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All human research procedures were conducted in strict adherence to the ethical principles outlined in the Declaration of Helsinki, and written informed consent was obtained from all subjects prior to their participation (Approval No. cqbykyll-20240918-2). Regarding animal experimentation, all protocols were approved by the Institutional Animal Care and Use Committee (IACUC) of Chongqing Medical University and were performed in accordance with the Guide for the Care and Use of Laboratory Animals (Approval No. IACUC-CQMU-2024-0407).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publish","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflicts of interest to declare.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"355"}}