{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T08:50:29Z","timestamp":1776934229081,"version":"3.51.2"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Chem Res"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s00044-021-02808-4","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T05:02:31Z","timestamp":1635310951000},"page":"2301-2315","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bio-evaluation of fluoro and trifluoromethyl-substituted salicylanilides against multidrug-resistant S. aureus"],"prefix":"10.1007","volume":"30","author":[{"given":"Jhajan","family":"Lal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Kaul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Akhir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shabina B.","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidharth","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9762-9160","authenticated-orcid":false,"given":"Damodara N.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"2808_CR1","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1179\/2047773215Y.0000000030","volume":"109","author":"F Prestinaci","year":"2015","unstructured":"Prestinaci F, Pezzotti P, Pantosti A. Antimicrobial resistance: a global multifaceted phenomenon. Pathog Glob Health. 2015;109:309\u201318. https:\/\/doi.org\/10.1179\/2047773215Y.0000000030.","journal-title":"Pathog Glob Health"},{"key":"2808_CR2","doi-asserted-by":"publisher","first-page":"275","DOI":"10.4103\/0974-777x.68535","volume":"2","author":"PS Loomba","year":"2010","unstructured":"Loomba PS, Taneja J, Mishra B. Methicillin and vancomycin resistant S. aureus in hospitalized patients. J Glob Infect Dis. 2010;2:275\u201383. https:\/\/doi.org\/10.4103\/0974-777x.68535.","journal-title":"J Glob Infect Dis"},{"key":"2808_CR3","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1086\/317542","volume":"32","author":"SK Fridkin","year":"2001","unstructured":"Fridkin SK. Vancomycin-intermediate and -resistant Staphylococcus aureus: what the infectious disease specialist needs to know. Clin Infect Dis. 2001;32:108\u201315. https:\/\/doi.org\/10.1086\/317542.","journal-title":"Clin Infect Dis"},{"key":"2808_CR4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jare.2019.10.005","volume":"21","author":"Y Cong","year":"2020","unstructured":"Cong Y, Yang S, Rao X. Vancomycin resistant Staphylococcus aureus infections: a review of case updating and clinical features. J Adv Res. 2020;21:169\u201376. https:\/\/doi.org\/10.1016\/j.jare.2019.10.005.","journal-title":"J Adv Res"},{"key":"2808_CR5","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nrmicro.2017.42","volume":"15","author":"RA Fisher","year":"2017","unstructured":"Fisher RA, Gollan B, Helaine S. Persistent bacterial infections and persister cells. Nat Rev Microbiol. 2017;15:453\u201364. https:\/\/doi.org\/10.1038\/nrmicro.2017.42.","journal-title":"Nat Rev Microbiol"},{"key":"2808_CR6","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1586\/14787210.2015.1100533","volume":"13","author":"M Bhattacharya","year":"2015","unstructured":"Bhattacharya M, Wozniak DJ, Stoodley P, Hall-Stoodley L. Prevention and treatment of Staphylococcus aureus biofilms. Expert Rev Anti Infect Ther. 2015;13:1499\u2013516. https:\/\/doi.org\/10.1586\/14787210.2015.1100533.","journal-title":"Expert Rev Anti Infect Ther"},{"key":"2808_CR7","doi-asserted-by":"publisher","first-page":"e1006012","DOI":"10.1371\/journal.ppat.1006012","volume":"12","author":"EM Waters","year":"2016","unstructured":"Waters EM, Rowe SE, O\u2019Gara JP, Conlon BP. Convergence of Staphylococcus aureus persister and biofilm research: can biofilms be defined as communities of adherent persister cells? PLoS Pathog. 2016;12:e1006012 https:\/\/doi.org\/10.1371\/journal.ppat.1006012.","journal-title":"PLoS Pathog"},{"key":"2808_CR8","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1093\/cid\/cis527","volume":"55","author":"P Tattevin","year":"2012","unstructured":"Tattevin P, Schwartz BS, Graber CJ, Volinski J, Bhukhen A, Bhukhen A. et al. Concurrent epidemics of skin and soft tissue infection and bloodstream infection due to community-associated methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2012;55:781\u20138. https:\/\/doi.org\/10.1093\/cid\/cis527.","journal-title":"Clin Infect Dis"},{"key":"2808_CR9","doi-asserted-by":"publisher","DOI":"10.1186\/cc13948","volume":"18","author":"B Spellberg","year":"2014","unstructured":"Spellberg B. The future of antibiotics. Crit Care. 2014;18:228 https:\/\/doi.org\/10.1186\/cc13948.","journal-title":"Crit Care"},{"key":"2808_CR10","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41429-020-0291-8","volume":"73","author":"MS Butler","year":"2020","unstructured":"Butler MS, Paterson DL. Antibiotics in the clinical pipeline in October 2019. J Antibiot. 2020;73:329\u201364. https:\/\/doi.org\/10.1038\/s41429-020-0291-8.","journal-title":"J Antibiot"},{"key":"2808_CR11","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1172\/jci18535","volume":"111","author":"FD Lowy","year":"2003","unstructured":"Lowy FD. Antimicrobial resistance: the example of Staphylococcus aureus. J Clin Invest. 2003;111:1265\u201373. https:\/\/doi.org\/10.1172\/jci18535.","journal-title":"J Clin Invest"},{"key":"2808_CR12","doi-asserted-by":"publisher","first-page":"8375","DOI":"10.1021\/jm3007596","volume":"55","author":"A Fomovska","year":"2012","unstructured":"Fomovska A, Wood RD, Mui E, Dubey JP, Ferreira LR, Hickman MR. et al. Salicylanilide inhibitors of Toxoplasma gondii. J Med Chem. 2012;55:8375\u201391. https:\/\/doi.org\/10.1021\/jm3007596.","journal-title":"J Med Chem"},{"key":"2808_CR13","doi-asserted-by":"publisher","first-page":"2939","DOI":"10.1021\/jm9803572","volume":"41","author":"MJ Macielag","year":"1998","unstructured":"Macielag MJ, Demers JP, Fraga-Spano SA, Hlasta DJ, Johnson SG, Kanojia RM. et al. Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria. J Med Chem. 1998;41:2939\u201345. https:\/\/doi.org\/10.1021\/jm9803572.","journal-title":"J Med Chem"},{"key":"2808_CR14","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/sj.bjp.0706873","volume":"149","author":"R De La Fuente","year":"2006","unstructured":"De La Fuente R, Sonawane ND, Arumainayagam D, Verkman AS. Small molecules with antimicrobial activity against E. coli and P. aeruginosa identified by high-throughput screening. Br J Pharm. 2006;149:551\u20139. https:\/\/doi.org\/10.1038\/sj.bjp.0706873.","journal-title":"Br J Pharm"},{"key":"2808_CR15","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.bmcl.2008.11.080","volume":"19","author":"A Imramovsk\u00fd","year":"2009","unstructured":"Imramovsk\u00fd A, Vin\u0161ov\u00e1 J, F\u00e9rriz JM, Buchta V, Jamp\u00edlek J. Salicylanilide esters of N-protected amino acids as novel antimicrobial agents. Bioorg Med Chem Lett. 2009;19:348\u201351. https:\/\/doi.org\/10.1016\/j.bmcl.2008.11.080.","journal-title":"Bioorg Med Chem Lett"},{"key":"2808_CR16","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.bmc.2012.10.056","volume":"21","author":"I-Y Lee","year":"2013","unstructured":"Lee I-Y, Gruber TD, Samuels A, Yun M, Nam B, Kang M. et al. Structure\u2013activity relationships of antitubercular salicylanilides consistent with disruption of the proton gradient via proton shuttling. Bioorg Med Chem. 2013;21:114\u201326. https:\/\/doi.org\/10.1016\/j.bmc.2012.10.056.","journal-title":"Bioorg Med Chem"},{"key":"2808_CR17","doi-asserted-by":"publisher","first-page":"426","DOI":"10.5606\/ArchRheumatol.2019.7100","volume":"34","author":"A Al-Gareeb","year":"2019","unstructured":"Al-Gareeb A, Gorial F, Mahmood A. The anti-rheumatoid activity of niclosamide in collagen-induced arthritis in rats. Arch Rheumatol. 2019;34:426\u201333. https:\/\/doi.org\/10.5606\/ArchRheumatol.2019.7100.","journal-title":"Arch Rheumatol"},{"key":"2808_CR18","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.21873\/anticanres.14082","volume":"40","author":"WH Chai","year":"2020","unstructured":"Chai WH, Li YR, Lin SH, Chao YH, Chen CH, Chan PC. et al. Antihelminthic niclosamide induces autophagy and delayed apoptosis inhuman non-small lung cancer cells in vitro and in vivo. Anticancer Res. 2020;40:1405\u201317. https:\/\/doi.org\/10.21873\/anticanres.14082.","journal-title":"Anticancer Res"},{"key":"2808_CR19","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1021\/acsinfecdis.0c00052","volume":"6","author":"J Xu","year":"2020","unstructured":"Xu J, Shi PY, Li H, Zhou J. Broad spectrum antiviral agent niclosamide and its therapeutic potential. ACS Infect Dis. 2020;6:909\u201315. https:\/\/doi.org\/10.1021\/acsinfecdis.0c00052.","journal-title":"ACS Infect Dis"},{"key":"2808_CR20","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1021\/acs.jmedchem.9b01950","volume":"63","author":"J Xu","year":"2020","unstructured":"Xu J, Berastegui-Cabrera J, Chen H, Pach\u00f3n J, Zhou J, S\u00e1nchez-C\u00e9spedes J. Structure\u2013activity relationship studies on diversified salicylanilide derivatives as potent inhibitors of human adenovirus infection. J Med Chem. 2020;63:3142\u201360. https:\/\/doi.org\/10.1021\/acs.jmedchem.9b01950.","journal-title":"J Med Chem"},{"key":"2808_CR21","doi-asserted-by":"publisher","first-page":"e89189","DOI":"10.1371\/journal.pone.0089189","volume":"9","author":"R Rajamuthiah","year":"2014","unstructured":"Rajamuthiah R, Fuchs BB, Jayamani E, Kim Y, Larkins-Ford J, Conery A. et al. Whole animal automated platform for drug discovery against multi-drug resistant Staphylococcus aureus. PLoS One. 2014;9:e89189. https:\/\/doi.org\/10.1371\/journal.pone.0089189.","journal-title":"PLoS One"},{"key":"2808_CR22","doi-asserted-by":"publisher","first-page":"e0124595","DOI":"10.1371\/journal.pone.0124595","volume":"10","author":"R Rajamuthiah","year":"2015","unstructured":"Rajamuthiah R, Fuchs BB, Conery AL, Kim W, Jayamani E, Kwon B. et al. Repurposing salicylanilide anthelmintic drugs to combat drug resistant Staphylococcus aureus. PLoS One. 2015;10:e0124595. https:\/\/doi.org\/10.1371\/journal.pone.0124595.","journal-title":"PLoS One"},{"key":"2808_CR23","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.ijantimicag.2018.02.003","volume":"51","author":"H Mohammad","year":"2018","unstructured":"Mohammad H, AbdelKhalek A, Abutaleb NS, Seleem MN. Repurposing niclosamide for intestinal decolonization of vancomycin-resistant enterococci. Int J Antimicrob Agents. 2018;51:897\u2013904. https:\/\/doi.org\/10.1016\/j.ijantimicag.2018.02.003.","journal-title":"Int J Antimicrob Agents"},{"key":"2808_CR24","doi-asserted-by":"publisher","first-page":"665","DOI":"10.3390\/antibiotics9100665","volume":"9","author":"IE Escobar","year":"2020","unstructured":"Escobar IE, White A, Kim W, Mylonakis E. New antimicrobial bioactivity against multidrug-resistant gram-positive bacteria of kinase inhibitor IMD0354. Antibiotics. 2020;9:665 https:\/\/doi.org\/10.3390\/antibiotics9100665.","journal-title":"Antibiotics"},{"key":"2808_CR25","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0163-7258(82)90064-x","volume":"19","author":"P Andrews","year":"1982","unstructured":"Andrews P, Thyssen J, Lorke D. The biology and toxicology of molluscicides, Bayluscide. Pharm Ther. 1982;19:245\u201395. https:\/\/doi.org\/10.1016\/0163-7258(82)90064-x.","journal-title":"Pharm Ther"},{"key":"2808_CR26","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1016\/j.bmcl.2019.03.032","volume":"29","author":"J Xu","year":"2019","unstructured":"Xu J, Pach\u00f3n-Ib\u00e1\u00f1ez ME, Cebrero-Cangueiro T, Chen H, S\u00e1nchez-C\u00e9spedes J, Zhou J. Discovery of niclosamide and its O-alkylamino-tethered derivatives as potent antibacterial agents against carbapenemase-producing and\/or colistin resistant Enterobacteriaceae isolates. Bioorg Med Chem Lett. 2019;29:1399\u2013402. https:\/\/doi.org\/10.1016\/j.bmcl.2019.03.032.","journal-title":"Bioorg Med Chem Lett"},{"key":"2808_CR27","doi-asserted-by":"publisher","first-page":"5822","DOI":"10.1021\/acs.jmedchem.7b01788","volume":"61","author":"NA Meanwell","year":"2018","unstructured":"Meanwell NA. Fluorine and fluorinated motifs in the design and application of bioisosteres for drug design. J Med Chem. 2018;61:5822\u201380. https:\/\/doi.org\/10.1021\/acs.jmedchem.7b01788.","journal-title":"J Med Chem"},{"key":"2808_CR28","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1002\/chem.202003135","volume":"27","author":"R Hevey","year":"2021","unstructured":"Hevey R. The role of fluorine in glycomimetic drug design. Chem Eur J. 2021;27:2240\u201353. https:\/\/doi.org\/10.1002\/chem.202003135.","journal-title":"Chem Eur J"},{"key":"2808_CR29","doi-asserted-by":"publisher","first-page":"10633","DOI":"10.1021\/acsomega.0c00830","volume":"5","author":"M Inoue","year":"2020","unstructured":"Inoue M, Sumii Y, Shibata N. Contribution of organofluorine compounds to pharmaceuticals. ACS Omega. 2020;5:10633\u201340. https:\/\/doi.org\/10.1021\/acsomega.0c00830.","journal-title":"ACS Omega"},{"key":"2808_CR30","doi-asserted-by":"publisher","first-page":"109","DOI":"10.4103\/0974-2727.119862","volume":"5","author":"ND Gade","year":"2013","unstructured":"Gade ND, Qazi MS. Fluoroquinolone therapy in Staphylococcus aureus infections: where do we stand? J Lab Physicians. 2013;5:109\u201312. https:\/\/doi.org\/10.4103\/0974-2727.119862.","journal-title":"J Lab Physicians"},{"key":"2808_CR31","doi-asserted-by":"publisher","unstructured":"Piccionello AP, Pibiri I, Buscemi S, Pace A. Recent development in fluorinated antibiotics. Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals. Elsevier Inc. 2019. https:\/\/doi.org\/10.1016\/B978-0-12-812733-9.00005-2.","DOI":"10.1016\/B978-0-12-812733-9.00005-2"},{"key":"2808_CR32","doi-asserted-by":"publisher","first-page":"634","DOI":"10.3109\/0886022X.2012.660855","volume":"34","author":"I Kocyigit","year":"2012","unstructured":"Kocyigit I, Dortdudak S, Sipahioglu M, Unal A, Yucel HE, Tokgoz B. et al. Levofloxacin-induced delirium: is it a dangerous drug in patients with renal dysfunction? Ren Fail. 2012;34:634\u20136. https:\/\/doi.org\/10.3109\/0886022X.2012.660855.","journal-title":"Ren Fail"},{"key":"2808_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.drup.2014.04.002","volume":"17","author":"RE Mendes","year":"2014","unstructured":"Mendes RE, Deshpande LM, Jones RN. Linezolid update: stable in vitro activity following more than a decade of clinical use and summary of associated resistance mechanisms. Drug Resist Updat. 2014;17:1\u201312. https:\/\/doi.org\/10.1016\/j.drup.2014.04.002.","journal-title":"Drug Resist Updat"},{"key":"2808_CR34","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1093\/jac\/dks354","volume":"68","author":"B Gu","year":"2013","unstructured":"Gu B, Kelesidis T, Tsiodras S, Hindler J, Humphries RM. The emerging problem of linezolid-resistant Staphylococcus. J Antimicrob Chemother. 2013;68:4\u201311. https:\/\/doi.org\/10.1093\/jac\/dks354.","journal-title":"J Antimicrob Chemother"},{"key":"2808_CR35","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/j.ijantimicag.2019.03.024","volume":"53","author":"R Thakare","year":"2019","unstructured":"Thakare R, Shukla M, Kaul G, Dasgupta A, Chopra S. Repurposing disulfiram for treatment of Staphylococcus aureus infections. Int J Antimicrob Agents. 2019;53:709\u201315. https:\/\/doi.org\/10.1016\/j.ijantimicag.2019.03.024.","journal-title":"Int J Antimicrob Agents"},{"key":"2808_CR36","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ejmech.2018.02.057","volume":"149","author":"DN Reddy","year":"2018","unstructured":"Reddy DN, Singh S, Ho CMW, Patel J, Schlesinger P, Rodgers S. et al. Design, synthesis, and biological evaluation of stable \u03b2(6.3)-Helices: discovery of non-hemolytic antibacterial peptides. Eur J Med Chem. 2018;149:193\u2013210. https:\/\/doi.org\/10.1016\/j.ejmech.2018.02.057.","journal-title":"Eur J Med Chem"},{"key":"2808_CR37","volume-title":"Performance standards for antimicrobial susceptibility testing; twenty-first informational supplement. CLSI document M100-S21","author":"CLSI.","year":"2012","unstructured":"CLSI. Performance standards for antimicrobial susceptibility testing; twenty-first informational supplement. CLSI document M100-S21. Wayne, PA: Clinical and Laboratory Standards Institute; 2012."},{"key":"2808_CR38","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/bjc.1987.190","volume":"56","author":"PR Twentyman","year":"1987","unstructured":"Twentyman PR, Luscombe M. A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity. Br J Cancer. 1987;56:279\u201385. https:\/\/doi.org\/10.1038\/bjc.1987.190.","journal-title":"Br J Cancer"},{"key":"2808_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/jac\/dkg301","volume":"52","author":"FC Odds","year":"2003","unstructured":"Odds FC. Synergy, antagonism, and what the chequerboard puts between them. J Antimicrob Chemother. 2003;52:1 https:\/\/doi.org\/10.1093\/jac\/dkg301.","journal-title":"J Antimicrob Chemother"}],"container-title":["Medicinal Chemistry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00044-021-02808-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00044-021-02808-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00044-021-02808-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T23:12:08Z","timestamp":1744153928000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00044-021-02808-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,27]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["2808"],"URL":"https:\/\/doi.org\/10.1007\/s00044-021-02808-4","relation":{},"ISSN":["1054-2523","1554-8120"],"issn-type":[{"value":"1054-2523","type":"print"},{"value":"1554-8120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,27]]},"assertion":[{"value":"23 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}