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NSOC is a\u00a0condition with complex genetically heterogeneous backgrounds for that several genes might be involved. Thus, this study investigated whether functional single nucleotide polymorphisms (SNPs) in genes that potentially influence the vitamin\u00a0D levels and parathyroid hormone (PTH) levels are associated with NSOC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Brazilian individuals with NSOC\u2014presenting cleft lip (CL), cleft lip and palate (CLP) and cleft palate (CP)\u2014and a\u00a0comparison group were selected. Individuals\u2019 DNA was obtained from epithelial cells of the oral mucosa. Nine SNPs in five genes (\n                      <jats:italic>VDR, CYP27B1, CYP24A1, SEC23A<\/jats:italic>\n                      and\n                      <jats:italic>PTH<\/jats:italic>\n                      ) were selected. Genotyping was performed by real-time polymerase chain reaction (PCR). The association between NSOC and vitamin\u00a0D related polymorphisms was analyzed by \u03a7\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0test at a\u00a0significance level of\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.005 (after Bonferroni correction).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The sample consisted of 274 individuals: 154 NSOC individuals and 120 controls. A\u00a0total of 43\u00a0(27.9%) had CL, 91 (59.1%) had CLP and 20 (13.0%) had CP. After Bonferroni correction, none of the SNPs were associated with NSOC (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&gt;\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>None of the studied SNPs in vitamin\u00a0D related and parathyroid hormone genes were associated with NSOC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00056-025-00614-w","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T18:11:11Z","timestamp":1759169471000},"page":"615-622","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between single nucleotide polymorphisms in vitamin\u00a0D related and parathyroid hormone genes with nonsyndromic oral cleft","Zusammenhang zwischen Einzelnukleotid-Polymorphismen in mit Vitamin\u00a0D und Parathormon assoziierten Genen und nichtsyndromalen oralen Spaltbildungen"],"prefix":"10.1007","volume":"87","author":[{"given":"Jana","family":"Marciniak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Fonseca-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela","family":"Scariot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svenja","family":"Beisel-Memmert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Daratsianos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Nascimento","family":"Meger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Vilalba Paniagua Machado","family":"do Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Kirschneck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Feltrin-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Calvano","family":"K\u00fcchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"614_CR1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8571541","author":"AB Al-Ghafari","year":"2019","unstructured":"Al-Ghafari\u00a0AB, Balamash\u00a0KS, Doghaither\u00a0HAA (2019) Relationship between serum vitamin\u00a0D and calcium levels and vitamin\u00a0D receptor gene polymorphisms in colorectal cancer. 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Bone 42(2):321\u2013331. https:\/\/doi.org\/10.1016\/j.bone.2007.09.057","journal-title":"Bone"}],"container-title":["Journal of Orofacial Orthopedics \/ Fortschritte der Kieferorthop\u00e4die"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00056-025-00614-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00056-025-00614-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00056-025-00614-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:01:17Z","timestamp":1793016077000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00056-025-00614-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,29]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["614"],"URL":"https:\/\/doi.org\/10.1007\/s00056-025-00614-w","relation":{},"ISSN":["1434-5293","1615-6714"],"issn-type":[{"value":"1434-5293","type":"print"},{"value":"1615-6714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,29]]},"assertion":[{"value":"10 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"J.\u00a0Marciniak, G.\u00a0Fonseca-Souza, R.\u00a0Scariot, S.\u00a0Beisel-Memmert, N.\u00a0Daratsianos, M.N.\u00a0Meger, T.V.P.M.\u00a0do Nascimento, C.\u00a0Kirschneck, J.\u00a0Feltrin-Souza and E.C.\u00a0K\u00fcchler declare that they have no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Ethics"}},{"value":"The study protocol followed the principles of the Declaration of Helsinki and was approved by the Research Ethics Committee of the State Health Department of Paran\u00e1 (protocol number 5.100.185) and by the Human Research Ethics Committee of the Health Sciences of the Federal University of Paran\u00e1 (protocol number 3.752.172). Assent was obtained from the children to ensure their understanding and willingness to participate while informed consent was secured from their legal guardians, granting official permission for their involvement in the study.","order":2,"name":"Ethics","label":"Ethical standards","group":{"name":"EthicsHeading","label":"Ethics"}}]}}