IJN.S476546","volume":"19","author":"E Briffault","year":"2024","unstructured":"Briffault E, Reyes R, Garcia-Garcia P, Rouco H, Diaz-Gomez L, Arnau MR, Evora C, Diaz-Rodriguez P, Delgado A (2024) SFRP1-Silencing GapmeR-Loaded Lipid-Polymer Hybrid Nanoparticles for Bone Regeneration in Osteoporosis: Effect of Dosing and Targeting Strategy. Int J Nanomed 19:12171\u201312188","journal-title":"Int J Nanomed"},{"key":"6170_CR41","doi-asserted-by":"publisher","first-page":"102144","DOI":"10.1016\/j.mtbio.2025.102144","volume":"34","author":"S Li","year":"2025","unstructured":"Li S, Sheng Y, You Y, Wang Y, Zhang Y, Tao J, Wu C, Jiang X (2025) Study on VEGFA mRNA delivery via GelMA hydrogel-encapsulated extracellular vesicles for enhanced bone regeneration. Mater Today Bio 34:102144","journal-title":"Mater Today Bio"},{"issue":"9","key":"6170_CR42","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.7150\/ijbs.32262","volume":"15","author":"MJ Kuang","year":"2019","unstructured":"Kuang MJ, Huang Y, Zhao XG, Zhang R, Ma JX, Wang DC, Ma XL (2019) Exosomes derived from Wharton\u2019s jelly of human umbilical cord mesenchymal stem cells reduce osteocyte apoptosis in glucocorticoid-induced osteonecrosis of the femoral head in rats via the miR\u201321-PTEN-AKT signalling pathway. Int J Biol Sci 15(9):1861\u20131871","journal-title":"Int J Biol Sci"},{"issue":"23","key":"6170_CR43","doi-asserted-by":"publisher","first-page":"13973","DOI":"10.1111\/jcmm.16006","volume":"24","author":"X Zhang","year":"2020","unstructured":"Zhang X, You JM, Dong XJ, Wu Y (2020) Administration of mircoRNA\u2013135b-reinforced exosomes derived from MSCs ameliorates glucocorticoid-induced osteonecrosis of femoral head (ONFH) in rats. J Cell Mol Med 24(23):13973\u201313983","journal-title":"J Cell Mol Med"},{"issue":"2","key":"6170_CR44","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1302\/0301-620X.96B2.31935","volume":"96\u2013B","author":"KJ Guo","year":"2014","unstructured":"Guo KJ, Zhao FC, Guo Y, Li FL, Zhu L, Zheng W (2014) The influence of age, gender and treatment with steroids on the incidence of osteonecrosis of the femoral head during the management of severe acute respiratory syndrome: a retrospective study. Bone Joint J 96\u2013B(2):259\u2013262","journal-title":"Bone Joint J"},{"issue":"2","key":"6170_CR45","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s00774-008-0021-y","volume":"27","author":"Y Imai","year":"2009","unstructured":"Imai Y, Nakamura T, Matsumoto T, Takaoka K, Kato S (2009) Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism. J Bone Min Metab 27(2):127\u2013130","journal-title":"J Bone Min Metab"},{"issue":"10","key":"6170_CR46","doi-asserted-by":"publisher","first-page":"110190","DOI":"10.4252\/wjsc.v17.i10.110190","volume":"17","author":"H Lv","year":"2025","unstructured":"Lv H, Zheng CF, Chen XY, Wei JH, Tao YZ, Feng L, Feng Z, Lu SJ (2025) Sclerostin-silenced human umbilical cord mesenchymal stem cells ameliorate bone metabolism in steroid-induced femoral head necrosis. World J Stem Cells 17(10):110190","journal-title":"World J Stem Cells"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-026-06170-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06170-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06170-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T17:08:33Z","timestamp":1774372113000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-026-06170-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6170"],"URL":"https:\/\/doi.org\/10.1007\/s00018-026-06170-9","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"assertion":[{"value":"9 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal studies were carried out with the ethical permission of the Ethics Committee of Southern Medical University Zhujiang Hospital (LAEC\u22122022\u2212045).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All authors read and approved the submission and final publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no potential conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"173"}}