{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:49:16Z","timestamp":1791823756578,"version":"4.3.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":89,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Zhejiang Provincial Key Research and Development Program of China","award":["2024C04045"],"award-info":[{"award-number":["2024C04045"]}]},{"name":"the Natural Science Foundation of China","award":["82372204"],"award-info":[{"award-number":["82372204"]}]},{"name":"the Natural Science Foundation of China","award":["82472234"],"award-info":[{"award-number":["82472234"]}]},{"name":"the Zhejiang Provincial Medical Science Foundation of China","award":["2022RC156"],"award-info":[{"award-number":["2022RC156"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-026-06344-5","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:45:22Z","timestamp":1784105122000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mesenchymal stem cell-derived exosomes alleviate post-resuscitation brain injury by inhibiting neuronal ferroptosis partly via the PRMT1\/SLC7A11\/GPX4 pathway"],"prefix":"10.1007","volume":"83","author":[{"given":"Lulu","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qijiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licai","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiefeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-8213","authenticated-orcid":false,"given":"Mao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"issue":"8","key":"6344_CR1","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1161\/CIR.0000000000001303","volume":"151","author":"SS Martin","year":"2025","unstructured":"Martin SS, Aday AW, Allen NB et al (2025) 2025 heart disease and stroke statistics: a report of US and global data from the American Heart Association. Circulation 151(8):e41\u2013e660","journal-title":"Circulation"},{"key":"6344_CR2","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.resuscitation.2021.02.007","volume":"161","author":"JT Gr\u00e4sner","year":"2021","unstructured":"Gr\u00e4sner JT, Herlitz J, Tjelmeland IBM et al (2021) European Resuscitation Council guidelines 2021: epidemiology of cardiac arrest in Europe. Resuscitation 161:61\u201379","journal-title":"Resuscitation"},{"issue":"12","key":"6344_CR3","doi-asserted-by":"publisher","first-page":"e923","DOI":"10.1016\/S2468-2667(23)00173-1","volume":"8","author":"J Zheng","year":"2023","unstructured":"Zheng J, Lv C, Zheng W et al (2023) Incidence, process of care, and outcomes of out-of-hospital cardiac arrest in China: a prospective study of the BASIC-OHCA registry. Lancet Public Health 8(12):e923\u2013e932","journal-title":"Lancet Public Health"},{"issue":"3","key":"6344_CR4","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.resuscitation.2008.09.017","volume":"79","author":"JP Nolan","year":"2008","unstructured":"Nolan JP, Neumar RW, Adrie C et al (2008) Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. Resuscitation 79(3):350\u2013379","journal-title":"Resuscitation"},{"issue":"12","key":"6344_CR5","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s00134-021-06548-2","volume":"47","author":"C Sandroni","year":"2021","unstructured":"Sandroni C, Cronberg T, Sekhon M (2021) Brain injury after cardiac arrest: pathophysiology, treatment, and prognosis. Intensive Care Med 47(12):1393\u20131414","journal-title":"Intensive Care Med"},{"issue":"16suppl2","key":"6344_CR6","first-page":"S366","volume":"142","author":"AR Panchal","year":"2020","unstructured":"Panchal AR, Bartos JA, Caba\u00f1as JG et al (2020) Part 3: adult basic and advanced life support: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation 142(16suppl2):S366\u2013S468","journal-title":"Circulation"},{"issue":"1","key":"6344_CR7","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1186\/s13054-024-05119-3","volume":"28","author":"FS Taccone","year":"2024","unstructured":"Taccone FS, Cariou A, Zorzi S et al (2024) Hypothermia versus normothermia in patients with cardiac arrest and shockable rhythm: a secondary analysis of the TTM-2 study. Crit Care 28(1):335","journal-title":"Crit Care"},{"key":"6344_CR8","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.resuscitation.2021.08.040","volume":"167","author":"A Granfeldt","year":"2021","unstructured":"Granfeldt A, Holmberg MJ, Nolan JP et al (2021) Targeted temperature management in adult cardiac arrest: Systematic review and meta-analysis. Resuscitation 167:160\u2013172","journal-title":"Resuscitation"},{"key":"6344_CR9","doi-asserted-by":"publisher","first-page":"110789","DOI":"10.1016\/j.resuscitation.2025.110789","volume":"215","author":"DW Simon","year":"2025","unstructured":"Simon DW, Kochanek PM (2025) Mesenchymal stem cell therapy for cardiac arrest: promise, challenges, and the path forward. Resuscitation 215:110789","journal-title":"Resuscitation"},{"key":"6344_CR10","doi-asserted-by":"publisher","first-page":"793829","DOI":"10.3389\/fphar.2021.793829","volume":"12","author":"J Xu","year":"2021","unstructured":"Xu J, Zhang M, Liu F et al (2021) Mesenchymal stem cells alleviate post-resuscitation cardiac and cerebral injuries by inhibiting cell pyroptosis and ferroptosis in a swine model of cardiac arrest. Front Pharmacol 12:793829","journal-title":"Front Pharmacol"},{"issue":"5","key":"6344_CR11","doi-asserted-by":"publisher","first-page":"e508","DOI":"10.1097\/CCM.0000000000002289","volume":"45","author":"TN Chung","year":"2017","unstructured":"Chung TN, Kim JH, Choi BY et al (2017) Effect of adipose-derived mesenchymal stem cell administration and mild hypothermia induction on delayed neuronal death after transient global cerebral ischemia. Crit Care Med 45(5):e508\u2013e515","journal-title":"Crit Care Med"},{"issue":"8\u20139","key":"6344_CR12","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1038\/s41417-022-00427-8","volume":"29","author":"B Sohrabi","year":"2022","unstructured":"Sohrabi B, Dayeri B, Zahedi E et al (2022) Mesenchymal stem cell (MSC)-derived exosomes as novel vehicles for delivery of miRNAs in cancer therapy. Cancer Gene Ther 29(8\u20139):1105\u20131116","journal-title":"Cancer Gene Ther"},{"issue":"1","key":"6344_CR13","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1186\/s13287-025-04318-1","volume":"16","author":"H Li","year":"2025","unstructured":"Li H, Bai L (2025) Advances in mesenchymal stem cell and exosome-based therapies for aging and age-related diseases. Stem Cell Res Ther 16(1):401","journal-title":"Stem Cell Res Ther"},{"key":"6344_CR14","doi-asserted-by":"publisher","unstructured":"Shen B, Chen J, Liu N et al Therapeutic mechanisms of umbilical cord mesenchymal stem cell-derived exosomes in ischemic stroke: A transcriptomic and metabolomic study. Neural Regen Res 2025 Aug 13. https:\/\/doi.org\/10.4103\/NRR.NRR-D-24-01219. Epub ahead of print.","DOI":"10.4103\/NRR.NRR-D-24-01219"},{"key":"6344_CR15","doi-asserted-by":"publisher","first-page":"110948","DOI":"10.1016\/j.brainresbull.2024.110948","volume":"211","author":"M Deng","year":"2024","unstructured":"Deng M, Hou Y, Liu J et al (2024) Mesenchymal stem cell-derived exosomes overexpressing SRC-3 protect mice from cerebral ischemia by inhibiting ferroptosis. Brain Res Bull 211:110948","journal-title":"Brain Res Bull"},{"issue":"4","key":"6344_CR16","doi-asserted-by":"publisher","first-page":"e70377","DOI":"10.1111\/cns.70377","volume":"31","author":"M Zhang","year":"2025","unstructured":"Zhang M, Zhang W, Chen Z et al (2025) LncRNA ENSSSCG00000035331 alleviates hippocampal neuronal ferroptosis and brain injury following porcine cardiopulmonary resuscitation by regulating the miR-let7a\/GPX4 axis. CNS Neurosci Ther 31(4):e70377","journal-title":"CNS Neurosci Ther"},{"issue":"3","key":"6344_CR17","doi-asserted-by":"publisher","first-page":"e70404","DOI":"10.1111\/jcmm.70404","volume":"29","author":"Z Chen","year":"2025","unstructured":"Chen Z, Wang S, Shu T et al (2025) Progress in research on regulated cell death in cerebral ischaemic injury after cardiac arrest. J Cell Mol Med 29(3):e70404","journal-title":"J Cell Mol Med"},{"issue":"22","key":"6344_CR18","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1038\/s41388-024-02996-4","volume":"43","author":"N Cao","year":"2024","unstructured":"Cao N, Zhang F, Yin J et al (2024) LPCAT2 inhibits colorectal cancer progression via the PRMT1\/SLC7A11 axis. Oncogene 43(22):1714\u20131725","journal-title":"Oncogene"},{"issue":"2","key":"6344_CR19","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1097\/00003246-199402000-00020","volume":"22","author":"RA Berg","year":"1994","unstructured":"Berg RA, Otto CW, Kern KB et al (1994) High-dose epinephrine results in greater early mortality after resuscitation from prolonged cardiac arrest in pigs: a prospective, randomized study. Crit Care Med 22(2):282\u2013290","journal-title":"Crit Care Med"},{"issue":"8","key":"6344_CR20","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/S0196-0644(05)81428-3","volume":"20","author":"RO Cummins","year":"1991","unstructured":"Cummins RO, Chamberlain DA, Abramson NS et al (1991) Recommended guidelines for uniform reporting of data from out-of-hospital cardiac arrest: the Utstein style. Ann Emerg Med 20(8):861\u2013874","journal-title":"Ann Emerg Med"},{"issue":"1","key":"6344_CR21","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1186\/s13287-023-03530-1","volume":"14","author":"X Jiang","year":"2023","unstructured":"Jiang X, Yang J, Lin Y et al (2023) Extracellular vesicles derived from human ESC-MSCs target macrophage and promote anti-inflammation process, angiogenesis, and functional recovery in ACS-induced severe skeletal muscle injury. Stem Cell Res Ther 14(1):331","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"6344_CR22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/s41419-025-07383-9","volume":"16","author":"M Cao","year":"2025","unstructured":"Cao M, Shao Z, Qian X et al (2025) TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression. Cell Death Dis 16(1):56","journal-title":"Cell Death Dis"},{"issue":"1","key":"6344_CR23","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s13578-025-01451-5","volume":"15","author":"X Zhang","year":"2025","unstructured":"Zhang X, Zhang W, Chen Z et al (2025) Stem cell-derived extracellular vesicles: novel therapeutics for cerebral injury following cardiac arrest and potential mechanisms. Cell Biosci 15(1):110","journal-title":"Cell Biosci"},{"issue":"1","key":"6344_CR24","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s43556-025-00277-4","volume":"6","author":"Y Wang","year":"2025","unstructured":"Wang Y, Wang H, Tan J et al (2025) Therapeutic effect of mesenchymal stem cells and their derived exosomes in diseases. Mol Biomed 6(1):34","journal-title":"Mol Biomed"},{"issue":"2","key":"6344_CR25","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1097\/TA.0000000000002698","volume":"89","author":"AM Williams","year":"2020","unstructured":"Williams AM, Wu Z, Bhatti UF et al (2020) Early single-dose exosome treatment improves neurologic outcomes in a 7-day swine model of traumatic brain injury and hemorrhagic shock. J Trauma Acute Care Surg 89(2):388\u2013396","journal-title":"J Trauma Acute Care Surg"},{"issue":"1","key":"6344_CR26","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s10565-025-10009-7","volume":"41","author":"J Zhang","year":"2025","unstructured":"Zhang J, Wang C, Yang G et al (2025) Olfactory mucosal mesenchymal stem cell-derived exosome Lnc A2M-AS1 ameliorates oxidative stress by regulating TP53INP1-mediated mitochondrial autophagy through interacting with IGF2BP1 in Parkinson\u2019s diseases. Cell Biol Toxicol 41(1):60","journal-title":"Cell Biol Toxicol"},{"issue":"6","key":"6344_CR27","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2174\/157488812804484611","volume":"7","author":"F Lv","year":"2012","unstructured":"Lv F, Lu M, Cheung KM et al (2012) Intrinsic properties of mesemchymal stem cells from human bone marrow, umbilical cord and umbilical cord blood comparing the different sources of MSC. Curr Stem Cell Res Ther 7(6):389\u2013399","journal-title":"Curr Stem Cell Res Ther"},{"issue":"9","key":"6344_CR28","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1038\/s41422-020-0354-1","volume":"30","author":"J Wu","year":"2020","unstructured":"Wu J, Song D, Li Z et al (2020) Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis. Cell Res 30(9):794\u2013809","journal-title":"Cell Res"},{"issue":"2","key":"6344_CR29","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1097\/TA.0000000000002563","volume":"88","author":"AM Williams","year":"2020","unstructured":"Williams AM, Bhatti UF, Brown JF et al (2020) Early single-dose treatment with exosomes provides neuroprotection and improves blood-brain barrier integrity in swine model of traumatic brain injury and hemorrhagic shock. J Trauma Acute Care Surg 88(2):207\u2013218","journal-title":"J Trauma Acute Care Surg"},{"key":"6344_CR30","doi-asserted-by":"publisher","first-page":"1593963","DOI":"10.3389\/fncel.2025.1593963","volume":"19","author":"Q Huang","year":"2025","unstructured":"Huang Q, Zhang H, Chen S et al (2025) Ferroptosis in central nervous system injuries: molecular mechanisms, diagnostic approaches, and therapeutic strategies. Front Cell Neurosci 19:1593963","journal-title":"Front Cell Neurosci"},{"issue":"3","key":"6344_CR31","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1097\/SHK.0000000000002058","volume":"59","author":"Z Ye","year":"2023","unstructured":"Ye Z, Zhang F, Wang P et al (2023) Baicalein relieves brain injury via inhibiting ferroptosis and endoplasmic reticulum stress in a rat model of cardiac arrest. Shock 59(3):434\u2013441","journal-title":"Shock"},{"issue":"3","key":"6344_CR32","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s11064-025-04412-z","volume":"50","author":"C Xing","year":"2025","unstructured":"Xing C, Fan X, Liu M et al (2025) Liraglutide inhibits autophagy to ameliorate post-cardiac arrest brain injury and ferroptosis in rats. Neurochem Res 50(3):161","journal-title":"Neurochem Res"},{"issue":"7","key":"6344_CR33","doi-asserted-by":"publisher","first-page":"4379","DOI":"10.1007\/s11010-025-05262-7","volume":"480","author":"C Jiang","year":"2025","unstructured":"Jiang C, Yan Y, Long T et al (2025) Ferroptosis: a potential therapeutic target in cardio-cerebrovascular diseases. Mol Cell Biochem 480(7):4379\u20134399","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"6344_CR34","doi-asserted-by":"publisher","first-page":"129776","DOI":"10.1016\/j.bbagen.2020.129776","volume":"1865","author":"M Hashimoto","year":"2021","unstructured":"Hashimoto M, Fukamizu A, Nakagawa T et al (2021) Roles of protein arginine methyltransferase 1 (PRMT1) in brain development and disease. Biochim Biophys Acta Gen Subj 1865(1):129776","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"6344_CR35","doi-asserted-by":"publisher","first-page":"627434","DOI":"10.1155\/2014\/627434","volume":"2014","author":"A Ferrigno","year":"2014","unstructured":"Ferrigno A, Rizzo V, Bianchi A et al (2014) Changes in ADMA\/DDAH pathway after hepatic ischemia\/reperfusion injury in rats: the role of bile. Biomed Res Int 2014:627434","journal-title":"Biomed Res Int"},{"issue":"11","key":"6344_CR36","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.17219\/acem\/75499","volume":"27","author":"M Trocha","year":"2018","unstructured":"Trocha M, Nowak B, Merwid-L\u0105d A et al (2018) The impact of sitagliptin, inhibitor of dipeptidyl peptidase-4 (DPP-4), on the ADMA-DDAH-NO pathway in ischemic and reperfused rat livers. Adv Clin Exp Med 27(11):1483\u20131490","journal-title":"Adv Clin Exp Med"},{"issue":"8","key":"6344_CR37","doi-asserted-by":"publisher","first-page":"4014","DOI":"10.1016\/j.apsb.2025.06.005","volume":"15","author":"T Liu","year":"2025","unstructured":"Liu T, Huang G, Guo X et al (2025) The protein arginine methyltransferase PRMT1 ameliorates cerebral ischemia-reperfusion injury by suppressing RIPK1-mediated necroptosis and apoptosis. Acta Pharm Sin B 15(8):4014\u20134029","journal-title":"Acta Pharm Sin B"},{"key":"6344_CR38","doi-asserted-by":"publisher","first-page":"102227","DOI":"10.1016\/j.plefa.2020.102227","volume":"165","author":"CY Wu","year":"2021","unstructured":"Wu CY, Couto E, Silva A, Citadin CT et al (2021) Palmitic acid methyl ester inhibits cardiac arrest-induced neuroinflammation and mitochondrial dysfunction. Prostaglandins Leukot Essent Fat Acids 165:102227","journal-title":"Prostaglandins Leukot Essent Fat Acids"},{"issue":"8","key":"6344_CR39","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1002\/mc.23550","volume":"62","author":"L Zhou","year":"2023","unstructured":"Zhou L, Jia X, Shang Y et al (2023) PRMT1 inhibition promotes ferroptosis sensitivity via ACSL1 upregulation in acute myeloid leukemia. Mol Carcinog 62(8):1119\u20131135","journal-title":"Mol Carcinog"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-026-06344-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06344-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06344-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:06:20Z","timestamp":1791821180000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-026-06344-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6344"],"URL":"https:\/\/doi.org\/10.1007\/s00018-026-06344-5","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"assertion":[{"value":"7 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Institutional Animal Care and Use Committee of the Second Affiliated Hospital, Zhejiang University School of Medicine (No. 2023-064).","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","label":"Competing Interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":3,"name":"Ethics","label":"Disclosures","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"369"}}