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All animal procedures were approved by the Ethics Committee for Animal Experiments of Zhejiang Chinese Medical University (No. 202502-0114). The study HC and TIN patients was approved by Ethical Committee (No. EC-LC-2024-40-01). All patients provided informed consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no commercial or financial relationships that could be interpreted as potential conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"182"}}