{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T23:48:59Z","timestamp":1794268139607,"version":"4.9.0"},"reference-count":117,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":56,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270561"],"award-info":[{"award-number":["82270561"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073156"],"award-info":[{"award-number":["82073156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific research project of Jiangsu Provincial Health Commission","award":["K2025015"],"award-info":[{"award-number":["K2025015"]}]},{"name":"Jiangsu Provincial Medical Key Discipline","award":["ZDXK202246"],"award-info":[{"award-number":["ZDXK202246"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-026-06249-3","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T20:54:02Z","timestamp":1778532842000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gastric intestinal metaplasia: unraveling the multifactorial pathogenesis and advancing risk stratification for gastric cancer prevention"],"prefix":"10.1007","volume":"83","author":[{"given":"Yuxin","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5382-2775","authenticated-orcid":false,"given":"Tongguo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weichang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"6249_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229\u2013263","journal-title":"CA Cancer J Clin"},{"key":"6249_CR2","first-page":"297","volume":"44","author":"P Correa","year":"1970","unstructured":"Correa P et al (1970) Carcinoma and intestinal metaplasia of the stomach in Colombian migrants. J Natl Cancer Inst 44:297\u2013306","journal-title":"J Natl Cancer Inst"},{"key":"6249_CR3","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1053\/j.gastro.2007.06.026","volume":"133","author":"P Correa","year":"2007","unstructured":"Correa P et al (2007) Carcinogenesis of Helicobacter pylori. Gastroenterology 133:659\u2013672","journal-title":"Gastroenterology"},{"key":"6249_CR4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nrm3043","volume":"12","author":"C Jopling","year":"2011","unstructured":"Jopling C et al (2011) Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat Rev Mol Cell Biol 12:79\u201389","journal-title":"Nat Rev Mol Cell Biol"},{"key":"6249_CR5","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1002\/path.5066","volume":"245","author":"JR Goldenring","year":"2018","unstructured":"Goldenring JR (2018) Pyloric metaplasia, pseudopyloric metaplasia, ulcer-associated cell lineage and spasmolytic polypeptide-expressing metaplasia: reparative lineages in the gastrointestinal mucosa. J Pathol 245:132\u2013137","journal-title":"J Pathol"},{"key":"6249_CR6","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/nrc.2017.68","volume":"17","author":"V Giroux","year":"2017","unstructured":"Giroux V et al (2017) Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequence. Nat Rev Cancer 17:594\u2013604","journal-title":"Nat Rev Cancer"},{"key":"6249_CR7","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1053\/j.gastro.2008.01.071","volume":"134","author":"AC de Vries","year":"2008","unstructured":"de Vries AC et al (2008) Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands. Gastroenterology 134:945\u2013952","journal-title":"Gastroenterology"},{"key":"6249_CR8","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1111\/jgh.13249","volume":"31","author":"CA Gonzalez","year":"2016","unstructured":"Gonzalez CA et al (2016) Incomplete type of intestinal metaplasia has the highest risk to progress to gastric cancer: results of the Spanish follow-up multicenter study. J Gastroenterol Hepatol 31:953\u2013958","journal-title":"J Gastroenterol Hepatol"},{"key":"6249_CR9","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1136\/gutjnl-2017-314498","volume":"68","author":"WJ den Hollander","year":"2019","unstructured":"den Hollander WJ et al (2019) Surveillance of premalignant gastric lesions: a multicentre prospective cohort study from low incidence regions. Gut 68:585\u2013593","journal-title":"Gut"},{"key":"6249_CR10","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1136\/gutjnl-2016-311685","volume":"67","author":"RM Mera","year":"2018","unstructured":"Mera RM et al (2018) Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial. Gut 67:1239\u20131246","journal-title":"Gut"},{"key":"6249_CR11","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1007\/s10120-015-0462-7","volume":"19","author":"HN Chen","year":"2016","unstructured":"Chen HN et al (2016) Helicobacter pylori eradication cannot reduce the risk of gastric cancer in patients with intestinal metaplasia and dysplasia: evidence from a meta-analysis. Gastric Cancer 19:166\u2013175","journal-title":"Gastric Cancer"},{"key":"6249_CR12","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/j.1440-1746.2008.05774.x","volume":"24","author":"RA Busuttil","year":"2009","unstructured":"Busuttil RA et al (2009) Intestinal metaplasia: a premalignant lesion involved in gastric carcinogenesis. J Gastroenterol Hepatol 24:193\u2013201","journal-title":"J Gastroenterol Hepatol"},{"key":"6249_CR13","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1002\/ijc.31571","volume":"143","author":"L Shao","year":"2018","unstructured":"Shao L et al (2018) Risk of gastric cancer among patients with gastric intestinal metaplasia. Int J Cancer 143:1671\u20131677","journal-title":"Int J Cancer"},{"key":"6249_CR14","doi-asserted-by":"publisher","first-page":"h3867","DOI":"10.1136\/bmj.h3867","volume":"351","author":"H Song","year":"2015","unstructured":"Song H et al (2015) Incidence of gastric cancer among patients with gastric precancerous lesions: observational cohort study in a low risk Western population. BMJ 351:h3867","journal-title":"BMJ"},{"key":"6249_CR15","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1053\/j.gastro.2019.12.001","volume":"158","author":"AJ Gawron","year":"2020","unstructured":"Gawron AJ et al (2020) AGA Technical Review on Gastric Intestinal Metaplasia-Natural History and Clinical Outcomes. Gastroenterology 158:705\u2013731e5","journal-title":"Gastroenterology"},{"key":"6249_CR16","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1136\/gutjnl-2021-324057","volume":"71","author":"JWJ Lee","year":"2022","unstructured":"Lee JWJ et al (2022) Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP). Gut 71:854\u2013863","journal-title":"Gut"},{"key":"6249_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1136\/gutjnl-2017-314600","volume":"68","author":"M Rugge","year":"2019","unstructured":"Rugge M et al (2019) Gastritis staging in the endoscopic follow-up for the secondary prevention of gastric cancer: a 5-year prospective study of 1755 patients. Gut 68:11\u201317","journal-title":"Gut"},{"key":"6249_CR18","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1053\/j.gastro.2019.12.002","volume":"158","author":"O Altayar","year":"2020","unstructured":"Altayar O et al (2020) AGA Technical Review on Gastric Intestinal Metaplasia-Epidemiology and Risk Factors. Gastroenterology 158:732\u2013744e16","journal-title":"Gastroenterology"},{"key":"6249_CR19","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1097\/MOG.0000000000000472","volume":"34","author":"DY Graham","year":"2018","unstructured":"Graham DY et al (2018) Guilt by association: intestinal metaplasia does not progress to gastric cancer. Curr Opin Gastroenterol 34:458\u2013464","journal-title":"Curr Opin Gastroenterol"},{"key":"6249_CR20","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1097\/MOG.0000000000000576","volume":"35","author":"DY Graham","year":"2019","unstructured":"Graham DY et al (2019) Diagnosis: gastric intestinal metaplasia - what to do next? Curr Opin Gastroenterol 35:535\u2013543","journal-title":"Curr Opin Gastroenterol"},{"key":"6249_CR21","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1053\/j.gastro.2021.10.036","volume":"162","author":"JR Goldenring","year":"2022","unstructured":"Goldenring JR et al (2022) Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond. Gastroenterology 162:415\u2013430","journal-title":"Gastroenterology"},{"key":"6249_CR22","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1136\/gut.2003.034629","volume":"53","author":"WK Leung","year":"2004","unstructured":"Leung WK et al (2004) Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication. Gut 53:1244\u20131249","journal-title":"Gut"},{"key":"6249_CR23","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/j.ccell.2023.10.004","volume":"41","author":"KK Huang","year":"2023","unstructured":"Huang KK et al (2023) Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression. Cancer Cell 41:2019\u20132037 e8","journal-title":"Cancer Cell"},{"key":"6249_CR24","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ccell.2017.11.018","volume":"33","author":"KK Huang","year":"2018","unstructured":"Huang KK et al (2018) Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer. Cancer Cell 33:137\u2013150e5","journal-title":"Cancer Cell"},{"key":"6249_CR25","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.jcmgh.2017.01.013","volume":"3","author":"Y Hayakawa","year":"2017","unstructured":"Hayakawa Y et al (2017) The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models. Cell Mol Gastroenterol Hepatol 3:331\u2013338","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"6249_CR26","doi-asserted-by":"publisher","first-page":"84","DOI":"10.18632\/genesandcancer.40","volume":"6","author":"A Shvartsur","year":"2015","unstructured":"Shvartsur A et al (2015) Trop2 and its overexpression in cancers: regulation and clinical\/therapeutic implications. Genes Cancer 6:84\u2013105","journal-title":"Genes Cancer"},{"key":"6249_CR27","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1136\/jcp.2008.060590","volume":"62","author":"G Muhlmann","year":"2009","unstructured":"Muhlmann G et al (2009) TROP2 expression as prognostic marker for gastric carcinoma. J Clin Pathol 62:152\u2013158","journal-title":"J Clin Pathol"},{"key":"6249_CR28","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/path.5469","volume":"251","author":"KM Riera","year":"2020","unstructured":"Riera KM et al (2020) Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosa. J Pathol 251:336\u2013347","journal-title":"J Pathol"},{"key":"6249_CR29","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/1476-4598-9-253","volume":"9","author":"R Cubas","year":"2010","unstructured":"Cubas R et al (2010) Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer 9:253","journal-title":"Mol Cancer"},{"key":"6249_CR30","doi-asserted-by":"publisher","first-page":"63382","DOI":"10.18632\/oncotarget.18817","volume":"8","author":"H Zhao","year":"2017","unstructured":"Zhao H et al (2017) Identification of AQP3 and CD24 as biomarkers for carcinogenesis of gastric intestinal metaplasia. Oncotarget 8:63382\u201363391","journal-title":"Oncotarget"},{"key":"6249_CR31","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41586-020-1973-x","volume":"578","author":"SH Tan","year":"2020","unstructured":"Tan SH et al (2020) AQP5 enriches for stem cells and cancer origins in the distal stomach. Nature 578:437\u2013443","journal-title":"Nature"},{"key":"6249_CR32","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jcmgh.2021.08.017","volume":"13","author":"SH Lee","year":"2022","unstructured":"Lee SH et al (2022) Up-regulation of Aquaporin 5 Defines Spasmolytic Polypeptide-Expressing Metaplasia and Progression to Incomplete Intestinal Metaplasia. Cell Mol Gastroenterol Hepatol 13:199\u2013217","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"6249_CR33","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1136\/gutjnl-2019-319002","volume":"69","author":"V Krishnan","year":"2020","unstructured":"Krishnan V et al (2020) DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia. Gut 69:1738\u20131749","journal-title":"Gut"},{"key":"6249_CR34","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1053\/j.gastro.2019.12.008","volume":"158","author":"S Sultan","year":"2020","unstructured":"Sultan S (2020) The vexing problem of incidental gastric intestinal metaplasia: do the AGA guidelines help? Gastroenterology 158:473\u2013474","journal-title":"Gastroenterology"},{"key":"6249_CR35","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/S0928-8244(03)00299-2","volume":"40","author":"W Zhou","year":"2004","unstructured":"Zhou W et al (2004) The diversity of vacA and cagA genes of Helicobacter pylori in East Asia. FEMS Immunol Med Microbiol 40:81\u201387","journal-title":"FEMS Immunol Med Microbiol"},{"key":"6249_CR36","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.micpath.2018.06.023","volume":"122","author":"AF Sheikh","year":"2018","unstructured":"Sheikh AF et al (2018) CagA and vacA allelic combination of Helicobacter pylori in gastroduodenal disorders. Microb Pathog 122:144\u2013150","journal-title":"Microb Pathog"},{"key":"6249_CR37","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1158\/1055-9965.EPI-16-1024","volume":"26","author":"JH Song","year":"2017","unstructured":"Song JH et al (2017) High Salt Intake Is Associated with Atrophic Gastritis with Intestinal Metaplasia. Cancer Epidemiol Biomarkers Prev 26:1133\u20131138","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"6249_CR38","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1001\/jamaoncol.2017.4573","volume":"4","author":"S Sorscher","year":"2018","unstructured":"Sorscher S (2018) Ascertainment Bias and Estimating Penetrance. JAMA Oncol 4:587","journal-title":"JAMA Oncol"},{"key":"6249_CR39","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1046\/j.1523-5378.2001.00042.x","volume":"6","author":"M Asaka","year":"2001","unstructured":"Asaka M et al (2001) Atrophic gastritis and intestinal metaplasia in Japan: results of a large multicenter study. Helicobacter 6:294\u2013299","journal-title":"Helicobacter"},{"key":"6249_CR40","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1097\/PAS.0000000000000384","volume":"39","author":"RM Genta","year":"2015","unstructured":"Genta RM et al (2015) Characteristics of the gastric mucosa in patients with intestinal metaplasia. Am J Surg Pathol 39:700\u2013704","journal-title":"Am J Surg Pathol"},{"key":"6249_CR41","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1007\/s10620-015-3591-2","volume":"60","author":"CE Choi","year":"2015","unstructured":"Choi CE et al (2015) High Prevalence of Gastric Preneoplastic Lesions in East Asians and Hispanics in the USA. Dig Dis Sci 60:2070\u20132076","journal-title":"Dig Dis Sci"},{"key":"6249_CR42","first-page":"1325","volume":"161","author":"SC Shah","year":"2021","unstructured":"Shah SC et al (2021) AGA Clinical Practice Update on the Diagnosis and Management of Atrophic Gastritis. Expert Rev Gastroenterol 161:1325\u20131332 e7","journal-title":"Expert Rev Gastroenterol"},{"key":"6249_CR43","doi-asserted-by":"crossref","unstructured":"Dixon MF et al (1996) Classification and grading of gastritis. The updated Sydney system. International workshop on the histopathology of gastritis, Houston 1994. Am J Surg Pathol 20:1161-81","DOI":"10.1097\/00000478-199610000-00001"},{"key":"6249_CR44","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1136\/gutjnl-2022-327827","volume":"72","author":"M Rugge","year":"2023","unstructured":"Rugge M et al (2023) Autoimmune gastritis: long-term natural history in naive Helicobacter pylori-negative patients. Gut 72:30\u201338","journal-title":"Gut"},{"key":"6249_CR45","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1080\/003655202317284156","volume":"37","author":"F Petersson","year":"2002","unstructured":"Petersson F et al (2002) Prevalence of subtypes of intestinal metaplasia in the general population and in patients with autoimmune chronic atrophic gastritis. Scand J Gastroenterol 37:262\u2013266","journal-title":"Scand J Gastroenterol"},{"key":"6249_CR46","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1177\/2050640616644142","volume":"5","author":"S Jeong","year":"2017","unstructured":"Jeong S et al (2017) Distinct metaplastic and inflammatory phenotypes in autoimmune and adenocarcinoma-associated chronic atrophic gastritis. United Eur Gastroenterol J 5:37\u201344","journal-title":"United Eur Gastroenterol J"},{"key":"6249_CR47","first-page":"4823","volume":"59","author":"JG Fox","year":"1999","unstructured":"Fox JG et al (1999) High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL\/6 mice. Cancer Res 59:4823\u20134828","journal-title":"Cancer Res"},{"key":"6249_CR48","doi-asserted-by":"publisher","first-page":"381","DOI":"10.14309\/ajg.0000000000000498","volume":"115","author":"MC Tan","year":"2020","unstructured":"Tan MC et al (2020) Demographic and Lifestyle Risk Factors for Gastric Intestinal Metaplasia Among US Veterans. Am J Gastroenterol 115:381\u2013387","journal-title":"Am J Gastroenterol"},{"key":"6249_CR49","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1007\/s10620-020-06399-9","volume":"66","author":"MC Tan","year":"2021","unstructured":"Tan MC et al (2021) Dietary Factors and Gastric Intestinal Metaplasia Risk Among US Veterans. Dig Dis Sci 66:1600\u20131610","journal-title":"Dig Dis Sci"},{"key":"6249_CR50","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1158\/0008-5472.CAN-18-2268","volume":"79","author":"K Kim","year":"2019","unstructured":"Kim K et al (2019) Smoking and Urinary Cotinine Levels Are Predictors of Increased Risk for Gastric Intestinal Metaplasia. Cancer Res 79:676\u2013684","journal-title":"Cancer Res"},{"key":"6249_CR51","doi-asserted-by":"publisher","first-page":"1115250","DOI":"10.3389\/fphys.2023.1115250","volume":"14","author":"M Wang","year":"2023","unstructured":"Wang M et al (2023) The role of bile acid in intestinal metaplasia. Front Physiol 14:1115250","journal-title":"Front Physiol"},{"key":"6249_CR52","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/den.12030","volume":"25","author":"T Matsuhisa","year":"2013","unstructured":"Matsuhisa T et al (2013) Relation between bile acid reflux into the stomach and the risk of atrophic gastritis and intestinal metaplasia: a multicenter study of 2283 cases. Dig Endosc 25:519\u2013525","journal-title":"Dig Endosc"},{"key":"6249_CR53","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1111\/1751-2980.12986","volume":"22","author":"LY Zhang","year":"2021","unstructured":"Zhang LY et al (2021) Bile reflux is an independent risk factor for precancerous gastric lesions and gastric cancer: An observational cross-sectional study. J Dig Dis 22:282\u2013290","journal-title":"J Dig Dis"},{"key":"6249_CR54","first-page":"696","volume":"53","author":"M Younes","year":"2023","unstructured":"Younes M et al (2023) Incomplete Intestinal Metaplasia of the Stomach Is more Related to Bile Reflux than Chronic Gastritis. Ann Clin Lab Sci 53:696\u2013700","journal-title":"Ann Clin Lab Sci"},{"key":"6249_CR55","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/00004836-199812000-00011","volume":"27","author":"A Zullo","year":"1998","unstructured":"Zullo A et al (1998) Gastric pathology in cholecystectomy patients: role of Helicobacter pylori and bile reflux. J Clin Gastroenterol 27:335\u2013338","journal-title":"J Clin Gastroenterol"},{"key":"6249_CR56","doi-asserted-by":"publisher","first-page":"2120744","DOI":"10.1080\/19490976.2022.2120744","volume":"14","author":"D Jin","year":"2022","unstructured":"Jin D et al (2022) Deoxycholic acid induces gastric intestinal metaplasia by activating STAT3 signaling and disturbing gastric bile acids metabolism and microbiota. Gut Microbes 14:2120744","journal-title":"Gut Microbes"},{"key":"6249_CR57","doi-asserted-by":"publisher","first-page":"1121190","DOI":"10.3389\/fnagi.2023.1121190","volume":"15","author":"S Han","year":"2023","unstructured":"Han S et al (2023) The combined associations of depression and cognitive impairment with functional disability and mortality in older adults: a population-based study from the NHANES 2011\u20132014. Front Aging Neurosci 15:1121190","journal-title":"Front Aging Neurosci"},{"key":"6249_CR58","first-page":"1409","volume":"12","author":"L Zhang","year":"2022","unstructured":"Zhang L et al (2022) HDAC6\/FOXP3\/HNF4alpha axis promotes bile acids induced gastric intestinal metaplasia. Am J Cancer Res 12:1409\u20131422","journal-title":"Am J Cancer Res"},{"key":"6249_CR59","first-page":"879","volume":"54","author":"JH Yu","year":"2019","unstructured":"Yu JH et al (2019) Bile acids promote gastric intestinal metaplasia by upregulating CDX2 and MUC2 expression via the FXR\/NF-kappaB signalling pathway. Int J Oncol 54:879\u2013892","journal-title":"Int J Oncol"},{"key":"6249_CR60","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41420-022-00960-3","volume":"8","author":"C Li","year":"2022","unstructured":"Li C et al (2022) IL-37 isoform D acts as an inhibitor of soluble ST2 to boost type 2 immune homeostasis in white adipose tissue. Cell Death Discov 8:163","journal-title":"Cell Death Discov"},{"key":"6249_CR61","doi-asserted-by":"publisher","first-page":"414","DOI":"10.5009\/gnl220394","volume":"18","author":"X Yang","year":"2024","unstructured":"Yang X et al (2024) GATA4 Forms a Positive Feedback Loop with CDX2 to Transactivate MUC2 in Bile Acids-Induced Gastric Intestinal Metaplasia. Gut Liver 18:414\u2013425","journal-title":"Gut Liver"},{"key":"6249_CR62","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1136\/gutjnl-2017-315318","volume":"68","author":"T Li","year":"2019","unstructured":"Li T et al (2019) MicroRNA-92a-1-5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia. Gut 68:1751\u20131763","journal-title":"Gut"},{"key":"6249_CR63","doi-asserted-by":"publisher","first-page":"173566","DOI":"10.1016\/j.ejphar.2020.173566","volume":"887","author":"X Xu","year":"2020","unstructured":"Xu X et al (2020) Deoxycholic acid-stimulated macrophage-derived exosomes promote intestinal metaplasia and suppress proliferation in human gastric epithelial cells. Eur J Pharmacol 887:173566","journal-title":"Eur J Pharmacol"},{"key":"6249_CR64","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41420-020-0290-3","volume":"6","author":"Z Ni","year":"2020","unstructured":"Ni Z et al (2020) TGR5-HNF4alpha axis contributes to bile acid-induced gastric intestinal metaplasia markers expression. Cell Death Discov 6:56","journal-title":"Cell Death Discov"},{"key":"6249_CR65","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1053\/j.gastro.2023.08.028","volume":"165","author":"K Sugano","year":"2023","unstructured":"Sugano K et al (2023) Gastric Intestinal metaplasia: real culprit or innocent bystander as a precancerous condition for gastric cancer? Gastroenterology 165:1352\u20131366e1","journal-title":"Gastroenterology"},{"key":"6249_CR66","first-page":"3554","volume":"48","author":"P Correa","year":"1988","unstructured":"Correa P (1988) A human model of gastric carcinogenesis. Cancer Res 48:3554\u20133560","journal-title":"Cancer Res"},{"key":"6249_CR67","first-page":"627","volume":"41","author":"GN Stemmermann","year":"1968","unstructured":"Stemmermann GN et al (1968) Intestinal metaplasia of the gastric mucosa: a gross and microscopic study of its distribution in various disease states. J Natl Cancer Inst 41:627\u2013634","journal-title":"J Natl Cancer Inst"},{"key":"6249_CR68","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1177\/13.3.211","volume":"13","author":"SS Spicer","year":"1965","unstructured":"Spicer SS (1965) Diamine Methods for Differentialing Mucosubstances Histochemically. J Histochem Cytochem 13:211\u2013234","journal-title":"J Histochem Cytochem"},{"key":"6249_CR69","doi-asserted-by":"publisher","first-page":"593","DOI":"10.4161\/cbt.3.7.913","volume":"3","author":"RJ Guo","year":"2004","unstructured":"Guo RJ et al (2004) The role of Cdx proteins in intestinal development and cancer. Cancer Biol Ther 3:593\u2013601","journal-title":"Cancer Biol Ther"},{"key":"6249_CR70","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1007\/s00535-011-0391-0","volume":"46","author":"H Sakamoto","year":"2011","unstructured":"Sakamoto H et al (2011) Cell lineage dynamics in the process leading to intestinal metaplasia. J Gastroenterol 46:620\u2013628","journal-title":"J Gastroenterol"},{"key":"6249_CR71","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1136\/gut.2003.032482","volume":"53","author":"H Mutoh","year":"2004","unstructured":"Mutoh H et al (2004) Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice. Gut 53:1416\u20131423","journal-title":"Gut"},{"key":"6249_CR72","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s005350200002","volume":"37","author":"A Eda","year":"2002","unstructured":"Eda A et al (2002) Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. J Gastroenterol 37:94\u2013100","journal-title":"J Gastroenterol"},{"key":"6249_CR73","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0304-3835(01)00753-4","volume":"176","author":"YQ Bai","year":"2002","unstructured":"Bai YQ et al (2002) Ectopic expression of homeodomain protein CDX2 in intestinal metaplasia and carcinomas of the stomach. Cancer Lett 176:47\u201355","journal-title":"Cancer Lett"},{"key":"6249_CR74","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nature14966","volume":"525","author":"D Grun","year":"2015","unstructured":"Grun D et al (2015) Single-cell messenger RNA sequencing reveals rare intestinal cell types. Nature 525:251\u2013255","journal-title":"Nature"},{"key":"6249_CR75","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1158\/2159-8290.CD-22-0824","volume":"13","author":"K Nowicki-Osuch","year":"2023","unstructured":"Nowicki-Osuch K et al (2023) Single-Cell RNA Sequencing Unifies Developmental Programs of Esophageal and Gastric Intestinal Metaplasia. Cancer Discov 13:1346\u20131363","journal-title":"Cancer Discov"},{"key":"6249_CR76","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00535-023-02073-9","volume":"59","author":"QY Tong","year":"2024","unstructured":"Tong QY et al (2024) Gastric intestinal metaplasia: progress and remaining challenges. J Gastroenterol 59:285\u2013301","journal-title":"J Gastroenterol"},{"key":"6249_CR77","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1002\/path.1827","volume":"207","author":"N Oue","year":"2005","unstructured":"Oue N et al (2005) Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. J Pathol 207:185\u2013198","journal-title":"J Pathol"},{"key":"6249_CR78","doi-asserted-by":"crossref","unstructured":"Wang Y et al (2020) Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine. J Exp Med 217:e20191130","DOI":"10.1084\/jem.20191130"},{"key":"6249_CR79","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1016\/j.celrep.2019.04.052","volume":"27","author":"P Zhang","year":"2019","unstructured":"Zhang P et al (2019) Dissecting the Single-Cell Transcriptome Network Underlying Gastric Premalignant Lesions and Early Gastric Cancer. Cell Rep 27:1934\u20131947 e5","journal-title":"Cell Rep"},{"key":"6249_CR80","doi-asserted-by":"publisher","first-page":"16085","DOI":"10.1074\/jbc.M112.445551","volume":"288","author":"SS Khurana","year":"2013","unstructured":"Khurana SS et al (2013) The hyaluronic acid receptor CD44 coordinates normal and metaplastic gastric epithelial progenitor cell proliferation. J Biol Chem 288:16085\u201316097","journal-title":"J Biol Chem"},{"key":"6249_CR81","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.humpath.2004.12.002","volume":"36","author":"R Birbe","year":"2005","unstructured":"Birbe R et al (2005) Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract. Hum Pathol 36:170\u2013179","journal-title":"Hum Pathol"},{"key":"6249_CR82","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1053\/j.gastro.2021.05.058","volume":"161","author":"H Jeong","year":"2021","unstructured":"Jeong H et al (2021) WFDC2 Promotes Spasmolytic Polypeptide-Expressing Metaplasia Through the Up-Regulation of IL33 in Response to Injury. Gastroenterology 161:953\u2013967 e15","journal-title":"Gastroenterology"},{"key":"6249_CR83","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.3748\/wjg.v22.i6.2060","volume":"22","author":"AF Vidal","year":"2016","unstructured":"Vidal AF et al (2016) hsa-miR-29c and hsa-miR-135b differential expression as potential biomarker of gastric carcinogenesis. World J Gastroenterol 22:2060\u20132070","journal-title":"World J Gastroenterol"},{"key":"6249_CR84","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jcmgh.2019.08.008","volume":"9","author":"T Shimizu","year":"2020","unstructured":"Shimizu T et al (2020) Decrease in MiR-148a Expression During Initiation of Chief Cell Transdifferentiation. Cell Mol Gastroenterol Hepatol 9:61\u201378","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"6249_CR85","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1097\/CM9.0000000000003621","volume":"138","author":"K Lin","year":"2025","unstructured":"Lin K et al (2025) Long non-coding RNA PVT1 mediates bile acid-induced gastric intestinal metaplasia via a miR-34b-5p\/HNF4alpha positive feedback loop. Chin Med J (Engl) 138:2324\u20132335","journal-title":"Chin Med J (Engl)"},{"key":"6249_CR86","doi-asserted-by":"publisher","first-page":"e00483","DOI":"10.14309\/ctg.0000000000000483","volume":"13","author":"V Petkevicius","year":"2022","unstructured":"Petkevicius V et al (2022) Differential Expression of Long Noncoding RNA HOTAIR in Intestinal Metaplasia and Gastric Cancer. Clin Transl Gastroenterol 13:e00483","journal-title":"Clin Transl Gastroenterol"},{"key":"6249_CR87","first-page":"639","volume":"79","author":"PH Schmidt","year":"1999","unstructured":"Schmidt PH et al (1999) Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab Invest 79:639\u2013646","journal-title":"Lab Invest"},{"key":"6249_CR88","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1053\/j.gastro.2019.09.037","volume":"158","author":"J Burclaff","year":"2020","unstructured":"Burclaff J et al (2020) Proliferation and Differentiation of Gastric Mucous Neck and Chief Cells During Homeostasis and Injury-induced Metaplasia. Gastroenterology 158:598\u2013609e5","journal-title":"Gastroenterology"},{"key":"6249_CR89","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/ncb3541","volume":"19","author":"M Leushacke","year":"2017","unstructured":"Leushacke M et al (2017) Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach. Nat Cell Biol 19:774\u2013786","journal-title":"Nat Cell Biol"},{"key":"6249_CR90","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1053\/j.gastro.2010.09.005","volume":"139","author":"KT Nam","year":"2010","unstructured":"Nam KT et al (2010) Mature chief cells are cryptic progenitors for metaplasia in the stomach. Gastroenterology 139:2028\u20132037 e9","journal-title":"Gastroenterology"},{"key":"6249_CR91","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1136\/gutjnl-2019-318930","volume":"69","author":"KA Bockerstett","year":"2020","unstructured":"Bockerstett KA et al (2020) Single-cell transcriptional analyses of spasmolytic polypeptide-expressing metaplasia arising from acute drug injury and chronic inflammation in the stomach. Gut 69:1027\u20131038","journal-title":"Gut"},{"key":"6249_CR92","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jcmgh.2023.05.009","volume":"16","author":"SG Willet","year":"2023","unstructured":"Willet SG et al (2023) SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia. Cell Mol Gastroenterol Hepatol 16:325\u2013339","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"6249_CR93","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1053\/j.gastro.2010.04.023","volume":"138","author":"JR Goldenring","year":"2010","unstructured":"Goldenring JR et al (2010) Spasmolytic polypeptide-expressing metaplasia and intestinal metaplasia: time for reevaluation of metaplasias and the origins of gastric cancer. Gastroenterology 138:2207\u20132210","journal-title":"Gastroenterology"},{"key":"6249_CR94","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1053\/j.gastro.2015.11.049","volume":"150","author":"E Choi","year":"2016","unstructured":"Choi E et al (2016) Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions. Gastroenterology 150:918\u2013930 e13","journal-title":"Gastroenterology"},{"key":"6249_CR95","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/j.ccell.2015.10.003","volume":"28","author":"Y Hayakawa","year":"2015","unstructured":"Hayakawa Y et al (2015) Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell 28:800\u2013814","journal-title":"Cancer Cell"},{"issue":"Suppl 1","key":"6249_CR96","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1046\/j.1365-2036.1996.22164001.x","volume":"10","author":"RP Logan","year":"1996","unstructured":"Logan RP (1996) Adherence of Helicobacter pylori. Aliment Pharmacol Ther 10(Suppl 1):3\u201315","journal-title":"Aliment Pharmacol Ther"},{"key":"6249_CR97","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1158\/0008-5472.CAN-15-2272","volume":"76","author":"N Asano","year":"2016","unstructured":"Asano N et al (2016) Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses. Cancer Res 76:1135\u20131145","journal-title":"Cancer Res"},{"key":"6249_CR98","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1158\/1541-7786.MCR-19-0181","volume":"17","author":"SI Choi","year":"2019","unstructured":"Choi SI et al (2019) CDX1 Expression Induced by CagA-Expressing Helicobacter pylori Promotes Gastric Tumorigenesis. Mol Cancer Res 17:2169\u20132183","journal-title":"Mol Cancer Res"},{"key":"6249_CR99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2020.1809331","volume":"12","author":"HY Chen","year":"2020","unstructured":"Chen HY et al (2020) Caudal type homeoboxes as a driving force in Helicobacter pylori infection-induced gastric intestinal metaplasia. Gut Microbes 12:1\u201312","journal-title":"Gut Microbes"},{"key":"6249_CR100","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1046\/j.1365-2036.2001.01029.x","volume":"15","author":"S Sanduleanu","year":"2001","unstructured":"Sanduleanu S et al (2001) Double gastric infection with Helicobacter pylori and non-Helicobacter pylori bacteria during acid-suppressive therapy: increase of pro-inflammatory cytokines and development of atrophic gastritis. Aliment Pharmacol Ther 15:1163\u20131175","journal-title":"Aliment Pharmacol Ther"},{"key":"6249_CR101","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s12866-019-1666-5","volume":"19","author":"J Gong","year":"2019","unstructured":"Gong J et al (2019) Change of the duodenal mucosa-associated microbiota is related to intestinal metaplasia. BMC Microbiol 19:275","journal-title":"BMC Microbiol"},{"key":"6249_CR102","doi-asserted-by":"publisher","first-page":"4202","DOI":"10.1038\/srep04202","volume":"4","author":"F Aviles-Jimenez","year":"2014","unstructured":"Aviles-Jimenez F et al (2014) Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer. Sci Rep 4:4202","journal-title":"Sci Rep"},{"key":"6249_CR103","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3389\/fcimb.2018.00202","volume":"8","author":"JJ Gao","year":"2018","unstructured":"Gao JJ et al (2018) Association Between Gut Microbiota and Helicobacter pylori-Related Gastric Lesions in a High-Risk Population of Gastric Cancer. Front Cell Infect Microbiol 8:202","journal-title":"Front Cell Infect Microbiol"},{"key":"6249_CR104","doi-asserted-by":"publisher","first-page":"997","DOI":"10.3389\/fmicb.2020.00997","volume":"11","author":"Z Wang","year":"2020","unstructured":"Wang Z et al (2020) Changes of the Gastric Mucosal Microbiome Associated With Histological Stages of Gastric Carcinogenesis. Front Microbiol 11:997","journal-title":"Front Microbiol"},{"key":"6249_CR105","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.cell.2024.01.004","volume":"187","author":"K Fu","year":"2024","unstructured":"Fu K et al (2024) Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice. Cell 187:882\u2013896e17","journal-title":"Cell"},{"key":"6249_CR106","unstructured":"Barbara G et al (2016) The intestinal microenvironment and functional gastrointestinal disorders. Gastroenterology"},{"key":"6249_CR107","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1172\/JCI82529","volume":"126","author":"L Ding","year":"2016","unstructured":"Ding L et al (2016) Schlafen 4-expressing myeloid-derived suppressor cells are induced during murine gastric metaplasia. J Clin Invest 126:2867\u20132880","journal-title":"J Clin Invest"},{"key":"6249_CR108","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1053\/j.gastro.2014.02.007","volume":"146","author":"CP Petersen","year":"2014","unstructured":"Petersen CP et al (2014) Macrophages promote progression of spasmolytic polypeptide-expressing metaplasia after acute loss of parietal cells. Gastroenterology 146:1727\u201338e8","journal-title":"Gastroenterology"},{"key":"6249_CR109","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1053\/j.gastro.2021.04.075","volume":"161","author":"JT Busada","year":"2021","unstructured":"Busada JT et al (2021) Glucocorticoids and Androgens Protect From Gastric Metaplasia by Suppressing Group 2 Innate Lymphoid Cell Activation. Gastroenterology 161:637\u2013652 e4","journal-title":"Gastroenterology"},{"key":"6249_CR110","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.4049\/jimmunol.165.2.1022","volume":"165","author":"LE Smythies","year":"2000","unstructured":"Smythies LE et al (2000) Helicobacter pylori-induced mucosal inflammation is Th1 mediated and exacerbated in IL-4, but not IFN-gamma, gene-deficient mice. J Immunol 165:1022\u20131029","journal-title":"J Immunol"},{"key":"6249_CR111","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/path.5214","volume":"247","author":"LH Osaki","year":"2019","unstructured":"Osaki LH et al (2019) Interferon-gamma directly induces gastric epithelial cell death and is required for progression to metaplasia. J Pathol 247:513\u2013523","journal-title":"J Pathol"},{"key":"6249_CR112","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1136\/gutjnl-2016-312779","volume":"67","author":"CP Petersen","year":"2018","unstructured":"Petersen CP et al (2018) A signalling cascade of IL-33 to IL-13 regulates metaplasia in the mouse stomach. Gut 67:805\u2013817","journal-title":"Gut"},{"key":"6249_CR113","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1053\/j.gastro.2020.08.051","volume":"159","author":"AR Meyer","year":"2020","unstructured":"Meyer AR et al (2020) Group 2 Innate Lymphoid Cells Coordinate Damage Response in the Stomach. Gastroenterology 159:2077\u20132091 e8","journal-title":"Gastroenterology"},{"key":"6249_CR114","doi-asserted-by":"publisher","first-page":"113236","DOI":"10.1016\/j.celrep.2023.113236","volume":"42","author":"A Tsubosaka","year":"2023","unstructured":"Tsubosaka A et al (2023) Stomach encyclopedia: Combined single-cell and spatial transcriptomics reveal cell diversity and homeostatic regulation of human stomach. Cell Rep 42:113236","journal-title":"Cell Rep"},{"key":"6249_CR115","first-page":"4306","volume":"128","author":"V Fock","year":"2015","unstructured":"Fock V et al (2015) Neuregulin-1-mediated ErbB2-ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation. J Cell Sci 128:4306\u20134316","journal-title":"J Cell Sci"},{"key":"6249_CR116","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.stem.2020.06.021","volume":"27","author":"T Jarde","year":"2020","unstructured":"Jarde T et al (2020) Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium. Cell Stem Cell 27:646\u2013662 e7","journal-title":"Cell Stem Cell"},{"key":"6249_CR117","first-page":"209","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H et al (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 71:209\u2013249","journal-title":"CA Cancer J Clin"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-026-06249-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06249-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06249-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T01:54:10Z","timestamp":1783302850000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-026-06249-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":117,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6249"],"URL":"https:\/\/doi.org\/10.1007\/s00018-026-06249-3","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"16 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 April 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"267"}}