{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:58:50Z","timestamp":1790467130415,"version":"4.1.0"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":47,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cell. Mol. Life Sci."],"DOI":"10.1007\/s00018-026-06370-3","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T02:43:37Z","timestamp":1786329817000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Post-translational modifications of integrins: molecular mechanisms and pathological implications"],"prefix":"10.1007","volume":"83","author":[{"given":"Xiao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2151-9322","authenticated-orcid":false,"given":"Xiaofan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"issue":"6","key":"6370_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","volume":"110","author":"RO Hynes","year":"2002","unstructured":"Hynes RO (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110(6):673\u2013687","journal-title":"Cell"},{"issue":"21","key":"6370_CR2","doi-asserted-by":"publisher","first-page":"3844","DOI":"10.1016\/j.cell.2022.09.017","volume":"185","author":"JE Rothman","year":"2022","unstructured":"Rothman JE (2022) The gripping story of integrins. Cell 185(21):3844\u20133848","journal-title":"Cell"},{"issue":"1\u20132","key":"6370_CR3","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s10555-011-9341-9","volume":"31","author":"M Deb","year":"2011","unstructured":"Deb M, Sengupta D, Patra SK (2011) Integrin-epigenetics: a system with imperative impact on cancer. Cancer Metastasis Rev 31(1\u20132):221\u2013234","journal-title":"Cancer Metastasis Rev"},{"issue":"2","key":"6370_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.ccr.2004.06.025","volume":"6","author":"DE White","year":"2004","unstructured":"White DE, Kurpios NA, Zuo D, Hassell JA, Blaess S, Mueller U, Muller WJ (2004) Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 6(2):159\u2013170","journal-title":"Cancer Cell"},{"issue":"5565","key":"6370_CR5","first-page":"151","volume":"296","author":"J-P Xiong","year":"2022","unstructured":"Xiong J-P, Stehle T, Zhang R, Joachimiak A, Frech M, Goodman SL, Arnaout MA (2022) Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand. Sci 296(5565):151\u2013155","journal-title":"Sci Adv"},{"issue":"1","key":"6370_CR6","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cbpa.2003.12.009","volume":"8","author":"ON Jensen","year":"2004","unstructured":"Jensen ON (2004) Modification-specific proteomics: characterization of post-translational modifications by mass spectrometry. Curr Opin Chem Biol 8(1):33\u201341","journal-title":"Curr Opin Chem Biol"},{"key":"6370_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106413","volume":"183","author":"S Sun","year":"2022","unstructured":"Sun S, Qiao B, Han Y, Wang B, Wei S, Chen Y (2022) Posttranslational modifications of platelet adhesion receptors. Pharmacol Res 183:106413","journal-title":"Pharmacol Res"},{"issue":"3","key":"6370_CR8","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.261","volume":"4","author":"Q Zhong","year":"2020","unstructured":"Zhong Q, Xiao X, Qiu Y, Xu Z, Chen C, Chong B, Zhao X, Hai S, Li S, An Z, Dai L (2020) Protein posttranslational modifications in health and diseases: functions, regulatory mechanisms, and therapeutic implications. MedComm 4(3):e261","journal-title":"MedComm"},{"issue":"4","key":"6370_CR9","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/s41417-022-00464-3","volume":"30","author":"H Wang","year":"2023","unstructured":"Wang H, Yang L, Liu M, Luo J (2023) Protein post-translational modifications in the regulation of cancer hallmarks. Cancer Gene Ther 30(4):529\u2013547","journal-title":"Cancer Gene Ther"},{"issue":"6","key":"6370_CR10","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/s41556-025-01663-4","volume":"27","author":"JRW Conway","year":"2025","unstructured":"Conway JRW, Joshi O, Kaivola J, Follain G, Gounis M, K\u00fchl D, Ivaska J (2025) Dynamic regulation of integrin \u03b21 phosphorylation supports invasion of breast cancer cells. Nat Cell Biol 27(6):1021\u20131034","journal-title":"Nat Cell Biol"},{"key":"6370_CR11","doi-asserted-by":"crossref","unstructured":"Tan Z, Cao L, Wu Y, Wang B, Song Z, Yang J, Cheng L, Yang X, Zhou X, Dai Z, Li X, Guan F (2020) Bisecting GlcNAc modification diminishes the pro-metastatic functions of small extracellular vesicles from breast cancer cells. J Extracell Vesicles 10(1):12005","DOI":"10.1002\/jev2.12005"},{"key":"6370_CR12","doi-asserted-by":"publisher","first-page":"105713","DOI":"10.1016\/j.phrs.2021.105713","volume":"170","author":"Y Qi","year":"2021","unstructured":"Qi Y, Yao R, Zhang W, Cui Q (2021) KAT1 triggers YTHDF2-mediated ITGB1 mRNA instability to alleviate the progression of diabetic retinopathy. Pharmacol Res 170:105713","journal-title":"Pharmacol Res"},{"issue":"10","key":"6370_CR13","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1681\/ASN.2022010013","volume":"33","author":"V Binder","year":"2022","unstructured":"Binder V, Chru\u015bcicka-Smaga B, Bergum B, Jaisson S, Gillery P, Sivertsen J, Hervig T, Kaminska M, Tilvawala R, Nemmara VV, Thompson PR, Potempa J, Marti H-P, Mydel P (2022) Carbamylation of integrin \u03b1 IIb \u03b2 3: the mechanistic link to platelet dysfunction in ESKD. J Am Soc Nephrol 33(10):1841\u20131856","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"6370_CR14","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s00018-022-04126-3","volume":"79","author":"O Ciesielski","year":"2022","unstructured":"Ciesielski O, Biesiekierska M, Panthu B, Soszy\u0144ski M, Pirola L, Balcerczyk A (2022) Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives. Cell Mol Life Sci 79(2):94","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"6370_CR15","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1186\/bcr2905","volume":"13","author":"H Lahlou","year":"2011","unstructured":"Lahlou H, Muller WJ (2011) \u03b21-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer. Breast Cancer Res 13(6):229","journal-title":"Breast Cancer Res"},{"key":"6370_CR16","doi-asserted-by":"publisher","DOI":"10.1017\/S0033583519000088","volume":"52","author":"CG Gahmberg","year":"2019","unstructured":"Gahmberg CG, Gr\u00f6nholm M, Madhavan S, Jahan F, Mikkola E, Viazmina L, Koivunen E (2019) Regulation of cell adhesion: a collaborative effort of integrins, their ligands, cytoplasmic actors, and phosphorylation. Q Rev Biophys 52:e10","journal-title":"Q Rev Biophys"},{"key":"6370_CR17","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1084\/jem.163.5.1132","volume":"163","author":"R R","year":"1986","unstructured":"R R, T AS (1986) The requirement for lymphocyte function-associated antigen 1 in homotypic leukocyte adhesion stimulated by phorbol ester. J Exp Med 163:1132\u20131149","journal-title":"J Exp Med"},{"issue":"1","key":"6370_CR18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12929-015-0159-6","volume":"22","author":"EJ Park","year":"2015","unstructured":"Park EJ, Yuki Y, Kiyono H, Shimaoka M (2015) Structural basis of blocking integrin activation and deactivation for anti-inflammation. J Biomed Sci 22(1):51","journal-title":"J Biomed Sci"},{"issue":"1","key":"6370_CR19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/s41698-017-0045-7","volume":"2","author":"X Xiang","year":"2018","unstructured":"Xiang X, Wang Y, Zhang H, Piao J, Muthusamy S, Wang L, Deng Y, Zhang W, Kuang R, Billadeau DD, Huang S, Lai J, Urrutia R, Kang N (2018) Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a \u03b21-integrin-FAK-YAP1\/TAZ signaling pathway. NPJ precision Oncol 2(1):2","journal-title":"NPJ precision Oncol"},{"issue":"5","key":"6370_CR20","first-page":"1343","volume":"25","author":"X Liu","year":"2011","unstructured":"Liu X, Yan Z, Huang L, Guo M, Zhang Z, Guo C (2011) Cell surface heat shock protein 90 modulates prostate cancer cell adhesion and invasion through the integrin-\u03b21\/focal adhesion kinase\/c-Src signaling pathway. Oncol Rep 25(5):1343\u20131351","journal-title":"Oncol Rep"},{"key":"6370_CR21","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.biocel.2018.03.008","volume":"98","author":"J Zhan","year":"2018","unstructured":"Zhan J, Zhang H (2018) Kindlins: Roles in development and cancer progression. Int J Biochem Cell Biol 98:93\u2013103","journal-title":"Int J Biochem Cell Biol"},{"issue":"10","key":"6370_CR22","doi-asserted-by":"publisher","first-page":"281","DOI":"10.3390\/v8100281","volume":"8","author":"M Klundert","year":"2016","unstructured":"van de Klundert MA, van den Biggelaar M, Kootstra NA, Zaaijer HL (2016) Hepatitis B Virus Protein X Induces Degradation of Talin-1. Viruses 8(10):281","journal-title":"Viruses"},{"issue":"7","key":"6370_CR23","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1038\/s41388-020-01594-4","volume":"40","author":"T-C Kuo","year":"2021","unstructured":"Kuo T-C, Wu M-H, Yang S-H, Chen S-T, Hsu T-W, Jhuang J-Y, Liao Y-Y, Tien Y-W, Huang M-C (2021) C1GALT1 high expression is associated with poor survival of patients with pancreatic ductal adenocarcinoma and promotes cell invasiveness through integrin \u03b1v. Oncogene 40(7):1242\u20131254","journal-title":"Oncogene"},{"issue":"8","key":"6370_CR24","doi-asserted-by":"publisher","first-page":"e70536","DOI":"10.1002\/jmv.70536","volume":"97","author":"L Zheng","year":"2025","unstructured":"Zheng L, Pan T, Wang H, Tian J, He Z (2025) Involvement of integrin \u03b23 O-glycosylation in human cytomegalovirus internalization into fibroblasts. J Med Virol 97(8):e70536","journal-title":"J Med Virol"},{"issue":"4","key":"6370_CR25","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1182\/blood.2022016995","volume":"141","author":"A Mar\u00edn-Qu\u00edlez","year":"2023","unstructured":"Mar\u00edn-Qu\u00edlez A, Di Buduo CA, D\u00edaz-Ajenjo L, Abbonante V, Vuelta E, Soprano PM, Miguel-Garc\u00eda C, Santos-M\u00ednguez S, Serramito-G\u00f3mez I, Ruiz-Sala P, Pe\u00f1arrubia MJ, Pardal E, Hern\u00e1ndez-Rivas JM, Gonz\u00e1lez-Porras JR, Garc\u00eda-Tu\u00f1\u00f3n I, Benito R, Rivera J, Balduini A, Bastida JM (2023) Novel variants in GALE cause syndromic macrothrombocytopenia by disrupting glycosylation and thrombopoiesis. Blood 141(4):406\u2013421","journal-title":"Blood"},{"issue":"9","key":"6370_CR26","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1158\/1541-7786.MCR-23-0108","volume":"21","author":"AJ Macke","year":"2023","unstructured":"Macke AJ, Pachikov AN, Divita TE, Morris ME, LaGrange CA, Holzapfel MS, Kubyshkin AV, Zyablitskaya EY, Makalish TP, Eremenko SN, Qiu H, Riethoven J-JM, Hemstreet GP, Petrosyan A (2023) Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression. Mol Cancer Res 21(9):958\u2013974","journal-title":"Mol Cancer Res"},{"issue":"4","key":"6370_CR27","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.3390\/ijms22041770","volume":"22","author":"L Cao","year":"2021","unstructured":"Cao L, Wu Y, Wang X, Li X, Tan Z, Guan F (2021) Role of site-specific glycosylation in the I-like domain of integrin \u03b21 in small extracellular vesicle-mediated malignant behavior and FAK activation. Int J Mol Sci 22(4):1770","journal-title":"Int J Mol Sci"},{"issue":"6","key":"6370_CR28","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1002\/cac2.70016","volume":"45","author":"R Zhao","year":"2025","unstructured":"Zhao R, Pan Z, Qiu J, Li B, Qi Y, Gao Z, Qiu W, Tang W, Guo X, Deng L, Li G, Xue H (2025) Blocking ITGA5 potentiates the efficacy of anti-PD\u20101 therapy on glioblastoma by remodeling tumor\u2010associated macrophages. Cancer Commun 45(6):677\u2013701","journal-title":"Cancer Commun"},{"issue":"1","key":"6370_CR29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41389-023-00494-y","volume":"12","author":"P-D Chen","year":"2023","unstructured":"Chen P-D, Liao Y-Y, Cheng Y-C, Wu H-Y, Wu Y-M, Huang M-C (2023) Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway. Oncogenesis 12(1):49","journal-title":"Oncogenesis"},{"issue":"11","key":"6370_CR30","doi-asserted-by":"publisher","first-page":"5310","DOI":"10.3390\/ijms26115310","volume":"26","author":"GM Ferreira","year":"2025","unstructured":"Ferreira GM, Cuello HA, Nogueira AC, Castillo JO, Rojo S, Gulino CA, Segatori VI, Gabri MR (2025) N-Glycosylation as a key requirement for the positive interaction of integrin and uPAR in glioblastoma. Int J Mol Sci 26(11):5310","journal-title":"Int J Mol Sci"},{"issue":"10","key":"6370_CR31","doi-asserted-by":"publisher","first-page":"103168","DOI":"10.1016\/j.isci.2021.103168","volume":"24","author":"Y-L Huang","year":"2021","unstructured":"Huang Y-L, Liang C-Y, Labitzky V, Ritz D, Oliveira T, Cumin C, Estermann M, Lange T, Everest-Dass AV, Jacob F (2021) Site-specific N-glycosylation of integrin \u03b12 mediates collagen-dependent cell survival. iScience 24(10):103168","journal-title":"iScience"},{"issue":"4","key":"6370_CR32","doi-asserted-by":"publisher","first-page":"100213","DOI":"10.1016\/j.mcpro.2022.100213","volume":"21","author":"MM Gaye","year":"2022","unstructured":"Gaye MM, Ward CM, Piasecki AJ, Stahl VL, Karagianni A, Costello CE, Ravid K (2022) Characterization of glycoproteoforms of integrins \u03b12 and \u03b21 in megakaryocytes in the occurrence of JAK2V617F mutation-induced primary myelofibrosis. Mol Cell Proteomics 21(4):100213","journal-title":"Mol Cell Proteomics"},{"issue":"7911","key":"6370_CR33","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/s41586-022-04758-2","volume":"605","author":"M Rossi","year":"2022","unstructured":"Rossi M, Altea-Manzano P, Demicco M, Doglioni G, Bornes L, Fukano M, Vandekeere A, Cuadros AM, Fern\u00e1ndez-Garc\u00eda J, Riera-Domingo C, Jauset C, Planque M, Alkan HF, Nittner D, Zuo D, Broadfield LA, Parik S, Pane AA, Rizzollo F, Rinaldi G, Zhang T, Teoh ST, Aurora AB, Karras P, Vermeire I, Broekaert D, Van Elsen J, Knott MML, Orth MF, Demeyer S, Eelen G, Dobrolecki LE, Bassez A, Van Brussel T, Sotlar K, Lewis MT, Bartsch H, Wuhrer M, Van Veelen P, Carmeliet P, Cools J, Morrison SJ, Marine J-C, Lambrechts D, Mazzone M, Hannon GJ, Lunt SY, Gr\u00fcnewald TGP, Park M, Van Rheenen J, Fendt S-M (2022) PHGDH heterogeneity potentiates cancer cell dissemination and metastasis. Nature 605(7911):747\u2013753","journal-title":"Nature"},{"key":"6370_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-023-00527-9","volume":"29","author":"M Lin","year":"2024","unstructured":"Lin M, Xu X, Zhou X, Feng H, Wang R, Yang Y, Li J, Fan N, Jiang Y, Li X, Guan F, Tan Z (2024) Sialylation on vesicular integrin \u03b21 determined endocytic entry of small extracellular vesicles into recipient cells. Cell Mol Biol Lett 29:1","journal-title":"Cell Mol Biol Lett"},{"key":"6370_CR35","doi-asserted-by":"crossref","unstructured":"Lenza MP, Egia-Mendikute L, Anto\u00f1ana-Vildosola A, Soares CO, Coelho H, Corzana F, Bosch A, Manisha P, Quintana JI, Oyenarte I, Unione L, Moure MJ, Azkargorta M, Atxabal U, Sobczak K, Elortza F, Sutherland JD, Barrio R, Marcelo F, Jim\u00e9nez-Barbero J, Palazon A,\u00a0Ere\u00f1o-Orbea J (2023) Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b. Nat Commun 14(1)1):3496","DOI":"10.1038\/s41467-023-39119-8"},{"issue":"4","key":"6370_CR36","doi-asserted-by":"publisher","first-page":"e202101301","DOI":"10.26508\/lsa.202101301","volume":"5","author":"RT B\u00f6ttcher","year":"2022","unstructured":"B\u00f6ttcher RT, Strohmeyer N, Aretz J, F\u00e4ssler R (2022) New insights into the phosphorylation of the threonine motif of the \u03b21 integrin cytoplasmic domain. Life Sci Alliance 5(4):e202101301","journal-title":"Life Sci Alliance"},{"key":"6370_CR37","doi-asserted-by":"crossref","unstructured":"Zhu Z, Liu H, Feng L, Lu L, Zhu J, Liang Q, Lan Z, Ye Y, Wang S, Chen A, Yan J (2025) Loss of ADAMTS5 promotes vascular calcification via versican\/integrin \u03b21\/FAK signal. Atheroscler 404:119190","DOI":"10.1016\/j.atherosclerosis.2025.119190"},{"key":"6370_CR38","doi-asserted-by":"crossref","unstructured":"Zhiping C, Zhenxing L, Tanxing C, Xin Y, Haiqing J, Wei X, Xiaobin Z, Huashan L, Liang H, Li X, Guolin L, Liang K (2026) ANGPTL3 promotes colorectal carcinoma progression and metastasis through regulating COL1A2 transcription via interacting with integrin \u03b1V\u03b23. Cancer Lett 17(638):218150","DOI":"10.1016\/j.canlet.2025.218150"},{"key":"6370_CR39","doi-asserted-by":"crossref","unstructured":"Hwang HJ, Kang D, Kim J-R, Choi JH, Ryu J-K, Herman AB, Ko Y-G, Park HJ, Gorospe M, Lee J-S (2024) FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4\/mTORC2\/p53 signaling pathway. JCI Insight 9(7):e172678","DOI":"10.1172\/jci.insight.172678"},{"key":"6370_CR40","doi-asserted-by":"crossref","unstructured":"Te Molder L, Kreft M, Heemskerk N, Schuring J, de Pereda JM, Wilhelmsen K, Sonnenberg A (2021) EGFR-dependent tyrosine phosphorylation of integrin \u03b24 is not required for downstream signaling events in cancer cell lines. Sci Rep 11(1):8675","DOI":"10.1038\/s41598-021-88134-6"},{"key":"6370_CR41","doi-asserted-by":"crossref","unstructured":"Lu CH, Lee CE, Zhang W, Yang Y, Valencia LA, You H, Tsai CT, Cui B (2026) FCHo2, not talin, enables inside-out activation of integrin \u0251v\u03b25 in curved adhesions. Nat Commun 2419","DOI":"10.1101\/2025.11.28.691229"},{"issue":"6","key":"6370_CR42","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1242\/jcs.01679","volume":"118","author":"K Kaabeche","year":"2005","unstructured":"Kaabeche K, Guenou H, Bouvard D, Didelot Ng, Listrat A, Marie PJ (2005) Cbl-mediated ubiquitination of \u03b15 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation. J Cell Sci 118(6):1223\u20131232","journal-title":"J Cell Sci"},{"issue":"3","key":"6370_CR43","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1172\/JCI122779","volume":"129","author":"G Zhao","year":"2019","unstructured":"Zhao G, Gong L, Su D, Jin Y, Guo C, Yue M, Yao S, Qin Z, Ye Y, Tang Y, Wu Q, Zhang J, Cui B, Ding Q, Huang H, Hu L, Chen Y, Zhang P, Hu G, Chen L, Wong K-K, Gao D, Ji H (2019) Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin \u03b21. J Clin Invest 129(3):972\u2013987","journal-title":"J Clin Invest"},{"issue":"4","key":"6370_CR44","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.bbrc.2016.09.144","volume":"479","author":"N Yang","year":"2016","unstructured":"Yang N, Yu F, Shao G, Fu Y, Kong W (2016) The E3 ubiquitin ligase c-Cbl mediates integrin \u03b21 ubiquitination during dilated cardiomyopathy. Biochem Biophys Res Commun 479(4):728\u2013735","journal-title":"Biochem Biophys Res Commun"},{"key":"6370_CR45","doi-asserted-by":"crossref","unstructured":"Tang T, Chen H, Hu L, Ye J, Jing C, Xu C, Wu X, Chen Y, Chen Z, Zhou H, Fan L, Fu X, Qian C, Chen J, Tan Z, Liu J, Zeng H, Chen G, Liu F (2024) TIMP1 protects against blood-brain barrier disruption after subarachnoid haemorrhage by inhibiting ubiquitination of astrocytic \u03b21-integrin. Stroke and Vasc Neurol 9(6):671\u2013684","DOI":"10.1136\/svn-2023-002956"},{"issue":"20","key":"6370_CR46","doi-asserted-by":"publisher","first-page":"3481","DOI":"10.1242\/jcs.204628","volume":"130","author":"SR Gillespie","year":"2017","unstructured":"Gillespie SR, Tedesco LJ, Wang L, Bernstein AM (2017) The deubiquitylase USP10 regulates integrin \u03b21 and \u03b25 and fibrotic wound healing. J Cell Sci 130(20):3481\u20133495","journal-title":"J Cell Sci"},{"key":"6370_CR47","doi-asserted-by":"publisher","first-page":"5687","DOI":"10.1038\/s44319-024-00300-9","volume":"25","author":"Y Kaikai","year":"2024","unstructured":"Kaikai Y, Guan MW, Shiny SG, Florian B, Reinhard F (2024) The USP12\/46 deubiquitinases protect integrins from ESCRT-mediated lysosomal degradation. EMBO Rep 25:5687\u20135718","journal-title":"EMBO Rep"},{"issue":"1","key":"6370_CR48","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1186\/s12964-024-01685-9","volume":"22","author":"Y Shi","year":"2024","unstructured":"Shi Y, Fang N, Wu Y, Xu H, Ning A, Zhang W, Liu Y, Tao X, Chen Q, Tian T, Zhang L, Chu M, Cui J (2024) NEDD4L mediates ITGB4 ubiquitination and degradation to suppress esophageal carcinoma progression. Cell Commun Signal CCS 22(1):302","journal-title":"Cell Commun Signal CCS"},{"issue":"1","key":"6370_CR49","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1038\/s41598-021-81851-y","volume":"11","author":"VV Strelnikov","year":"2021","unstructured":"Strelnikov VV, Kuznetsova EB, Tanas AS, Rudenko VV, Kalinkin AI, Poddubskaya EV, Kekeeva TV, Chesnokova GG, Trotsenko ID, Larin SS, Kutsev SI, Zaletaev DV, Nemtsova MV, Simonova OA (2021) Abnormal promoter DNA hypermethylation of the integrin, nidogen, and dystroglycan genes in breast cancer. Sci Rep 11(1):2264","journal-title":"Sci Rep"},{"issue":"1","key":"6370_CR50","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s11658-025-00739-1","volume":"30","author":"H Fu","year":"2025","unstructured":"Fu H, Gao B, Zhou X, Hao Y, Liu C, Lan A, Tang J, Zhou F (2025) DNA dioxygenase TET2 deficiency aggravates sepsis-induced acute lung injury by targeting ITGA10 via the PI3K\/AKT signaling pathway. Cell Mol Biol Lett 30(1):60","journal-title":"Cell Mol Biol Lett"},{"issue":"1","key":"6370_CR51","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s13148-023-01433-9","volume":"15","author":"S Roy Choudhury","year":"2023","unstructured":"Roy Choudhury S, Byrum SD, Alkam D, Ashby C, Zhan F, Tackett AJ, Van Rhee F (2023) Expression of integrin \u03b2-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics. Clin Epigenetics 15(1):18","journal-title":"Clin Epigenetics"},{"issue":"6","key":"6370_CR52","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1002\/ijc.32673","volume":"146","author":"T Lyu","year":"2019","unstructured":"Lyu T, Jiang Y, Jia N, Che X, Li Q, Yu Y, Hua K, Bast RC, Feng W (2019) SMYD3 promotes implant metastasis of ovarian cancer via H3K4 trimethylation of integrin promoters. Int J Cancer 146(6):1553\u20131567","journal-title":"Int J Cancer"},{"issue":"1","key":"6370_CR53","doi-asserted-by":"publisher","first-page":"28934","DOI":"10.1038\/s41598-025-14342-z","volume":"15","author":"B Ke","year":"2025","unstructured":"Ke B, Jin P, Wang X-J, Zhang R-p, Liu N, Ma G (2025) Pan-cancer landscape of ITGAV and its potential role in gastric cancer. Sci Rep 15(1):28934","journal-title":"Sci Rep"},{"key":"6370_CR54","doi-asserted-by":"crossref","unstructured":"Wang Z, Shang J, Qiu Y, Cheng H, Tao M, Xie E, Pei X, Li W, Zhang L, Wu A, Li G (2024) Suppression of the METTL3-m6A-integrin \u03b21 axis by extracellular acidification impairs T cell infiltration and antitumor activity. Cell Rep 43(2):113796","DOI":"10.1016\/j.celrep.2024.113796"},{"key":"6370_CR55","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jare.2023.03.010","volume":"56","author":"X Ying","year":"2024","unstructured":"Ying X, Huang Y, Liu B, Hu W, Ji D, Chen C, Zhang H, liang Y, lv Y, Ji W (2024) Targeted m6A demethylation of ITGA6 mRNA by a multisite dCasRx\u2013m6A editor inhibits bladder cancer development. J Adv Res 56:57\u201368","journal-title":"J Adv Res"},{"issue":"3","key":"6370_CR56","first-page":"1012","volume":"10","author":"E Li","year":"2020","unstructured":"Li E, Wei B, Wang X, Kang R (2020) METTL3 enhances cell adhesion through stabilizing integrin \u03b21 mRNA via an m6A-HuR-dependent mechanism in prostatic carcinoma. Am J cancer Res 10(3):1012\u20131025","journal-title":"Am J cancer Res"},{"key":"6370_CR57","doi-asserted-by":"crossref","unstructured":"Liu Z, Sun T, Piao C, Zhang Z, Kong C (2022) METTL14-mediated N6-methyladenosine modification of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma. Cell Commun Signal 20(1):36","DOI":"10.1186\/s12964-022-00831-5"},{"issue":"11","key":"6370_CR58","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1038\/s41375-022-01696-w","volume":"36","author":"M Li","year":"2022","unstructured":"Li M, Ye J, Xia Y, Li M, Li G, Hu X, Su X, Wang D, Zhao X, Lu F, Li J, Ma D, Sun T, Ji C (2022) METTL3 mediates chemoresistance by enhancing AML homing and engraftment via ITGA4. Leukemia 36(11):2586\u20132595","journal-title":"Leukemia"},{"issue":"1","key":"6370_CR59","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.jcmgh.2022.09.013","volume":"15","author":"M Schonfeld","year":"2023","unstructured":"Schonfeld M, Villar MT, Artigues A, Weinman SA, Tikhanovich I (2023) Arginine Methylation of Integrin Alpha-4 Prevents Fibrosis Development in Alcohol-Associated Liver Disease. Cell Mol Gastroenterol Hepatol 15(1):39\u201359","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"2","key":"6370_CR60","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10616-026-00911-1","volume":"78","author":"X Xu","year":"2026","unstructured":"Xu X, Sun L, Zhang H, Pan H, Zhai C (2026) Shexiang Tongxin dropping pills attenuate cardiac remodeling in myocardial infarction rats by inhibiting Glycolysis via ITGB2 methylation. Cytotechnology 78(2):53","journal-title":"Cytotechnology"},{"issue":"6","key":"6370_CR61","doi-asserted-by":"publisher","first-page":"110129","DOI":"10.1016\/j.isci.2024.110129","volume":"27","author":"A Sidib\u00e9","year":"2024","unstructured":"Sidib\u00e9 A, Mykuliak VV, Zhang P, Hyt\u00f6nen VP, Wu J, Wehrle-Haller B (2024) Acetyl-NPKY of integrin-\u03b21 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity. iScience 27(6):110129","journal-title":"iScience"},{"issue":"3","key":"6370_CR62","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202205462","volume":"10","author":"M Wu","year":"2023","unstructured":"Wu M, Zhang J-B, Xiong Y-W, Zhao Y-X, Zheng M-G, Huang X-L, Huang F, Wu X-X, Li X, Fan W-J, Hu L, Zeng Y-Y, Cheng X-J, Yue J-C, Du J-J, Chen N-N, Wei W-X, Yao Q-H, Lu X-M, Huang C, Deng J, Chang Z-J, Liu H-B, Zhao TC, Chinn YE (2023) Promotion of lung cancer metastasis by SIRT2-mediated extracellular protein deacetylation. Adv Sci 10(3):e2205462","journal-title":"Adv Sci"},{"key":"6370_CR63","doi-asserted-by":"crossref","unstructured":"Yang F, Wang M (2025) Yin Yang 1 protein-activated N-acetyltransferase 10 drives cell malignant progression of osteosarcoma through ac4C acetylation of integrin \u03b23. J Bone Oncol 53:10070153","DOI":"10.1016\/j.jbo.2025.100701"},{"issue":"48","key":"6370_CR64","doi-asserted-by":"publisher","first-page":"9689","DOI":"10.1021\/bi3012324","volume":"51","author":"J Isaac","year":"2012","unstructured":"Isaac J, Tarapore P, Zhang X, Lam Y-W, Ho S-M (2012) Site-Specific S-Nitrosylation of Integrin \u03b16 Increases the Extent of Prostate Cancer Cell Migration by Enhancing Integrin \u03b21 Association and Weakening Adherence to Laminin-1. Biochemistry 51(48):9689\u20139697","journal-title":"Biochemistry"},{"issue":"1","key":"6370_CR65","doi-asserted-by":"publisher","first-page":"102765","DOI":"10.1016\/j.jbc.2022.102765","volume":"299","author":"Q Yao","year":"2023","unstructured":"Yao Q, Cui Q, Liu J, Xie X, Jiang T, Wang H, Zhao Z, Zhao W, Du X, Lai B, Xiao L, Wang N (2023) Free fatty acids stabilize integrin \u03b21 via S-nitrosylation to promote monocyte\u2013endothelial adhesion. J Biol Chem 299(1):102765","journal-title":"J Biol Chem"},{"issue":"21","key":"6370_CR66","doi-asserted-by":"publisher","first-page":"6429","DOI":"10.1021\/bi0620712","volume":"46","author":"GM Walsh","year":"2007","unstructured":"Walsh GM, Leane D, Moran N, Keyes TE, Forster RJ, Kenny D, O\u2019Neill S (2007) S-Nitrosylation of Platelet \u03b1IIb\u03b23 As Revealed by Raman Spectroscopy. Biochemistry 46(21):6429\u20136436","journal-title":"Biochemistry"},{"issue":"6","key":"6370_CR67","first-page":"110129","volume":"27","author":"D Veron","year":"2022","unstructured":"Veron D, Aggarwal PK, Li Q, Moeckel G, Kashgarian M, Tufro A (2022) Podocyte VEGF-A knockdown induces diffuse glomerulosclerosis in diabetic and in eNOS knockout mice. Front Pharmacol 27(6):110129","journal-title":"Front Pharmacol"},{"key":"6370_CR68","doi-asserted-by":"crossref","unstructured":"Majumdar U, Choudhury TZ, Manivannan S, Ueyama Y, Basu M, Garg V (2022) Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide. Front Cardiovasc Med 9:742850","DOI":"10.3389\/fcvm.2022.742850"},{"key":"6370_CR69","doi-asserted-by":"crossref","unstructured":"Zhai Y, Chen L, Zhao Q, Zheng Z-H, Chen Z-N, Bian H, Yang X, Lu H-Y, Lin P, Chen X, Chen R, Sun H-Y, Fan L-N, Zhang K, Wang B, Sun X-X, Feng Z, Zhu Y-M, Zhou J-S, Chen S-R, Zhang T, Chen S-Y, Chen J-J, Zhang K, Wang Y, Chang Y, Zhang R, Zhang B, Wang L-J, Li X-M, He Q, Yang X-M, Nan G, Xie R-H, Yang L, Yang J-H, Zhu P (2023) Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity. Sci 379(6637):eabg2482","DOI":"10.1126\/science.abg2482"},{"key":"6370_CR70","doi-asserted-by":"publisher","first-page":"144322","DOI":"10.1016\/j.ijbiomac.2025.144322","volume":"313","author":"L Zheng","year":"2025","unstructured":"Zheng L, Pan T, Wang H, He Z, Tian J (2025) Integrin \u03b23 N125 glycosylation is essential for human cytomegalovirus entry into fibroblasts. Int J Biol Macromol 313:144322","journal-title":"Int J Biol Macromol"},{"issue":"3","key":"6370_CR71","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.tibs.2021.11.003","volume":"47","author":"CG Gahmberg","year":"2022","unstructured":"Gahmberg CG, Gr\u00f6nholm M (2022) How integrin phosphorylations regulate cell adhesion and signaling. Trends Biochem Sci 47(3):265\u2013278","journal-title":"Trends Biochem Sci"},{"key":"6370_CR72","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.jare.2025.06.020","volume":"81","author":"H Kong","year":"2026","unstructured":"Kong H, Han J, Guo L, Zhang X-A (2026) Targeting post-translational modifications: novel insights into bone metabolic diseases. J Adv Res 81:301\u2013328","journal-title":"J Adv Res"},{"key":"6370_CR73","doi-asserted-by":"crossref","unstructured":"Cloutier G, Seltana A, Fallah S, Beaulieu J-F (2023) Integrin \u03b17\u03b21 represses intestinal absorptive cell differentiation. Experimental Cell Res 430(2):113723","DOI":"10.1016\/j.yexcr.2023.113723"},{"key":"6370_CR74","doi-asserted-by":"crossref","unstructured":"Matrullo G, Filomeni G, Rizza S (2025) Redox regulation of focal adhesions. Redox Biol 80:103514","DOI":"10.1016\/j.redox.2025.103514"},{"issue":"6","key":"6370_CR75","doi-asserted-by":"publisher","first-page":"jcs264792","DOI":"10.1242\/jcs.264792","volume":"139","author":"BH Dickson","year":"2026","unstructured":"Dickson BH, Tasnim T, Nicholson RA, Stanlake N, Lam AL, Vrieze AM, Blythe EN, Dekaban GA, Heit B (2026) Mertk coordinates efferocytosis by regulating integrin localization and activation. J Cell Sci 139(6):jcs264792","journal-title":"J Cell Sci"},{"key":"6370_CR76","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.matbio.2014.08.001","volume":"40","author":"C Zeltz","year":"2014","unstructured":"Zeltz C, Gullberg D (2014) Post-translational modifications of integrin ligands as pathogenic mechanisms in disease. Matrix Biol 40:5\u20139","journal-title":"Matrix Biol"},{"key":"6370_CR77","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.19328","volume":"13","author":"Y Li","year":"2025","unstructured":"Li Y, Peng S, Xu J, Liu W, Luo Q (2025) Integrin signaling in tumor biology: mechanisms of intercellular crosstalk and emerging targeted therapies. PeerJ 13:e19328","journal-title":"PeerJ"},{"issue":"1","key":"6370_CR78","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s12916-026-04671-9","volume":"24","author":"Q Zeng","year":"2026","unstructured":"Zeng Q, Zhang Y, Yang Y, Liu X, Dong X, Pan Y, Hu L, Zhang A, Yang J, Luo Q, Lai X, Zhu G, Zhang X, He Y (2026) Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma. BMC Med 24(1):126","journal-title":"BMC Med"},{"issue":"2","key":"6370_CR79","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2026.104601","volume":"31","author":"B Niebel","year":"2026","unstructured":"Niebel B, Chen W, Mukai K, Henry C (2026) LYTACs and other extracellular targeted protein degradation TACnologies: guiding principles and potential clinical prospects. Drug Discov Today 31(2):104601","journal-title":"Drug Discov Today"},{"issue":"7","key":"6370_CR80","doi-asserted-by":"publisher","first-page":"6897","DOI":"10.1021\/acs.jmedchem.4c02975","volume":"68","author":"M Ma","year":"2025","unstructured":"Ma M, Zhou Z, Chen H, Shen Q, Zhou J (2025) Deubiquitinase-Targeting Chimeras (DUBTACs) as a Potential Paradigm-Shifting Drug Discovery Approach. J Med Chem 68(7):6897\u20136915","journal-title":"J Med Chem"},{"issue":"33","key":"6370_CR81","doi-asserted-by":"publisher","first-page":"29875","DOI":"10.1021\/jacs.5c06306","volume":"147","author":"L Chen","year":"2025","unstructured":"Chen L, Deng Z, Xiong Y, Liu J, Huang D, Wang J, Chen Y, Inuzuka H, Xie L, Chen X, Jin J, Wei W, D.-T.C., Therapy C (2025) Deubiquitinase-Targeting Chimeras Mediated Stabilization of Tumor Suppressive E3 Ligase Proteins as a Strategy for Cancer Therapy. J Am Chem Soc 147(33):29875\u201329883","journal-title":"J Am Chem Soc"},{"issue":"6","key":"6370_CR82","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/s10585-025-10378-7","volume":"42","author":"PH Megalamani","year":"2025","unstructured":"Megalamani PH, Harduin-Lepers A, Manasa J, Gurav MJ, Sanji AS, Chachadi VB (2025) Adhesion to aggression: unravelling sLea and sLex in cancer metastasis. Clin Exp Metastasis 42(6):58","journal-title":"Clin Exp Metastasis"}],"container-title":["Cellular and Molecular Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00018-026-06370-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06370-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00018-026-06370-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:34:54Z","timestamp":1790465694000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00018-026-06370-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":82,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6370"],"URL":"https:\/\/doi.org\/10.1007\/s00018-026-06370-3","relation":{},"ISSN":["1420-9071"],"issn-type":[{"value":"1420-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"assertion":[{"value":"14 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":3,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"345"}}