{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:20:24Z","timestamp":1788344424544,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ministry of Higher Education, Science, and Technology of the Republic of Indonesia","award":["206\/UN19.5.1.3\/AL.04\/2026"],"award-info":[{"award-number":["206\/UN19.5.1.3\/AL.04\/2026"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Chem Res"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s00044-026-03608-4","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:21:41Z","timestamp":1786692101000},"page":"1774-1800","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and mechanistic evaluation of chalcone\u2013quinoline\u2013triazole hybrids as antifungal CYP51 inhibitors"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1103-8261","authenticated-orcid":false,"given":"Rudi","family":"Hendra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahmad Setiawan","family":"Rabby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengku Anggia","family":"Fitri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilwan Yuda","family":"Teruna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neni","family":"Frimayanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"3608_CR1","unstructured":"Division WHOAR, WHOCoNT D. Partnership; WHOGCa. WHO fungal priority pathogens list to guide research, development and public health action. World Health Organization; 2022."},{"issue":"1","key":"3608_CR2","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1186\/s12879-024-09442-6","volume":"24","author":"A Keyvanfar","year":"2024","unstructured":"Keyvanfar A, Najafiarab H, Talebian N, Tafti MF, Adeli G, Ghasemi Z, et al. Drug-resistant oral candidiasis in patients with HIV infection: a systematic review and meta-analysis. BMC Infect Dis. 2024;24(1):546.","journal-title":"BMC Infect Dis"},{"issue":"9","key":"3608_CR3","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3390\/jof9090913","volume":"9","author":"ML Cristina","year":"2023","unstructured":"Cristina ML, Spagnolo AM, Sartini M, Carbone A, Oliva M, Schinca E, et al. An overview on Candida auris in healthcare settings. J Fungi. 2023;9(9):913. https:\/\/doi.org\/10.3390\/jof9090913.","journal-title":"J Fungi"},{"issue":"4","key":"3608_CR4","doi-asserted-by":"publisher","first-page":"641","DOI":"10.3390\/stresses4040041","volume":"4","author":"D Elia\u0161","year":"2024","unstructured":"Elia\u0161 D, T\u00f3th Hervay N, Gbelsk\u00e1 Y. Ergosterol Biosynthesis and Regulation Impact the Antifungal Resistance and Virulence of Candida spp. Stresses. 2024;4(4):641\u201362. https:\/\/doi.org\/10.3390\/stresses4040041.","journal-title":"Stresses"},{"issue":"1","key":"3608_CR5","doi-asserted-by":"publisher","first-page":"68","DOI":"10.2174\/0118715249274215231205062701","volume":"24","author":"N Singh","year":"2024","unstructured":"Singh N, Kumari V, Agrawal K, Kulshreshtha M. Molecular Pathway, Epidemiological Data and Treatment Strategies of Fungal Infection (Mycoses): A Comprehensive Review. Cent Nerv Syst Agents Med Chem. 2024;24(1):68\u201381. https:\/\/doi.org\/10.2174\/0118715249274215231205062701.","journal-title":"Cent Nerv Syst Agents Med Chem"},{"issue":"3","key":"3608_CR6","doi-asserted-by":"publisher","first-page":"140206","DOI":"10.1016\/j.bbapap.2019.02.008","volume":"1868","author":"BC Monk","year":"2020","unstructured":"Monk BC, Sagatova AA, Hosseini P, Ruma YN, Wilson RK, Keniya MV. Fungal Lanosterol 14\u03b1-demethylase: A target for next-generation antifungal design. Biochim et Biophys Acta (BBA)-Proteins Proteom. 2020;1868(3):140206. https:\/\/doi.org\/10.1016\/j.bbapap.2019.02.008.","journal-title":"Biochim et Biophys Acta (BBA)-Proteins Proteom"},{"issue":"14","key":"3608_CR7","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1002\/cmdc.202000250","volume":"15","author":"FA Binjubair","year":"2020","unstructured":"Binjubair FA, Parker JE, Warrilow AG, Puri K, Braidley PJ, Tatar E, et al. Small-molecule inhibitors targeting sterol 14\u03b1\u2010Demethylase (CYP51): synthesis, molecular modelling and evaluation against Candida albicans. ChemMedChem. 2020;15(14):1294\u2013309. https:\/\/doi.org\/10.1002\/cmdc.202000250.","journal-title":"ChemMedChem"},{"issue":"13","key":"3608_CR8","doi-asserted-by":"publisher","first-page":"7075","DOI":"10.1080\/07391102.2025.2479847","volume":"43","author":"RSP Rao","year":"2025","unstructured":"Rao RSP, Pinto L, Suravajhala R, Shenoy BD, Sashindran V, Ghate SD. Azole resistance: insights from Y132 substitutions in Candida sterol 14\u03b1-demethylase utilizing molecular dynamics simulations. J Biomol Struct Dyn. 2025;43(13):7075\u201383. https:\/\/doi.org\/10.1080\/07391102.2025.2479847.","journal-title":"J Biomol Struct Dyn"},{"issue":"1","key":"3608_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14656566.2024.2433605","volume":"26","author":"J Raposa","year":"2025","unstructured":"Raposa J, Vazquez JA. New pharmacotherapeutic strategies for drug-resistant Candida infections: a review. Expert Opin Pharmacother. 2025;26(1):1\u201311. https:\/\/doi.org\/10.1080\/14656566.2024.2433605.","journal-title":"Expert Opin Pharmacother"},{"issue":"22","key":"3608_CR10","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.3390\/cells12222655","volume":"12","author":"KM Czajka","year":"2023","unstructured":"Czajka KM, Venkataraman K, Brabant-Kirwan D, Santi SA, Verschoor C, Appanna VD, et al. Molecular mechanisms associated with antifungal resistance in pathogenic Candida species. Cells. 2023;12(22):2655. https:\/\/doi.org\/10.3390\/cells12222655.","journal-title":"Cells"},{"issue":"5","key":"3608_CR11","doi-asserted-by":"publisher","first-page":"4367","DOI":"10.1021\/acsomega.4c06897","volume":"10","author":"R Ahsan","year":"2025","unstructured":"Ahsan R, Paul S, Alam MS, Rahman AM. Synthesis, biological properties, in silico ADME, molecular docking studies, and FMO analysis of chalcone derivatives as promising antioxidant and antimicrobial agents. ACS omega. 2025;10(5):4367\u201387. https:\/\/doi.org\/10.1021\/acsomega.4c06897.","journal-title":"ACS omega"},{"issue":"11","key":"3608_CR12","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.3390\/ph14111131","volume":"14","author":"M Gargantilla","year":"2021","unstructured":"Gargantilla M, L\u00f3pez-Fern\u00e1ndez J, Camarasa M-J, Persoons L, Daelemans D, Priego E-M, et al. Inhibition of XPO-1 mediated nuclear export through the michael-acceptor character of chalcones. Pharmaceuticals. 2021;14(11):1131. https:\/\/doi.org\/10.3390\/ph14111131.","journal-title":"Pharmaceuticals"},{"key":"3608_CR13","doi-asserted-by":"publisher","first-page":"129927","DOI":"10.1016\/j.bmcl.2024.129927","volume":"112","author":"R Khandelwal","year":"2024","unstructured":"Khandelwal R, Vasava M, Abhirami R, Karsharma M. Recent advances in triazole synthesis via click chemistry and their pharmacological applications: A review. Bioorg Med Chem Lett. 2024;112:129927. https:\/\/doi.org\/10.1016\/j.bmcl.2024.129927.","journal-title":"Bioorg Med Chem Lett"},{"key":"3608_CR14","doi-asserted-by":"publisher","first-page":"127984","DOI":"10.1016\/j.bmcl.2021.127984","volume":"41","author":"AR Nesaragi","year":"2021","unstructured":"Nesaragi AR, Kamble RR, Bayannavar PK, Shaikh SKJ, Hoolageri SR, Kodasi B, et al. Microwave assisted regioselective synthesis of quinoline appended triazoles as potent anti-tubercular and antifungal agents via copper (I) catalyzed cycloaddition. Bioorg Med Chem Lett. 2021;41:127984. https:\/\/doi.org\/10.1016\/j.bmcl.2021.127984.","journal-title":"Bioorg Med Chem Lett"},{"key":"3608_CR15","doi-asserted-by":"publisher","first-page":"101173","DOI":"10.1016\/j.rechem.2023.101173","volume":"6","author":"A Bhukal","year":"2023","unstructured":"Bhukal A, Kumar V, Kumar L, Lal K. Recent advances in chalcone-triazole hybrids as potential pharmacological agents. Results Chem. 2023;6:101173. https:\/\/doi.org\/10.1016\/j.rechem.2023.101173.","journal-title":"Results Chem"},{"issue":"36","key":"3608_CR16","doi-asserted-by":"publisher","first-page":"e202401828","DOI":"10.1002\/slct.202401828","volume":"9","author":"N Glanzmann","year":"2024","unstructured":"Glanzmann N, de Oliveira Lemos AS, Meinel RS, Torres Branca M, Mayrink NS, Da Costa Nunes IK, et al. New quinoline derivatives and their antimicrobial potential against Candida albicans and Staphylococcus aureus. ChemistrySelect. 2024;9(36):e202401828. https:\/\/doi.org\/10.1002\/slct.202401828.","journal-title":"ChemistrySelect"},{"issue":"10","key":"3608_CR17","doi-asserted-by":"publisher","first-page":"999","DOI":"10.3390\/pathogens14100999","volume":"14","author":"ME Krummenauer","year":"2025","unstructured":"Krummenauer ME, Camargo MS, Silva Lopes GCB, Feliciani da Luz M, Silva Trentin Dd L, et al. Antifungal Activity of 8-Hydroxyquinoline Derivatives Against Candida auris, Candida haemulonii, Cryptococcus neoformans, and Cryptococcus gattii Complex. Pathogens. 2025;14(10):999. https:\/\/doi.org\/10.3390\/pathogens14100999.","journal-title":"Pathogens"},{"key":"3608_CR18","doi-asserted-by":"publisher","unstructured":"Tidke AD, Adole VA, Deshmukh DV, Shinde RA, Kapadnis KH. Exploring Quinoline-linked Chalcones as broad-Spectrum antimicrobial agents: Synthesis, antibacterial, antifungal, molecular docking, pharmacokinetics, and DFT investigation. Bioorg Chem. 2025;109389. https:\/\/doi.org\/10.1016\/j.bioorg.2025.109389.","DOI":"10.1016\/j.bioorg.2025.109389"},{"issue":"4","key":"3608_CR19","doi-asserted-by":"publisher","first-page":"831","DOI":"10.3390\/molecules23040831","volume":"23","author":"D Osmaniye","year":"2018","unstructured":"Osmaniye D, Kaya Cavusoglu B, Saglik BN, Levent S, Acar Cevik U, Atli O, et al. Synthesis and anticandidal activity of new imidazole-chalcones. Molecules. 2018;23(4):831. https:\/\/doi.org\/10.3390\/molecules23040831.","journal-title":"Molecules"},{"key":"3608_CR20","doi-asserted-by":"publisher","first-page":"153755","DOI":"10.1016\/j.tetlet.2022.153755","volume":"95","author":"A Frank","year":"2022","unstructured":"Frank A, Hamidi N, Xue F. Regioselective alkylation of 2, 4-dihydroxybenzyaldehydes and 2, 4-dihydroxyacetophenones. Tetrahedron Lett. 2022;95:153755. https:\/\/doi.org\/10.1016\/j.tetlet.2022.153755.","journal-title":"Tetrahedron Lett"},{"issue":"6","key":"3608_CR21","doi-asserted-by":"publisher","first-page":"e6433","DOI":"10.1002\/pat.6433","volume":"35","author":"A Servesh","year":"2024","unstructured":"Servesh A, Lokesh Kumar S, Govindaraju S, Tabassum S, Raj Prasad J, Kumar N, et al. Recent advances in polyethylene glycol as a dual-functional agent in heterocycle synthesis: Solvent and catalyst. Polym Adv Technol. 2024;35(6):e6433. https:\/\/doi.org\/10.1002\/pat.6433.","journal-title":"Polym Adv Technol"},{"issue":"1","key":"3608_CR22","doi-asserted-by":"publisher","first-page":"001","DOI":"10.7324\/JAPS.2021.11s101","volume":"11","author":"K Goyal","year":"2021","unstructured":"Goyal K, Kaur R, Goyal A, Awasthi R, Chalcones. A review on synthesis and pharmacological activities. J Appl Pharm Sci. 2021;11(1):001\u201314. https:\/\/doi.org\/10.7324\/JAPS.2021.11s101.","journal-title":"J Appl Pharm Sci"},{"key":"3608_CR23","doi-asserted-by":"publisher","first-page":"127746","DOI":"10.1016\/j.bmcl.2020.127746","volume":"33","author":"R Gondru","year":"2021","unstructured":"Gondru R, Kanugala S, Raj S, Kumar CG, Pasupuleti M, Banothu J, et al. 1, 2, 3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies. Bioorg Med Chem Lett. 2021;33:127746. https:\/\/doi.org\/10.1016\/j.bmcl.2020.127746.","journal-title":"Bioorg Med Chem Lett"},{"issue":"03","key":"3608_CR24","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1055\/s-0039-1691576","volume":"31","author":"GP Kudalkar","year":"2020","unstructured":"Kudalkar GP, Tiwari VK, Lee JD, Berkowitz DB. A Hammett Study of Clostridium acetobutylicum Alcohol Dehydrogenase (CaADH): An enzyme with remarkable substrate promiscuity and utility for organic synthesis. Synlett. 2020;31(03):237\u201347.","journal-title":"Synlett"},{"issue":"4","key":"3608_CR25","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.22146\/ijc.105255","volume":"25","author":"M Rohim","year":"2025","unstructured":"Rohim M, Haryani Y, Frimayanti N, Muttaqin FZ, Teruna HY, Hendra R. Design, Synthesis, and Antifungal Analysis of Pyrazoline Derivatives Against Candida Species: A Comprehensive In Vitro and In Silico Approach. Indones J Chem. 2025;25(4):1226\u201343. https:\/\/doi.org\/10.22146\/ijc.105255.","journal-title":"Indones J Chem"},{"issue":"10","key":"3608_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/molecules29102373","volume":"29","author":"R Hendra","year":"2024","unstructured":"Hendra R, Agustha A, Frimayanti N, Abdulah R, Teruna HY. Antifungal Potential of Secondary Metabolites Derived from Arcangelisia flava (L.) Merr.: An Analysis of In Silico Enzymatic Inhibition and In Vitro Efficacy against Candida Species. Molecules. 2024;29(10):1\u201313. https:\/\/doi.org\/10.3390\/molecules29102373.","journal-title":"Molecules"},{"issue":"17","key":"3608_CR27","doi-asserted-by":"publisher","first-page":"10101","DOI":"10.1021\/acs.jafc.4c09699","volume":"73","author":"H Xin","year":"2025","unstructured":"Xin H, Liu Y, Deng T, Fu H, Wang Y, Hu C, et al. Discovery of potential antifungal agents: chalcone derivatives containing thiourea and piperidine moieties. J Agric Food Chem. 2025;73(17):10101\u20139. https:\/\/doi.org\/10.1021\/acs.jafc.4c09699.","journal-title":"J Agric Food Chem"},{"issue":"1","key":"3608_CR28","doi-asserted-by":"publisher","first-page":"9387102","DOI":"10.1155\/2017\/9387102","volume":"2017","author":"N\u00d6 Can","year":"2017","unstructured":"Can N\u00d6, Acar \u00c7evik U, Sa\u011fl\u0131k BN, Levent S, Korkut B, \u00d6zkay Y, et al. Synthesis, molecular docking studies, and antifungal activity evaluation of new benzimidazole-triazoles as potential lanosterol 14\u03b1\u2010demethylase inhibitors. J Chem. 2017;2017(1):9387102. https:\/\/doi.org\/10.1155\/2017\/9387102.","journal-title":"J Chem"},{"issue":"7","key":"3608_CR29","doi-asserted-by":"publisher","first-page":"688","DOI":"10.3390\/jof8070688","volume":"8","author":"IA Rather","year":"2022","unstructured":"Rather IA, Sabir JS, Asseri AH, Wani MY, Ahmad A. Triazole derivatives target 14\u03b1\u2013demethylase (LDM) enzyme in Candida albicans causing ergosterol biosynthesis inhibition. J Fungi. 2022;8(7):688. https:\/\/doi.org\/10.3390\/jof8070688.","journal-title":"J Fungi"},{"key":"3608_CR30","doi-asserted-by":"publisher","first-page":"144240","DOI":"10.1016\/j.ijbiomac.2025.144240","volume":"315","author":"K Lal","year":"2025","unstructured":"Lal K, Grover A, Ragshaniya A, Aslam M, Singh P, Kumari K. Current advancements and future perspectives of 1, 2, 3-triazoles to target lanosterol 14\u03b1-demethylase (CYP51), a cytochrome P450 enzyme: A computational approach. Int J Biol Macromol. 2025;315:144240.","journal-title":"Int J Biol Macromol"},{"issue":"15","key":"3608_CR31","doi-asserted-by":"publisher","first-page":"2333","DOI":"10.1055\/a-2577-0837","volume":"36","author":"K Kavita","year":"2025","unstructured":"Kavita K, Kumar S, Maikhuri VK, Deo G, Tiwari MK, Maity J, et al. Design, Synthesis, and In Silico Studies of 1, 2, 3-Triazole-Linked Coumarin\u2013Chalcone Hybrids as Potential Antifungal Agents. Synlett. 2025;36(15):2333\u20139. https:\/\/doi.org\/10.1055\/a-2577-0837.","journal-title":"Synlett"},{"issue":"7","key":"3608_CR32","doi-asserted-by":"publisher","first-page":"881","DOI":"10.2174\/1573406415666190724145158","volume":"16","author":"BC Marques","year":"2020","unstructured":"Marques BC, Santos MB, Anselmo DB, Monteiro DA, Gomes E, Saiki MF, et al. Methoxychalcones: effect of methoxyl group on the antifungal, antibacterial and antiproliferative activities. Med Chem. 2020;16(7):881\u201391. https:\/\/doi.org\/10.2174\/1573406415666190724145158.","journal-title":"Med Chem"},{"key":"3608_CR33","doi-asserted-by":"publisher","DOI":"10.1039\/D5MD00907C","author":"AB Pinheiro","year":"2026","unstructured":"Pinheiro AB, Saha S, Madduri M, Roy U, Menon LS, Biswas S, et al. Microwave-assisted single-step synthesis of cyclic and acyclic \u03b2-aminosulfones and evaluation of their antifungal activity targeting CYP51. RSC Med Chem. 2026. https:\/\/doi.org\/10.1039\/D5MD00907C.","journal-title":"RSC Med Chem"},{"issue":"2","key":"3608_CR34","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1134\/S1070363217020281","volume":"87","author":"V Sunitha","year":"2017","unstructured":"Sunitha V, Kishore Kumar A, Shankar B, Anil Kumar A, Krishna T, Lincoln CA, et al. Synthesis and antimicrobial activity of some novel benzofuran based 1, 2, 3-triazoles. Russ J Gen Chem. 2017;87(2):322\u201330. https:\/\/doi.org\/10.1134\/S1070363217020281.","journal-title":"Russ J Gen Chem"},{"key":"3608_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/5729217","volume":"2022","author":"R Hendra","year":"2022","unstructured":"Hendra R, Khodijah R, Almurdani M, Haryani Y, Nugraha AS, Frimayanti N, et al. Free Radical Scavenging, Anti-Infectious, and Toxicity Activities from Stenochlaena palustris (Burm. f.) Bedd. Extracts. Adv Pharmacol Pharm Sci. 2022;2022:1\u20138. https:\/\/doi.org\/10.1155\/2022\/5729217.","journal-title":"Adv Pharmacol Pharm Sci"},{"issue":"19","key":"3608_CR36","doi-asserted-by":"publisher","first-page":"6300","DOI":"10.3390\/molecules27196300","volume":"27","author":"S Mijatovic","year":"2022","unstructured":"Mijatovic S, Stankovic JA, Calovski IC, Dubljanin E, Pljevljakusic D, Bigovic D, et al. Antifungal activity of Lavandula angustifolia essential oil against Candida albicans: time-kill study on pediatric sputum isolates. Molecules. 2022;27(19):6300. https:\/\/doi.org\/10.3390\/molecules27196300.","journal-title":"Molecules"},{"issue":"24","key":"3608_CR37","doi-asserted-by":"publisher","first-page":"5959","DOI":"10.3390\/molecules25245959","volume":"25","author":"R Ortiz-Andrade","year":"2020","unstructured":"Ortiz-Andrade R, Araujo-Le\u00f3n JA, S\u00e1nchez-Recillas A, Navarrete-Vazquez G, Gonz\u00e1lez-S\u00e1nchez AA, Hidalgo-Figueroa S, et al. Toxicological screening of four bioactive citroflavonoids: in vitro, in vivo, and in silico approaches. Molecules. 2020;25(24):5959. https:\/\/doi.org\/10.3390\/molecules25245959.","journal-title":"Molecules"},{"issue":"1","key":"3608_CR38","doi-asserted-by":"publisher","first-page":"6792069","DOI":"10.1155\/2020\/6792069","volume":"2020","author":"SL De Rodr\u00edguez","year":"2020","unstructured":"De Rodr\u00edguez SL, Ram\u00edrez-Garza R, Serna Sald\u00edvar SO. Environmentally friendly methods for flavonoid extraction from plant material: Impact of their operating conditions on yield and antioxidant properties. Sci World J. 2020;2020(1):6792069. https:\/\/doi.org\/10.1155\/2020\/6792069.","journal-title":"Sci World J"}],"container-title":["Medicinal Chemistry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00044-026-03608-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00044-026-03608-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00044-026-03608-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:04:03Z","timestamp":1788343443000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00044-026-03608-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,14]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["3608"],"URL":"https:\/\/doi.org\/10.1007\/s00044-026-03608-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-9845462\/v1","asserted-by":"object"}]},"ISSN":["1054-2523","1554-8120"],"issn-type":[{"value":"1054-2523","type":"print"},{"value":"1554-8120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,14]]},"assertion":[{"value":"28 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}