{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:27:18Z","timestamp":1782311238568,"version":"3.54.5"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"vor","delay-in-days":45,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970703"],"award-info":[{"award-number":["31970703"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32570891"],"award-info":[{"award-number":["32570891"]}],"id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515010593"],"award-info":[{"award-number":["2025A1515010593"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012472"],"award-info":[{"award-number":["2022A1515012472"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010544"],"award-info":[{"award-number":["2021A1515010544"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-026-06183-4","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:05:47Z","timestamp":1776751547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["SLC25A21 promotes ferroptosis by inducing mitochondrial GPX4 deficiency in colorectal cancer"],"prefix":"10.1007","volume":"83","author":[{"given":"Wanjun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimei","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meihua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caibin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8872-0592","authenticated-orcid":false,"given":"Daici","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"issue":"3","key":"6183_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u2013249. https:\/\/doi.org\/10.3322\/caac.21660","journal-title":"CA Cancer J Clin"},{"issue":"13","key":"6183_CR2","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1007\/s40265-019-01165-2","volume":"79","author":"J Taieb","year":"2019","unstructured":"Taieb J, Jung A, Sartore-Bianchi A et al (2019) The evolving biomarker landscape for treatment selection in metastatic colorectal cancer. Drugs 79(13):1375\u20131394. https:\/\/doi.org\/10.1007\/s40265-019-01165-2","journal-title":"Drugs"},{"key":"6183_CR3","doi-asserted-by":"publisher","DOI":"10.1093\/gastro\/goae055","volume":"12","author":"H Fu","year":"2024","unstructured":"Fu H, Lu X, Ji T et al (2024) Integrated analysis of colorectal cancer metastasis identifies characteristics of tumor cell during metastasis. Gastroenterol Rep (Oxf) 12:e55. https:\/\/doi.org\/10.1093\/gastro\/goae055","journal-title":"Gastroenterol Rep (Oxf)"},{"issue":"5","key":"6183_CR4","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41580-023-00689-6","volume":"25","author":"J Yuan","year":"2024","unstructured":"Yuan J, Ofengeim D (2024) A guide to cell death pathways. Nat Rev Mol Cell Biol 25(5):379\u2013395. https:\/\/doi.org\/10.1038\/s41580-023-00689-6","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"6183_CR5","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1080\/15548627.2024.2319901","volume":"20","author":"X Chen","year":"2024","unstructured":"Chen X, Tsvetkov AS, Shen H et al (2024) International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis. Autophagy 20(6):1213\u20131246. https:\/\/doi.org\/10.1080\/15548627.2024.2319901","journal-title":"Autophagy"},{"issue":"5","key":"6183_CR6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060\u20131072. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042","journal-title":"Cell"},{"issue":"2","key":"6183_CR7","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.747","volume":"12","author":"X Xue","year":"2022","unstructured":"Xue X, Ma L, Zhang X et al (2022) Tumour cells are sensitised to ferroptosis via RB1CC1-mediated transcriptional reprogramming. Clin Transl Med 12(2):e747. https:\/\/doi.org\/10.1002\/ctm2.747","journal-title":"Clin Transl Med"},{"issue":"12","key":"6183_CR8","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JP Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli JP, Schneider M, Proneth B et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16(12):1180\u20131191. https:\/\/doi.org\/10.1038\/ncb3064","journal-title":"Nat Cell Biol"},{"issue":"5","key":"6183_CR9","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","volume":"18","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G et al (2021) Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol 18(5):280\u2013296. https:\/\/doi.org\/10.1038\/s41571-020-00462-0","journal-title":"Nat Rev Clin Oncol"},{"issue":"9","key":"6183_CR10","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.7150\/ijbs.83348","volume":"19","author":"J Li","year":"2023","unstructured":"Li J, Jia Y, Ding Y et al (2023) The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks. Int J Biol Sci 19(9):2756\u20132771. https:\/\/doi.org\/10.7150\/ijbs.83348","journal-title":"Int J Biol Sci"},{"key":"6183_CR11","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2020.02.027","volume":"152","author":"F Ursini","year":"2020","unstructured":"Ursini F, Maiorino M (2020) Lipid peroxidation and ferroptosis: the role of GSH and GPx4. Free Radic Biol Med 152:175\u2013185. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2020.02.027","journal-title":"Free Radic Biol Med"},{"issue":"10","key":"6183_CR12","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1080\/15548627.2023.2218764","volume":"19","author":"Y Xie","year":"2023","unstructured":"Xie Y, Kang R, Klionsky DJ et al (2023) GPX4 in cell death, autophagy, and disease. Autophagy 19(10):2621\u20132638. https:\/\/doi.org\/10.1080\/15548627.2023.2218764","journal-title":"Autophagy"},{"issue":"1","key":"6183_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-023-00487-0","volume":"28","author":"W Liu","year":"2023","unstructured":"Liu W, Chen S, Xie W et al (2023) MCCC2 is a novel mediator between mitochondria and telomere and functions as an oncogene in colorectal cancer. Cell Mol Biol Lett 28(1):80. https:\/\/doi.org\/10.1186\/s11658-023-00487-0","journal-title":"Cell Mol Biol Lett"},{"key":"6183_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.682710","volume":"11","author":"Y Wang","year":"2021","unstructured":"Wang Y, Gao J, Hu S et al (2021) SLC25A21 suppresses cell growth in bladder cancer via an oxidative stress-mediated mechanism. Front Oncol 11:682710. https:\/\/doi.org\/10.3389\/fonc.2021.682710","journal-title":"Front Oncol"},{"issue":"12","key":"6183_CR15","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1038\/s41419-024-07308-y","volume":"15","author":"Y Liu","year":"2024","unstructured":"Liu Y, Xu Y, Hao Q et al (2024) SLC25A21 correlates with the prognosis of adult acute myeloid leukemia through inhibiting the growth of leukemia cells via downregulating CXCL8. Cell Death Dis 15(12):911\u2013921. https:\/\/doi.org\/10.1038\/s41419-024-07308-y","journal-title":"Cell Death Dis"},{"key":"6183_CR16","doi-asserted-by":"publisher","first-page":"682710","DOI":"10.1172\/jci","volume":"11","author":"S-S Hu","year":"2021","unstructured":"Hu S-S, Han Y, Tan T et al (2021) SLC25A21 downregulation promotes kras-mutant colorectal cancer progression by increasing glutamine anaplerosis. Front Oncol 11:682710. https:\/\/doi.org\/10.1172\/jci","journal-title":"Front Oncol"},{"issue":"10","key":"6183_CR17","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1038\/gim.2017.251","volume":"20","author":"V Boczonadi","year":"2018","unstructured":"Boczonadi V, King MS, Smith AC et al (2018) Mitochondrial oxodicarboxylate carrier deficiency is associated with mitochondrial DNA depletion and spinal muscular atrophy\u2013like disease. Genet Med 20(10):1224\u20131235. https:\/\/doi.org\/10.1038\/gim.2017.251","journal-title":"Genet Med"},{"issue":"21","key":"6183_CR18","doi-asserted-by":"publisher","first-page":"7252","DOI":"10.1158\/1078-0432.CCR-04-0713","volume":"10","author":"RL Camp","year":"2004","unstructured":"Camp RL, Dolled-Filhart M, Rimm DL (2004) X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 10(21):7252\u20137259. https:\/\/doi.org\/10.1158\/1078-0432.CCR-04-0713","journal-title":"Clin Cancer Res"},{"key":"6183_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.675555","volume":"9","author":"J Zheng","year":"2021","unstructured":"Zheng J, Zhou Z, Qiu Y et al (2021) A prognostic ferroptosis-related lncRNAs signature associated with immune landscape and radiotherapy response in glioma. Front Cell Dev Biol 9:675555. https:\/\/doi.org\/10.3389\/fcell.2021.675555","journal-title":"Front Cell Dev Biol"},{"issue":"D1","key":"6183_CR20","doi-asserted-by":"publisher","first-page":"D571","DOI":"10.1093\/nar\/gkac935","volume":"51","author":"N Zhou","year":"2023","unstructured":"Zhou N, Yuan X, Du Q et al (2023) Ferrdb v2: update of the manually curated database of ferroptosis regulators and ferroptosis-disease associations. Nucleic Acids Res 51(D1):D571\u2013D582. https:\/\/doi.org\/10.1093\/nar\/gkac935","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"6183_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01170-9","volume":"21","author":"X Wang","year":"2023","unstructured":"Wang X, Tan X, Zhang J et al (2023) The emerging roles of MAPK-AMPK in ferroptosis regulatory network. Cell Commun Signal 21(1):200. https:\/\/doi.org\/10.1186\/s12964-023-01170-9","journal-title":"Cell Commun Signal"},{"key":"6183_CR22","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.jot.2023.02.005","volume":"39","author":"C Zhao","year":"2023","unstructured":"Zhao C, Sun G, Li Y et al (2023) Forkhead box O3 attenuates osteoarthritis by suppressing ferroptosis through inactivation of NF-\u03baB\/MAPK signaling. J Orthop Translat 39:147\u2013162. https:\/\/doi.org\/10.1016\/j.jot.2023.02.005","journal-title":"J Orthop Translat"},{"issue":"1","key":"6183_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-03009-z","volume":"21","author":"X Li","year":"2024","unstructured":"Li X, Quan P, Si Y et al (2024) The microRNA-211-5p\/P2RX7\/ERK\/GPX4 axis regulates epilepsy-associated neuronal ferroptosis and oxidative stress. J Neuroinflammation 21(1):13. https:\/\/doi.org\/10.1186\/s12974-023-03009-z","journal-title":"J Neuroinflammation"},{"key":"6183_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116697","volume":"175","author":"Q He","year":"2024","unstructured":"He Q, Lin Y, Chen B et al (2024) Vitamin K2 ameliorates osteoarthritis by suppressing ferroptosis and extracellular matrix degradation through activation GPX4\u2019s dual functions. Biomed Pharmacother 175:116697. https:\/\/doi.org\/10.1016\/j.biopha.2024.116697","journal-title":"Biomed Pharmacother"},{"issue":"10","key":"6183_CR25","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.4103\/1673-5374.391193","volume":"19","author":"L Feng","year":"2024","unstructured":"Feng L, Wang C, Zhang C et al (2024) p38 MAPK inhibitor SB202190 suppresses ferroptosis in the glutamate-induced retinal excitotoxicity glaucoma model. Neural Regen Res 19(10):2299\u20132309. https:\/\/doi.org\/10.4103\/1673-5374.391193","journal-title":"Neural Regen Res"},{"issue":"1","key":"6183_CR26","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/s41420-025-02669-5","volume":"11","author":"Y Wang","year":"2025","unstructured":"Wang Y, Moura AK, Zuo R et al (2025) Defective lipid droplet biogenesis exacerbates oleic acid-induced cellular homeostasis disruption and ferroptosis in mouse cardiac endothelial cells. Cell Death Discov 11(1):317\u2013374. https:\/\/doi.org\/10.1038\/s41420-025-02669-5","journal-title":"Cell Death Discov"},{"key":"6183_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115547","volume":"167","author":"Y Yang","year":"2023","unstructured":"Yang Y, Wang Y, Deng Y et al (2023) Fructus lycii and salvia miltiorrhiza bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa. Biomed Pharmacother 167:115547. https:\/\/doi.org\/10.1016\/j.biopha.2023.115547","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"6183_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-022-00432-x","volume":"11","author":"S Li","year":"2023","unstructured":"Li S, Shen S, Ge W et al (2023) Long non-coding RNA SLC25A21-AS1 inhibits the development of epithelial ovarian cancer by specifically inducing PTBP3 degradation. Biomark Res 11(1):12. https:\/\/doi.org\/10.1186\/s40364-022-00432-x","journal-title":"Biomark Res"},{"issue":"2","key":"6183_CR29","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2379601","volume":"46","author":"C Pan","year":"2024","unstructured":"Pan C, Zhao H, Cai X et al (2024) The connection between autophagy and ferroptosis in AKI: recent advances regarding selective autophagy. Ren Fail 46(2):2379601. https:\/\/doi.org\/10.1080\/0886022X.2024.2379601","journal-title":"Ren Fail"},{"issue":"10","key":"6183_CR30","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06154-8","volume":"14","author":"S Liu","year":"2023","unstructured":"Liu S, Yao S, Yang H et al (2023) Autophagy: regulator of cell death. Cell Death Dis 14(10):648. https:\/\/doi.org\/10.1038\/s41419-023-06154-8","journal-title":"Cell Death Dis"},{"issue":"1","key":"6183_CR31","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1161\/CIRCRESAHA.123.322512","volume":"133","author":"M Tong","year":"2023","unstructured":"Tong M, Mukai R, Mareedu S et al (2023) Distinct roles of DRP1 in conventional and alternative mitophagy in obesity cardiomyopathy. Circ Res 133(1):6\u201321. https:\/\/doi.org\/10.1161\/CIRCRESAHA.123.322512","journal-title":"Circ Res"},{"issue":"2","key":"6183_CR32","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.pep.2007.01.012","volume":"53","author":"C Chu","year":"2007","unstructured":"Chu C, Cheng D (2007) Expression, purification, characterization of human 3-methylcrotonyl-CoA carboxylase (MCCC). Protein Expr Purif 53(2):421\u2013427. https:\/\/doi.org\/10.1016\/j.pep.2007.01.012","journal-title":"Protein Expr Purif"},{"issue":"11","key":"6183_CR33","doi-asserted-by":"publisher","first-page":"8225","DOI":"10.1074\/jbc.M009607200","volume":"276","author":"G Fiermonte","year":"2001","unstructured":"Fiermonte G, Dolce V, Palmieri L et al (2001) Identification of the human mitochondrial oxodicarboxylate carrier. J Biol Chem 276(11):8225\u20138230. https:\/\/doi.org\/10.1074\/jbc.M009607200","journal-title":"J Biol Chem"},{"key":"6183_CR34","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jare.2023.02.012","volume":"55","author":"Y Bi","year":"2024","unstructured":"Bi Y, Liu S, Qin X et al (2024) FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner. J Adv Res 55:45\u201360. https:\/\/doi.org\/10.1016\/j.jare.2023.02.012","journal-title":"J Adv Res"},{"issue":"2","key":"6183_CR35","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s00259-017-3836-8","volume":"45","author":"K Kim","year":"2018","unstructured":"Kim K, Shim H, Hwang J et al (2018) The role of interim FDG PET-CT after induction chemotherapy as a predictor of concurrent chemoradiotherapy efficacy and prognosis for head and neck cancer. Eur J Nucl Med Mol Imaging 45(2):170\u2013178. https:\/\/doi.org\/10.1007\/s00259-017-3836-8","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"6183_CR36","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.960738","volume":"13","author":"J Liu","year":"2022","unstructured":"Liu J, Shen H, Gu W et al (2022) Prediction of prognosis, immunogenicity and efficacy of immunotherapy based on glutamine metabolism in lung adenocarcinoma. Front Immunol 13:960738. https:\/\/doi.org\/10.3389\/fimmu.2022.960738","journal-title":"Front Immunol"},{"issue":"1","key":"6183_CR37","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31218-2","volume":"13","author":"B Wiernicki","year":"2022","unstructured":"Wiernicki B, Maschalidi S, Pinney J et al (2022) Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity. Nat Commun 13(1):3676. https:\/\/doi.org\/10.1038\/s41467-022-31218-2","journal-title":"Nat Commun"},{"issue":"3","key":"6183_CR38","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1007\/s43657-025-00220-1","volume":"5","author":"Z Jiang","year":"2025","unstructured":"Jiang Z, Liu X, Peng L et al (2025) A simpler, more convenient and more comfortable approach for treating multiple keratinocytic carcinoma. Phenomics 5(3):333\u2013337. https:\/\/doi.org\/10.1007\/s43657-025-00220-1","journal-title":"Phenomics"},{"issue":"2","key":"6183_CR39","doi-asserted-by":"publisher","DOI":"10.1093\/pcmedi\/pbae011","volume":"7","author":"G Li","year":"2024","unstructured":"Li G, Chen L, Bai H et al (2024) Depletion of squalene epoxidase in synergy with glutathione peroxidase 4 inhibitor RSL3 overcomes oxidative stress resistance in lung squamous cell carcinoma. Precis Clin Med 7(2):e11. https:\/\/doi.org\/10.1093\/pcmedi\/pbae011","journal-title":"Precis Clin Med"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-026-06183-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06183-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06183-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:27:23Z","timestamp":1780626443000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-026-06183-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6183"],"URL":"https:\/\/doi.org\/10.1007\/s00018-026-06183-4","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"9 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were conducted in accordance with the Declaration of Helsinki and approved by the Human Medical Ethics Committee of the Sixth Affiliated Hospital of Sun Yat-sen University (approval number: 2022ZSLYEC-469). This study was approved by the Animal Ethical and Welfare Committee of the Sixth Affiliated Hospital of Sun Yat-sen University (IACUG-20230912).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no potential conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"241"}}