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The project is approved by the Animal Care and Use Committee of the Institute of Physiology of the Czech Academy of Sciences, as well as by the Resort Professional Commission of the CAS for Approval of Projects of Experiments on Animals. The animals are housed in facilities accredited by the Czech Ministry of Agriculture. Experiments were carried out under veterinary supervision, complying with Act No. 246\/1992 Coll. and Decree No. 419\/2012 Coll., implementing Directive 2010\/63\/EU of the European Parliament and of the Council regarding the protection of animals used for scientific purposes. 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