{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:50:11Z","timestamp":1791507011994,"version":"4.3.4"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:00:00Z","timestamp":1783987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":87,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-026-06330-x","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:54:57Z","timestamp":1784037297000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["LAMP2A-dependent chaperone mediated autophagy regulates Notch signaling and\u00a0controls neural stem cell differentiation"],"prefix":"10.1007","volume":"83","author":[{"given":"Daphne","family":"Antoniou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Xilouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Gkikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Vlachakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matina","family":"Tsampoula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Malissovas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Mastori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Kaltezioti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elpinickie","family":"Ninou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kyrousi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Taraviras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Stefanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-2857","authenticated-orcid":false,"given":"Panagiotis K.","family":"Politis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,14]]},"reference":[{"key":"6330_CR1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008359","author":"B Martynoga","year":"2012","unstructured":"Martynoga B, Drechsel D, Guillemot F (2012) Molecular control of neurogenesis: a view from the mammalian cerebral cortex. Cold Spring Harb Perspect Biol. https:\/\/doi.org\/10.1101\/cshperspect.a008359","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"9","key":"6330_CR2","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/ncb0910-823","volume":"12","author":"N Mizushima","year":"2010","unstructured":"Mizushima N, Levine B (2010) Autophagy in mammalian development and differentiation. Nat Cell Biol 12(9):823\u201330","journal-title":"Nat Cell Biol"},{"key":"6330_CR3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cca.2017.01.028","volume":"468","author":"JA Jacob","year":"2017","unstructured":"Jacob JA et al (2017) Autophagy: an overview and its roles in cancer and obesity. Clin Chim Acta 468:85\u201389","journal-title":"Clin Chim Acta"},{"issue":"10","key":"6330_CR4","doi-asserted-by":"publisher","first-page":"e387","DOI":"10.1038\/oncsis.2017.85","volume":"6","author":"J Tang","year":"2017","unstructured":"Tang J et al (2017) Impaired p65 degradation by decreased chaperone-mediated autophagy activity facilitates epithelial-to-mesenchymal transition. Oncogenesis 6(10):e387","journal-title":"Oncogenesis"},{"issue":"Pt 4","key":"6330_CR5","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1242\/jcs.073874","volume":"124","author":"S Kaushik","year":"2011","unstructured":"Kaushik S et al (2011) Chaperone-mediated autophagy at a glance. J Cell Sci 124(Pt 4):495\u20139","journal-title":"J Cell Sci"},{"key":"6330_CR6","doi-asserted-by":"crossref","unstructured":"Wu X et al (2016)\u00a0Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun 7:10533","DOI":"10.1038\/ncomms10533"},{"key":"6330_CR7","doi-asserted-by":"crossref","unstructured":"Fimia GM et al (2007)\u00a0Ambra1 regulates autophagy and development of the nervous system. Nature 447(7148):1121-5","DOI":"10.1038\/nature05925"},{"issue":"1","key":"6330_CR8","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/s10545-013-9617-z","volume":"37","author":"F Majer","year":"2014","unstructured":"Majer F et al (2014) Mosaic tissue distribution of the tandem duplication of LAMP2 exons 4 and 5 demonstrates the limits of Danon disease cellular and molecular diagnostics. J Inherit Metab Dis 37(1):117\u201324","journal-title":"J Inherit Metab Dis"},{"key":"6330_CR9","doi-asserted-by":"crossref","unstructured":"Rothaug M et al (2015)\u00a0LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease. Acta Neuropathol Commun 3:6","DOI":"10.1186\/s40478-014-0182-y"},{"issue":"2","key":"6330_CR10","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.ajhg.2013.06.013","volume":"93","author":"A Piton","year":"2013","unstructured":"Piton A, Redin C, Mandel JL (2013) XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencing. Am J Hum Genet 93(2):368\u201383","journal-title":"Am J Hum Genet"},{"key":"6330_CR11","doi-asserted-by":"crossref","unstructured":"Saha T (2012) LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy.Autophagy 8(11):1643-56","DOI":"10.4161\/auto.21654"},{"key":"6330_CR12","doi-asserted-by":"crossref","unstructured":"Cuervo AM et al (2004)\u00a0Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305(5688):1292-5","DOI":"10.1126\/science.1101738"},{"issue":"10","key":"6330_CR13","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1038\/jcbfm.2009.83","volume":"29","author":"X Wang","year":"2009","unstructured":"Wang X et al (2009) Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in vivo. J Cereb Blood Flow Metab 29(10):1644\u201354","journal-title":"J Cereb Blood Flow Metab"},{"key":"6330_CR14","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399411001803","volume":"13","author":"M Xilouri","year":"2011","unstructured":"Xilouri M, Stefanis L (2011) Autophagic pathways in Parkinson disease and related disorders. Expert Rev Mol Med 13:e8","journal-title":"Expert Rev Mol Med"},{"issue":"47","key":"6330_CR15","doi-asserted-by":"publisher","first-page":"15816","DOI":"10.1523\/JNEUROSCI.1865-14.2014","volume":"34","author":"V Kaltezioti","year":"2014","unstructured":"Kaltezioti V et al (2014) Prox1 regulates Olig2 expression to modulate binary fate decisions in spinal cord neurons. J Neurosci 34(47):15816\u201331","journal-title":"J Neurosci"},{"issue":"12","key":"6330_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000565","volume":"8","author":"V Kaltezioti","year":"2010","unstructured":"Kaltezioti V et al (2010) Prox1 regulates the notch1-mediated inhibition of neurogenesis. PLoS Biol 8(12):e1000565","journal-title":"PLoS Biol"},{"issue":"5","key":"6330_CR17","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.febslet.2008.01.052","volume":"582","author":"PK Politis","year":"2008","unstructured":"Politis PK et al (2008) BM88\/Cend1 is involved in histone deacetylase inhibition-mediated growth arrest and differentiation of neuroblastoma cells. FEBS Lett 582(5):741\u20138","journal-title":"FEBS Lett"},{"key":"6330_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mcn.2018.12.006","volume":"95","author":"OR Brekk","year":"2018","unstructured":"Brekk OR et al (2018) Impairment of chaperone-mediated autophagy affects neuronal homeostasis through altered expression of DJ-1 and CRMP-2 proteins. Mol Cell Neurosci 95:1\u201312","journal-title":"Mol Cell Neurosci"},{"issue":"11","key":"6330_CR19","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1080\/15548627.2016.1214777","volume":"12","author":"M Xilouri","year":"2016","unstructured":"Xilouri M et al (2016) Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats. Autophagy 12(11):2230\u20132247","journal-title":"Autophagy"},{"issue":"Pt A","key":"6330_CR20","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.mcn.2015.01.003","volume":"66","author":"M Xilouri","year":"2015","unstructured":"Xilouri M, Stefanis L (2015) Chaperone mediated autophagy to the rescue: a new-fangled target for the treatment of neurodegenerative diseases. Mol Cell Neurosci 66(Pt A):29\u201336","journal-title":"Mol Cell Neurosci"},{"issue":"4","key":"6330_CR21","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/nn.3350","volume":"16","author":"SJ Orenstein","year":"2013","unstructured":"Orenstein SJ et al (2013) Interplay of LRRK2 with chaperone-mediated autophagy. Nat Neurosci 16(4):394\u2013406","journal-title":"Nat Neurosci"},{"key":"6330_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/srep06010","volume":"4","author":"X Lv","year":"2014","unstructured":"Lv X et al (2014) The crucial role of Atg5 in cortical neurogenesis during early brain development. Sci Rep 4:6010","journal-title":"Sci Rep"},{"issue":"1","key":"6330_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04994-x","volume":"7","author":"Q Han","year":"2017","unstructured":"Han Q et al (2017) Downregulation of ATG5-dependent macroautophagy by chaperone-mediated autophagy promotes breast cancer cell metastasis. Sci Rep 7(1):4759","journal-title":"Sci Rep"},{"issue":"11","key":"6330_CR24","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1080\/15548627.2018.1491489","volume":"14","author":"AR Issa","year":"2018","unstructured":"Issa AR et al (2018) The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain. Autophagy 14(11):1898\u20131910","journal-title":"Autophagy"},{"key":"6330_CR25","doi-asserted-by":"crossref","unstructured":"Xilouri M et al (2013)\u00a0Boosting chaperone-mediated autophagy in vivo mitigates alpha-synuclein-induced neurodegeneration. Brain\u00a0136(Pt 7):2130-46","DOI":"10.1093\/brain\/awt131"},{"issue":"15","key":"6330_CR26","doi-asserted-by":"publisher","first-page":"E1936","DOI":"10.1073\/pnas.1421480112","volume":"112","author":"A Amador-Arjona","year":"2015","unstructured":"Amador-Arjona A et al (2015) SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis. Proc Natl Acad Sci U S A 112(15):E1936-45","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"6330_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155167","volume":"11","author":"AI Packard","year":"2016","unstructured":"Packard AI, Lin B, Schwob JE (2016) Sox2 and Pax6 play counteracting roles in regulating neurogenesis within the murine olfactory epithelium. PLoS One 11(5):e0155167","journal-title":"PLoS One"},{"key":"6330_CR28","doi-asserted-by":"crossref","unstructured":"Boyer LA et al (2005)\u00a0Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122(6):947\u2009\u2212\u200956","DOI":"10.1016\/j.cell.2005.08.020"},{"issue":"6","key":"6330_CR29","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.cell.2008.02.039","volume":"132","author":"J Kim","year":"2008","unstructured":"Kim J et al (2008) An extended transcriptional network for pluripotency of embryonic stem cells. Cell 132(6):1049\u201361","journal-title":"Cell"},{"issue":"6","key":"6330_CR30","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1002\/dvdy.21885","volume":"238","author":"B Yan","year":"2009","unstructured":"Yan B, Neilson KM, Moody SA (2009) Notch signaling downstream of foxD5 promotes neural ectodermal transcription factors that inhibit neural differentiation. Dev Dyn 238(6):1358\u201365","journal-title":"Dev Dyn"},{"issue":"6","key":"6330_CR31","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/nn1475","volume":"8","author":"K Yoon","year":"2005","unstructured":"Yoon K, Gaiano N (2005) Notch signaling in the mammalian central nervous system: insights from mouse mutants. Nat Neurosci 8(6):709\u201315","journal-title":"Nat Neurosci"},{"issue":"11","key":"6330_CR32","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1038\/nn1131","volume":"6","author":"M Bylund","year":"2003","unstructured":"Bylund M, Andersson E, Novitch BG, Muhr J (2003) Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nat Neurosci 6(11):1162\u20138","journal-title":"Nat Neurosci"},{"key":"6330_CR33","doi-asserted-by":"crossref","unstructured":"Juste YR, Cuervo AM (2019)\u00a0Analysis of chaperone-mediated autophagy. Methods Mol Biol\u00a01880:703\u2013727","DOI":"10.1007\/978-1-4939-8873-0_47"},{"key":"6330_CR34","doi-asserted-by":"crossref","unstructured":"Klionsky DJ et al (2016)\u00a0Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy\u00a012(1):1-222","DOI":"10.1080\/15548627.2015.1100356"},{"key":"6330_CR35","doi-asserted-by":"crossref","unstructured":"Vogiatzi T et al (2008)\u00a0Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells. J Biol Chem\u00a0283(35):23542-56","DOI":"10.1074\/jbc.M801992200"},{"key":"6330_CR36","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1042\/EBC20170057","volume":"61","author":"S Catarino","year":"2017","unstructured":"Catarino S, Pereira P, Girao H (2017) Molecular control of chaperone-mediated autophagy. Essays Biochem 61:663\u2013674","journal-title":"Essays Biochem"},{"key":"6330_CR37","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.tem.2009.10.003","volume":"21","author":"AM Cuervo","year":"2010","unstructured":"Cuervo AM (2010) Chaperone-mediated autophagy: selectivity pays off. Trends Endocrinol Metab 21:142\u2013150","journal-title":"Trends Endocrinol Metab"},{"key":"6330_CR38","doi-asserted-by":"crossref","unstructured":"Kaushik S, Cuervo AM (2012)\u00a0Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol\u00a022:407\u2013417","DOI":"10.1016\/j.tcb.2012.05.006"},{"key":"6330_CR39","doi-asserted-by":"publisher","first-page":"337","DOI":"10.5483\/BMBRep.2016.49.6.212","volume":"49","author":"JS Park","year":"2016","unstructured":"Park JS, Kim DH, Yoon SY (2016) Regulation of amyloid precursor protein processing by its KFERQ motif. BMB Rep 49:337\u2013342","journal-title":"BMB Rep"},{"issue":"8","key":"6330_CR40","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.1093\/emboj\/18.8.2196","volume":"18","author":"T Ohtsuka","year":"1999","unstructured":"Ohtsuka T et al (1999) Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J 18(8):2196\u2013207","journal-title":"EMBO J"},{"issue":"45","key":"6330_CR41","doi-asserted-by":"publisher","first-page":"19162","DOI":"10.1073\/pnas.0902834106","volume":"106","author":"Y Zhang","year":"2009","unstructured":"Zhang Y et al (2009) Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination. Proc Natl Acad Sci U S A 106(45):19162\u20137","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"6330_CR42","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.devcel.2008.08.012","volume":"15","author":"F Cecconi","year":"2008","unstructured":"Cecconi F, Levine B (2008) The role of autophagy in mammalian development: cell makeover rather than cell death. Dev Cell 15(3):344\u201357","journal-title":"Dev Cell"},{"issue":"6","key":"6330_CR43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001350","volume":"10","author":"DP Srivastava","year":"2012","unstructured":"Srivastava DP et al (2012) An autism-associated variant of Epac2 reveals a role for Ras\/Epac2 signaling in controlling basal dendrite maintenance in mice. PLoS Biol 10(6):e1001350","journal-title":"PLoS Biol"},{"issue":"14","key":"6330_CR44","doi-asserted-by":"publisher","first-page":"5139","DOI":"10.1523\/JNEUROSCI.21-14-05139.2001","volume":"21","author":"EA Nimchinsky","year":"2001","unstructured":"Nimchinsky EA, Oberlander AM, Svoboda K (2001) Abnormal development of dendritic spines in FMR1 knock-out mice. J Neurosci 21(14):5139\u201346","journal-title":"J Neurosci"},{"issue":"3","key":"6330_CR45","doi-asserted-by":"publisher","first-page":"133","DOI":"10.5607\/en.2013.22.3.133","volume":"22","author":"KM Lee","year":"2013","unstructured":"Lee KM, Hwang SK, Lee JA (2013) Neuronal autophagy and neurodevelopmental disorders. Exp Neurobiol 22(3):133\u201342","journal-title":"Exp Neurobiol"},{"issue":"8","key":"6330_CR46","doi-asserted-by":"publisher","first-page":"383","DOI":"10.5483\/BMBRep.2013.46.8.164","volume":"46","author":"KM Chung","year":"2013","unstructured":"Chung KM, Yu SW (2013) Interplay between autophagy and programmed cell death in mammalian neural stem cells. BMB Rep 46(8):383\u201390","journal-title":"BMB Rep"},{"issue":"1","key":"6330_CR47","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0304-3940(00)01368-9","volume":"291","author":"M Biebl","year":"2000","unstructured":"Biebl M et al (2000) Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult rat brain. Neurosci Lett 291(1):17\u201320","journal-title":"Neurosci Lett"},{"key":"6330_CR48","doi-asserted-by":"crossref","unstructured":"Yang Z et al (2010)\u00a0LAMP2 microdeletions in patients with Danon disease. Circ Cardiovasc Genet\u00a03(2):129\u2009\u2212\u200937","DOI":"10.1161\/CIRCGENETICS.109.901785"},{"issue":"7104","key":"6330_CR49","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nature04940","volume":"442","author":"A Androutsellis-Theotokis","year":"2006","unstructured":"Androutsellis-Theotokis A et al (2006) Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 442(7104):823\u20136","journal-title":"Nature"},{"key":"6330_CR50","doi-asserted-by":"crossref","unstructured":"Ahmed S et al (2009)\u00a0Transcription factors and neural stem cell self-renewal, growth and differentiation. Cell Adh Migr 3(4):412\u2009\u2212\u200924","DOI":"10.4161\/cam.3.4.8803"},{"issue":"5415","key":"6330_CR51","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1126\/science.284.5415.770","volume":"284","author":"S Artavanis-Tsakonas","year":"1999","unstructured":"Artavanis-Tsakonas S, Rand MD, Lake RJ (1999) Notch signaling: cell fate control and signal integration in development. Science 284(5415):770\u20136","journal-title":"Science"},{"key":"6330_CR52","doi-asserted-by":"crossref","unstructured":"Corbin JG et al (2008)\u00a0Regulation of neural progenitor cell development in the nervous system. J Neurochem\u00a0106(6):2272-87","DOI":"10.1111\/j.1471-4159.2008.05522.x"},{"issue":"10","key":"6330_CR53","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1038\/nn.2397","volume":"12","author":"R Favaro","year":"2009","unstructured":"Favaro R et al (2009) Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh. Nat Neurosci 12(10):1248\u201356","journal-title":"Nat Neurosci"},{"key":"6330_CR54","doi-asserted-by":"crossref","unstructured":"Matsumoto A, Onoyama I, Sunabori T et al (2011)\u00a0Fbxw7-dependent degradation of Notch is required for control of stemness and neuronal-glial differentiation in neural stem cells. J Biol Chem\u00a0286(15):13754-64","DOI":"10.1074\/jbc.M110.194936"},{"issue":"25","key":"6330_CR55","doi-asserted-by":"publisher","first-page":"23196","DOI":"10.1074\/jbc.M302827200","volume":"278","author":"MA McGill","year":"2003","unstructured":"McGill MA, McGlade CJ (2003) Mammalian Numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem 278(25):23196\u2013203","journal-title":"J Biol Chem"},{"issue":"22","key":"6330_CR56","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2022113383","volume":"42","author":"Z Ma","year":"2023","unstructured":"Ma Z, Zeng Y, Wang M et al (2023) N4BP1 mediates RAM domain-dependent notch signaling turnover during neocortical development. EMBO J 42(22):e113383","journal-title":"EMBO J"},{"key":"6330_CR57","doi-asserted-by":"crossref","unstructured":"Foskolou IP et al (2013) Prox1 suppresses the proliferation of neuroblastoma cells via a dual action in p27-Kip1 and Cdc25A. Oncogene 32(8):947\u201360","DOI":"10.1038\/onc.2012.129"},{"key":"6330_CR58","doi-asserted-by":"crossref","unstructured":"Kyrousi C et al (2015) Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche. Development\u00a0142(21):3661-74","DOI":"10.1242\/dev.126342"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-026-06330-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06330-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06330-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:09:52Z","timestamp":1791504592000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-026-06330-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,14]]},"references-count":58,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6330"],"URL":"https:\/\/doi.org\/10.1007\/s00018-026-06330-x","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,14]]},"assertion":[{"value":"4 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study protocol was approved by the local ethics committee (Athens Prefecture Veterinarian Service; K3237\/11-05-2012) and took place in the animal facilities of the Center for Experimental Surgery of the Biomedical Research Foundation of the Academy of Athens. All animals were handled in strict accordance with good animal practice as defined by the relevant European and Greek animal welfare bodies.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflicts of interest with the contents of this article.","order":2,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"366"}}