{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:47:58Z","timestamp":1791870478737,"version":"4.3.4"},"reference-count":115,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Chem Res"],"DOI":"10.1007\/s00044-026-03629-z","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:35:15Z","timestamp":1791869715000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coumarin scaffolds in breast cancer research: derivatives, hybrids, and therapeutic potential"],"prefix":"10.1007","author":[{"family":"Shagufta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irshad","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isha","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maimonah","family":"Al Zubaidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aayat","family":"Aladhamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"3629_CR1","doi-asserted-by":"publisher","first-page":"9347","DOI":"10.1038\/s41598-025-93883-9","volume":"15","author":"Y Cai","year":"2025","unstructured":"Cai Y, Dai F, Ye Y, Qian J. The global burden of breast cancer among women of reproductive age: a comprehensive analysis. Sci Rep. 2025;15:9347. https:\/\/doi.org\/10.1038\/s41598-025-93883-9.","journal-title":"Sci Rep"},{"key":"3629_CR2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12964-023-01302-1","volume":"22","author":"SU Khan","year":"2024","unstructured":"Khan SU, Fatima K, Aisha S, Malik F. Unveiling the mechanisms and challenges of cancer drug resistance. Cell Commun Signal. 2024;22:109. https:\/\/doi.org\/10.1186\/s12964-023-01302-1.","journal-title":"Cell Commun Signal"},{"key":"3629_CR3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41392-024-01856-7","volume":"9","author":"B Liu","year":"2024","unstructured":"Liu B, Zhou H, Tan L, Siu KTH, Guan X-Y. Exploring treatment options in cancer: tumor treatment strategies. Signal Transduct Target Ther. 2024;9:175. https:\/\/doi.org\/10.1038\/s41392-024-01856-7.","journal-title":"Signal Transduct Target Ther"},{"key":"3629_CR4","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3390\/biomedicines12010201","volume":"12","author":"P Chunarkar-Patil","year":"2024","unstructured":"Chunarkar-Patil P, Kaleem M, Mishra R, Ray S, Ahmad A, Verma D, Bhayye S, Dubey R, Singh HN, Kumar S. Anticancer drug discovery based on natural products: from computational approaches to clinical studies. Biomedicines. 2024;12:201. https:\/\/doi.org\/10.3390\/biomedicines12010201.","journal-title":"Biomedicines"},{"key":"3629_CR5","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","volume":"20","author":"AG Atanasov","year":"2021","unstructured":"Atanasov AG, Zotchev SB, Dirsch VM, the International Natural Product Sciences Taskforce, Supuran CT. Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 2021;20:200\u201316. https:\/\/doi.org\/10.1038\/s41573-020-00114-z.","journal-title":"Nat Rev Drug Discov"},{"key":"3629_CR6","doi-asserted-by":"publisher","first-page":"189241","DOI":"10.1016\/j.bbcan.2024.189241","volume":"1880","author":"R Deng","year":"2025","unstructured":"Deng R, Zong G-F, Wang X, Yue B-J, Cheng P, Tao R-Z, Li X, Wei Z-H, Lu Y. Promises of natural products as clinical applications for cancer. Biochim Biophys Acta Rev Cancer. 2025;1880:189241. https:\/\/doi.org\/10.1016\/j.bbcan.2024.189241.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"3629_CR7","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.2174\/138527210792927708","volume":"14","author":"PG Grothaus","year":"2010","unstructured":"Grothaus PG, Cragg GM, Newman DJ. Plant natural products in anticancer drug discovery. Curr Org Chem. 2010;14:1677\u201390. https:\/\/doi.org\/10.2174\/138527210792927708.","journal-title":"Curr Org Chem"},{"issue":"6","key":"3629_CR8","doi-asserted-by":"publisher","first-page":"412","DOI":"10.2174\/0113895575386481250811052953","volume":"26","author":"A Gangwar","year":"2026","unstructured":"Gangwar A, Das A, Jaitak V. Progress in Heterocyclic Hybrids for Breast Cancer Therapy: Emerging Trends, Hybridization Techniques, Mechanistic Pathways and SAR Insights. Mini Rev Med Chem. 2026;26(6):412\u201355. https:\/\/doi.org\/10.2174\/0113895575386481250811052953.","journal-title":"Mini Rev Med Chem"},{"key":"3629_CR9","doi-asserted-by":"publisher","first-page":"117629","DOI":"10.1016\/j.ejmech.2025.117629","volume":"291","author":"K Khan","year":"2025","unstructured":"Khan K, Ali R, Khatoon S, Khan A, Kumar P, Ahamad S, Saquib M, Hussain MK. The Groebke\u2013Blackburn\u2013Bienaym\u00e9 (GBB) reaction: A powerful tool for generating diverse heterocyclic scaffold libraries in anticancer drug discovery. Eur J Med Chem. 2025;291:117629. https:\/\/doi.org\/10.1016\/j.ejmech.2025.117629.","journal-title":"Eur J Med Chem"},{"issue":"10","key":"3629_CR10","doi-asserted-by":"publisher","first-page":"4540","DOI":"10.1039\/d5md00403a","volume":"16","author":"M Matthew Ward, Niamh","year":"2025","unstructured":"Matthew Ward, Niamh M. O\u2019Boyle; Analysis of the structural diversity of heterocycles amongst European medicines agency approved pharmaceuticals (2014\u20132023). RSC Med Chem. 2025;16(10):4540\u201370. https:\/\/doi.org\/10.1039\/d5md00403a.","journal-title":"RSC Med Chem"},{"key":"3629_CR11","doi-asserted-by":"publisher","first-page":"117791","DOI":"10.1016\/j.bmc.2024.117791","volume":"109","author":"G La Monica","year":"2024","unstructured":"La Monica G, Bono A, Alamia F, Lauria A, Martorana A. Bioisosteric heterocyclic analogues of natural bioactive flavonoids by scaffold-hopping approaches: State-of-the-art and perspectives in medicinal chemistry. Bioorg Med Chem. 2024;109:117791. https:\/\/doi.org\/10.1016\/j.bmc.2024.117791.","journal-title":"Bioorg Med Chem"},{"key":"3629_CR12","doi-asserted-by":"publisher","first-page":"124","DOI":"10.2174\/1568026618666180329115523","volume":"18","author":"TM Pereira","year":"2018","unstructured":"Pereira TM, Franco DP, Vitorio F, Kummerle AE. Coumarin compounds in medicinal chemistry: some important examples from the last years. Curr Top Med Chem. 2018;18:124\u201348. https:\/\/doi.org\/10.2174\/1568026618666180329115523.","journal-title":"Curr Top Med Chem"},{"issue":"9","key":"3629_CR13","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.3390\/antibiotics11091156","volume":"11","author":"OM Tsivileva","year":"2022","unstructured":"Tsivileva OM, Koftin OV, Evseeva NV. Coumarins as Fungal Metabolites with Potential Medicinal Properties. Antibiot (Basel). 2022;11(9):1156. https:\/\/doi.org\/10.3390\/antibiotics11091156 . PMID: 36139936; PMCID: PMC9495007.","journal-title":"Antibiot (Basel)"},{"key":"3629_CR14","doi-asserted-by":"publisher","first-page":"1362992","DOI":"10.3389\/fchem.2024.1362992","volume":"12","author":"A Citarella","year":"2024","unstructured":"Citarella A, Vittorio S, Dank C, Ielo L. Syntheses, reactivity, and biological applications of coumarins. Front Chem. 2024;12:1362992. https:\/\/doi.org\/10.3389\/fchem.2024.1362992.","journal-title":"Front Chem"},{"key":"3629_CR15","doi-asserted-by":"publisher","first-page":"6492346","DOI":"10.1155\/2021\/6492346","volume":"2021","author":"J Sharifi-Rad","year":"2021","unstructured":"Sharifi-Rad J, Cruz-Martins N, L\u00f3pez-Jornet P, Lopez EP, Harun N, Yeskaliyeva B, Beyatli A, Sytar O, Shaheen S, Sharopov F, Taheri Y, Docea AO, Calina D, Cho WC. Natural coumarins: exploring the pharmacological complexity and underlying molecular mechanisms. Oxid Med Cell Longev. 2021;2021:6492346. https:\/\/doi.org\/10.1155\/2021\/6492346.","journal-title":"Oxid Med Cell Longev"},{"key":"3629_CR16","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1039\/d3md00511a","volume":"15","author":"M Koley","year":"2023","unstructured":"Koley M, Han J, Soloshonok VA, Mojumder S, Javahershenas R, Makarem A. Latest developments in coumarin-based anticancer agents: mechanism of action and structure-activity relationship studies. RSC Med Chem. 2023;15:10\u201354. https:\/\/doi.org\/10.1039\/d3md00511a.","journal-title":"RSC Med Chem"},{"key":"3629_CR17","doi-asserted-by":"publisher","first-page":"155479","DOI":"10.1016\/j.phymed.2024.155479","volume":"128","author":"L Xue","year":"2024","unstructured":"Xue L, Singla RK, He S, Arrasate S, Gonz\u00e1lez-D\u00edaz H, Miao L, Shen B. Warfarin\u2014a natural anticoagulant: a review of research trends for precision medication. Phytomedicine. 2024;128:155479. https:\/\/doi.org\/10.1016\/j.phymed.2024.155479.","journal-title":"Phytomedicine"},{"key":"3629_CR18","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1365-4362.1980.tb03732.x","volume":"19","author":"JA Pakkish","year":"1980","unstructured":"Pakkish JA, LeVine MJ, Fitzpatrick TB. Oral methoxsalen photochemotherapy of psoriasis and mycosis fungoides. Int J Dermatol. 1980;19:379\u201386. https:\/\/doi.org\/10.1111\/j.1365-4362.1980.tb03732.x.","journal-title":"Int J Dermatol"},{"key":"3629_CR19","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3389\/fimmu.2015.00123","volume":"6","author":"N Nagy","year":"2015","unstructured":"Nagy N, Kuipers HF, Frymoyer AR, Ishak HD, Bollyky JB, Wight TN, Bollyky PL. 4-methylumbelliferone treatment and hyaluronan inhibition as a therapeutic strategy in inflammation, autoimmunity, and cancer. Front Immunol. 2015;6:123. https:\/\/doi.org\/10.3389\/fimmu.2015.00123.","journal-title":"Front Immunol"},{"key":"3629_CR20","doi-asserted-by":"publisher","first-page":"112832","DOI":"10.1016\/j.ejmech.2020.112832","volume":"207","author":"HL Qin","year":"2020","unstructured":"Qin HL, Zhang ZW, Ravindar L, et al. Antibacterial activities with the structure-activity relationship of coumarin derivatives. Eur J Med Chem. 2020;207:112832. https:\/\/doi.org\/10.1016\/j.ejmech.2020.112832.","journal-title":"Eur J Med Chem"},{"key":"3629_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10406638.2023.2201458","volume":"1","author":"MT Sayed","year":"2023","unstructured":"Sayed MT, Elsharbasy SA, Aziem A. Enaminones as building blocks in heterocyclic synthesis: novel routes for synthesis of coumarin analogs and study of their biological activities. Polycycl Aromat Compd. 2023;1:1\u201312. https:\/\/doi.org\/10.1080\/10406638.2023.2201458.","journal-title":"Polycycl Aromat Compd"},{"key":"3629_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/11795514211042023","volume":"14","author":"S Ran\u0111elovi\u0107","year":"2021","unstructured":"Ran\u0111elovi\u0107 S, Bipat R. A review of coumarins and coumarin-related compounds for their potential antidiabetic effect. Clin Med Insights Endocrinol Diabetes. 2021;14:1\u201310. https:\/\/doi.org\/10.1177\/11795514211042023.","journal-title":"Clin Med Insights Endocrinol Diabetes"},{"key":"3629_CR23","doi-asserted-by":"publisher","unstructured":"Bryskier A, Klich M. (2005) Coumarin antibiotics: novobiocin, coumermycin, and clorobiocin. In: Bryskier A, editor Antimicrobial Agents. https:\/\/doi.org\/10.1128\/9781555815929.ch29","DOI":"10.1128\/9781555815929.ch29"},{"issue":"1","key":"3629_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/17568919.2024.2437974","volume":"17","author":"BS Baaiu","year":"2025","unstructured":"Baaiu BS, Saleh NM, Alshref Aldirsi AF, Abdel-Aziem A. Synthesis of new coumarin derivatives and assessment of their antimicrobial efficacy. Future Med Chem. 2025;17(1):9\u201318. https:\/\/doi.org\/10.1080\/17568919.2024.2437974.","journal-title":"Future Med Chem"},{"key":"3629_CR25","doi-asserted-by":"publisher","first-page":"1326","DOI":"10.3390\/ph16091326","volume":"9","author":"MN Joy","year":"2023","unstructured":"Joy MN, Guda MR, Zyryanov GV. Evaluation of anti-inflammatory and anti-tubercular activity of 4-methyl-7-substituted coumarin hybrids and their structure-activity relationships. Pharmaceuticals. 2023;9:1326. https:\/\/doi.org\/10.3390\/ph16091326.","journal-title":"Pharmaceuticals"},{"key":"3629_CR26","doi-asserted-by":"publisher","first-page":"38892","DOI":"10.1039\/C5RA05643H","volume":"5","author":"J Grover","year":"2015","unstructured":"Grover J, Jachak SM. Coumarins as privileged scaffold for anti-inflammatory drug development. RSC Adv. 2015;5:38892\u2013905. https:\/\/doi.org\/10.1039\/C5RA05643H.","journal-title":"RSC Adv"},{"key":"3629_CR27","doi-asserted-by":"publisher","first-page":"24","DOI":"10.5530\/srp.2017.1.6","volume":"8","author":"Y Al-Majedy","year":"2017","unstructured":"Al-Majedy Y, Al-Amiery A, Kadhum AA, et al. Antioxidant activity of coumarins. Syst Rev Pharm. 2017;8:24\u201330. https:\/\/doi.org\/10.5530\/srp.2017.1.6.","journal-title":"Syst Rev Pharm"},{"key":"3629_CR28","doi-asserted-by":"publisher","first-page":"3929","DOI":"10.2174\/092986711803414395","volume":"18","author":"I Kostova","year":"2011","unstructured":"Kostova I, Bhatia S, Grigorov P, et al. Coumarins as antioxidants. Curr Med Chem. 2011;18:3929\u201351. https:\/\/doi.org\/10.2174\/092986711803414395.","journal-title":"Curr Med Chem"},{"key":"3629_CR29","doi-asserted-by":"publisher","first-page":"4809","DOI":"10.1080\/10406638.2021.1916543","volume":"42","author":"A Abdel-Aziem","year":"2022","unstructured":"Abdel-Aziem A, Baaiu BS, El-Sawy ER. Reactions and antibacterial activity of 6-bromo-3-(2-bromoacetyl)-2H-chromen-2-one. Polycycl Aromat Compd. 2022;42:4809\u201318. https:\/\/doi.org\/10.1080\/10406638.2021.1916543.","journal-title":"Polycycl Aromat Compd"},{"key":"3629_CR30","doi-asserted-by":"publisher","DOI":"10.1080\/17518253.2024.2353319","author":"A Abdel-Aziem","year":"2024","unstructured":"Abdel-Aziem A. Green synthesis of novel coumarin derivatives via grinding approach and their antimicrobial evaluation. Green Chem Lett Rev. 2024. https:\/\/doi.org\/10.1080\/17518253.2024.2353319.","journal-title":"Green Chem Lett Rev"},{"key":"3629_CR31","doi-asserted-by":"publisher","first-page":"102050","DOI":"10.1016\/j.tube.2020.102050","volume":"127","author":"DS Reddy","year":"2021","unstructured":"Reddy DS, Kongot M, Kumar A. Coumarin hybrid derivatives as promising leads to treat tuberculosis: recent developments and critical aspects of structural design to exhibit anti-tubercular activity. Tuberculosis. 2021;127:102050. https:\/\/doi.org\/10.1016\/j.tube.2020.102050.","journal-title":"Tuberculosis"},{"key":"3629_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10406638.2021.1998152","volume":"42","author":"A Abdel-Aziem","year":"2021","unstructured":"Abdel-Aziem A, Abdelhamid AO. Synthesis of coumarin analogues clubbed with 1,3,4-thiadiazine or thiazole and their anticancer activity. Polycycl Aromat Compd. 2021;42:1\u201310. https:\/\/doi.org\/10.1080\/10406638.2021.1998152.","journal-title":"Polycycl Aromat Compd"},{"key":"3629_CR33","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.bioorg.2018.10.056","volume":"83","author":"Z Najafi","year":"2019","unstructured":"Najafi Z, Mahdavi M, Saeedi M, et al. Novel tacrine-coumarin hybrids linked to 1,2,3-triazole as anti-Alzheimer\u2019s compounds: in vitro and in vivo biological evaluation and docking study. Bioorg Chem. 2019;83:303\u201316. https:\/\/doi.org\/10.1016\/j.bioorg.2018.10.056.","journal-title":"Bioorg Chem"},{"key":"3629_CR34","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1016\/j.bmc.2011.12.042","volume":"20","author":"P Anand","year":"2012","unstructured":"Anand P, Singh B, Singh N. A review on coumarins as acetylcholinesterase inhibitors for Alzheimer\u2019s disease. Bioorg Med Chem. 2012;20:1175\u201380. https:\/\/doi.org\/10.1016\/j.bmc.2011.12.042.","journal-title":"Bioorg Med Chem"},{"key":"3629_CR35","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1007\/s00706-021-02821-8","volume":"152","author":"CP Kaushik","year":"2021","unstructured":"Kaushik CP, Chahal M. Synthesis, antimalarial and antioxidant activity of coumarin appended 1,4-disubstituted 1,2,3-triazoles. Monatsh Chem. 2021;152:1001\u201312. https:\/\/doi.org\/10.1007\/s00706-021-02821-8.","journal-title":"Monatsh Chem"},{"key":"3629_CR36","doi-asserted-by":"publisher","first-page":"e03217","DOI":"10.1016\/j.heliyon.2020.e03217","volume":"6","author":"S Mishra","year":"2020","unstructured":"Mishra S, Pandey A, Manvati S. Coumarin: an emerging antiviral agent. Heliyon. 2020;6:e03217. https:\/\/doi.org\/10.1016\/j.heliyon.2020.e03217.","journal-title":"Heliyon"},{"key":"3629_CR37","doi-asserted-by":"publisher","first-page":"104863","DOI":"10.1016\/j.fitote.2021.104863","volume":"150","author":"Z Xu","year":"2021","unstructured":"Xu Z, Chen Q, Zhang Y, et al. Coumarin-based derivatives with potential anti-HIV activity. Fitoterapia. 2021;150:104863. https:\/\/doi.org\/10.1016\/j.fitote.2021.104863.","journal-title":"Fitoterapia"},{"key":"3629_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10406638.2022.2050268","volume":"1","author":"JY l-Humaidi","year":"2022","unstructured":"l-Humaidi JY, Nayl AA, Abdalla MM, et al. Synthesis and biological activity evaluation of some new coumarin derivatives as potent anticonvulsant and CNS-depressant agents. Polycycl Aromat Compd. 2022;1:1\u201310. https:\/\/doi.org\/10.1080\/10406638.2022.2050268.","journal-title":"Polycycl Aromat Compd"},{"key":"3629_CR39","doi-asserted-by":"publisher","DOI":"10.1007\/s43450-021-00169-y","author":"EJT Sierra","year":"2021","unstructured":"Sierra EJT, Cordeiro CF, de Figueiredo Diniz L, et al. Coumarins as potential antiprotozoal agents: biological activities and mechanism of action. Rev Bras Farmacogn. 2021. https:\/\/doi.org\/10.1007\/s43450-021-00169-y.","journal-title":"Rev Bras Farmacogn"},{"key":"3629_CR40","doi-asserted-by":"publisher","first-page":"5556","DOI":"10.3390\/molecules26185556","volume":"26","author":"X Wang","year":"2021","unstructured":"Wang X, Zhou H, Wang X, et al. Coumarin derivatives with potential antidepressant effects. Molecules. 2021;26:5556. https:\/\/doi.org\/10.3390\/molecules26185556.","journal-title":"Molecules"},{"key":"3629_CR41","doi-asserted-by":"publisher","first-page":"209","DOI":"10.17179\/excli2019-1903","volume":"19","author":"A Worachartcheewan","year":"2020","unstructured":"Worachartcheewan A, Prachayasittikul V, Prachayasittikul S. Rational design of novel coumarins: a potential trend for antioxidants in cosmetics. EXCLI J. 2020;19:209\u201326. https:\/\/doi.org\/10.17179\/excli2019-1903.","journal-title":"EXCLI J"},{"key":"3629_CR42","doi-asserted-by":"publisher","first-page":"56","DOI":"10.2478\/acs-2020-000","volume":"13","author":"K Hrobo\u0148ov\u00e1","year":"2020","unstructured":"Hrobo\u0148ov\u00e1 K, \u0160pa\u010dkov\u00e1 A. Application of selective polymeric sorbents for simple coumarins extraction from deodorant samples. Acta Chim Slovaca. 2020;13:56\u201362. https:\/\/doi.org\/10.2478\/acs-2020-000.","journal-title":"Acta Chim Slovaca"},{"key":"3629_CR43","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.3390\/molecules21111501","volume":"21","author":"J Chen","year":"2016","unstructured":"Chen J, Yu Y, Li S, et al. Resveratrol and coumarin: novel agricultural antibacterial agent against Ralstonia solanacearum in vitro and in vivo. Molecules. 2016;21:1501. https:\/\/doi.org\/10.3390\/molecules21111501.","journal-title":"Molecules"},{"key":"3629_CR44","doi-asserted-by":"publisher","first-page":"100038","DOI":"10.1016\/j.ejmcr.2022.100038","volume":"5","author":"A Rawat","year":"2022","unstructured":"Rawat A, Vijaya Bhaskar Reddy A. Recent advances on anticancer activity of coumarin derivatives. Eur J Med Chem Rep. 2022;5:100038. https:\/\/doi.org\/10.1016\/j.ejmcr.2022.100038.","journal-title":"Eur J Med Chem Rep"},{"key":"3629_CR45","doi-asserted-by":"publisher","first-page":"e4696","DOI":"10.1002\/fsn3.4696","volume":"13","author":"M Shahbaz","year":"2025","unstructured":"Shahbaz M, Perween A, Momal U, Imran M, Ul Hassan MH, Naeem H, Mujtaba A, Hussain M, Alsagaby SA, Al Abdulmonem W, Abdelgawad MA, El-Ghorab AH, Selim S, Mostafa EM, Al Jbawi E. Recent perspectives on anticancer potential of coumarin against different human malignancies: an updated review. Food Sci Nutr. 2025;13:e4696. https:\/\/doi.org\/10.1002\/fsn3.4696.","journal-title":"Food Sci Nutr"},{"key":"3629_CR46","doi-asserted-by":"publisher","first-page":"595","DOI":"10.3390\/pharmaceutics1705059","volume":"17","author":"TP Kubrak","year":"2025","unstructured":"Kubrak TP, Makuch-Kocka A, Aebisher D. Coumarins in anticancer therapy: mechanisms of action, potential applications and research perspectives. Pharmaceutics. 2025;17:595. https:\/\/doi.org\/10.3390\/pharmaceutics1705059.","journal-title":"Pharmaceutics"},{"key":"3629_CR47","doi-asserted-by":"publisher","first-page":"111587","DOI":"10.1016\/j.ejmech.2019.111587","volume":"181","author":"L Zhang","year":"2019","unstructured":"Zhang L, Xu Z. Coumarin-containing hybrids and their anticancer activities. Eur J Med Chem. 2019;181:111587. https:\/\/doi.org\/10.1016\/j.ejmech.2019.111587.","journal-title":"Eur J Med Chem"},{"key":"3629_CR48","doi-asserted-by":"publisher","first-page":"142149","DOI":"10.1016\/j.molstruc.2025.142149","volume":"1337","author":"P Kumari","year":"2025","unstructured":"Kumari P, Kaur M. Coumarin-based hybrid compounds: a new approach to cancer therapy. J Mol Struct. 2025;1337:142149. https:\/\/doi.org\/10.1016\/j.molstruc.2025.142149.","journal-title":"J Mol Struct"},{"key":"3629_CR49","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.2174\/092986710790936284","volume":"17","author":"ME Riveiro","year":"2010","unstructured":"Riveiro ME, De Kimpe N, Moglioni A, Vazquez R, Monczor F, Shayo C, Davio C. Coumarins: old compounds with novel promising therapeutic perspectives. Curr Med Chem. 2010;17:1380\u201394. https:\/\/doi.org\/10.2174\/092986710790936284.","journal-title":"Curr Med Chem"},{"key":"3629_CR50","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1007\/s00044-025-03518-x","volume":"35","author":"AI Shagufta","year":"2026","unstructured":"Shagufta AI, Bazbouz LZ, Ali A W M E, Abdellatif S. Advances in quercetin-based therapeutics for breast cancer: natural, synthetic, and nanotechnology-driven approaches. Med Chem Res. 2026;35:278\u2013303. https:\/\/doi.org\/10.1007\/s00044-025-03518-x.","journal-title":"Med Chem Res"},{"key":"3629_CR51","doi-asserted-by":"publisher","first-page":"e0330624","DOI":"10.1371\/journal.pone.0330624","volume":"20","author":"D Mustafov","year":"2025","unstructured":"Mustafov D, Siddiqui SS, Shagufta, Ahmad I, Charlton J, Gkantalis J, Rodriguez P, Braoudaki M. New chalcone compound exhibits microRNA-mediated anticancer properties in glioblastoma. PLoS ONE. 2025;20:e0330624. https:\/\/doi.org\/10.1371\/journal.pone.0330624.","journal-title":"PLoS ONE"},{"key":"3629_CR52","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1007\/s00044-025-03411-7","volume":"34","author":"AI Shagufta","year":"2025","unstructured":"Shagufta AI, Bazbouz LZ, et al. Pharmacological significance of palbociclib and its derivatives in cancer treatment and prevention: an update. Med Chem Res. 2025;34:1237\u201352. https:\/\/doi.org\/10.1007\/s00044-025-03411-7.","journal-title":"Med Chem Res"},{"key":"3629_CR53","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1080\/17568919.2025.2479418","volume":"17","author":"AI Shagufta","year":"2025","unstructured":"Shagufta AI, Nasar NA, Zerin S. Designing molecular hybrids as novel breast cancer therapeutics. Future Med Chem. 2025;17:857\u20139. https:\/\/doi.org\/10.1080\/17568919.2025.2479418.","journal-title":"Future Med Chem"},{"key":"3629_CR54","doi-asserted-by":"publisher","first-page":"31789","DOI":"10.1021\/acsomega.4c02991","volume":"9","author":"D Mustafov","year":"2024","unstructured":"Mustafov D, Siddiqui SS, Kukol A, Lambrou GI, Shagufta, Ahmad I, Braoudaki M. MicroRNA-dependent mechanisms underlying the function of a \u03b2-amino carbonyl compound in glioblastoma cells. ACS Omega. 2024;9:31789\u2013802.","journal-title":"ACS Omega"},{"key":"3629_CR55","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1039\/D3MD00632H","volume":"15","author":"AI Shagufta","year":"2024","unstructured":"Shagufta AI, Nelson DJ, Hussain MI, Nasar NA. Potential of covalently linked tamoxifen hybrids for cancer treatment: recent update. RSC Med Chem. 2024;15:1877\u201398.","journal-title":"RSC Med Chem"},{"key":"3629_CR56","doi-asserted-by":"publisher","first-page":"1254911","DOI":"10.3389\/fimmu.2023.1254911","volume":"14","author":"MS Ahmad","year":"2023","unstructured":"Ahmad MS, Braoudaki M, Patel H, Ahmad I, Shagufta, Siddiqui SS. Novel Siglec-15-Sia axis inhibitor leads to colorectal cancer cell death by targeting miR-6715b-3p and oncogenes. Front Immunol. 2023;14:1254911. https:\/\/doi.org\/10.3389\/fimmu.2023.1254911.","journal-title":"Front Immunol"},{"key":"3629_CR57","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1039\/D2MD00356B","volume":"14","author":"I Shagufta, Ahmad","year":"2023","unstructured":"Shagufta, Ahmad I. Therapeutic significance of molecular hybrids for breast cancer research and treatment. RSC Med Chem. 2023;14:218\u201338. https:\/\/doi.org\/10.1039\/D2MD00356B.","journal-title":"RSC Med Chem"},{"key":"3629_CR58","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1039\/C9MD00570F","volume":"11","author":"I Shagufta, Ahmad","year":"2020","unstructured":"Shagufta, Ahmad I, Mathew S, Rehman S. Recent progress in selective estrogen receptor downregulators (SERDs) for the treatment of breast cancer. RSC Med Chem. 2020;11:438\u201354.","journal-title":"RSC Med Chem"},{"key":"3629_CR59","doi-asserted-by":"publisher","first-page":"119521","DOI":"10.1016\/j.ica.2020.119521","volume":"506","author":"I Shagufta, Ahmad","year":"2020","unstructured":"Shagufta, Ahmad I. Transition metal complexes as proteasome inhibitors for cancer treatment. Inorg Chim Acta. 2020;506:119521. https:\/\/doi.org\/10.1016\/j.ica.2020.119521.","journal-title":"Inorg Chim Acta"},{"key":"3629_CR60","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.ejmech.2017.11.056","volume":"143","author":"AI Shagufta","year":"2018","unstructured":"Shagufta AI. Tamoxifen a pioneering drug: an update on the therapeutic potential of tamoxifen derivatives. Eur J Med Chem. 2018;143:515\u201331. https:\/\/doi.org\/10.1016\/j.ejmech.2017.11.056.","journal-title":"Eur J Med Chem"},{"key":"3629_CR61","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1039\/C7MD00055A","volume":"8","author":"I Shagufta, Ahmad","year":"2017","unstructured":"Shagufta, Ahmad I. An insight into the therapeutic potential of quinazoline derivatives as anticancer agents. MedChemComm. 2017;8:871\u201385. https:\/\/doi.org\/10.1039\/C7MD00055A.","journal-title":"MedChemComm"},{"key":"3629_CR62","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ejmech.2015.07.064","volume":"102","author":"I Ahmad","year":"2015","unstructured":"Ahmad I, Shagufta. Recent developments in steroidal and nonsteroidal aromatase inhibitors for the chemoprevention of estrogen-dependent breast cancer. Eur J Med Chem. 2015;102:375\u201386. https:\/\/doi.org\/10.1016\/j.ejmech.2015.07.064.","journal-title":"Eur J Med Chem"},{"key":"3629_CR63","doi-asserted-by":"publisher","first-page":"144426","DOI":"10.1016\/j.molstruc.2025.144426","volume":"1352","author":"H Firoz","year":"2026","unstructured":"Firoz H, Ali R, Khan FA, Kakkar P, Soni RK, Assiri MA, Ahamad S, Saquib M, Hussain MK. Coumarins as versatile scaffolds: innovative synthetic strategies for generating diverse heterocyclic libraries in drug discovery. J Mol Struct. 2026;1352:144426. https:\/\/doi.org\/10.1016\/j.molstruc.2025.144426.","journal-title":"J Mol Struct"},{"key":"3629_CR64","doi-asserted-by":"publisher","first-page":"6490","DOI":"10.3390\/molecules26216490","volume":"26","author":"K Pavi\u0107","year":"2021","unstructured":"Pavi\u0107 K, Beus M, Poje G, Uzelac L, Kralj M, Raji\u0107 Z. Synthesis and biological evaluation of harmirins, novel harmine\u2013coumarin hybrids as potential anticancer agents. Molecules. 2021;26:6490. https:\/\/doi.org\/10.3390\/molecules26216490.","journal-title":"Molecules"},{"key":"3629_CR65","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.sjbs.2020.10.020","volume":"28","author":"KS Kumar","year":"2020","unstructured":"Kumar KS, Kotra V, Kola NPK, Devi CP, Anusha N, Babu BH, Adil SF, Shaik MR, Khan M, Al-Warthan A, Alduhaish O, Alam MM. ZnCl\u2082-catalyzed new coumarinyl-chalcones as cytotoxic agents. Saudi J Biol Sci. 2020;28:386\u201394. https:\/\/doi.org\/10.1016\/j.sjbs.2020.10.020.","journal-title":"Saudi J Biol Sci"},{"key":"3629_CR66","doi-asserted-by":"publisher","first-page":"5688","DOI":"10.3390\/molecules27175688","volume":"27","author":"WA El-Sayed","year":"2022","unstructured":"El-Sayed WA, Alminderej FM, Mounier MM, Nossier ES, Saleh SM, Kassem AF. New 1,2,3-triazole\u2013coumarin\u2013glycoside hybrids and their 1,2,4-triazolyl thioglycoside analogs targeting mitochondria apoptotic pathway: synthesis, anticancer activity and docking simulation. Molecules. 2022;27:5688. https:\/\/doi.org\/10.3390\/molecules27175688.","journal-title":"Molecules"},{"key":"3629_CR67","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1021\/acsmedchemlett.4c00596","volume":"16","author":"AD Zuti\u00e3o","year":"2025","unstructured":"Zuti\u00e3o AD, Pachane BC, Nunes PSG, Vidal HDA, Selistre-De-Araujo HS, Corr\u00eaa AG, Cominetti MR, Fuzer AM. Enhanced cytotoxicity of [10]-gingerol\u2013coumarin\u2013triazole hybrid as a theranostic agent for triple negative breast cancer. ACS Med Chem Lett. 2025;16:436\u201343. https:\/\/doi.org\/10.1021\/acsmedchemlett.4c00596.","journal-title":"ACS Med Chem Lett"},{"key":"3629_CR68","doi-asserted-by":"publisher","first-page":"3450","DOI":"10.3390\/molecules28083450","volume":"28","author":"NY Kim","year":"2023","unstructured":"Kim NY, Vishwanath D, Xi Z, Nagaraja O, Swamynayaka A, Kumar Harish K, Basappa S, Madegowda M, Pandey V, Sethi G, Lobie PE, Ahn KS, Basappa B. Discovery of pyrimidine- and coumarin-linked hybrid molecules as inducers of JNK phosphorylation through ROS generation in breast cancer cells. Molecules. 2023;28:3450. https:\/\/doi.org\/10.3390\/molecules28083450.","journal-title":"Molecules"},{"key":"3629_CR69","doi-asserted-by":"publisher","first-page":"428","DOI":"10.3390\/ph15040428","volume":"15","author":"RM Abdelnaby","year":"2022","unstructured":"Abdelnaby RM, Rateb HS, Ali O, Saad AS, Nadeem RI, Abou-Seri SM, Amin KM, Younis NS, Abdelhady R. Dual PI3K\/Akt inhibitors bearing coumarin\u2013thiazolidine pharmacophores as potential apoptosis inducers in MCF-7 cells. Pharmaceuticals. 2022;15:428. https:\/\/doi.org\/10.3390\/ph15040428.","journal-title":"Pharmaceuticals"},{"key":"3629_CR70","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.3390\/molecules26082273","volume":"26","author":"MO Sarhan","year":"2021","unstructured":"Sarhan MO, Abd El-Karim SS, Anwar MM, Gouda RH, Zaghary WA, Khedr MA. Discovery of new coumarin-based lead with potential anticancer, CDK4 inhibition and selective radiotheranostic effect: synthesis, 2D & 3D QSAR, molecular dynamics, in vitro cytotoxicity, radioiodination, and biodistribution studies. Molecules. 2021;26:2273. https:\/\/doi.org\/10.3390\/molecules26082273.","journal-title":"Molecules"},{"key":"3629_CR71","doi-asserted-by":"publisher","first-page":"13370","DOI":"10.1038\/s41598-023-40232-3","volume":"13","author":"FN Takla","year":"2023","unstructured":"Takla FN, et al. Developing multitarget coumarin-based anti-breast cancer agents: synthesis and molecular modeling study. Sci Rep. 2023;13:13370. https:\/\/doi.org\/10.1038\/s41598-023-40232-3.","journal-title":"Sci Rep"},{"key":"3629_CR72","doi-asserted-by":"publisher","first-page":"5612","DOI":"10.1016\/j.bmc.2018.10.006","volume":"26","author":"S Dhawan","year":"2018","unstructured":"Dhawan S, Kerru N, Awolade P, Singh-Pillay A, Saha ST, Kaur M, Jonnalagadda SB, Singh P. Synthesis, computational studies and antiproliferative activities of coumarin-tagged 1,3,4-oxadiazole conjugates against MDA-MB-231 and MCF-7 human breast cancer cells. Bioorg Med Chem. 2018;26:5612\u201323. https:\/\/doi.org\/10.1016\/j.bmc.2018.10.006.","journal-title":"Bioorg Med Chem"},{"key":"3629_CR73","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1248\/bpb.b20-00035","volume":"43","author":"Y Yamaguchi","year":"2020","unstructured":"Yamaguchi Y, Nishizono N, Oda K. Evaluation of synthesized ester or amide coumarin derivatives on aromatase inhibitory activity. Biol Pharm Bull. 2020;43:1179\u201387. https:\/\/doi.org\/10.1248\/bpb.b20-00035.","journal-title":"Biol Pharm Bull"},{"key":"3629_CR74","doi-asserted-by":"publisher","first-page":"717","DOI":"10.3390\/molecules25030717","volume":"25","author":"N Zhao","year":"2020","unstructured":"Zhao N, Yang F, Han L, Qu Y, Ge D, Zhang H. Development of coumarin-based hydroxamates as histone deacetylase inhibitors with antitumor activities. Molecules. 2020;25:717. https:\/\/doi.org\/10.3390\/molecules25030717.","journal-title":"Molecules"},{"key":"3629_CR75","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.4155\/fmc-2023-0375","volume":"16","author":"MG Salem","year":"2024","unstructured":"Salem MG, Alqahtani AM, Mali SN, Alshwyeh HA, Jawarkar RD, Altamimi AS, Alshawwa SZ, Al-Olayan E, Saied EM, Youssef MF. Synthesis and antiproliferative evaluation of novel 3,5,8-trisubstituted coumarins against breast cancer. Future Med Chem. 2024;16:1053\u201373. https:\/\/doi.org\/10.4155\/fmc-2023-0375.","journal-title":"Future Med Chem"},{"key":"3629_CR76","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3390\/molecules28010089","volume":"28","author":"V Niranjan","year":"2022","unstructured":"Niranjan V, Jayaprasad S, Uttarkar A, Kusanur R, Kumar J. Design of novel coumarin derivatives as NUDT5 antagonists that act by restricting ATP synthesis in breast cancer cells. Molecules. 2022;28:89. https:\/\/doi.org\/10.3390\/molecules28010089.","journal-title":"Molecules"},{"key":"3629_CR77","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/cbdd.14028","volume":"99","author":"EY Ahmed","year":"2022","unstructured":"Ahmed EY, et al. Design, synthesis, and molecular modeling of coumarin derivatives as MDM2 inhibitors targeting breast cancer. Chem Biol Drug Des. 2022;99:609\u201319. https:\/\/doi.org\/10.1111\/cbdd.14028.","journal-title":"Chem Biol Drug Des"},{"key":"3629_CR78","doi-asserted-by":"publisher","unstructured":"Patil JV, Soman SS, Umar S, Girase P, Balakrishnan S. Synthesis of pyrazolone derivatives of coumarin as anticancer agents. ChemistrySelect. 2024;9. https:\/\/doi.org\/10.1002\/slct.202303391.","DOI":"10.1002\/slct.202303391"},{"issue":"1","key":"3629_CR79","doi-asserted-by":"publisher","first-page":"144426","DOI":"10.1016\/j.molstruc.2025.144426","volume":"1352","author":"H Firoz","year":"2026","unstructured":"Firoz H, Ali R, Khan FA, Kakkar P, Soni RK, Assiri MA, Ahamad S, Saquib M, Hussain MK. Coumarins as versatile scaffolds: Innovative synthetic strategies for generating diverse heterocyclic libraries in drug discovery. J Mol Struct. 2026;1352(1):144426. https:\/\/doi.org\/10.1016\/j.molstruc.2025.144426.","journal-title":"J Mol Struct"},{"issue":"24","key":"3629_CR80","doi-asserted-by":"publisher","first-page":"5848","DOI":"10.1002\/slct.202101346","volume":"6","author":"A Bouhaoui","year":"2021","unstructured":"Bouhaoui A, Eddahmi M, Dib M, Khouili M, Aires A, Catto M, Bouissane L. Synthesis and biological properties of coumarin derivatives: A review. ChemistrySelect. 2021;6(24):5848\u201370. https:\/\/doi.org\/10.1002\/slct.202101346.","journal-title":"ChemistrySelect"},{"issue":"5","key":"3629_CR81","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1039\/c7cy02139a","volume":"8","author":"H Phuc","year":"2018","unstructured":"Phuc H, Pham SH, Doan, Hang TT, Tran, Ngoc N, Nguyen, Anh NQ, Phan HV, Le, Thach N, Tu, Nam TS, Phan. A new transformation of coumarins via direct C\u2013H bond activation utilizing an iron\u2013organic framework as a recyclable catalyst. Catal Sci Technol. 2018;8(5):1267\u201371. https:\/\/doi.org\/10.1039\/c7cy02139a.","journal-title":"Catal Sci Technol"},{"key":"3629_CR82","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1039\/JS8682100053","volume":"21","author":"WH Perkin","year":"1868","unstructured":"Perkin WH. VI.\u2014On the artificial production of coumarin and formation of its homologues. J Chem Soc. 1868;21:53\u201363. https:\/\/doi.org\/10.1039\/JS8682100053.","journal-title":"J Chem Soc"},{"key":"3629_CR83","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1002\/cber.188401701248","volume":"17","author":"v Pechmann","year":"1884","unstructured":"Pechmann v, H. Neue Bildungsweise der Cumarine. Synthese des Daphnetins. I. Ber. Dtsch Chem Ges. 1884;17:929\u201336. https:\/\/doi.org\/10.1002\/cber.188401701248.","journal-title":"Dtsch Chem Ges"},{"key":"3629_CR84","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.1080\/00397911.2014.926374","volume":"44","author":"RH Vekariya","year":"2014","unstructured":"Vekariya RH, Patel HD. Recent advances in the synthesis of coumarin derivatives via Knoevenagel condensation: A review. Synth Commun. 2014;44:2756\u201388.","journal-title":"Synth Commun"},{"issue":"10","key":"3629_CR85","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1248\/cpb.42.2170","volume":"42","author":"T Harayama","year":"1994","unstructured":"Harayama T, Nakatsuka K, Nishioka H, Murakami K, Hayashida N, Ishii H. Convenient synthesis of a simple coumarin from salicylaldehyde and Wittig reagent. II: Synthesis of bromo- and methoxycarbonylcoumarins. Chem Pharm Bull. 1994;42(10):2170\u20133. https:\/\/doi.org\/10.1248\/cpb.42.2170.","journal-title":"Chem Pharm Bull"},{"issue":"7","key":"3629_CR86","doi-asserted-by":"publisher","first-page":"993","DOI":"10.2174\/1573407215666191111120604","volume":"16","author":"MA Gouda","year":"2020","unstructured":"Gouda MA, Hussein BHM, El-Demerdash A, Ibrahim ME, Salem MA, Helal MH, Hamama WS. A review: Synthesis and medicinal importance of coumarins and their analogues (Part II). Curr Bioact Compd. 2020;16(7):993\u20131008. https:\/\/doi.org\/10.2174\/1573407215666191111120604.","journal-title":"Curr Bioact Compd"},{"issue":"7","key":"3629_CR87","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3184\/174751912X13371652436057","volume":"36","author":"B Zhao","year":"2012","unstructured":"Zhao B, Fan M-J, Liu Z, Hu L-F, Song B, Wang L-Y, Deng Q-G. Reformatsky reaction promoted by an ionic liquid ([Bmim]Cl) in the synthesis of \u03b2-hydroxyl ketone derivatives bearing a coumarin unit. J Chem Res. 2012;36(7):393\u20135. https:\/\/doi.org\/10.3184\/174751912X13371652436057.","journal-title":"J Chem Res"},{"issue":"24","key":"3629_CR88","doi-asserted-by":"publisher","first-page":"4846","DOI":"10.1039\/d2ob00491g","volume":"20","author":"SM Farid","year":"2022","unstructured":"Farid SM, Seifinoferest B, Gholamhosseyni M, Larijani B. Mohammad Mahdavi; Modern metal-catalyzed and organocatalytic methods for synthesis of coumarin derivatives: a review. Org Biomol Chem. 2022;20(24):4846\u201383. https:\/\/doi.org\/10.1039\/d2ob00491g.","journal-title":"Org Biomol Chem"},{"issue":"15","key":"3629_CR89","doi-asserted-by":"publisher","first-page":"4518","DOI":"10.1021\/ja0286573","volume":"125","author":"BM Trost","year":"2003","unstructured":"Trost BM, Toste FD, Greenman K. Atom economy. Palladium-catalyzed formation of coumarins by addition of phenols and alkynoates via a net C-H insertion. J Am Chem Soc. 2003;125(15):4518\u201326. https:\/\/doi.org\/10.1021\/ja0286573.","journal-title":"J Am Chem Soc"},{"issue":"22","key":"3629_CR90","doi-asserted-by":"publisher","first-page":"7516","DOI":"10.1021\/jo000861q","volume":"65","author":"C Jia","year":"2000","unstructured":"Jia C, Piao D, Kitamura T, Fujiwara Y. New method for preparation of coumarins and quinolinones via Pd-catalyzed intramolecular hydroarylation of C-C triple bonds. J Org Chem. 2000;65(22):7516\u201322. https:\/\/doi.org\/10.1021\/jo000861q.","journal-title":"J Org Chem"},{"issue":"44","key":"3629_CR91","doi-asserted-by":"publisher","first-page":"29483","DOI":"10.1021\/acsomega.1c03469","volume":"6","author":"V Ortiz-de-Elguea","year":"2021","unstructured":"Ortiz-de-Elguea V, Carral-Menoyo A, Sim\u00f3n-Vidal L, Martinez-Nunes M, Barbolla I, Lete MG, Sotomayor N, Lete E. Pd(II)-Catalyzed Fujiwara-Moritani Reactions for the Synthesis and Functionalization of Substituted Coumarins. ACS Omega. 2021;6(44):29483\u201394. https:\/\/doi.org\/10.1021\/acsomega.1c03469.","journal-title":"ACS Omega"},{"key":"3629_CR92","doi-asserted-by":"publisher","unstructured":"Zhao Y, Han F, Yang L. Access to Coumarins by Rhodium-Catalyzed Oxidative Annulation of Aryl Thiocarbamates with Internal Alkynes. Org Lett. March 2015;20(6):1477\u201380. https:\/\/doi.org\/10.1021\/acs.orglett.5b00364.","DOI":"10.1021\/acs.orglett.5b00364"},{"key":"3629_CR93","doi-asserted-by":"publisher","first-page":"180","DOI":"10.3762\/bjoc.9.21","volume":"9","author":"MS Reddy","year":"2013","unstructured":"Reddy MS, Thirupathi N, Haribabu M. Tandem aldehyde\u2013alkyne\u2013amine coupling\/cycloisomerization: A new synthesis of coumarins. Beilstein J Org Chem. 2013;9:180\u20134. https:\/\/doi.org\/10.3762\/bjoc.9.21.","journal-title":"Beilstein J Org Chem"},{"key":"3629_CR94","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1080\/14756366.2022.2056734","volume":"37","author":"HO Tawfik","year":"2022","unstructured":"Tawfik HO, Shaldam MA, Nocentini A, Salem R, Almahli H, Al-Rashood ST, Supuran CT, Eldehna WM. Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity. J Enzyme Inhib Med Chem. 2022;37:1043\u201352. https:\/\/doi.org\/10.1080\/14756366.2022.2056734.","journal-title":"J Enzyme Inhib Med Chem"},{"key":"3629_CR95","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1007\/s11094-021-02535-5","volume":"55","author":"EM Radwan","year":"2022","unstructured":"Radwan EM, Abdel-Hamid AM, El Sayed NS, El-Kerdawy AM, Abdel-Monem SM. Synthesis and cytotoxicity against human breast carcinoma cell evaluation of some new 3,4-disubstituted coumarin derivatives. Pharm Chem J. 2022;55:1040\u20139. https:\/\/doi.org\/10.1007\/s11094-021-02535-5.","journal-title":"Pharm Chem J"},{"key":"3629_CR96","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s11030-020-10082-6","volume":"25","author":"L Gkionis","year":"2020","unstructured":"Gkionis L, Kavetsou E, Kalospyros A, Manousakis D, Sanz MG, Butterworth S, Detsi A, Tirella A. Investigation of the cytotoxicity of bioinspired coumarin analogues towards human breast cancer cells. Mol Divers. 2020;25:307\u201321. https:\/\/doi.org\/10.1007\/s11030-020-10082-6.","journal-title":"Mol Divers"},{"key":"3629_CR97","doi-asserted-by":"publisher","first-page":"112424","DOI":"10.1016\/j.ejmech.2020.112424","volume":"200","author":"J Xu","year":"2020","unstructured":"Xu J, Li H, Wang X, Huang J, Li S, Liu C, Dong R, Zhu G, Duan C, Jiang F, Zhang Y, Zhu Y, Zhang T, Chen Y, Tang W, Lu T. Discovery of coumarin derivatives as potent and selective cyclin-dependent kinase 9 (CDK9) inhibitors with high antitumour activity. Eur J Med Chem. 2020;200:112424. https:\/\/doi.org\/10.1016\/j.ejmech.2020.112424.","journal-title":"Eur J Med Chem"},{"issue":"4","key":"3629_CR98","doi-asserted-by":"publisher","first-page":"786","DOI":"10.3390\/molecules26040786","volume":"26","author":"J Zhang","year":"2021","unstructured":"Zhang J, Tan Y, Li G, Chen L, Nie M, Wang Z, Ji H. Coumarin sulfonamides and amides derivatives: design, synthesis, and antitumor activity in vitro. Molecules. 2021;26(4):786. https:\/\/doi.org\/10.3390\/molecules26040786.","journal-title":"Molecules"},{"key":"3629_CR99","doi-asserted-by":"publisher","first-page":"13370","DOI":"10.1038\/s41598-023-40232-3","volume":"13","author":"FN Takla","year":"2023","unstructured":"Takla FN, Abdel-Hamid AM, El-Sayed NS, El-Kerdawy AM, Abdel-Monem SM. Developing multitarget coumarin based anti-breast cancer agents: synthesis and molecular modeling study. Sci Rep. 2023;13:13370. https:\/\/doi.org\/10.1038\/s41598-023-40232-3.","journal-title":"Sci Rep"},{"key":"3629_CR100","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3390\/cryst13071037","volume":"13","author":"T Al-Warhi","year":"2023","unstructured":"Al-Warhi T, Al-Tel TH, Mahmoud AM, Khanfar MA, El-Agamy DS, Alzahrani KJ. Novel 3-substituted 8-methoxycoumarin derivatives as anti-breast cancer drugs. Crystals. 2023;13:1037. https:\/\/doi.org\/10.3390\/cryst13071037.","journal-title":"Crystals"},{"key":"3629_CR101","doi-asserted-by":"publisher","first-page":"5134","DOI":"10.3390\/molecules25215134","volume":"25","author":"S Garc\u00eda","year":"2020","unstructured":"Garc\u00eda S, Mercado-S\u00e1nchez I, Bahena L, Alcaraz Y, Garc\u00eda-Revilla MA, Robles J, Santos-Mart\u00ednez N, Ordaz-Rosado D, Garc\u00eda-Becerra R, Vazquez MA. Design of Fluorescent Coumarin-Hydroxamic Acid Derivatives as Inhibitors of HDACs: Synthesis, Anti-Proliferative Evaluation and Docking Studies. Molecules. 2020;25:5134. https:\/\/doi.org\/10.3390\/molecules25215134.","journal-title":"Molecules"},{"key":"3629_CR102","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3390\/molecules27030637","volume":"27","author":"K Pr\u0161ir","year":"2022","unstructured":"Pr\u0161ir K, Horak E, Kralj M, Uzelac L, Liekens S, Steinberg IM, Kri\u0161tafor S. Design, synthesis, spectroscopic characterisation and in vitro cytostatic evaluation of novel bis(coumarin-1,2,3-triazolyl)benzenes and hybrid coumarin-1,2,3-triazolyl-aryl derivatives. Molecules. 2022;27:637. https:\/\/doi.org\/10.3390\/molecules27030637.","journal-title":"Molecules"},{"issue":"30","key":"3629_CR103","doi-asserted-by":"publisher","first-page":"305602","DOI":"10.1088\/1361-6528\/ad403e","volume":"35","author":"B Arvas","year":"2024","unstructured":"Arvas B, Ucar B, Acar T, Varli HS, Arvas MB, Aydogan F, Yolacan C. Synthesis of novel coumarin\u2013triazole hybrids and first evaluation of the 4-phenyl-substituted hybrid-loaded PLGA nanoparticle delivery system for anticancer activity. Nanotechnology. 2024;35(30):305602. https:\/\/doi.org\/10.1088\/1361-6528\/ad403e.","journal-title":"Nanotechnology"},{"key":"3629_CR104","doi-asserted-by":"publisher","first-page":"110308","DOI":"10.1016\/j.abb.2025.110308","volume":"765","author":"A Saekee","year":"2025","unstructured":"Saekee A, et al. Synthesis, anti-proliferation, apoptosis induction in breast cancer cells, and aromatase inhibition of coumarin\u2013triazole hybrids: in vitro and in silico studies. Arch Biochem Biophys. 2025;765:110308. https:\/\/doi.org\/10.1016\/j.abb.2025.110308.","journal-title":"Arch Biochem Biophys"},{"issue":"2","key":"3629_CR105","doi-asserted-by":"publisher","first-page":"689","DOI":"10.3390\/molecules28020689","volume":"28","author":"TZ Abolibda","year":"2023","unstructured":"Abolibda TZ, Fathalla M, Farag B, Zaki MEA, Gomha SM. Synthesis and molecular docking of some novel 3-thiazolyl-coumarins as inhibitors of VEGFR-2 kinase. Molecules. 2023;28(2):689. https:\/\/doi.org\/10.3390\/molecules28020689.","journal-title":"Molecules"},{"key":"3629_CR106","doi-asserted-by":"publisher","first-page":"3450","DOI":"10.3390\/molecules28083450","volume":"28","author":"NY Kim","year":"2023","unstructured":"Kim NY, Vishwanath D, Xi Z, Nagaraja O, Swamynayaka A, Harish KK, Basappa S, Madegowda M, Pandey V, Sethi G, Lobie PE, Ahn KS, Basappa B. Discovery of pyrimidine- and coumarin-linked hybrid molecules as inducers of JNK phosphorylation through ROS generation in breast cancer cells. Molecules. 2023;28:3450. https:\/\/doi.org\/10.3390\/molecules28083450.","journal-title":"Molecules"},{"key":"3629_CR107","doi-asserted-by":"publisher","first-page":"101279","DOI":"10.1016\/j.jscs.2021.101279","volume":"25","author":"N Ramalakshmi","year":"2021","unstructured":"Ramalakshmi N, Manimegalai P, Bhandare RR, Kumar SA, Shaik AB. 2D-QSAR modeling, docking studies, synthesis and in vitro evaluation of 1,3,4-thiadiazole-tethered coumarin derivatives as antiproliferative agents. J Saudi Chem Soc. 2021;25:101279. https:\/\/doi.org\/10.1016\/j.jscs.2021.101279.","journal-title":"J Saudi Chem Soc"},{"key":"3629_CR108","doi-asserted-by":"publisher","first-page":"6153","DOI":"10.3390\/molecules27196153","volume":"27","author":"H Shang","year":"2022","unstructured":"Shang H, Hu Y, Li J, Li L, Tian Y, Li X, Wu Q, Zou Z. The synthesis and biological evaluation of aloe-emodin\u2013coumarin hybrids as potential antitumor agents. Molecules. 2022;27:6153. https:\/\/doi.org\/10.3390\/molecules27196153.","journal-title":"Molecules"},{"issue":"3","key":"3629_CR109","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1021\/acsmedchemlett.4c00596","volume":"16","author":"AD Zuti\u00e3o","year":"2025","unstructured":"Zuti\u00e3o AD, Pachane BC, Nunes PSG, Vidal HDA, Selistre-De-Araujo HS, Corr\u00eaa AG, Cominetti MR, Fuzer AM. Enhanced cytotoxicity of [10]-gingerol\u2013coumarin\u2013triazole hybrid as a theranostic agent for triple-negative breast cancer. ACS Med Chem Lett. 2025;16(3):436\u201343. https:\/\/doi.org\/10.1021\/acsmedchemlett.4c00596.","journal-title":"ACS Med Chem Lett"},{"key":"3629_CR110","doi-asserted-by":"publisher","first-page":"1231450","DOI":"10.3389\/fphar.2023.1231450","volume":"14","author":"NA Alhakamy","year":"2023","unstructured":"Alhakamy NA, Saquib M, Sanobar N, Khan MF, Ansari WA, Arif DO, Irfan M, Khan MI, Hussain MK. Natural product-inspired synthesis of coumarin\u2013chalcone hybrids as potential anti-breast cancer agents. Front Pharmacol. 2023;14:1231450. https:\/\/doi.org\/10.3389\/fphar.2023.1231450.","journal-title":"Front Pharmacol"},{"key":"3629_CR111","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1111\/cbdd.14028","volume":"99","author":"EY Ahmed","year":"2022","unstructured":"Ahmed EY, El-Hallouty SM, El-Husseiny WM, Abdel-Halim M, El-Sayed WM. Design, synthesis, and molecular modeling of coumarin derivatives as MDM2 inhibitors targeting breast cancer. Chem Biol Drug Des. 2022;99:609\u201319. https:\/\/doi.org\/10.1111\/cbdd.14028.","journal-title":"Chem Biol Drug Des"},{"issue":"21","key":"3629_CR112","doi-asserted-by":"publisher","first-page":"4167","DOI":"10.3390\/molecules30214167","volume":"30","author":"VB Hacholli","year":"2025","unstructured":"Hacholli VB, R SM, Kumar HPBMLSP, Szeleszczuk A, Gackowski \u0141. Coumarin Derivatives as Anticancer Agents: Mechanistic Landscape with an Emphasis on Breast Cancer. Molecules. 2025;30(21):4167. https:\/\/doi.org\/10.3390\/molecules30214167.","journal-title":"Molecules"},{"key":"3629_CR113","doi-asserted-by":"publisher","first-page":"116179","DOI":"10.1016\/j.ejmech.2024.116179","volume":"267","author":"AK Yadav","year":"2024","unstructured":"Yadav AK, Shrestha RM, Yadav PN. Anticancer mechanism of coumarin-based derivatives. Eur J Med Chem. 2024;267:116179. https:\/\/doi.org\/10.1016\/j.ejmech.2024.116179.","journal-title":"Eur J Med Chem"},{"issue":"6","key":"3629_CR114","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.3390\/biomedicines12061192","volume":"12","author":"A Singh","year":"2024","unstructured":"Singh A, Singh K, Kaur K, Singh A, Sharma A, Kaur K, Kaur J, Kaur G, Kaur U, Kaur H, Singh P, Bedi PMS. Coumarin as an elite scaffold in anti-breast cancer drug development: Design strategies, mechanistic insights, and structure\u2013activity relationships. Biomedicines. 2024;12(6):1192. https:\/\/doi.org\/10.3390\/biomedicines12061192.","journal-title":"Biomedicines"},{"issue":"8","key":"3629_CR115","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s12032-025-02844-9","volume":"42","author":"MS Al Hasan","year":"2025","unstructured":"Al Hasan MS, Emon Y, Alshahrani MY, Mizan M, Uddin MB, Hasan AMW, Sayeed MA, Mia E, Yana NT, Hossan R, Islam MT. Coumarin derivatives as anticancer agents targeting PI3K-AKT-mTOR pathway: A comprehensive literature review. Med Oncol. 2025;42(8):301. https:\/\/doi.org\/10.1007\/s12032-025-02844-9.","journal-title":"Med Oncol"}],"container-title":["Medicinal Chemistry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00044-026-03629-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00044-026-03629-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00044-026-03629-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T05:35:16Z","timestamp":1791869716000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00044-026-03629-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":115,"alternative-id":["3629"],"URL":"https:\/\/doi.org\/10.1007\/s00044-026-03629-z","relation":{},"ISSN":["1054-2523","1554-8120"],"issn-type":[{"value":"1054-2523","type":"print"},{"value":"1554-8120","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"12 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}