{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:00:15Z","timestamp":1790258415651,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Orofac Orthop"],"DOI":"10.1007\/s00056-026-00690-6","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:04:41Z","timestamp":1790255081000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of different clear aligner systems with fixed orthodontic treatment in terms of endocrine-disrupting monomer release, treatment effectiveness and efficiency","Vergleich verschiedener Clear-Aligner-Systeme mit festsitzender kieferorthop\u00e4discher Behandlung hinsichtlich der Freisetzung endokrin wirksamer Monomere sowie Behandlungseffektivit\u00e4t und -effizienz"],"prefix":"10.1007","author":[{"given":"Nizami","family":"Hashimli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Yagci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Cadir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"690_CR1","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/cjaf091","author":"ZM Alhafi","year":"2025","unstructured":"Alhafi\u00a0ZM et\u00a0al (2025) Quality and stability of orthodontic treatment outcomes with clear aligners versus fixed appliances: A\u00a0systematic review and meta-analysis. Eur J Orthod. https:\/\/doi.org\/10.1093\/ejo\/cjaf091","journal-title":"Eur J Orthod"},{"issue":"4","key":"690_CR2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ejwf.2022.04.003","volume":"11","author":"ZM Alhafi","year":"2022","unstructured":"Alhafi\u00a0ZM, Rajeh\u00a0N (2022) Evaluation of the effectiveness of modified aligner appliance with nickel-titanium springs in treatment of mild crowding of lower incisors: A randomized controlled clinical trial. J\u00a0World Fed Orthod 11(4):107\u2013113. https:\/\/doi.org\/10.1016\/j.ejwf.2022.04.003","journal-title":"J World Fed Orthod"},{"key":"690_CR3","doi-asserted-by":"publisher","DOI":"10.5195\/d3000.2024.532","author":"ZM Alhafi","year":"2024","unstructured":"Alhafi\u00a0ZM et\u00a0al (2024) Assessment of the alignment acceleration of the lower incisors using a single aligner appliance modified with nickel-titanium coils: A randomized controlled clinical trial in adults. Dentistry 3000. https:\/\/doi.org\/10.5195\/d3000.2024.532","journal-title":"Dentistry 3000"},{"key":"690_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2024.07.1028","author":"BA Avan","year":"2024","unstructured":"Avan\u00a0BA et\u00a0al (2024) Do beverages cause bisphenol\u2011A release from thermoplastic orthodontic appliances? Int Dent J. https:\/\/doi.org\/10.1016\/j.identj.2024.07.1028","journal-title":"Int Dent J"},{"issue":"3","key":"690_CR5","doi-asserted-by":"publisher","first-page":"391","DOI":"10.2319\/062113-466","volume":"84","author":"PH Buschang","year":"2014","unstructured":"Buschang\u00a0PH et\u00a0al (2014) Comparative time efficiency of aligner therapy and conventional edgewise braces. Angle Orthod 84(3):391\u2013396. https:\/\/doi.org\/10.2319\/062113-466","journal-title":"Angle Orthod"},{"issue":"6","key":"690_CR6","doi-asserted-by":"publisher","first-page":"721","DOI":"10.2319\/010923-17.1","volume":"93","author":"\u00d6 \u00c7if\u00e7i","year":"2023","unstructured":"\u00c7if\u00e7i \u00d6, Dumanl\u0131\u00a0G (2023) Evaluation of bisphenol release of different clear aligner materials using LC-MS\/MS. Angle Orthod 93(6):721\u2013726. https:\/\/doi.org\/10.2319\/010923-17.1","journal-title":"Angle Orthod"},{"issue":"2","key":"690_CR7","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3758\/BF03193146","volume":"39","author":"F Faul","year":"2007","unstructured":"Faul\u00a0F et\u00a0al (2007) G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 39(2):175\u2013191. https:\/\/doi.org\/10.3758\/BF03193146","journal-title":"Behav Res Methods"},{"key":"690_CR8","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2015.3978","volume":"13","author":"K Grob","year":"2015","unstructured":"Grob\u00a0K et\u00a0al (2015) Scientific opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary. EFSA J 13:3978. https:\/\/doi.org\/10.2903\/j.efsa.2015.3978","journal-title":"EFSA J"},{"issue":"1","key":"690_CR9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.51847\/skGajuit2m","volume":"5","author":"JP Grodzicki","year":"2025","unstructured":"Grodzicki\u00a0JP, Rypel\u00a0J (2025) Evaluation of cytotoxicity and endocrine disruption in orthodontic retainer materials: A\u00a0comprehensive analysis. Ann Orthod Periodontics Spec 5(1):75\u201392. https:\/\/doi.org\/10.51847\/skGajuit2m","journal-title":"Ann Orthod Periodontics Spec"},{"issue":"2","key":"690_CR10","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.ajodo.2016.06.041","volume":"151","author":"J Gu","year":"2017","unstructured":"Gu\u00a0J et\u00a0al (2017) Evaluation of Invisalign treatment effectiveness and efficiency compared with conventional fixed appliances using the PAR index. AJO DO Clin Companion 151(2):259\u2013266. https:\/\/doi.org\/10.1016\/j.ajodo.2016.06.041","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"3","key":"690_CR11","doi-asserted-by":"publisher","first-page":"288","DOI":"10.2334\/josnusd.19-0221","volume":"62","author":"P Gul","year":"2020","unstructured":"Gul\u00a0P, Alp\u00a0HH, \u00d6zcan\u00a0M (2020) Monomer release from bulk-fill composite resins in different curing protocols. J\u00a0Oral Sci 62(3):288\u2013292. https:\/\/doi.org\/10.2334\/josnusd.19-0221","journal-title":"J Oral Sci"},{"key":"690_CR12","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.envint.2011.04.010","volume":"42","author":"Y Huang","year":"2012","unstructured":"Huang\u00a0Y et\u00a0al (2012) Bisphenol A (BPA) in China: Sources, environmental levels, and potential human health impacts. Environ Int 42:91\u201399. https:\/\/doi.org\/10.1016\/j.envint.2011.04.010","journal-title":"Environ Int"},{"issue":"8","key":"690_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/ma13081843","volume":"13","author":"A Iliadi","year":"2020","unstructured":"Iliadi\u00a0A et\u00a0al (2020) Safety considerations for thermoplastic-type appliances used as orthodontic aligners or retainers: A\u00a0systematic review and meta-analysis. Materials 13(8):1843. https:\/\/doi.org\/10.3390\/ma13081843","journal-title":"Materials"},{"key":"690_CR14","doi-asserted-by":"publisher","DOI":"10.21926\/rpm.2103034","author":"S Katras","year":"2021","unstructured":"Katras\u00a0S et\u00a0al (2021) Bisphenol A release from orthodontic clear aligners: An in vitro study. Recent Prog Mater. https:\/\/doi.org\/10.21926\/rpm.2103034","journal-title":"Recent Prog Mater"},{"key":"690_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-018-0695-z","volume":"19","author":"Y Ke","year":"2019","unstructured":"Ke\u00a0Y, Zhu\u00a0Y, Zhu\u00a0M (2019) A comparison of treatment effectiveness between clear aligner and fixed appliance therapies. BMC Oral Health 19:24. https:\/\/doi.org\/10.1186\/s12903-018-0695-z","journal-title":"BMC Oral Health"},{"issue":"1","key":"690_CR16","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ajodo.2024.08.013","volume":"167","author":"V Knode","year":"2025","unstructured":"Knode\u00a0V et\u00a0al (2025) Directly printed aligner therapy: A 12-month evaluation of application and effectiveness. AJO DO Clin Companion 167(1):73\u201379. https:\/\/doi.org\/10.1016\/j.ajodo.2024.08.013","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"1","key":"690_CR17","first-page":"5","volume":"66","author":"A Konieczna","year":"2015","unstructured":"Konieczna\u00a0A, Rutkowska\u00a0A, Rachon\u00a0D (2015) Health risk of exposure to bisphenol A (BPA). Rocz Panstw Zakl Hig 66(1):5\u201311","journal-title":"Rocz Panstw Zakl Hig"},{"issue":"7","key":"690_CR18","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3290\/j.qi.a40511","volume":"49","author":"V Lanteri","year":"2018","unstructured":"Lanteri\u00a0V et\u00a0al (2018) The efficacy of orthodontic treatment for anterior crowding with Invisalign compared with fixed appliances using the Peer Assessment Rating Index. Quintessence Int 49(7):581\u2013587. https:\/\/doi.org\/10.3290\/j.qi.a40511","journal-title":"Quintessence Int"},{"issue":"3","key":"690_CR19","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3390\/polym16030371","volume":"16","author":"P Narongdej","year":"2024","unstructured":"Narongdej\u00a0P et\u00a0al (2024) Advancements in clear aligner fabrication: A comprehensive review of direct-3D printing technologies. Polymers 16(3):371\u2013371. https:\/\/doi.org\/10.3390\/polym16030371","journal-title":"Polymers"},{"issue":"3","key":"690_CR20","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1177\/14653125231160570","volume":"50","author":"P E","year":"2023","unstructured":"Peter E, George\u00a0SA (2023) Bisphenol\u2011A release from thermoplastic clear aligner materials: A\u00a0systematic review. J\u00a0Orthod 50(3):276\u2013286. https:\/\/doi.org\/10.1177\/14653125231160570","journal-title":"J Orthod"},{"issue":"3","key":"690_CR21","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.ajodo.2016.07.022","volume":"151","author":"AS Raghavan","year":"2017","unstructured":"Raghavan\u00a0AS et\u00a0al (2017) Comparative evaluation of salivary bisphenol A levels in patients wearing vacuum-formed and Hawley retainers: An in vivo study. AJO DO Clin Companion 151(3):471\u2013476. https:\/\/doi.org\/10.1016\/j.ajodo.2016.07.022","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"2","key":"690_CR22","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1093\/ejo\/14.2.125","volume":"14","author":"S Richmond","year":"1992","unstructured":"Richmond\u00a0S et\u00a0al (1992) The development of the PAR Index (Peer Assessment Rating): Reliability and validity. Eur J Orthod 14(2):125\u2013139. https:\/\/doi.org\/10.1093\/ejo\/14.2.125","journal-title":"Eur J Orthod"},{"key":"690_CR23","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-4-26","volume":"4","author":"M Saghaei","year":"2004","unstructured":"Saghaei\u00a0M (2004) Random allocation software for parallel group randomized trials. BMC Med Res Methodol 4:26. https:\/\/doi.org\/10.1186\/1471-2288-4-26","journal-title":"BMC Med Res Methodol"},{"issue":"4","key":"690_CR24","first-page":"263","volume":"43","author":"OC Tuncay","year":"2009","unstructured":"Tuncay\u00a0OC et\u00a0al (2009) Effectiveness of a compliance indicator for clear aligners. J\u00a0Clin Orthod 43(4):263\u2013268","journal-title":"J Clin Orthod"},{"issue":"4","key":"690_CR25","doi-asserted-by":"publisher","DOI":"10.1289\/EHP13812","volume":"132","author":"FS Vom Saal","year":"2024","unstructured":"Vom Saal\u00a0FS et\u00a0al (2024) The conflict between regulatory agencies over the lowering of the tolerable daily intake for BPA by EFSA. Environ Health Perspect 132(4):045001. https:\/\/doi.org\/10.1289\/EHP13812","journal-title":"Environ Health Perspect"},{"issue":"3","key":"690_CR26","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1093\/ejo\/cjac056","volume":"45","author":"A Willi","year":"2023","unstructured":"Willi\u00a0A et\u00a0al (2023) Leaching from a 3D-printed aligner resin. Eur J Orthod 45(3):244\u2013249. https:\/\/doi.org\/10.1093\/ejo\/cjac056","journal-title":"Eur J Orthod"},{"issue":"1","key":"690_CR27","doi-asserted-by":"publisher","DOI":"10.4103\/1735-3327.372658","volume":"20","author":"M Yazdi","year":"2023","unstructured":"Yazdi\u00a0M et\u00a0al (2023) A systematic review of biocompatibility and safety of orthodontic clear aligners and transparent vacuum-formed thermoplastic retainers: Bisphenol\u2011A release, adverse effects, cytotoxicity, and estrogenic effects. Dent Res J 20(1):41. https:\/\/doi.org\/10.4103\/1735-3327.372658","journal-title":"Dent Res J"}],"container-title":["Journal of Orofacial Orthopedics \/ Fortschritte der Kieferorthop\u00e4die"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00056-026-00690-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00056-026-00690-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00056-026-00690-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:04:42Z","timestamp":1790255082000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00056-026-00690-6"}},"subtitle":["An in\u00a0vivo randomized clinical trial","Eine randomisierte klinische In-vivo-Studie"],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":27,"alternative-id":["690"],"URL":"https:\/\/doi.org\/10.1007\/s00056-026-00690-6","relation":{},"ISSN":["1434-5293","1615-6714"],"issn-type":[{"value":"1434-5293","type":"print"},{"value":"1615-6714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"assertion":[{"value":"25 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Clinical Research Ethics Committee of the Erciyes University, with the decision dated 09.08.2023 and numbered 2023\/490. This trial was registered at ClinicalTrials.gov, registration number (ID): NCT06685029. Written informed consent was obtained from the parents or legal guardians of all participants before inclusion in the study. No harmful effects were observed during the interventions applied to the patients. The protocol was not published prior to the start of the trial.","order":2,"name":"Ethics","label":"Ethical standards","group":{"name":"EthicsHeading","label":"Declarations"}}]}}