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Amino-substituted 2-aza- and 3-azabicyclo[3.2.2]nonanes with antiplasmodial and antitrypanosomal activity were linked via aminoalkyl linkers to the 2,8-bis(trifluoromethyl)quinoline scaffold of mefloquine. All newly synthesized compounds were characterized by IR spectroscopy, NMR spectroscopy, and HRMS. Their antiplasmodial activities were examined in vitro against the NF54 strain of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    and their antitrypanosomal activity against the STIB900 strain of\n                    <jats:italic>Trypanosoma brucei rhodesiense<\/jats:italic>\n                    . Most of the compounds showed antiprotozoal activity in submicromolar concentration. Structure-activity relationships concerning the linker length as well as the amino substituent and ring position of the nitrogen in the bicyclic ring system were discussed. The most promising of the newly synthesized compounds was a 2-azabicyclononane with an aminopropyl linker and a 4-methylpiperazinyl substituent at a bridgehead atom. It showed excellent antiplasmodial and antitrypanosomal activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009\u2264\u20090.065 \u00b5M).\n                  <\/jats:p>","DOI":"10.1007\/s00044-026-03628-0","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:56:12Z","timestamp":1791262572000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bicyclononane-2,8-bis(trifluoromethyl)quinoline hybrids: synthesis, antiplasmodial and antitrypanosomal activity"],"prefix":"10.1007","author":[{"given":"Johanna","family":"Dolensky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Seebacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Maria","family":"Pferschy-Wenzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Zehentner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Saf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"M\u00e4ser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Cal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Weis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"3628_CR1","unstructured":"WHO World Malaria Report. 2025, World Health Organization, Geneva, Switzerland, 2025 https:\/\/www.who.int\/publications\/i\/item\/9789240117822"},{"key":"3628_CR2","unstructured":"WHO. factsheet https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/malaria 31.03.2026"},{"issue":"8","key":"3628_CR3","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/S1473-3099(21)00142-0","volume":"21","author":"A Uwimana","year":"2021","unstructured":"Uwimana A, Umulisa N, Venkatesan M, Svigel SS, Zhou Z, Munyaneza T, et al. 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