{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:28:04Z","timestamp":1786519684207,"version":"build-2736575974"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100019550","name":"Scheme for Promotion of Academic and Research Collaboration","doi-asserted-by":"publisher","award":["SPARC\/2024-2025\/HCARE\/P3444"],"award-info":[{"award-number":["SPARC\/2024-2025\/HCARE\/P3444"]}],"id":[{"id":"10.13039\/501100019550","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Chem Res"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1007\/s00044-026-03596-5","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:16:48Z","timestamp":1784265408000},"page":"1515-1528","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and synthesis of pyrrolo[2,3-d]pyrimidine linked diazospiro and piperazine \u2013 piperidine libraries as anticancer agents"],"prefix":"10.1007","volume":"35","author":[{"given":"Sridhar","family":"Guda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9179-3768","authenticated-orcid":false,"given":"Srilakshmi V","family":"Patri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Reddy V","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Thumma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh Kumar","family":"Guru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"3596_CR1","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1039\/D3MD00479A","volume":"15","author":"V Thumma","year":"2024","unstructured":"Thumma V, Mallikanti V, Matta R, Dharavath R, Jalapathi P. RSC Med Chem. 2024;15:1283.","journal-title":"RSC Med Chem"},{"key":"3596_CR2","doi-asserted-by":"publisher","first-page":"e202204020","DOI":"10.1002\/slct.202204020","volume":"7","author":"V Mallikanti","year":"2022","unstructured":"Mallikanti V, Thumma V, Veeranki KC, Gali S. J Pochampally ChemistrySelect. 2022;7:e202204020.","journal-title":"J Pochampally ChemistrySelect"},{"key":"3596_CR3","doi-asserted-by":"publisher","first-page":"143865","DOI":"10.1016\/j.molstruc.2025.143865","volume":"1349","author":"R Bhukya","year":"2026","unstructured":"Bhukya R, Vanga MK, Thumma V, Mudiraj A, Ranjan N, Phanithi PB, et al. J Mol Struct. 2026;1349:143865.","journal-title":"J Mol Struct"},{"key":"3596_CR4","doi-asserted-by":"publisher","first-page":"e202404362","DOI":"10.1002\/slct.202404362","volume":"10","author":"S Rejinthala","year":"2025","unstructured":"Rejinthala S, Endoori S, Thumma V, Mondal T. ChemistrySelect. 2025;10:e202404362.","journal-title":"ChemistrySelect"},{"key":"3596_CR5","doi-asserted-by":"publisher","first-page":"e202403184","DOI":"10.1002\/cbdv.202403184","volume":"22","author":"R Bhukya","year":"2025","unstructured":"Bhukya R, Vanga MK, Bhukya C, Thumma V, Jadhav R. Chem Biodivers. 2025;22:e202403184.","journal-title":"Chem Biodivers"},{"key":"3596_CR6","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.jhep.2022.08.021","volume":"77","author":"H Rumgay","year":"2022","unstructured":"Rumgay H, Arnold M, Ferlay J, Lesi O, Cabasag CJ, Vignat J, et al. J Hepatol. 2022;77:1598.","journal-title":"J Hepatol"},{"key":"3596_CR7","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1039\/D4MD00015C","volume":"15","author":"MK Vanga","year":"2024","unstructured":"Vanga MK, Bhukya R, Thumma V, Ambadipudi SSSSS, Nayak VL, Andugulapati SB, et al. RSC Med Chem. 2024;15:1709.","journal-title":"RSC Med Chem"},{"key":"3596_CR8","doi-asserted-by":"publisher","first-page":"363","DOI":"10.2174\/1568026620999201124154231","volume":"21","author":"C Shang","year":"2021","unstructured":"Shang C, Hou Y, Meng T, Shi M, Cui G. Curr Top Med Chem. 2021;21:363.","journal-title":"Curr Top Med Chem"},{"key":"3596_CR9","doi-asserted-by":"publisher","first-page":"109157","DOI":"10.1016\/j.bioorg.2025.109157","volume":"166","author":"SY Ewieda","year":"2025","unstructured":"Ewieda SY, Ahmed EM, Gohar NA, Ibrahim SG, Essa MA, Nemr MTM. Bioorg Chem. 2025;166:109157.","journal-title":"Bioorg Chem"},{"key":"3596_CR10","doi-asserted-by":"publisher","first-page":"109486","DOI":"10.1016\/j.bioorg.2026.109486","volume":"170","author":"SY Ewieda","year":"2026","unstructured":"Ewieda SY, Ahmed EM, Halim PA, Ibrahim SG, Gouda KM, Abdalla M, et al. Bioorg Chem. 2026;170:109486.","journal-title":"Bioorg Chem"},{"key":"3596_CR11","doi-asserted-by":"publisher","first-page":"107534","DOI":"10.1016\/j.bioorg.2024.107534","volume":"150","author":"T Li","year":"2024","unstructured":"Li T, Zhou Y, Fu X, Yang L, Liu H, Zhou X, et al. Bioorg Chem. 2024;150:107534.","journal-title":"Bioorg Chem"},{"key":"3596_CR12","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1111\/cas.14554","volume":"111","author":"Y Yap","year":"2020","unstructured":"Yap Y, Chiu J, Ito Y, Ishikawa T, Aruga T, Kim SJ, et al. Cancer Sci. 2020;111:3313.","journal-title":"Cancer Sci"},{"key":"3596_CR13","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1021\/acs.jmedchem.0c01952","volume":"64","author":"RR Davis","year":"2021","unstructured":"Davis RR, Li B, Yun SY, Chan A, Nareddy P, Gunawan S, et al. J Med Chem. 2021;64:2228.","journal-title":"J Med Chem"},{"key":"3596_CR14","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1186\/1471-2474-14-298","volume":"14","author":"Y He","year":"2013","unstructured":"He Y, Wong AY, Chan EW, Lau WC, Man KK, Chui CS, et al. BMC Musculoskelet Disord. 2013;14:298.","journal-title":"BMC Musculoskelet Disord"},{"key":"3596_CR15","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1002\/phar.2438","volume":"40","author":"SCJ Jorgensen","year":"2020","unstructured":"Jorgensen SCJ, Tse CLY, Burry L, Dresser LD. Pharmacotherapy: J Hum Pharmacol Drug Therapy. 2020;40:843.","journal-title":"Pharmacotherapy: J Hum Pharmacol Drug Therapy"},{"key":"3596_CR16","doi-asserted-by":"publisher","first-page":"107867","DOI":"10.1016\/j.bioorg.2024.107867","volume":"153","author":"M Sai Madhurya","year":"2024","unstructured":"Sai Madhurya M, Thakur V, Dastari S, Shankaraiah N. Bioorg Chem. 2024;153:107867.","journal-title":"Bioorg Chem"},{"key":"3596_CR17","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1055\/s-0044-101256","volume":"68","author":"M Adel","year":"2018","unstructured":"Adel M, Serya R, Lasheen D, Abouzid K. Drug Res. 2018;68:485.","journal-title":"Drug Res"},{"key":"3596_CR18","doi-asserted-by":"publisher","first-page":"108672","DOI":"10.1016\/j.bioorg.2025.108672","volume":"163","author":"SY Ewieda","year":"2025","unstructured":"Ewieda SY, Salem M, Elshewy A, Abdalla M, El-Manawaty M, Abdelhady HK, et al. Bioorg Chem. 2025;163:108672.","journal-title":"Bioorg Chem"},{"key":"3596_CR19","doi-asserted-by":"crossref","unstructured":"Nemr MTM, Fadaly WAA, Abdelaziz MA. ChemistrySelect 2025;10.","DOI":"10.1002\/slct.202504601"},{"key":"3596_CR20","doi-asserted-by":"crossref","unstructured":"Nemr MTM, Mohamed LW, Sayed HS, Mikhail DS. Drug Dev Res. 2026;87:e70259","DOI":"10.1002\/ddr.70259"},{"key":"3596_CR21","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.3390\/ijms24032937","volume":"24","author":"NA Frolov","year":"2023","unstructured":"Frolov NA, Vereshchagin AN. Int J Mol Sci. 2023;24:2937.","journal-title":"Int J Mol Sci"},{"key":"3596_CR22","doi-asserted-by":"crossref","unstructured":"Vardanyan R. Piperidine-Based Drug Discovery. Elsevier; 2017. pp. 299\u2013332.","DOI":"10.1016\/B978-0-12-805157-3.00010-7"},{"key":"3596_CR23","doi-asserted-by":"publisher","first-page":"798","DOI":"10.2174\/1570193X19666220119120211","volume":"19","author":"S Alghamdi","year":"2022","unstructured":"Alghamdi S, Alshehri MM, Asif M. Mini Rev Org Chem. 2022;19:798.","journal-title":"Mini Rev Org Chem"},{"key":"3596_CR24","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1002\/cmdc.202100045","volume":"16","author":"RR Kumar","year":"2021","unstructured":"Kumar RR, Sahu B, Pathania S, Singh PK, Akhtar MJ, Kumar B. ChemMedChem. 2021;16:1878.","journal-title":"ChemMedChem"},{"key":"3596_CR25","doi-asserted-by":"publisher","first-page":"e202302393","DOI":"10.1002\/slct.202302393","volume":"8","author":"S Ambala","year":"2023","unstructured":"Ambala S, Thumma V, Mallikanti V, Aitha S, Matta R. J Pochampally ChemistrySelect. 2023;8:e202302393.","journal-title":"J Pochampally ChemistrySelect"},{"key":"3596_CR26","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s11094-022-02597-z","volume":"56","author":"M Al-Ghorbani","year":"2022","unstructured":"Al-Ghorbani M, Gouda MA, Baashen M, Alharbi O, Almalki FA, Ranganatha LV. Pharm Chem J. 2022;56:29.","journal-title":"Pharm Chem J"},{"key":"3596_CR27","doi-asserted-by":"publisher","first-page":"26311","DOI":"10.1021\/acs.jmedchem.5c02429","volume":"68","author":"J Wu","year":"2025","unstructured":"Wu J, Ma C, Wei M, Chen X, Wang W, Gao J, et al. J Med Chem. 2025;68:26311.","journal-title":"J Med Chem"},{"key":"3596_CR28","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1021\/acschemneuro.3c00074","volume":"14","author":"M Dichiara","year":"2023","unstructured":"Dichiara M, Ambrosio FA, Barbaraci C, Gonz\u00e1lez-Cano R, Costa G, Parenti C, et al. ACS Chem Neurosci. 2023;14:1845.","journal-title":"ACS Chem Neurosci"},{"key":"3596_CR29","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1039\/D1NJ02453A","volume":"46","author":"MSR Gangireddy","year":"2022","unstructured":"Gangireddy MSR, Badavath VN, Velez C, Loeanurit N, Thakur A, Maddipati VC, et al. New J Chem. 2022;46:1087.","journal-title":"New J Chem"},{"key":"3596_CR30","doi-asserted-by":"crossref","unstructured":"Adarasandi R, Gundla R, Paidikondala K, Putta P, Lakkoju B, Kolli B. ChemistrySelect. 2025;10.","DOI":"10.1002\/slct.202404738"},{"key":"3596_CR31","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.1158\/0008-5472.CAN-14-2312","volume":"75","author":"SK Guru","year":"2015","unstructured":"Guru SK, Pathania AS, Kumar S, Ramesh D, Kumar M, Rana S, et al. Cancer Res. 2015;75:2886.","journal-title":"Cancer Res"}],"container-title":["Medicinal Chemistry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00044-026-03596-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00044-026-03596-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00044-026-03596-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T06:34:52Z","timestamp":1786516492000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00044-026-03596-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,17]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["3596"],"URL":"https:\/\/doi.org\/10.1007\/s00044-026-03596-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9892839\/v1","asserted-by":"object"}]},"ISSN":["1054-2523","1554-8120"],"issn-type":[{"value":"1054-2523","type":"print"},{"value":"1554-8120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,17]]},"assertion":[{"value":"2 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}