{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:12:18Z","timestamp":1793650338024,"version":"4.5.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008967","name":"Philipps-Universit\u00e4t Marburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008967","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orofac Orthop"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/objectives<\/jats:title>\n                    <jats:p>Mandibular advancement devices (MADs) represent an established second-line therapy for obstructive sleep apnea (OSA), but therapeutic responses vary considerably. The primary aim of this retrospective pilot cohort study was to evaluate craniofacial characteristics, particularly the ANB angle, as potential diagnostic predictors of treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Anamnestic, clinical, and poly(somno)graphic data were collected from OSA patients before MAD insertion (t0) and after final titration with poly(somno)graphic confirmation (t1). Cephalometric measurements, including hyoid bone position, were analyzed. Patients were stratified based on the ANB angle (ANB\u202f\u2264\u20094\u00b0: group\u00a01; ANB\u202f&gt;\u20094\u00b0: group\u00a02). Statistical analysis included independent t\u2011tests, Pearson correlations, receiver operating characteristic (ROC) curve analysis, and multiple regression models to identify predictors of treatment response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A\u00a0total of 38\u00a0patients (mean age 57.6\u202f\u00b1\u200911.7 years; 52% male) were included. Group\u00a02 showed significantly greater reductions in Apnea\u2013Hypopnea Index (AHI) at t1 (\u221284.6% vs. \u221239.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&lt;\u20090.001). ROC analysis identified an optimal ANB cut-off of 4.7\u00b0 (AUC\u202f=\u20090.791), with 75% sensitivity and 81.2% specificity. In addition to ANB, higher Wits values and a\u00a0smaller Bj\u00f6rk polygon sum (hypodivergent pattern) independently predicted greater AHI reduction. Reductions in AHI were significantly correlated with improvements in Epworth Sleepiness Scale (ESS) scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cephalometric parameters predict a\u00a0favorable response to MAD therapy for OSA. Integrating cephalometric analysis into the diagnostic workflow may improve patient selection and prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00056-025-00632-8","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T10:22:46Z","timestamp":1766139766000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mandibular advancement devices in obstructive sleep apnea: diagnostic predictors for treatment response and clinical implications","Unterkieferprotrusionsschienen bei obstruktiver Schlafapnoe: diagnostische Pr\u00e4diktoren f\u00fcr das Therapieansprechen und klinische Implikationen"],"prefix":"10.1007","author":[{"given":"Janine","family":"Sambale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Koehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Reichelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Korbmacher-Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,19]]},"reference":[{"key":"632_CR1","doi-asserted-by":"publisher","first-page":"101211","DOI":"10.1016\/j.smrv.2019.101211","volume":"48","author":"A Alessandri-Bonetti","year":"2019","unstructured":"Alessandri-Bonetti\u00a0A, Bortolotti\u00a0F, Moreno-Hay\u00a0I, Michelotti\u00a0A, Cordaro\u00a0M, Alessandri-Bonetti\u00a0G, Okeson\u00a0JP (2019) Effects of mandibular advancement device for obstructive sleep apnea on temporomandibular disorders: a\u00a0systematic review and meta-analysis. 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Sambale, U. Koehler, J. Reichelt and H. Korbmacher-Steiner declare that there are no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This retrospective pilot cohort study was conducted in accordance with the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guidelines and adhered to the principles of the Declaration of Helsinki. Ethical approval was obtained from the Ethics Committee of the University Marburg (reference no. 25-18 RS) and informed consent was obtained from all participants prior to their inclusion in the study. Patient data were pseudonymized and analyzed retrospectively.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics"}}]}}