{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:58:30Z","timestamp":1778648310932,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orofac Orthop"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1007\/s00056-020-00226-6","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T14:08:43Z","timestamp":1589983723000},"page":"286-300","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Angle class\u00a0II correction: stepwise mandibular advancement or bite jumping?","Therapie der Angle-Klasse\u00a0II: Schrittweise mandibul\u00e4re Vorverlagerung oder Bite-Jumping?"],"prefix":"10.1007","volume":"81","author":[{"given":"Michael","family":"Kn\u00f6sel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo Enrique","family":"Espinoza-Espinoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Sandoval-Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Zaror","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"226_CR1","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/S0889-5406(03)00345-7","volume":"124","author":"K O\u2019Brien","year":"2003","unstructured":"O\u2019Brien\u00a0K, Wright\u00a0J, Conboy\u00a0F, Sanjie\u00a0Y, Mandall\u00a0N, Chadwick\u00a0S, Connolly\u00a0I, Cook\u00a0P, Birnie\u00a0D, Hammond\u00a0M, Harradine\u00a0N, Lewis\u00a0D, McDade\u00a0C, Mitchell\u00a0L, Murray\u00a0A, O\u2019Neill\u00a0J, Read\u00a0M, Robinson\u00a0S, Roberts-Harry\u00a0D, Sandler\u00a0J, Shaw\u00a0I (2003) Effectiveness of treatment for Class II malocclusion with the Herbst or Twin-block appliances: a randomized, controlled trial. Am J Orthod Dentofacial Orthop 124:128\u2013137","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"226_CR2","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/S0889-5406(03)00352-4","volume":"124","author":"K O\u2019Brien","year":"2003","unstructured":"O\u2019Brien\u00a0K, Wright\u00a0J, Conboy\u00a0F, Sanjie\u00a0Y, Mandall\u00a0N, Chadwick\u00a0S, Connolly\u00a0I, Cook\u00a0P, Birnie\u00a0D, Hammond\u00a0M, Harradine\u00a0N, Lewis\u00a0D, McDade\u00a0C, Mitchell\u00a0L, Murray\u00a0A, O\u2019Neill\u00a0J, Read\u00a0M, Robinson\u00a0S, Roberts-Harry\u00a0D, Sandler\u00a0J, Shaw\u00a0I (2003) Effectiveness of early orthodontic treatment with the Twin-block appliance: a\u00a0multicenter, randomized, controlled trial. Part 1: dental and skeletal effects. Am J Orthod Dentofacial Orthop 124:234\u2013243","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"226_CR3","first-page":"CD003452","volume":"11","author":"B Thiruvenkatachari","year":"2013","unstructured":"Thiruvenkatachari\u00a0B, Harrison\u00a0JE, Worthington\u00a0HV, O\u2019Brien\u00a0KD (2013) Orthodontic treatment for prominent upper front teeth (Class II malocclusion) in children. Cochrane Database Syst Rev 11:CD3452","journal-title":"Cochrane Database Syst Rev"},{"key":"226_CR4","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1093\/ejo\/cju071","volume":"37","author":"V Koretsi","year":"2015","unstructured":"Koretsi\u00a0V, Zymperdikas\u00a0VF, Papageorgiou\u00a0SN, Papadopoulos\u00a0MA (2015) Treatment effects of removable functional appliances in patients with Class II malocclusion: a\u00a0systematic review and meta-analysis. Eur J Orthod 37:418\u2013434","journal-title":"Eur J Orthod"},{"key":"226_CR5","doi-asserted-by":"publisher","first-page":"e0141198","DOI":"10.1371\/journal.pone.0141198","volume":"10","author":"G Perinetti","year":"2015","unstructured":"Perinetti\u00a0G, Primo\u017ei\u010d\u00a0J, Franchi\u00a0L, Contardo\u00a0L (2015) Treatment effects of removable functional appliances in pre-pubertal and pubertal Class II patients: a\u00a0systematic review and meta-analysis of controlled studies. PLoS ONE 10:e141198","journal-title":"PLoS ONE"},{"key":"226_CR6","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ajodo.2014.06.011","volume":"147","author":"H Pancherz","year":"2015","unstructured":"Pancherz\u00a0H, Bjerklin\u00a0K, Hashemi\u00a0K (2015) Late adult skeletofacial growth after adolescent Herbst therapy: a\u00a032-year longitudinal follow-up study. Am J Orthod Dentofacial Orthop 147:19\u201328","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"226_CR7","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.ajodo.2004.03.024","volume":"126","author":"P Banks","year":"2004","unstructured":"Banks\u00a0P, Wright\u00a0J, O\u2019Brien\u00a0K (2004) Incremental versus maximum bite advancement during Twin-block therapy: a randomized controlled clinical trial. Am J Orthod Dentofacial Orthop 126:583\u2013588","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"226_CR8","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1093\/ejo\/cjv057","volume":"38","author":"X Yang","year":"2016","unstructured":"Yang\u00a0X, Zhu\u00a0Y, Long\u00a0H, Zhou\u00a0Y, Jian\u00a0F, Ye\u00a0N, Gao\u00a0M, Lai\u00a0W (2016) The effectiveness of the Herbst appliance for patients with Class II malocclusion: a\u00a0meta-analysis. Eur J Orthod 38:324\u2013333","journal-title":"Eur J Orthod"},{"key":"226_CR9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.ajodo.2006.09.064","volume":"134","author":"U H\u00e4gg","year":"2008","unstructured":"H\u00e4gg\u00a0U, Rabie\u00a0AB, Bendeus\u00a0M, Wong\u00a0RW, Wey\u00a0MC, Du\u00a0X, Peng\u00a0J (2008) Condylar growth and mandibular positioning with stepwise vs maximum advancement. Am J Orthod Dentofacial Orthop 134:525\u2013536","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"226_CR10","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/sj.ebd.6401171","volume":"17","author":"P Madurantakam","year":"2016","unstructured":"Madurantakam\u00a0P (2016) Fixed or removable function appliances for Class II malocclusions. Evid Based Dent 17:52\u201353","journal-title":"Evid Based Dent"},{"key":"226_CR11","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1093\/ejo\/cjv086","volume":"38","author":"MM Pacha","year":"2016","unstructured":"Pacha\u00a0MM, Fleming\u00a0PS, Johal\u00a0A (2016) A comparison of the efficacy of fixed versus removable functional appliances in children with Class II malocclusion: a systematic review. Eur J Orthod 38:621\u2013630","journal-title":"Eur J Orthod"},{"key":"226_CR12","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1093\/ejo\/13.6.471","volume":"13","author":"K Hansen","year":"1991","unstructured":"Hansen\u00a0K, Pancherz\u00a0H, H\u00e4gg\u00a0U (1991) Long-term effects of the Herbst appliance in relation to the treatment growth period: a\u00a0cephalometric study. Eur J Orthod 13:471\u2013481","journal-title":"Eur J Orthod"},{"key":"226_CR13","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1093\/ejo\/20.4.375","volume":"20","author":"S Ruf","year":"1998","unstructured":"Ruf\u00a0S, Pancherz\u00a0H (1998) Temporomandibular joint growth adaptation in Herbst treatment: a\u00a0prospective magnetic resonance imaging and cephalometric roentgenographic study. Eur J Orthod 20:375\u2013388","journal-title":"Eur J Orthod"},{"key":"226_CR14","first-page":"233","volume":"9","author":"SK Purkayastha","year":"2008","unstructured":"Purkayastha\u00a0SK, Rabie\u00a0ABM, Wong\u00a0R (2008) Treatment of skeletal Class II malocclusion in adults: stepwise vs single-step advancement with the Herbst appliance. World J Orthod 9:233\u2013243","journal-title":"World J Orthod"},{"key":"226_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1053\/sodo.2003.34023","volume":"9","author":"AB Rabie","year":"2003","unstructured":"Rabie\u00a0AB, Chayanupatkul\u00a0A, Urban H\u00e4gg\u00a0U (2003) Stepwise advancement using fixed functional appliances: experimental perspective. Semin Orthod 9:41\u201346","journal-title":"Semin Orthod"},{"key":"226_CR16","doi-asserted-by":"publisher","first-page":"82","DOI":"10.2319\/032416-241.1","volume":"87","author":"I Aras","year":"2017","unstructured":"Aras\u00a0I, Pasaoglu\u00a0A, Olmez\u00a0S, Unal\u00a0I, Tuncer\u00a0AV, Aras\u00a0A (2017) Comparison of stepwise vs single-step advancement with the Functional Mandibular Advancer in Class II division 1 treatment. Angle Orthod 87:82\u201387","journal-title":"Angle Orthod"},{"key":"226_CR17","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1093\/ejo\/cjm018","volume":"29","author":"MC Wey","year":"2007","unstructured":"Wey\u00a0MC, Bendeus\u00a0M, Li\u00a0P, H\u00e4gg\u00a0U, Rabie\u00a0ABM, Robinson\u00a0W (2007) Stepwise advancement versus maximum jumping with headgear activator. Eur J Orthod 29:283\u2013293","journal-title":"Eur J Orthod"},{"key":"226_CR18","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/ejo\/24.2.167","volume":"24","author":"X Du","year":"2002","unstructured":"Du\u00a0X, H\u00e4gg\u00a0U, Rabie\u00a0ABM (2002) Effects of headgear Herbst and mandibular step-by-step advancement versus conventional Herbst appliance and maximal jumping of the mandible. Eur J Orthod 24:167\u2013174","journal-title":"Eur J Orthod"},{"key":"226_CR19","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/S0889-5406(00)70231-9","volume":"117","author":"JC Voudouris","year":"2000","unstructured":"Voudouris\u00a0JC, Kuftinec\u00a0MM (2000) Improved clinical use of Twin-block and Herbst as a\u00a0result of radiating viscoelastic tissue forces on the condyle and fossa in treatment and long-term retention: growth relativity. Am J Orthod Dentofacial Orthop 117:247\u2013266","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"226_CR20","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00056-007-0703-4","volume":"68","author":"T Schi\u00f6th","year":"2007","unstructured":"Schi\u00f6th\u00a0T, von Bremen\u00a0J, Pancherz\u00a0H, Ruf\u00a0S (2007) Complications during Herbst appliance treatment with reduced mandibular cast splints: a\u00a0prospective, clinical multicenter study. J\u00a0Orofac Orthop 68:321\u2013327","journal-title":"J Orofac Orthop"},{"key":"226_CR21","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1093\/ejo\/cjv034","volume":"38","author":"VF Zymperdikas","year":"2016","unstructured":"Zymperdikas\u00a0VF, Koretsi\u00a0V, Papageorgiou\u00a0SN, Papadopoulos\u00a0MA (2016) Treatment effects of fixed functional appliances in patients with Class II malocclusion: a\u00a0systematic review and meta-analysis. Eur J Orthod 38:113\u2013126","journal-title":"Eur J Orthod"},{"key":"226_CR22","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.jebdp.2017.07.008","volume":"18","author":"R Nucera","year":"2018","unstructured":"Nucera\u00a0R, Militi\u00a0A, Lo Giudice\u00a0A, Longo\u00a0V, Fastuca\u00a0R, Caprioglio\u00a0A, Cordasco\u00a0G, Papadopoulos\u00a0MA (2018) Skeletal and dental effectiveness of treatment of Class II malocclusion with headgear: a systematic review and meta-analysis. J\u00a0Evid Based Dent Pract 18:41\u201358","journal-title":"J Evid Based Dent Pract"},{"key":"226_CR23","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/ejo\/cjv009","volume":"38","author":"NC Bock","year":"2016","unstructured":"Bock\u00a0NC, von Bremen\u00a0J, Ruf\u00a0S (2016) Stability of Class II fixed functional appliance therapy\u2014a systematic review and meta-analysis. Eur J Orthod 38:129\u2013139","journal-title":"Eur J Orthod"},{"key":"226_CR24","doi-asserted-by":"publisher","first-page":"1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher\u00a0D, Liberati\u00a0A, Tetzlaff\u00a0J, Altman\u00a0DG, The PRISMA Group (2009) Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med 6:1000097","journal-title":"PLoS Med"},{"key":"226_CR25","unstructured":"Higgins JPT, Green S (eds) (2011) \u201cCochrane Handbook for Systematic Reviews of Interventions Version 5.1.0\u201d,The Cochrane Collaboration. http:\/\/handbook.cochrane.org. Accessed 13.03.2019"},{"key":"226_CR26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/2046-4053-2-81","volume":"2","author":"MW Langendam","year":"2013","unstructured":"Langendam\u00a0MW, Akl\u00a0EA, Dahm\u00a0P, Glasziou\u00a0P, Guyatt\u00a0G, Sch\u00fcnemann\u00a0HJ (2013) Assessing and presenting summaries of evidence in Cochrane Reviews. Syst Rev 2:81","journal-title":"Syst Rev"},{"key":"226_CR27","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/0889-5406(89)90353-3","volume":"96","author":"F Falck","year":"1989","unstructured":"Falck\u00a0F, Fr\u00e4nkel\u00a0R (1989) Clinical relevance of step-by-step mandibular advancement in the treatment of mandibular retrusion using the Fr\u00e4nkel appliance. Am J Orthod Dentofacial Orthop 96:333\u2013341","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"226_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.odw.2015.09.001","volume":"75","author":"N Sakai","year":"2016","unstructured":"Sakai\u00a0N, Miyazawa\u00a0K, Tsutsui\u00a0T, Tabuchi\u00a0M, Shibata\u00a0M, Goto\u00a0S (2016) Comparative study of the treatment effects of bionator and bite jumping appliances on Class II malocclusions. Orthod Waves 75:1\u20139","journal-title":"Orthod Waves"},{"key":"226_CR29","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1093\/ejo\/20.5.501","volume":"20","author":"HM Illing","year":"1998","unstructured":"Illing\u00a0HM, Morris\u00a0DO, Lee\u00a0RT (1998) A prospective evaluation of Bass, Bionator and Twin Block appliances. Part I\u2014the hard tissues. Eur J Orthod 20:501\u2013516","journal-title":"Eur J Orthod"},{"key":"226_CR30","doi-asserted-by":"publisher","first-page":"e9","DOI":"10.1016\/j.ejwf.2013.12.003","volume":"3","author":"UH Doshi","year":"2014","unstructured":"Doshi\u00a0UH, Mahindra\u00a0R (2014) Effective temporomandibular joint growth changes after stepwise and maximum advancement with Twin Block appliance. J\u00a0World Fed Orthod 3:e9\u2013e14","journal-title":"J World Fed Orthod"},{"key":"226_CR31","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s11325-013-0859-7","volume":"18","author":"B Bishop","year":"2014","unstructured":"Bishop\u00a0B, Verrett\u00a0R, Girvan\u00a0T (2014) A randomized crossover study comparing two mandibular repositioning appliances for treatment of obstructive sleep apnea. Sleep Breath 18:125\u2013131","journal-title":"Sleep Breath"},{"key":"226_CR32","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1007\/s00056-016-0062-0","volume":"77","author":"I Aras","year":"2016","unstructured":"Aras\u00a0I, Pasaoglu\u00a0A, Olmez\u00a0S, Unal\u00a0I, Aras\u00a0A (2016) Upper airway changes following single-step or stepwise advancement using the Functional Mandibular Advancer. J\u00a0Orofac Orthop 77:454\u2013462","journal-title":"J Orofac Orthop"},{"key":"226_CR33","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.ajodo.2004.11.012","volume":"127","author":"DS Gill","year":"2005","unstructured":"Gill\u00a0DS, Lee\u00a0RT (2005) Prospective clinical trial comparing the effects of conventional Twin-block and mini-block appliances: Part 1. Hard tissue changes. Am J Orthod Dentofacial Orthop 127:465\u2013472","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"226_CR34","first-page":"101","volume":"20","author":"S Kumar","year":"1996","unstructured":"Kumar\u00a0S, Sidhu\u00a0S, Kharbanda\u00a0OP (1996) A cephalometric evaluation of the dental and facial-skeletal effects using the Bionator with stepwise protrusive activations. J\u00a0Clin Pediatr Dent 20:101\u2013108","journal-title":"J Clin Pediatr Dent"},{"key":"226_CR35","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ajodo.2018.02.014","volume":"155","author":"NG Amuk","year":"2019","unstructured":"Amuk\u00a0NG, Baysal\u00a0A, Coskun\u00a0R, Kurt\u00a0G (2019a) Effectiveness of incremental vs maximum bite advancement during Herbst appliance therapy in late adolescent and young adult patients. Am J Orthod Dentofacial Orthop 155:48\u201356","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"226_CR36","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1093\/ejo\/cjz011","volume":"41","author":"N Gul Amuk","year":"2019","unstructured":"Gul Amuk\u00a0N, Kurt\u00a0G, Baysal\u00a0A, Turker\u00a0G (2019b) Changes in pharyngeal airway dimensions following incremental and maximum bite advancement during Herbst-rapid palatal expander appliance therapy in late adolescent and young adult patients: a\u00a0randomized non-controlled prospective clinical study. Eur J Orthod 41:322\u2013330","journal-title":"Eur J Orthod"},{"key":"226_CR37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1053\/sodo.2003.34025","volume":"9","author":"U H\u00e4gg","year":"2003","unstructured":"H\u00e4gg\u00a0U, Du\u00a0X, Rabie\u00a0AB, Bendeus\u00a0M (2003) What does headgear add to Herbst treatment and to retention? Semin Orthod 9:57\u201366","journal-title":"Semin Orthod"},{"key":"226_CR38","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.2319\/110308-556R.1","volume":"79","author":"A Chaiyongsirisern","year":"2009","unstructured":"Chaiyongsirisern\u00a0A, Rabie\u00a0AB, Wong\u00a0RWK (2009) Stepwise Advancement Herbst Appliance versus Mandibular Sagittal Split Osteotomy. Angle Orthod 79:1084\u20131094","journal-title":"Angle Orthod"}],"container-title":["Journal of Orofacial Orthopedics \/ Fortschritte der Kieferorthop\u00e4die"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00056-020-00226-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00056-020-00226-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00056-020-00226-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T07:10:08Z","timestamp":1621494608000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00056-020-00226-6"}},"subtitle":["A\u00a0systematic review and meta-analysis of skeletal, dental and condylar effects","Ein systematisches Review mit Metaanalyse skelettaler, dentaler und kondyl\u00e4rer Effekte"],"short-title":[],"issued":{"date-parts":[[2020,5,20]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["226"],"URL":"https:\/\/doi.org\/10.1007\/s00056-020-00226-6","relation":{},"ISSN":["1434-5293","1615-6714"],"issn-type":[{"value":"1434-5293","type":"print"},{"value":"1615-6714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,20]]},"assertion":[{"value":"10 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M.\u00a0Kn\u00f6sel, G.\u00a0Espinoza-Espinoza, P.\u00a0Sandoval-Vidal and C.\u00a0Zaror declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}