{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:03:48Z","timestamp":1789340628443,"version":"build-2803163510"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":81,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE16-0016-01"],"award-info":[{"award-number":["ANR-18-CE16-0016-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-026-06298-8","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T03:33:58Z","timestamp":1782358438000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Divergent molecular and circuit mechanisms underlie light entrainment of retinal and suprachiasmatic nucleus circadian clocks"],"prefix":"10.1007","volume":"83","author":[{"given":"A","family":"Jandot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Calligaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Dianak-Shoori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Tartour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Sandu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Haddjeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CP","family":"Ribelayga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Ananthasubramaniam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Padmanabhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MP","family":"Felder-Schmittbuhl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9168-3801","authenticated-orcid":false,"given":"Ouria","family":"Dkhissi-Benyahya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"6298_CR1","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1073\/PNAS.93.2.560","volume":"93","author":"D Baylor","year":"1996","unstructured":"Baylor D (1996) How photons start vision. Proc Natl Acad Sci U S A 93:560\u2013565. https:\/\/doi.org\/10.1073\/PNAS.93.2.560","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6298_CR2","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1038\/nn.2617","volume":"13","author":"CM Altimus","year":"2010","unstructured":"Altimus CM, G\u00fcler AD, Alam NM et al (2010) Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities. Nat Neurosci 13:1107\u20131112. https:\/\/doi.org\/10.1038\/nn.2617","journal-title":"Nat Neurosci"},{"key":"6298_CR3","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.neuron.2007.02.005","volume":"53","author":"O Dkhissi-Benyahya","year":"2007","unstructured":"Dkhissi-Benyahya O, Gronfier C, De Vanssay W et al (2007) Modeling the Role of Mid-Wavelength Cones in Circadian Responses to Light. Neuron 53:677\u2013687. https:\/\/doi.org\/10.1016\/j.neuron.2007.02.005","journal-title":"Neuron"},{"key":"6298_CR4","doi-asserted-by":"publisher","first-page":"768","DOI":"10.3109\/07420521003695704","volume":"27","author":"A Dollet","year":"2010","unstructured":"Dollet A, Albrecht U, Cooper HM, Dkhissi-Benyahya O (2010) Cones are required for normal temporal responses to light of phase shifts and clock gene expression. Chronobiol Int 27:768\u2013781. https:\/\/doi.org\/10.3109\/07420521003695704","journal-title":"Chronobiol Int"},{"key":"6298_CR5","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nature01761","volume":"424","author":"S Hattar","year":"2003","unstructured":"Hattar S, Lucas RJ, Mrosovsky N et al (2003) Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. Nature 424:75\u201381. https:\/\/doi.org\/10.1038\/nature01761","journal-title":"Nature"},{"key":"6298_CR6","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.neuron.2010.04.037","volume":"66","author":"GS Lall","year":"2010","unstructured":"Lall GS, Revell VL, Momiji H et al (2010) Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance. Neuron 66:417\u2013428. https:\/\/doi.org\/10.1016\/j.neuron.2010.04.037","journal-title":"Neuron"},{"key":"6298_CR7","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/88443","volume":"4","author":"RJ Lucas","year":"2001","unstructured":"Lucas RJ, Douglas RH, Foster RG (2001) Characterization of an ocular photopigment capable of driving pupillary constriction in mice. Nat Neurosci 4:621\u2013626","journal-title":"Nat Neurosci"},{"key":"6298_CR8","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1126\/science.1077293","volume":"299","author":"RJ Lucas","year":"2003","unstructured":"Lucas RJ, Hattar S, Takao M et al (2003) Diminished pupillary light reflex at high irradiances in melanopsin- knockout mice. Science 299:245\u2013247","journal-title":"Science"},{"key":"6298_CR9","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1126\/science.1076848","volume":"298","author":"S Panda","year":"2002","unstructured":"Panda S, Sato TK, Castrucci AM et al (2002) Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science 298:2213\u20132216. https:\/\/doi.org\/10.1126\/science.1076848","journal-title":"Science"},{"key":"6298_CR10","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1126\/science.1086179","volume":"301","author":"S Panda","year":"2003","unstructured":"Panda S, Provencio I, Tu DC et al (2003) Melanopsin is required for non-image-forming photic responses in blind mice. Science 301:525\u2013527. https:\/\/doi.org\/10.1126\/science.1086179","journal-title":"Science"},{"key":"6298_CR11","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1126\/science.272.5260.419","volume":"272","author":"G Tosini","year":"1996","unstructured":"Tosini G, Menaker M (1996) Circadian rhythms in cultured mammalian retina. Science 272:419\u2013421","journal-title":"Science"},{"key":"6298_CR12","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.cell.2007.06.045","volume":"130","author":"KF Storch","year":"2007","unstructured":"Storch KF, Paz C, Signorovitch J et al (2007) Intrinsic Circadian Clock of the Mammalian Retina: Importance for Retinal Processing of Visual Information. Cell 130:730\u2013741. https:\/\/doi.org\/10.1016\/j.cell.2007.06.045","journal-title":"Cell"},{"key":"6298_CR13","doi-asserted-by":"publisher","first-page":"4856","DOI":"10.1167\/iovs.18-24957","volume":"59","author":"M-PP Felder-Schmittbuhl","year":"2018","unstructured":"Felder-Schmittbuhl M-PP, Buhr ED, Dkhissi-Benyahya O et al (2018) Ocular Clocks: Adapting Mechanisms for Eye Functions and Health. Invest Ophthalmol Vis Sci 59:4856\u20134870. https:\/\/doi.org\/10.1167\/iovs.18-24957","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6298_CR14","doi-asserted-by":"publisher","first-page":"3495","DOI":"10.1167\/IOVS.08-3145","volume":"50","author":"C Bobu","year":"2009","unstructured":"Bobu C, Hicks D (2009) Regulation of retinal photoreceptor phagocytosis in a diurnal mammal by circadian clocks and ambient lighting. Invest Ophthalmol Vis Sci 50:3495\u20133502. https:\/\/doi.org\/10.1167\/IOVS.08-3145","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6298_CR15","first-page":"1257","volume":"19","author":"AI Goldman","year":"1980","unstructured":"Goldman AI, Teirstein PS, Brien PO (1980) Disc shedding in the rod outer segment of the rat retina. Invest Ophthalmol Vis Sci 19:1257\u20131267","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6298_CR16","first-page":"2873","volume":"16","author":"A Krigel","year":"2010","unstructured":"Krigel A, Felder-Schmittbuhl M-P, Hicks D (2010) Circadian-clock driven cone-like photoreceptor phagocytosis in the neural retina leucine zipper gene knockout mouse. Mol Vis 16:2873\u20132881","journal-title":"Mol Vis"},{"key":"6298_CR17","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1126\/science.982063","volume":"194","author":"MM LaVail","year":"1976","unstructured":"LaVail MM (1976) Rod outer segment disk shedding in rat retina: relationship to cyclic lighting. Science 194:1071\u20131074","journal-title":"Science"},{"key":"6298_CR18","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.preteyeres.2005.01.003","volume":"24","author":"PM Iuvone","year":"2005","unstructured":"Iuvone PM, Tosini G, Pozdeyev N et al (2005) Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Prog Retin Eye Res 24:433\u2013456. https:\/\/doi.org\/10.1016\/j.preteyeres.2005.01.003","journal-title":"Prog Retin Eye Res"},{"key":"6298_CR19","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.1111\/j.1460-9568.2005.04512.x","volume":"22","author":"K Sakamoto","year":"2005","unstructured":"Sakamoto K, Liu C, Kasamatsu M et al (2005) Dopamine regulates melanopsin mRNA expression in intrinsically photosensitive retinal ganglion cells. Eur J Neurosci 22:3129\u20133136. https:\/\/doi.org\/10.1111\/j.1460-9568.2005.04512.x","journal-title":"Eur J Neurosci"},{"key":"6298_CR20","doi-asserted-by":"publisher","first-page":"605067","DOI":"10.3389\/fncel.2020.605067","volume":"14","author":"J Cao","year":"2021","unstructured":"Cao J, Ribelayga CP, Mangel SC (2021) A Circadian Clock in the Retina Regulates Rod-Cone Gap Junction Coupling and Neuronal Light Responses via Activation of Adenosine A2A Receptors. Front Cell Neurosci 14:605067. https:\/\/doi.org\/10.3389\/fncel.2020.605067","journal-title":"Front Cell Neurosci"},{"key":"6298_CR21","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1113\/jphysiol.2014.284919","volume":"593","author":"NG Jin","year":"2015","unstructured":"Jin NG, Chuang AZ, Masson PJ, Ribelayga CP (2015) Rod electrical coupling is controlled by a circadian clock and dopamine in mouse retina. J Physiol 593:1597\u20131631. https:\/\/doi.org\/10.1113\/jphysiol.2014.284919","journal-title":"J Physiol"},{"key":"6298_CR22","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.neuron.2008.07.017","volume":"59","author":"CP Ribelayga","year":"2008","unstructured":"Ribelayga CP, Cao Y, Mangel SC (2008) The Circadian Clock in the Retina Controls Rod-Cone Coupling. Neuron 59:790\u2013801. https:\/\/doi.org\/10.1016\/j.neuron.2008.07.017","journal-title":"Neuron"},{"key":"6298_CR23","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1177\/0748730408325874","volume":"23","author":"MA Cameron","year":"2008","unstructured":"Cameron MA, Barnard AR, Hut RA et al (2008) Electroretinography of wild-type and Cry mutant mice reveals circadian tuning of photopic and mesopic retinal responses. J Biol Rhythms 23:489\u2013501. https:\/\/doi.org\/10.1177\/0748730408325874","journal-title":"J Biol Rhythms"},{"key":"6298_CR24","doi-asserted-by":"publisher","first-page":"9359","DOI":"10.1523\/JNEUROSCI.0711-12.2012","volume":"32","author":"CR Jackson","year":"2012","unstructured":"Jackson CR, Ruan G-XX, Aseem F et al (2012) Retinal dopamine mediates multiple dimensions of light-adapted vision. J Neurosci 32:9359\u20139368. https:\/\/doi.org\/10.1523\/JNEUROSCI.0711-12.2012","journal-title":"J Neurosci"},{"key":"6298_CR25","doi-asserted-by":"publisher","first-page":"9703","DOI":"10.1073\/pnas.0601940103","volume":"103","author":"G-X Ruan","year":"2006","unstructured":"Ruan G-X, Zhang D-QQ, Zhou T-R et al (2006) Circadian organization of the mammalian retina. Proc Natl Acad Sci U S A 103:9703\u20139708. https:\/\/doi.org\/10.1073\/pnas.0601940103","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6298_CR26","doi-asserted-by":"publisher","unstructured":"Mure LS, Le HD, Benegiamo G et al (2018) Diurnal transcriptome atlas of a primate across major neural and peripheral tissues. Sci (80-):359. https:\/\/doi.org\/10.1126\/science.aao0318","DOI":"10.1126\/science.aao0318"},{"key":"6298_CR27","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0896-6273(90)90303-W","volume":"5","author":"JM Kornhauser","year":"1990","unstructured":"Kornhauser JM, Nelson DE, Mayo KE, Takahashi JS (1990) Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus. Neuron 5:127\u2013134","journal-title":"Neuron"},{"key":"6298_CR28","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/cne.903240202","volume":"324","author":"CS Colwell","year":"1992","unstructured":"Colwell CS, Foster RG (1992) Photic regulation of fos-like immunoreactivity in the suprachiasmatic nucleus of the mouse. J Comp Neurol 324:135\u2013142","journal-title":"J Comp Neurol"},{"key":"6298_CR29","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/S0896-6273(00)80417-1","volume":"19","author":"LP Shearman","year":"1997","unstructured":"Shearman LP, Zylka MJ, Weaver DR et al (1997) Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron 19:1261\u20131269","journal-title":"Neuron"},{"key":"6298_CR30","doi-asserted-by":"publisher","first-page":"3268","DOI":"10.1016\/J.NEURON.2021.07.026","volume":"109","author":"P Xu","year":"2021","unstructured":"Xu P, Berto S, Kulkarni A et al (2021) NPAS4 regulates the transcriptional response of the suprachiasmatic nucleus to light and circadian behavior. Neuron 109:3268. https:\/\/doi.org\/10.1016\/J.NEURON.2021.07.026","journal-title":"Neuron"},{"key":"6298_CR31","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1126\/science.8097062","volume":"260","author":"DD Ginty","year":"1993","unstructured":"Ginty DD, Kornhauser JM, Thompson MA et al (1993) Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. Science 260:238\u2013241","journal-title":"Science"},{"key":"6298_CR32","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.1126\/science.279.5356.1544","volume":"279","author":"ME Morris","year":"1998","unstructured":"Morris ME, Viswanathan N, Kuhlman S et al (1998) A sreen for genes in the suprachiasmatic nucleus by light. Science 279:1544\u20131547","journal-title":"Science"},{"key":"6298_CR33","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/0896-6273(93)90053-T","volume":"10","author":"K Yoshida","year":"1993","unstructured":"Yoshida K, Kawamura K, Imaki J (1993) Differential expression of c-fos mRNA in rat retinal cells: Regulation by light\/dark cycle. Neuron 10:1049\u20131054","journal-title":"Neuron"},{"key":"6298_CR34","doi-asserted-by":"publisher","first-page":"3630","DOI":"10.1002\/cne.22421","volume":"518","author":"K Mat\u011bj\u016f","year":"2010","unstructured":"Mat\u011bj\u016f K, Sumovan\u00e1 A, Bendov\u00e1 Z (2010) Expression and light sensitivity of clock genes per1 and per2 and immediate-early gene c-fos within the retina of early postnatal wistar rats. J Comp Neurol 518:3630\u20133644. https:\/\/doi.org\/10.1002\/cne.22421","journal-title":"J Comp Neurol"},{"key":"6298_CR35","doi-asserted-by":"publisher","first-page":"7790","DOI":"10.1523\/JNEUROSCI.20-20-07790.2000","volume":"15","author":"O Dkhissi-Benyahya","year":"2000","unstructured":"Dkhissi-Benyahya O, Sicard B, Cooper HM (2000) Effects of irradiance and stimulus duration on early gene expression (Fos) in the suprachiasmatic nucleus: Temporal summation and reciprocity. J Neurosci Oct 15:20:7790\u20137797. https:\/\/doi.org\/10.1523\/JNEUROSCI.20-20-07790.2000","journal-title":"J Neurosci Oct"},{"key":"6298_CR36","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.1007\/s00018-013-1338-9","volume":"70","author":"O Dkhissi-Benyahya","year":"2013","unstructured":"Dkhissi-Benyahya O, Coutanson C, Knoblauch K et al (2013) The absence of melanopsin alters retinal clock function and dopamine regulation by light. Cell Mol Life Sci 70:3435\u20133447. https:\/\/doi.org\/10.1007\/s00018-013-1338-9","journal-title":"Cell Mol Life Sci"},{"key":"6298_CR37","unstructured":"Lahouaoui H, Coutanson C, Cooper HM et al (2016) Diabetic retinopathy alters light-induced clock gene expression and dopamine levels in the mouse retina. Mol Vis 22"},{"key":"6298_CR38","doi-asserted-by":"publisher","first-page":"e249","DOI":"10.1371\/journal.pbio.0060249","volume":"6","author":"G-XX Ruan","year":"2008","unstructured":"Ruan G-XX, Allen GC, Yamazaki S, McMahon DG (2008) An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA. PLoS Biol 6:e249. https:\/\/doi.org\/10.1371\/journal.pbio.0060249","journal-title":"PLoS Biol"},{"key":"6298_CR39","doi-asserted-by":"publisher","first-page":"e2006211","DOI":"10.1371\/journal.pbio.2006211","volume":"17","author":"H Calligaro","year":"2019","unstructured":"Calligaro H, Coutanson C, Najjar RPRP et al (2019) Rods contribute to the light-induced phase shift of the retinal clock in mammals. PLOS Biol 17:e2006211. https:\/\/doi.org\/10.1371\/journal.pbio.2006211","journal-title":"PLOS Biol"},{"key":"6298_CR40","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1098\/rspb.2010.1509","volume":"278","author":"MP Butler","year":"2011","unstructured":"Butler MP, Silver R (2011) Divergent photic thresholds in the non-image-forming visual system: entrainment, masking and pupillary light reflex. Proc R Soc B Biol Sci 278:745\u2013750. https:\/\/doi.org\/10.1098\/rspb.2010.1509","journal-title":"Proc R Soc B Biol Sci"},{"key":"6298_CR41","first-page":"106","volume":"26","author":"H Calligaro","year":"2020","unstructured":"Calligaro H, Kinane C, Bennis M et al (2020) A standardized method to assess the endogenous activity and the light\u2013response of the retinal clock in mammals. Mol Vis 26:106\u2013116","journal-title":"Mol Vis"},{"key":"6298_CR42","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/S1350-9462(00)00031-8","volume":"20","author":"SA Bloomfield","year":"2001","unstructured":"Bloomfield SA, Dacheux RF (2001) Rod vision: pathways and processing in the mammalian retina. Prog Retin Eye Res 20:351\u2013384","journal-title":"Prog Retin Eye Res"},{"key":"6298_CR43","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev-vision-091517-034055","volume":"4","author":"WN Grimes","year":"2018","unstructured":"Grimes WN, Songco-Aguas A, Rieke F (2018) Parallel processing of rod and cone signals: Retinal function and human perception. Annu Rev Vis Sci 4:123\u2013141","journal-title":"Annu Rev Vis Sci"},{"key":"6298_CR44","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1523\/JNEUROSCI.16-09-02934.1996","volume":"16","author":"T Euler","year":"1996","unstructured":"Euler T, Schneider H, W\u00e4 H (1996) Glutamate Responses of Bipolar Cells in a Slice Preparation of the Rat Retina. J Neurosci 16:2934\u20132944","journal-title":"J Neurosci"},{"key":"6298_CR45","doi-asserted-by":"crossref","unstructured":"Masu M, Iwakabe H, Tagawa Y et al (1995) Specific Deficit of the ON Response in Visual Transmission by Targeted Disruption of the mGluR6 Gene","DOI":"10.1016\/0092-8674(95)90354-2"},{"key":"6298_CR46","doi-asserted-by":"publisher","first-page":"10658","DOI":"10.1073\/pnas.92.23.10658","volume":"92","author":"SH Devries","year":"1995","unstructured":"Devries SH, Baylor DA, Baylor A (1995) An alternative pathway for signal flow from rod photoreceptors to ganglion cells in mammalian retina (gap junction\/2-amino-4-phosphonobutyric acid\/bipolar cell\/multielectrode recording). Proc Natl Acad Sci U S A 92:10658\u201310662","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6298_CR47","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1126\/science.6255566","volume":"211","author":"M Slaughter","year":"1981","unstructured":"Slaughter M, Miller R (1981) 2-Amino-4-Phosphonobutyric acid: a new pharmacological tool for retina research. Science 211:182\u2013184","journal-title":"Science"},{"key":"6298_CR48","doi-asserted-by":"publisher","first-page":"8616","DOI":"10.1523\/JNEUROSCI.21-21-08616.2001","volume":"21","author":"Y Tsukamoto","year":"2001","unstructured":"Tsukamoto Y, Morigiwa K, Ueda M, Sterling P (2001) Microcircuits for Night Vision in Mouse Retina. J Neurosci 21:8616\u20138623","journal-title":"J Neurosci"},{"key":"6298_CR49","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/nn.2507","volume":"13","author":"W Li","year":"2010","unstructured":"Li W, Chen S, Devries SH (2010) A fast rod photoreceptor signaling pathway in the mammalian retina. Nat Neurosci 13:414\u2013416. https:\/\/doi.org\/10.1038\/nn.2507","journal-title":"Nat Neurosci"},{"key":"6298_CR50","doi-asserted-by":"publisher","unstructured":"Sladek AL, Thoreson WB (2023) Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina. Front Ophthalmol 3. https:\/\/doi.org\/10.3389\/fopht.2023.1146785","DOI":"10.3389\/fopht.2023.1146785"},{"key":"6298_CR51","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/S0896-6273(00)80560-7","volume":"21","author":"A Soucy","year":"1999","unstructured":"Soucy A, Wang Y, Nirenberg S et al (1999) A novel signaling pathway from rod photoreceptors to ganglion cells in mammalian retina. Neuron 21:481\u2013493. https:\/\/doi.org\/10.1016\/S0896-6273(00)80560-7","journal-title":"Neuron"},{"key":"6298_CR52","doi-asserted-by":"publisher","first-page":"5339","DOI":"10.1073\/pnas.0308709101","volume":"101","author":"S-H Yoo","year":"2004","unstructured":"Yoo S-H, Yamazaki S, Lowrey PL et al (2004) PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues. Proc Natl Acad Sci U S A 101:5339\u20135346","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6298_CR53","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1093\/emboj\/18.3.623","volume":"18","author":"K Gauthier","year":"1999","unstructured":"Gauthier K, Chassande O, Plateroti M et al (1999) Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development. Embo J 18:623\u2013631","journal-title":"Embo J"},{"key":"6298_CR54","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/ng774","volume":"29","author":"AJ Mears","year":"2001","unstructured":"Mears AJ, Kondo M, Swain PK et al (2001) Nrl is required for rod photoreceptor development. Nat Genet 29:447\u2013452. https:\/\/doi.org\/10.1038\/ng774","journal-title":"Nat Genet"},{"key":"6298_CR55","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1073\/pnas.89.1.266","volume":"89","author":"A Swaroop","year":"1992","unstructured":"Swaroop A, Xu JZ, Pawar H et al (1992) A conserved retina-specific gene encodes a basic motif\/leucine zipper domain. Proc Natl Acad Sci U S A 89:266\u2013270","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6298_CR56","doi-asserted-by":"publisher","unstructured":"Jin N, Tian LM, Fahrenfort I et al (2022) Genetic elimination of rod\/cone coupling reveals the contribution of the secondary rod pathway to the retinal output. Sci Adv 8. https:\/\/doi.org\/10.1126\/sciadv.abm4491","DOI":"10.1126\/sciadv.abm4491"},{"key":"6298_CR57","doi-asserted-by":"publisher","unstructured":"Jin N, Zhang Z, Keung J et al (2020) Molecular and functional architecture of the mouse photoreceptor network. Sci Adv 6. https:\/\/doi.org\/10.1126\/SCIADV.ABA7232","DOI":"10.1126\/SCIADV.ABA7232"},{"key":"6298_CR58","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1177\/07487304241256004","volume":"39","author":"A Pastrick","year":"2024","unstructured":"Pastrick A, Diaz M, Adaya G et al (2024) Biological Sex Influences Daily Locomotor Rhythms in Mice Held Under Different Housing Conditions. J Biol Rhythms 39:351\u2013364. https:\/\/doi.org\/10.1177\/07487304241256004","journal-title":"J Biol Rhythms"},{"key":"6298_CR59","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1523\/JNEUROSCI.3591-11.2012","volume":"32","author":"JE Roger","year":"2012","unstructured":"Roger JE, Ranganath K, Zhao L et al (2012) Preservation of cone photoreceptors after a rapid yet transient degeneration and remodeling in cone-only Nrl-\/- mouse retina. J Neurosci 32:528\u2013541","journal-title":"J Neurosci"},{"key":"6298_CR60","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/NMETH.4197","volume":"14","author":"R Patro","year":"2017","unstructured":"Patro R, Duggal G, Love MI et al (2017) Salmon provides fast and bias-aware quantification of transcript expression. Nat Methods 14:417\u2013419. https:\/\/doi.org\/10.1038\/NMETH.4197","journal-title":"Nat Methods"},{"key":"6298_CR61","doi-asserted-by":"publisher","unstructured":"Soneson C, Love MI, Robinson MD (2016) Differential analyses for RNA-seq: Transcript-level estimates improve gene-level inferences. https:\/\/doi.org\/10.12688\/F1000RESEARCH.7563.2\/DOI. F1000Research 4:","DOI":"10.12688\/F1000RESEARCH.7563.2\/DOI"},{"key":"6298_CR62","doi-asserted-by":"publisher","unstructured":"Love MI, Huber W, Anders S (2014) Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. https:\/\/doi.org\/10.1186\/S13059-014-0550-8. Genome Biol 15:","DOI":"10.1186\/S13059-014-0550-8"},{"key":"6298_CR63","doi-asserted-by":"publisher","unstructured":"Chen H, Boutros PC (2011) VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R. BMC Bioinformatics 12. https:\/\/doi.org\/10.1186\/1471-2105-12-35","DOI":"10.1186\/1471-2105-12-35"},{"key":"6298_CR64","unstructured":"Carlson M (2024) org.Mm.eg.db: Genome wide annotation for Mouse. R package version 3.20.0"},{"key":"6298_CR65","doi-asserted-by":"publisher","first-page":"3292","DOI":"10.1038\/S41596-024-01020-Z","volume":"19","author":"S Xu","year":"2024","unstructured":"Xu S, Hu E, Cai Y et al (2024) Using clusterProfiler to characterize multiomics data. Nat Protoc 19:3292\u20133320. https:\/\/doi.org\/10.1038\/S41596-024-01020-Z","journal-title":"Nat Protoc"},{"key":"6298_CR66","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/S41593-020-0586-X","volume":"23","author":"S Wen","year":"2020","unstructured":"Wen S, Ma D, Zhao M et al (2020) Spatiotemporal single-cell analysis of gene expression in the mouse suprachiasmatic nucleus. Nat Neurosci 23:456\u2013467. https:\/\/doi.org\/10.1038\/S41593-020-0586-X","journal-title":"Nat Neurosci"},{"key":"6298_CR67","doi-asserted-by":"publisher","first-page":"28086","DOI":"10.1038\/srep28086","volume":"6","author":"S Hughes","year":"2016","unstructured":"Hughes S, Rodgers J, Hickey D et al (2016) Characterisation of light responses in the retina of mice lacking principle components of rod, cone and melanopsin phototransduction signalling pathways. Sci Rep 6:28086. https:\/\/doi.org\/10.1038\/srep28086","journal-title":"Sci Rep"},{"key":"6298_CR68","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1096\/fj.14-261214","volume":"29","author":"C Jaeger","year":"2015","unstructured":"Jaeger C, Sandu C, Malan A et al (2015) Circadian organization of the rodent retina involves strongly coupled, layer-specific oscillators. FASEB J 29:1493\u20131504. https:\/\/doi.org\/10.1096\/fj.14-261214","journal-title":"FASEB J"},{"key":"6298_CR69","doi-asserted-by":"publisher","unstructured":"Kinane C, Calligaro H, Jandot A et al (2023) Dopamine modulates the retinal clock through melanopsin-dependent regulation of cholinergic waves during development. BMC Biol 21. https:\/\/doi.org\/10.1186\/s12915-023-01647-6","DOI":"10.1186\/s12915-023-01647-6"},{"key":"6298_CR70","doi-asserted-by":"publisher","unstructured":"Park J, Zhu H, O\u2019Sullivan S et al (2016) Single-Cell Transcriptional Analysis Reveals Novel Neuronal Phenotypes and Interaction Networks Involved in the Central Circadian Clock. https:\/\/doi.org\/10.3389\/FNINS.2016.00481. Front Neurosci 10:","DOI":"10.3389\/FNINS.2016.00481"},{"key":"6298_CR71","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1016\/0042-6989(95)00114-F","volume":"35","author":"TD Lamb","year":"1995","unstructured":"Lamb TD (1995) Photoreceptor spectral sensitivities: common shape in the long-wavelength region. Vis Res 35:3083\u20133091","journal-title":"Vis Res"},{"key":"6298_CR72","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1073\/pnas.1516259112","volume":"112","author":"ED Buhr","year":"2015","unstructured":"Buhr ED, Yue WWS, Ren X et al (2015) Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. Proc Natl Acad Sci U S A 112:2\u20137. https:\/\/doi.org\/10.1073\/pnas.1516259112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"6298_CR73","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/J.CELL.2013.08.004","volume":"154","author":"A Jagannath","year":"2013","unstructured":"Jagannath A, Butler R, Godinho SIH et al (2013) The CRTC1-SIK1 pathway regulates entrainment of the circadian clock. Cell 154:1100\u20131111. https:\/\/doi.org\/10.1016\/J.CELL.2013.08.004","journal-title":"Cell"},{"key":"6298_CR74","doi-asserted-by":"publisher","first-page":"e2451","DOI":"10.1371\/journal.pone.0002451","volume":"3","author":"M Hatori","year":"2008","unstructured":"Hatori M, Le H, Vollmers C et al (2008) Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses. PLoS ONE 3:e2451. https:\/\/doi.org\/10.1371\/journal.pone.0002451","journal-title":"PLoS ONE"},{"key":"6298_CR75","doi-asserted-by":"publisher","unstructured":"Riedel CS, Georg B, Fahrenkrug J, Hannibal J (2020) Altered light induced EGR1 expression in the SCN of PACAP deficient mice. PLoS ONE 15. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0232748","DOI":"10.1371\/JOURNAL.PONE.0232748"},{"key":"6298_CR76","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1177\/074873098129000174","volume":"13","author":"TS Kilduff","year":"1998","unstructured":"Kilduff TS, Vugrinic C, Lee SL et al (1998) Characterization of the circadian system of NGFI-A and NGFI-A\/NGFI-B deficient mice. J Biol Rhythms 13:347\u2013357. https:\/\/doi.org\/10.1177\/074873098129000174","journal-title":"J Biol Rhythms"},{"key":"6298_CR77","doi-asserted-by":"publisher","first-page":"29603","DOI":"10.1074\/JBC.M115.668889\/ASSET\/C1A9ABC6-4E9B-4EFA-B21E-F29D13970364\/MAIN.ASSETS\/GR10.JPG","volume":"290","author":"X Qin","year":"2015","unstructured":"Qin X, Jiang Y, Tse YC et al (2015) Early growth response 1 (Egr-1) regulates N-methyl-daspartate receptor (NMDAR)-dependent transcription of PSD-95 and \u03b1-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) trafficking in hippocampal primary neurons. J Biol Chem 290:29603\u201329616. https:\/\/doi.org\/10.1074\/JBC.M115.668889\/ASSET\/C1A9ABC6-4E9B-4EFA-B21E-F29D13970364\/MAIN.ASSETS\/GR10.JPG","journal-title":"J Biol Chem"},{"key":"6298_CR78","doi-asserted-by":"publisher","first-page":"e37894","DOI":"10.1371\/JOURNAL.PONE.0037894","volume":"7","author":"M Shapiro-Reznik","year":"2012","unstructured":"Shapiro-Reznik M, Jilg A, Lerner H et al (2012) Diurnal Rhythms in Neurexins Transcripts and Inhibitory\/Excitatory Synapse Scaffold Proteins in the Biological Clock. PLoS ONE 7:e37894. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0037894","journal-title":"PLoS ONE"},{"key":"6298_CR79","doi-asserted-by":"publisher","first-page":"e10951","DOI":"10.1371\/JOURNAL.PONE.0010951","volume":"5","author":"Y Mizoro","year":"2010","unstructured":"Mizoro Y, Yamaguchi Y, Kitazawa R et al (2010) Activation of AMPA Receptors in the Suprachiasmatic Nucleus Phase-Shifts the Mouse Circadian Clock In Vivo and In Vitro. PLoS ONE 5:e10951. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0010951","journal-title":"PLoS ONE"},{"key":"6298_CR80","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1152\/JN.2002.88.2.817","volume":"88","author":"IS Miche","year":"2002","unstructured":"Miche IS, Itri J, Colwel ICS (2002) Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA\/KA glutamate receptors. J Neurophysiol 88:817\u2013828. https:\/\/doi.org\/10.1152\/JN.2002.88.2.817","journal-title":"J Neurophysiol"},{"key":"6298_CR81","doi-asserted-by":"publisher","unstructured":"Ang G, Brown LA, Tam SKE et al (2021) Deletion of AMPA receptor GluA1 subunit gene (Gria1) causes circadian rhythm disruption and aberrant responses to environmental cues. https:\/\/doi.org\/10.1038\/S41398-021-01690-3. Transl Psychiatry 11:","DOI":"10.1038\/S41398-021-01690-3"},{"key":"6298_CR82","doi-asserted-by":"publisher","first-page":"7576","DOI":"10.1523\/JNEUROSCI.2245-04.2004","volume":"24","author":"E Strettoi","year":"2004","unstructured":"Strettoi E, Mears AJ, Swaroop A (2004) Recruitment of the rod pathway by cones in the absence of rods. J Neurosci 24:7576\u20137582","journal-title":"J Neurosci"},{"key":"6298_CR83","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1167\/iovs.04-1427","volume":"46","author":"LL Daniele","year":"2005","unstructured":"Daniele LL, Lillo C, Lyubarsky AL et al (2005) Cone-like morphological, molecular, and electrophysiological features of the photoreceptors of the Nrl knockout mouse. Invest Ophthalmol Vis Sci 46:2156\u20132167. https:\/\/doi.org\/10.1167\/iovs.04-1427","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6298_CR84","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1167\/iovs.19-27242","volume":"60","author":"RA Bush","year":"2019","unstructured":"Bush RA, Tanikawa A, Zeng Y, Sieving PA (2019) Cone ERG Changes during Light Adaptation in Two All-Cone Mutant Mice: Implications for Rod-Cone Pathway Interactions. Investig Ophthalmol Vis Sci 60:3680\u20133688. https:\/\/doi.org\/10.1167\/iovs.19-27242","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"6298_CR85","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1469-7793.2000.t01-1-00211.x","volume":"1","author":"NC Aggelopoulos","year":"2000","unstructured":"Aggelopoulos NC, Meissl H (2000) Responses of neurones of the rat suprachiasmatic nucleus to retinal illumination under photopic and scotopic conditions. J Physiol 523 Pt 1:211\u2013222","journal-title":"J Physiol 523 Pt"},{"key":"6298_CR86","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.cub.2019.01.042","volume":"29","author":"V P\u00e9rez-Fern\u00e1ndez","year":"2019","unstructured":"P\u00e9rez-Fern\u00e1ndez V, Milosavljevic N, Allen AE et al (2019) Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina. Curr Biol 29:763\u2013774e5. https:\/\/doi.org\/10.1016\/j.cub.2019.01.042","journal-title":"Curr Biol"},{"key":"6298_CR87","doi-asserted-by":"publisher","first-page":"7920","DOI":"10.1038\/s41598-017-08172-x","volume":"7","author":"X Zhao","year":"2017","unstructured":"Zhao X, Wong KY, Zhang D-Q (2017) Mapping physiological inputs from multiple photoreceptor systems to dopaminergic amacrine cells in the mouse retina. Sci Rep 7:7920","journal-title":"Sci Rep"},{"key":"6298_CR88","doi-asserted-by":"publisher","unstructured":"Beier C, Bocchero U, Levy L et al (2022) Divergent outer retinal circuits drive image and non-image visual behaviors. Cell Rep 39. https:\/\/doi.org\/10.1016\/J.CELREP.2022.111003","DOI":"10.1016\/J.CELREP.2022.111003"},{"key":"6298_CR89","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1152\/JN.00384.2013","volume":"110","author":"RE Mazade","year":"2013","unstructured":"Mazade RE, Eggers ED (2013) Light adaptation alters the source of inhibition to the mouse retinal OFF pathway. J Neurophysiol 110:2113. https:\/\/doi.org\/10.1152\/JN.00384.2013","journal-title":"J Neurophysiol"},{"key":"6298_CR90","doi-asserted-by":"publisher","first-page":"11839","DOI":"10.1523\/JNEUROSCI.2191-08.2008","volume":"28","author":"R Chen","year":"2008","unstructured":"Chen R, Seo DO, Bell E et al (2008) Strong resetting of the mammalian clock by constant light followed by constant darkness. J Neurosci 28:11839\u201311847. https:\/\/doi.org\/10.1523\/JNEUROSCI.2191-08.2008","journal-title":"J Neurosci"},{"key":"6298_CR91","doi-asserted-by":"publisher","first-page":"2848","DOI":"10.1016\/j.cub.2022.04.092","volume":"32","author":"J West\u00f6","year":"2022","unstructured":"West\u00f6 J, Martyniuk N, Koskela S et al (2022) Retinal OFF ganglion cells allow detection of quantal shadows at starlight. Curr Biol 32:2848\u20132857e6. https:\/\/doi.org\/10.1016\/j.cub.2022.04.092","journal-title":"Curr Biol"},{"key":"6298_CR92","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1113\/JPHYSIOL.2007.131763","volume":"582","author":"ED Eggers","year":"2007","unstructured":"Eggers ED, McCall MA, Lukasiewicz PD (2007) Presynaptic inhibition differentially shapes transmission in distinct circuits in the mouse retina. J Physiol 582:569\u2013582. https:\/\/doi.org\/10.1113\/JPHYSIOL.2007.131763","journal-title":"J Physiol"},{"key":"6298_CR93","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1152\/JN.00448.2018","volume":"121","author":"RE Mazade","year":"2019","unstructured":"Mazade RE, Flood MD, Eggers ED (2019) Dopamine D1 receptor activation reduces local inner retinal inhibition to light-adapted levels. J Neurophysiol 121:1232\u20131243. https:\/\/doi.org\/10.1152\/JN.00448.2018","journal-title":"J Neurophysiol"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-026-06298-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06298-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06298-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T22:38:11Z","timestamp":1789339091000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-026-06298-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":93,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6298"],"URL":"https:\/\/doi.org\/10.1007\/s00018-026-06298-8","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,25]]},"assertion":[{"value":"20 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors do not have any potential conflict of interest.","order":1,"name":"Ethics","label":"Competing interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"328"}}