{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T18:34:56Z","timestamp":1769279696624,"version":"3.49.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T00:00:00Z","timestamp":1361491200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Herz"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1007\/s00059-013-3761-y","type":"journal-article","created":{"date-parts":[[2013,2,20]],"date-time":"2013-02-20T13:58:46Z","timestamp":1361368726000},"page":"779-784","source":"Crossref","is-referenced-by-count":22,"title":["Hyperhomocysteinemia is an independent risk factor in young patients with coronary artery disease in southern China","Hyperhomozystein\u00e4mie ist ein unabh\u00e4ngiger Risikofaktor bei jungen Patienten mit koronarer Herzkrankheit in S\u00fcdchina"],"prefix":"10.1007","volume":"38","author":[{"given":"Y.","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,2,22]]},"reference":[{"key":"3761_CR1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1155\/2011\/625939","volume":"31","author":"Huang","year":"2011","unstructured":"Huang Y, Hu Y, Mai W et al (2011) Plasma oxidized low-density lipoprotein is an independent risk factor in young patients with coronary artery disease. Dis Markers 31:295\u2013301","journal-title":"Dis Markers"},{"key":"3761_CR2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.ahj.2007.02.027","volume":"153","author":"Eichler","year":"2007","unstructured":"Eichler K, Puhan MA, Steurer J, Bachmann LM (2007) Prediction of first coronary events with the Framingham score: a systematic review. Am Heart J 153:722\u2013731, 731.e1\u20138","journal-title":"Am Heart J"},{"key":"3761_CR3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3132\/dvdr.2006.012","volume":"3","author":"Zarich","year":"2006","unstructured":"Zarich S, Luciano C, Hulford J, Abdullah A (2006) Prevalence of metabolic syndrome in young patients with acute MI: does the Framingham risk score underestimate cardiovascular risk in this population. Diab Vasc Dis Res 3:103\u2013107","journal-title":"Diab Vasc Dis Res"},{"key":"3761_CR4","doi-asserted-by":"crossref","first-page":"496","DOI":"10.7326\/0003-4819-151-7-200910060-00010","volume":"151","author":"Helfand","year":"2009","unstructured":"Helfand M, Buckley DI, Freeman M et al (2009) Emerging risk factors for coronary heart disease: a summary of systematic reviews conducted for the U.S. Preventive Services Task Force. Ann Intern Med 151:496\u2013507","journal-title":"Ann Intern Med"},{"key":"3761_CR5","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.2174\/092986712800493039","volume":"19","author":"Kampoli","year":"2012","unstructured":"Kampoli AM, Tousoulis D, Papageorgiou N et al (2012) Clinical utility of biomarkers in premature atherosclerosis. Curr Med Chem 19:2521\u20132533","journal-title":"Curr Med Chem"},{"key":"3761_CR6","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jacc.2011.05.028","volume":"58","author":"Veeranna","year":"2011","unstructured":"Veeranna V, Zalawadiya SK, Niraj A et al (2011) Homocysteine and reclassification of cardiovascular disease risk. J Am Coll Cardiol 58:1025\u20131033","journal-title":"J Am Coll Cardiol"},{"key":"3761_CR7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10545-010-9235-y","volume":"34","author":"Clarke","year":"2011","unstructured":"Clarke R, Halsey J, Bennett D, Lewington S (2011) Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials. J Inherit Metab Dis 34:83\u201391","journal-title":"J Inherit Metab Dis"},{"key":"3761_CR8","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0140-6736(11)60872-6","volume":"378","author":"Holmes","year":"2011","unstructured":"Holmes MV, Newcombe P, Hubacek JA et al (2011) Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Lancet 378:584\u2013594","journal-title":"Lancet"},{"key":"3761_CR9","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1001\/archinternmed.2010.348","volume":"170","author":"Clarke","year":"2010","unstructured":"Clarke R, Halsey J, Lewington S et al (2010) Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med 170:1622\u20131631","journal-title":"Arch Intern Med"},{"key":"3761_CR10","first-page":"569","volume":"J","author":"Cho","year":"2012","unstructured":"Cho DY, Kim KN, Kim KM et al (2012) Combination of high-sensitivity C-reactive protein and homocysteine may predict an increased risk of coronary artery disease in Korean population. Chin Med J (Engl) 25:569\u2013573","journal-title":"Chin Med"},{"key":"3761_CR11","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ahj.2008.02.024","volume":"156","author":"McCullough","year":"2008","unstructured":"McCullough PA, Li S, Jurkovitz CT et al (2008) Chronic kidney disease, prevalence of premature cardiovascular disease, and relationship to short-term mortality. Am Heart J 156:277\u2013283","journal-title":"Am Heart J"},{"key":"3761_CR12","first-page":"e25","volume":"15","author":"Oudi","year":"2010","unstructured":"Oudi ME, Aouni Z, Mazigh C et al (2010) Homocysteine and markers of inflammation in acute coronary syndrome. Exp Clin Cardiol 15:e25\u201328","journal-title":"Exp Clin Cardiol"},{"key":"3761_CR13","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","volume":"289","author":"Chobanian","year":"2003","unstructured":"Chobanian AV, Bakris GL, Black HR et al (2003) The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 289:2560\u20132572","journal-title":"JAMA"},{"key":"3761_CR14","unstructured":"(o A) (2003) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26(Suppl 1):S5\u201320"},{"key":"3761_CR15","first-page":"390","volume":"Cardiol","author":"The","year":"2007","unstructured":"The Association Committee of Prevention and Treatment of Dyslipidemia (2007) The 2007 guidelines for prevention and treatment of dyslipidemia in adults in China. Chin J Cardiol (Chin) 35:390\u2013419","journal-title":"Chin J"},{"key":"3761_CR16","doi-asserted-by":"crossref","first-page":"c154","DOI":"10.1136\/bmj.c154","volume":"340","author":"Logue","year":"2010","unstructured":"Logue J, Thompson L, Romanes F et al (2010) Management of obesity: summary of SIGN guideline. BMJ 340:c154","journal-title":"BMJ"},{"key":"3761_CR17","first-page":"3676","volume":"J","author":"Cui","year":"2011","unstructured":"Cui H, Wang F, Fan L et al (2011) Association factors of target organ damage: analysis of 17,682 elderly hypertensive patients in China. Chin Med J (Engl) 124:3676\u20133681","journal-title":"Chin Med"},{"key":"3761_CR18","first-page":"S301","volume":"8","author":"Talbert","year":"2002","unstructured":"Talbert RL (2002) New therapeutic options in the National Cholesterol Education Program Adult Treatment Panel III. Am J Manag Care 8(12 Suppl):S301\u2013307","journal-title":"Am J Manag Care"},{"key":"3761_CR19","doi-asserted-by":"crossref","first-page":"28A","DOI":"10.1016\/j.amjcard.2005.11.013","volume":"97","author":"Smith","year":"2006","unstructured":"Smith SC Jr (2006) Current and future directions of cardiovascular risk prediction. Am J Cardiol 97:28A\u201332A","journal-title":"Am J Cardiol"},{"key":"3761_CR20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/eurheartj\/ehn515","volume":"30","author":"Antoniades","year":"2009","unstructured":"Antoniades C, Antonopoulos AS, Tousoulis D et al (2009) Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J 30:6\u201315","journal-title":"Eur Heart J"},{"key":"3761_CR21","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1253\/circj.CJ-12-0039","volume":"76","author":"Banos-Gonzalez","year":"2012","unstructured":"Banos-Gonzalez MA, Angles-Cano E, Cardoso-Saldana G et al (2012) Lipoprotein(a) and homocysteine potentiate the risk of coronary artery disease in male subjects. Circ J 76:1953\u20131957","journal-title":"Circ J"},{"key":"3761_CR22","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1160\/TH09-06-0393","volume":"103","author":"Di","year":"2010","unstructured":"Di MMN, Tremoli E, Coppola A et al (2010) Homocysteine and arterial thrombosis: challenge and opportunity. Thromb Haemost 103:942\u2013961","journal-title":"Thromb Haemost"},{"key":"3761_CR23","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.2174\/092986712800493039","volume":"19","author":"Kampoli","year":"2012","unstructured":"Kampoli AM, Tousoulis D, Papageorgiou N et al (2012) Clinical utility of biomarkers in premature atherosclerosis. Curr Med Chem 19:2521\u20132533","journal-title":"Curr Med Chem"},{"key":"3761_CR24","first-page":"569","volume":"J","author":"Cho","year":"2012","unstructured":"Cho DY, Kim KN, Kim KM et al (2012) Combination of high-sensitivity C-reactive protein and homocysteine may predict an increased risk of coronary artery disease in Korean population. Chin Med J (Engl) 125:569\u2013573","journal-title":"Chin Med"},{"key":"3761_CR25","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/FPC.0b013e32834741ff","volume":"21","author":"Nagele","year":"2011","unstructured":"Nagele P, Meissner K, Francis A et al (2011) Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification. Pharmacogenet Genomics 21:426\u2013431","journal-title":"Pharmacogenet Genomics"},{"key":"3761_CR26","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1086\/301836","volume":"62","author":"Schneider","year":"1998","unstructured":"Schneider JA, Rees DC, Liu YT, Clegg JB (1998) Worldwide distribution of a common methylenetetrahydrofolate reductase mutation. Am J Hum Genet 62:1258\u20131260","journal-title":"Am J Hum Genet"},{"key":"3761_CR27","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1536\/ihj.52.280","volume":"52","author":"Chai","year":"2011","unstructured":"Chai HT, Chen YL, Chung SY et al (2011) Value and level of plasma homocysteine in patients with angina pectoris undergoing coronary angiographic study. Int Heart J 52:280\u2013285","journal-title":"Int Heart J"},{"key":"3761_CR28","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1093\/eurheartj\/ehq235","volume":"32","author":"Perrone-Filardi","year":"2011","unstructured":"Perrone-Filardi P, Achenbach S, Mohlenkamp S et al (2011) Cardiac computed tomography and myocardial perfusion scintigraphy for risk stratification in asymptomatic individuals without known cardiovascular disease: a position statement of the Working Group on Nuclear Cardiology and Cardiac CT of the European Society of Cardiology. Eur Heart J 32:1986\u20131993, 1993a, 1993b","journal-title":"Eur Heart J"},{"key":"3761_CR29","doi-asserted-by":"crossref","first-page":"e1001177","DOI":"10.1371\/journal.pmed.1001177","volume":"9","author":"Clarke","year":"2012","unstructured":"Clarke R, Bennett DA, Parish S et al (2012) Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias. PLoS Med 9:e1001177","journal-title":"PLoS Med"}],"container-title":["Herz"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00059-013-3761-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00059-013-3761-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00059-013-3761-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T23:20:46Z","timestamp":1562714446000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00059-013-3761-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,22]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["3761"],"URL":"https:\/\/doi.org\/10.1007\/s00059-013-3761-y","relation":{},"ISSN":["0340-9937","1615-6692"],"issn-type":[{"value":"0340-9937","type":"print"},{"value":"1615-6692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,22]]}}}