{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:36:09Z","timestamp":1760189769758},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Justus-Liebig-Universit\u00e4t Gie\u00dfen"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orofac Orthop"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>To assess a\u00a0potential association between lower incisor (LI) position changes during Herbst\u2013multibracket appliance (Herbst\u2013MBA) treatment and the development of labial gingival recessions (LGR).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>All class\u00a0II patients (Department of Orthodontics, University of Giessen, Giessen, Germany) who had undergone Herbst\u2013MBA treatment until 2015 with study models and lateral cephalograms available from before (T0) and after treatment plus \u226524\u00a0months of retention (T3) were included (<jats:italic>n<\/jats:italic>\u202f=\u2009259). Lateral cephalograms were evaluated regarding LI position changes: iiL\/ML (angle between LI long axis and mandibular plane [MP]), ii-ML<jats:sub>Pg<\/jats:sub> (distance between LI incisal edge and a\u00a0line perpendicular to MP through pogonion), apex-ML<jats:sub>Pg<\/jats:sub> (distance between LI apex and a\u00a0line perpendicular to MP through pogonion), ii-ML<jats:sub>ii<\/jats:sub> (distance between LI incisal edge and MP on a\u00a0line perpendicular to MP through incisal edge). Using study models the distance between the cementoenamel junction and the deepest point of the gingival margin was defined as LGR.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The following cephalometric mean changes were recorded (T0\u2013T3): iiL\/ML +5.9\u202f\u00b1\u20095.76\u00b0 (<jats:italic>p<\/jats:italic>\u202f=\u20090.929), ii-ML<jats:sub>Pg<\/jats:sub> \u22120.2\u202f\u00b1\u20090.25\u202fmm (<jats:italic>p<\/jats:italic>\u202f=\u20090.430), apex-ML<jats:sub>Pg<\/jats:sub> +0.1\u202f\u00b1\u20090.32\u202fmm (<jats:italic>p<\/jats:italic>\u202f=\u20090.363), ii-ML<jats:sub>ii<\/jats:sub> +0.1\u202f\u00b1\u20090.36\u202fmm (<jats:italic>p<\/jats:italic>\u202f=\u20090.206). The mean increase of LGR magnitude measured on the study models was 0.1\u202f\u00b1\u20090.35\u202fmm. However, no association with the cephalometric LI position changes was found (|R|\u202f\u2264\u20090.2).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>There is no association between the amount of LI position changes and the development of LGR during Herbst\u2013MBA treatment plus retention. Nevertheless, individual predisposition or excessive treatment changes and extraordinary treatment approaches, respectively, might still lead to development of LGR.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00056-020-00272-0","type":"journal-article","created":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T05:57:48Z","timestamp":1610603868000},"page":"363-371","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Herbst\u2013multibracket appliance treatment: is there an association between lower incisor position changes and the development of labial gingival recessions?"],"prefix":"10.1007","volume":"82","author":[{"given":"S.","family":"S\u00fcdwasser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. C.","family":"Bock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Jost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Killat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ruf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,13]]},"reference":[{"key":"272_CR1","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1007\/s00784-017-2056-8","volume":"21","author":"GS Antonarakis","year":"2017","unstructured":"Antonarakis\u00a0GS, Joss\u00a0CU, Triaca\u00a0A, Kuijpers-Jagtman\u00a0AM, Kiliaridis\u00a0S (2017) Gingival recessions of lower incisors after proclination by orthodontics alone or in combination with anterior mandibular alveolar process distraction osteogenesis. Clin Oral Invest 21:2569\u20132579","journal-title":"Clin Oral Invest"},{"key":"272_CR2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1067\/mod.2001.111403","volume":"119","author":"J \u00c5rtun","year":"2001","unstructured":"\u00c5rtun\u00a0J, Grob\u00e9ty\u00a0D (2001) Periodontal status of mandibular incisors after pronounced orthodontic advancement during adolescence: a follow-up evaluation. Am J Orthod Dentofacial Orthop 119:2\u201310","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"272_CR3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/0889-5406(87)90450-1","volume":"91","author":"J \u00c5rtun","year":"1987","unstructured":"\u00c5rtun\u00a0J, Krogstad\u00a0O (1987) Periodontal status of mandibular incisors following excessive proclination. A study in adults with surgically treated mandibular prognathism. Am J Orthod Dentofacial Orthop 91:225\u2013232","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"272_CR4","first-page":"33","volume":"27","author":"T Aziz","year":"2011","unstructured":"Aziz\u00a0T, Flores-Mir\u00a0C (2011) A systematic review of the association between appliance-induced labial movement of mandibular incisors and gingival recession. Aust Orthod\u00a0J 27:33\u201339","journal-title":"Aust Orthod J"},{"key":"272_CR5","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1902\/jop.1974.45.9.660","volume":"45","author":"KF Batenhorst","year":"1974","unstructured":"Batenhorst\u00a0KF, Bowers\u00a0GM, Williams\u00a0JE Jr (1974) Tissue changes resulting from facial tipping and extrusion of incisors in monkeys. J\u00a0Periodontol 45:660\u2013668","journal-title":"J Periodontol"},{"key":"272_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ortho.2019.08.025","volume":"18","author":"BSK Bin Bahar","year":"2020","unstructured":"Bin Bahar\u00a0BSK, Alkhalidy\u00a0SR, Kaklamanos\u00a0EG, Athanasiou\u00a0AE (2020) Do orthodontic patients develop more gingival recession in anterior teeth compared to untreated individual? A systematic review of controlled studies. Int Orthod 18:1\u20139","journal-title":"Int Orthod"},{"key":"272_CR7","doi-asserted-by":"publisher","first-page":"3653","DOI":"10.1007\/s00784-020-03243-2","volume":"24","author":"NC Bock","year":"2020","unstructured":"Bock\u00a0NC, Killat\u00a0S, Ruf\u00a0S (2020) Class II:2 malocclusion\u2014prevalence and progression of labial gingival recessions during Herbst-Multibracket appliance treatment. Clin Oral Invest 24:3653\u20133660","journal-title":"Clin Oral Invest"},{"key":"272_CR8","doi-asserted-by":"publisher","first-page":"535","DOI":"10.2319\/032918-239.1","volume":"89","author":"NC Bock","year":"2019","unstructured":"Bock\u00a0NC, Ruehl\u00a0J, Ruf\u00a0S (2019) Prevalence, magnitude, and incidence of labial gingival recession with Herbst-multibracket appliance treatment. A retrospective cohort study. Angle Orthod 89:535\u2013543","journal-title":"Angle Orthod"},{"key":"272_CR9","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/ejo\/cjw034","volume":"38","author":"NC Bock","year":"2016","unstructured":"Bock\u00a0NC, Ruf\u00a0S, Wiechmann\u00a0D, Jilek\u00a0T (2016) Herbst plus Lingual versus Herbst plus Labial: a\u00a0comparison of occlusal outcome and gingival health. Eur J Orthod 38:478\u2013484","journal-title":"Eur J Orthod"},{"key":"272_CR10","volume-title":"SPSS 21","author":"F Brosius","year":"2013","unstructured":"Brosius\u00a0F (2013) SPSS 21. Mitp-Verlag, Heidelberg, M\u00fcnchen, Landsberg, Frechen, Hamburg"},{"key":"272_CR11","first-page":"1425","volume":"9","author":"D Ciavarella","year":"2017","unstructured":"Ciavarella\u00a0D, Tepedino\u00a0M, Gallo\u00a0C, Montaruli\u00a0G, Zhurakivska\u00a0K, Coppola\u00a0L, Troiano\u00a0G, Chimenti\u00a0C, Laurenziello\u00a0M, Lo Russo\u00a0L (2017) Post-orthodontic position of lower incisors and gingival recession: a retrospective study. J\u00a0Clin Exp Dent 9:1425\u20131430","journal-title":"J Clin Exp Dent"},{"key":"272_CR12","first-page":"540","volume":"75","author":"MR de Almeida","year":"2005","unstructured":"de Almeida\u00a0MR, Henriques\u00a0JF, de Almeida\u00a0RR, Weber\u00a0U, McNamara\u00a0JA Jr (2005) Short-term treatment effects produced by the Herbst appliance in the mixed dentition. Angle Orthod 75:540\u2013547","journal-title":"Angle Orthod"},{"key":"272_CR13","doi-asserted-by":"publisher","first-page":"180","DOI":"10.20396\/bjos.v15i2.8648780","volume":"15","author":"MV de Oliveira","year":"2017","unstructured":"de Oliveira\u00a0MV, Pithon\u00a0MM, Lacerda\u00a0XML, Soares\u00a0RV, Horta\u00a0MCR, Oliveira\u00a0DD (2017) Incisor proclination and gingival recessions: Is there a\u00a0relationship? Braz J Oral Sci 15:180\u2013184","journal-title":"Braz J Oral Sci"},{"key":"272_CR14","doi-asserted-by":"publisher","first-page":"820","DOI":"10.2319\/101010-591.1","volume":"81","author":"T El-Fateh","year":"2011","unstructured":"El-Fateh\u00a0T, Ruf\u00a0S (2011) Herbst treatment with mandibular cast splints\u2014revisited. Angle Orthod 81:820\u2013827","journal-title":"Angle Orthod"},{"key":"272_CR15","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.ajodo.2017.08.020","volume":"153","author":"M Gebistorf","year":"2018","unstructured":"Gebistorf\u00a0M, Mijuskovic\u00a0M, Pandis\u00a0N, Fudalej\u00a0PS, Katsaros\u00a0C (2018) Gingival recession in orthodontic patients 10 to 15\u00a0years posttreatment: a retrospective cohort study. Am J Orthod Dentofacial Orthop 153:645\u2013655","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"272_CR16","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1053\/sodo.2003.34026","volume":"9","author":"K Hansen","year":"2003","unstructured":"Hansen\u00a0K (2003) Treatment and Posttreatment effects of the Herbst appliance on the dental arches and arch relationships. Semin Orthod 9:67\u201373","journal-title":"Semin Orthod"},{"key":"272_CR17","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/S0889-5406(97)70279-8","volume":"112","author":"K Hansen","year":"1997","unstructured":"Hansen\u00a0K, Koutsonas\u00a0G, Pancherz\u00a0H (1997) Long-term effects of Herbst treatment on the mandibular incisor segment: a cephalometric and biometric investigation. Am J Orthod Dentofac Orthop 112:92\u2013103","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"272_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00056-018-0159-8","volume":"80","author":"JJ Ji","year":"2018","unstructured":"Ji\u00a0JJ, Li\u00a0XD, Fan\u00a0Q, Liu\u00a0XJ, Yao\u00a0S, Zhou\u00a0Z, Yang\u00a0S, Shen\u00a0Y (2018) Prevalence of gingival recession after orthodontic treatment of infraversion and open bite. J\u00a0Orofac Orthop 80:1\u20138","journal-title":"J Orofac Orthop"},{"key":"272_CR19","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1093\/ejo\/cjx006","volume":"39","author":"K Klaus","year":"2017","unstructured":"Klaus\u00a0K, Stark\u00a0P, Serbesis\u00a0TSP, Pancherz\u00a0H, Ruf\u00a0S (2017) Excellent versus unacceptable orthodontic results: influencing factors. Eur J Orthod 39:615\u2013621","journal-title":"Eur J Orthod"},{"key":"272_CR20","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.ajodo.2003.12.026","volume":"127","author":"B Melsen","year":"2005","unstructured":"Melsen\u00a0B, Allais\u00a0D (2005) Factors of importance for the development of dehiscences during labial movement of mandibular incisors: a retrospective study of adult orthodontic patients. Am J Orthod Dentofacial Orthop 127:552\u2013561","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"272_CR21","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.ajodo.2015.10.012","volume":"149","author":"B Mislik","year":"2016","unstructured":"Mislik\u00a0B, Konstantonis\u00a0D, Katsadouris\u00a0A, Eliades\u00a0T (2016) University clinic and private practice treatment outcomes in Class I extraction and nonextraction patients: A comparative study with the American Board of Orthodontics Objective Grading System. Am J Orthod Dentofacial Orthop 149:253\u2013258","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"272_CR22","doi-asserted-by":"publisher","first-page":"221","DOI":"10.2319\/121807-591.1","volume":"79","author":"A Moro","year":"2009","unstructured":"Moro\u00a0A, Janson\u00a0G, de Freitas\u00a0MR, Henriques\u00a0JF, Petrelli\u00a0NE, Lauris\u00a0JP (2009) Class II correction with the Cantilever Bite Jumper: a\u00a0variant of the Herbst. Angle Orthod 79:221\u2013229","journal-title":"Angle Orthod"},{"key":"272_CR23","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.ajodo.2016.09.027","volume":"151","author":"JW Morris","year":"2017","unstructured":"Morris\u00a0JW, Campbell\u00a0PM, Tadlock\u00a0LP, Boley\u00a0J, Buschang\u00a0PH (2017) Prevalence of gingival recession after orthodontic tooth movements. Am J Orthod Dentofacial Orthop 151:851\u2013859","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"272_CR24","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/ejo\/3.1.49","volume":"3","author":"H Pancherz","year":"1981","unstructured":"Pancherz\u00a0H (1981) The effect of continuous bite jumping on the dentofacial complex: a\u00a0follow-up study after Herbst appliance treatment of class II malocclusions. Eur J Orthod 3:49\u201360","journal-title":"Eur J Orthod"},{"key":"272_CR25","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/S1073-8746(97)80056-4","volume":"3","author":"H Pancherz","year":"1997","unstructured":"Pancherz\u00a0H (1997) The effects, limitations, and long-term dentofacial adaptations to treatment with the Herbst appliance. Semin Orthod 3:232\u2013243","journal-title":"Semin Orthod"},{"key":"272_CR26","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.ajodo.2014.02.009","volume":"146","author":"H Pancherz","year":"2014","unstructured":"Pancherz\u00a0H, Bjerklin\u00a0K (2014) Mandibular incisor inclination, tooth irregularity, and gingival recessions after Herbst therapy: a\u00a032-year follow-up study. Am J Orthod Dentofacial Orthop 146:310\u2013318","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"272_CR27","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/ejo\/10.1.149","volume":"10","author":"H Pancherz","year":"1988","unstructured":"Pancherz\u00a0H, Hansen\u00a0K (1988) Mandibular anchorage in Herbst treatment. Eur J Orthod 10:149\u2013166","journal-title":"Eur J Orthod"},{"key":"272_CR28","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1093\/ejo\/cjy086","volume":"41","author":"F Pernet","year":"2019","unstructured":"Pernet\u00a0F, Vento\u00a0C, Pandis\u00a0N, Kiliaridis\u00a0S (2019) Long-term evaluation of lower incisors gingival recessions after orthodontic treatment. Eur J Orthod 41:559\u2013564","journal-title":"Eur J Orthod"},{"key":"272_CR29","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/ejo\/cjs045","volume":"35","author":"AM Renkema","year":"2013","unstructured":"Renkema\u00a0AM, Fudalej\u00a0PS, Renkema\u00a0A, Bronkhorst\u00a0E, Katsaros\u00a0C (2013) Gingival recessions and the change of inclination of mandibular incisors during orthodontic treatment. Eur J Orthod 35:249\u2013255","journal-title":"Eur J Orthod"},{"key":"272_CR30","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1093\/ejo\/cju073","volume":"37","author":"AM Renkema","year":"2015","unstructured":"Renkema\u00a0AM, Navratilova\u00a0Z, Mazurova\u00a0K, Katsaros\u00a0C, Fudaley\u00a0PS (2015) Gingival labial recessions and the post-treatment proclination of mandibular incisors. Eur J Orthod 37:508\u2013513","journal-title":"Eur J Orthod"},{"key":"272_CR31","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/S0889-5406(98)70244-6","volume":"114","author":"S Ruf","year":"1998","unstructured":"Ruf\u00a0S, Hansen\u00a0K, Pancherz\u00a0H (1998) Does orthodontic proclination of lower incisors in children and adolescents cause gingival recession? Am J Orthod Dentofacial Orthop 114:100\u2013106","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"272_CR32","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1590\/2177-6709.21.2.095-101.oar","volume":"21","author":"JP Schwartz","year":"2016","unstructured":"Schwartz\u00a0JP, Raveli\u00a0TB, Schwartz-Filho\u00a0HO, Raveli\u00a0DB (2016) Changes in alveolar bone support induced by the Herbst appliance: a\u00a0tomographic evaluation. Dental Press J Orthod 21:95\u2013101","journal-title":"Dental Press J Orthod"},{"key":"272_CR33","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ajodo.2010.02.029","volume":"139","author":"I Sifakakis","year":"2011","unstructured":"Sifakakis\u00a0I, Pandis\u00a0N, Eliades\u00a0T, Makou\u00a0M, Katsaros\u00a0C, Bourauel\u00a0C (2011) In-vitro assessment of the forces generated by lingual fixed retainers. Am J Orthod Dentofacial Orthop 139:44\u201348","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"272_CR34","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1902\/jop.1981.52.6.314","volume":"52","author":"GG Steiner","year":"1981","unstructured":"Steiner\u00a0GG, Pearson\u00a0JK, Ainamo\u00a0J (1981) Changes of the marginal periodontium as a\u00a0result of labial tooth movement in monkeys. J\u00a0Periodontol 52:314\u2013320","journal-title":"J Periodontol"},{"key":"272_CR35","first-page":"e22","volume":"41","author":"S S\u00fcdwasser","year":"2019","unstructured":"S\u00fcdwasser\u00a0S, Bock\u00a0NC, Baier\u00a0S, R\u00fchl\u00a0J, Ruf\u00a0S (2019) Herbst-Multibracket treatment: does the amount of lower incisor position changes correlate with the development of labial gingival recessions? Eur J Orthod 41:e22 (Abstract)","journal-title":"Eur J Orthod"},{"key":"272_CR36","first-page":"E073","volume":"11","author":"OM Tanaka","year":"2010","unstructured":"Tanaka\u00a0OM, Avila\u00a0ALR, Silva\u00a0GM, Anez\u00a0MCG, Taffarel\u00a0IP (2010) The effects of orthodontic movement on a\u00a0subepithelias connective tissue graft in the treatment of gingival recession. J\u00a0Contemp Dent Pract 11:E73\u2013E79","journal-title":"J Contemp Dent Pract"},{"key":"272_CR37","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s40510-018-0212-6","volume":"19","author":"M Tepedino","year":"2018","unstructured":"Tepedino\u00a0M, Franchi\u00a0L, Fabbro\u00a0O, Chimenti\u00a0C (2018) Post-orthodontic lower incisor inclination and gingival recessions\u2014a\u00a0systematic review. Prog Orthod 19:17","journal-title":"Prog Orthod"},{"key":"272_CR38","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1093\/ejo\/cjm053","volume":"29","author":"J von Bremen","year":"2007","unstructured":"von Bremen\u00a0J, Pancherz\u00a0H, Ruf\u00a0S (2007) Reduced mandibular cast splints\u2014an alternative in Herbst therapy: A prospective multicentre study. Eur J Orthod 29:609\u2013613","journal-title":"Eur J Orthod"},{"key":"272_CR39","first-page":"23","volume":"75","author":"D Weschler","year":"2004","unstructured":"Weschler\u00a0D, Pancherz\u00a0H (2004) Efficiency of Three Mandibular Anchorage Forms in Herbst Treatment: A Cephalometric Investigation. Angle Orthod 75:23\u201327","journal-title":"Angle Orthod"}],"container-title":["Journal of Orofacial Orthopedics \/ Fortschritte der Kieferorthop\u00e4die"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00056-020-00272-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00056-020-00272-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00056-020-00272-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T16:03:29Z","timestamp":1635264209000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00056-020-00272-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,13]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["272"],"URL":"https:\/\/doi.org\/10.1007\/s00056-020-00272-0","relation":{},"ISSN":["1434-5293","1615-6714"],"issn-type":[{"value":"1434-5293","type":"print"},{"value":"1615-6714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,13]]},"assertion":[{"value":"7 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical guidelines"}},{"value":"S.\u00a0S\u00fcdwasser, N.\u00a0C.\u00a0Bock, J.\u00a0Jost, S.\u00a0Killat and S.\u00a0Ruf declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The protocol for this retrospective investigation was approved by the ethical committee of University of Giessen, Giessen, Germany (80\/14). The study was retrospective, so\u2014in accordance with the ethical approval\u2014no written informed consent was obtained. The manuscript does not include data related to individual persons.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}