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Eight anatomical landmarks were manually annotated, identified on axial views, and confirmed on the rendered volume image. The coordinates of each landmark were exported and the ANB (\u00b0) and bisector\u2013Wits (mm) measurements were constructed. Dahlberg\u2019s D\u00a0tested the intraobserver reliability and two-sample Kolmogorov\u2013Smirnov test was executed to assess normality and to select the subsequent tests. Spearman\u2019s rank correlation coefficient\u00a0(\u03c1) was utilized to correlate the angular (ANB) and linear (bisector\u2013Wits) measurements, whereas the Siegel estimator for nonparametric linear regression was employed to establish norm values by the correlation equation. Significance was set at\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.05 with correlation coefficients exceeding \u03c1\u202f&gt;\u20090.70 deemed clinically relevant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      High (\u03c1\u202f=\u20090.773) and statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.001) correlations between the ANB and bisector\u2013Wits measurements were found. The obtained equation was the following: bisector\u2013Wits\u202f=\u20091.06\u202f\u00d7\u2009ANB\u202f\u2013\u20096.32. Therefore, the obtained rounded norm range for bisector\u2013Wits for skeletal class\u00a0I sagittal relationship was determined to be from \u22126.3\u00a0to \u22122.1\u202fmm (\u22124.2\u202f\u00b1\u20092.1\u202fmm). Values less than \u22126.3\u202fmm correspond to a\u00a0class\u00a0III, whereas greater than \u22122.1\u202fmm correspond to a\u00a0class\u00a0II skeletal relationship.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study revealed a\u00a0statistically significant correlation between the ANB and bisector\u2013Wits. From a\u00a03D perspective, the bisector\u2013Wits represents a\u00a0reliable parameter to assess maxilla\u2013mandibular skeletal discrepancies instead of the ANB angle, also adhering to radioprotection principles by limiting the FOV to the maxillary complex only and potentially reducing the radiation exposure in CBCT-based cephalometry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00056-025-00583-0","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T22:51:27Z","timestamp":1743547887000},"page":"280-287","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel approach to three-dimensional intermaxillary skeletal assessment","Innovativer Ansatz f\u00fcr ein dreidimensionales intermaxill\u00e4res skelettales Assessment"],"prefix":"10.1007","volume":"87","author":[{"given":"M.","family":"Serafin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Baldini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Perrotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Caprioglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,31]]},"reference":[{"issue":"3","key":"583_CR1","first-page":"142","volume":"22","author":"RA Riedel","year":"1952","unstructured":"Riedel\u00a0RA (1952) The relation of maxillary structures to cranium in malocclusion and in normal occlusion. 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Specifically, they have no financial interests, such as investments, grants, or patents, that could be perceived to influence the outcomes or interpretation of this manuscript. Additionally, there are no personal relationships, affiliations, or professional connections that could be seen as potential conflicts. Furthermore, the authors have no other interests, either personal or institutional, that might affect the impartiality or integrity of their work. This declaration ensures the transparency and integrity of the research presented.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The retrospective study protocol underwent thorough review and received approval from the Ethical Committee of the University of Milan (protocol number 71\/22, dated 21\u00a0July 2022). The procedures strictly adhered to the principles outlined in the World Medical Organization Declaration of Helsinki. A\u00a0signed informed consent for releasing data records obtained from the answers of the surveys for scientific purposes was obtained from all the responders.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}