{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:39:40Z","timestamp":1773301180587,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T00:00:00Z","timestamp":1468454400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Herz"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s00059-016-4459-8","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T13:05:48Z","timestamp":1468501548000},"page":"478-483","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Enzymes and signal pathways in the pathogenesis of alcoholic cardiomyopathy","Enzyme und Signalwege in der Pathogenese der alkoholischen Kardiomyopathie"],"prefix":"10.1007","volume":"41","author":[{"given":"E.","family":"Leibing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,14]]},"reference":[{"key":"4459_CR1","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/S0002-9149(00)00706-2","volume":"85","author":"A Gavazzi","year":"2000","unstructured":"Gavazzi A, De Maria R, Parolini M et\u00a0al (2000) Alcohol abuse and dilated cardiomyopathy in men. Am J Cardiol 85:1114\u20131118","journal-title":"Am J Cardiol"},{"key":"4459_CR2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0022-2275(20)31590-X","volume":"42","author":"MA Diczfalusy","year":"2001","unstructured":"Diczfalusy MA, Bj\u00f6rkhem I, Einarsson C et al (2001) Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humans. J Lipid Res 42:1025\u20131032","journal-title":"J Lipid Res"},{"key":"4459_CR3","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1006\/jmcc.1998.0812","volume":"30","author":"ME Beckemeier","year":"1998","unstructured":"Beckemeier ME, Bora PS (1998) Fatty acid ethyl esters: potentially toxic products of myocardial ethanol metabolism. J\u00a0Mol Cell Cardiol 30:2487\u20132494","journal-title":"J Mol Cell Cardiol"},{"key":"4459_CR4","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2353\/ajpath.2006.050537","volume":"168","author":"DM Yoerger","year":"2006","unstructured":"Yoerger DM, Best CA, McQuillan BM et\u00a0al (2006) Rapid fatty acid ethyl ester synthesis by porcine myocardium upon ethanol infusion into the left anterior descending coronary artery. Am J Pathol 168:1435\u20131442","journal-title":"Am J Pathol"},{"key":"4459_CR5","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1172\/JCI111022","volume":"72","author":"LG Lange","year":"1983","unstructured":"Lange LG, Sobel BE (1983) Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol. J\u00a0Clin Invest 72:724\u2013731","journal-title":"J Clin Invest"},{"key":"4459_CR6","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.yjmcc.2009.03.017","volume":"47","author":"SY Li","year":"2009","unstructured":"Li SY, Gilbert SA, Li Q et al (2009) Aldehyde dehydrogenase-2 (ALDH2) ameliorates chronic alcohol ingestion-induced myocardial insulin resistance and endoplasmic reticulum stress. J Mol Cell Cardiol 47:247\u2013255","journal-title":"J Mol Cell Cardiol"},{"key":"4459_CR7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nature11368","volume":"489","author":"JI Garaycoechea","year":"2012","unstructured":"Garaycoechea JI, Crossan GP, Langevin F et\u00a0al (2012) Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function. Nature 489:571\u2013575","journal-title":"Nature"},{"key":"4459_CR8","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1110\/ps.45001","volume":"10","author":"MS Niederhut","year":"2001","unstructured":"Niederhut MS, Gibbons BJ, Perez-Miller S et al (2001) Three-dimensional structures of the three human class I alcohol dehydrogenases. Protein Sci 10:697\u2013706","journal-title":"Protein Sci"},{"key":"4459_CR9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0014-5793(87)80152-7","volume":"215","author":"T Braun","year":"1987","unstructured":"Braun T, Bober E, Singh S et al (1987) Evidence for a signal peptide at the amino-terminal end of human mitochondrial aldehyde dehydrogenase. FEBS Lett 215:233\u2013236","journal-title":"FEBS Lett"},{"key":"4459_CR10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0888-7543(88)90012-2","volume":"2","author":"L Raghunathan","year":"1988","unstructured":"Raghunathan L, Hsu LC, Klisak I et al (1988) Regional localization of the human genes for aldehyde dehydrogenase-1 and aldehyde dehydrogenase-2. Genomics 2:267\u2013269","journal-title":"Genomics"},{"key":"4459_CR11","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0888-7543(88)90109-7","volume":"2","author":"LC Hsu","year":"1988","unstructured":"Hsu LC, Bendel RE, Yoshida A (1988) Genomic structure of the human mitochondrial aldehyde dehydrogenase gene. Genomics 2:57\u201365","journal-title":"Genomics"},{"key":"4459_CR12","first-page":"42","volume":"44","author":"MJ Stewart","year":"1996","unstructured":"Stewart MJ, Malek K, Crabb DW (1996) Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. J\u00a0Investig Med 44:42\u201346","journal-title":"J Investig Med"},{"key":"4459_CR13","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1110\/ps.8.12.2784","volume":"8","author":"L Ni","year":"1999","unstructured":"Ni L, Zhou J, Hurley TD et al (1999) Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms. Protein Sci 8:2784\u20132790","journal-title":"Protein Sci"},{"key":"4459_CR14","doi-asserted-by":"crossref","first-page":"7100","DOI":"10.1021\/bi034182w","volume":"42","author":"SJ Perez-Miller","year":"2003","unstructured":"Perez-Miller SJ, Hurley TD (2003) Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase. Biochemistry 42:7100\u20137109","journal-title":"Biochemistry"},{"key":"4459_CR15","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1291\/hypres.25.677","volume":"25","author":"S Takagi","year":"2002","unstructured":"Takagi S, Iwai N, Yamauchi R et\u00a0al (2002) Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Hypertens Res 25:677\u2013681","journal-title":"Hypertens Res"},{"key":"4459_CR16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cca.2007.03.016","volume":"382","author":"SA Jo","year":"2007","unstructured":"Jo SA, Kim EK, Park MH et\u00a0al (2007) A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men. Clin Chim Acta 382:43\u201347","journal-title":"Clin Chim Acta"},{"key":"4459_CR17","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1126\/science.1158554","volume":"321","author":"CH Chen","year":"2008","unstructured":"Chen CH, Budas GR, Churchill EN et al (2008) Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321:1493\u20131495","journal-title":"Science"},{"key":"4459_CR18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1620\/tjem.221.107","volume":"221","author":"Y Bian","year":"2010","unstructured":"Bian Y, Chen YG, Xu F et al (2010) The polymorphism in aldehyde dehydrogenase-2 gene is associated with elevated plasma levels of high-sensitivity C\u2011reactive protein in the early phase of myocardial infarction. Tohoku J Exp Med 221:107\u2013112","journal-title":"Tohoku J Exp Med"},{"key":"4459_CR19","first-page":"1155","volume":"16","author":"F Xu","year":"2011","unstructured":"Xu F, Chen YG, Xue L et\u00a0al (2011) Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome. J\u00a0Cell Mol Med 15:1955\u20131962. Erratum in. J\u00a0Cell Mol Med 16:1155","journal-title":"J Cell Mol Med"},{"key":"4459_CR20","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.yjmcc.2010.03.017","volume":"49","author":"H Ma","year":"2010","unstructured":"Ma H, Yu L, Byra EA et al (2010) Aldehyde dehydrogenase 2 knockout accentuates ethanol-induced cardiac depression: role of protein phosphatases. J Mol Cell Cardiol 49:322\u2013329","journal-title":"J Mol Cell Cardiol"},{"key":"4459_CR21","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1016\/j.jacc.2009.04.100","volume":"54","author":"H Ma","year":"2009","unstructured":"Ma H, Li J, Gao F et\u00a0al (2009) Aldehyde dehydrogenase 2 ameliorates acute cardiac toxicity of ethanol: role of protein phosphatase and forkhead transcription factor. J\u00a0Am Coll Cardiol 54:2187\u20132196","journal-title":"J Am Coll Cardiol"},{"key":"4459_CR22","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","volume":"96","author":"A Brunet","year":"1999","unstructured":"Brunet A, Bonni A, Zigmond MJ et\u00a0al (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857\u2013868","journal-title":"Cell"},{"key":"4459_CR23","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/eurheartj\/ehq253","volume":"32","author":"H Ma","year":"2011","unstructured":"Ma H, Guo R, Yu L et\u00a0al (2011) Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia\/reperfusion injury: role of autophagy paradox and toxic aldehyde. Eur Heart J 32:1025\u20131038","journal-title":"Eur Heart J"},{"key":"4459_CR24","doi-asserted-by":"crossref","first-page":"11244","DOI":"10.1074\/jbc.M308011200","volume":"279","author":"SY Li","year":"2004","unstructured":"Li SY, Gomelsky M, Duan J et al (2004) Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 mitogen-activated protein kinase. J Biol Chem 279:11244\u201311252","journal-title":"J Biol Chem"},{"key":"4459_CR25","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jash.2011.02.005","volume":"5","author":"H Choi","year":"2011","unstructured":"Choi H, Tostes RC, Webb RC (2011) Mitochondrial aldehyde dehydrogenase prevents ROS-induced vascular contraction in angiotensin-II hypertensive mice. J Am Soc Hypertens 5:154\u2013160","journal-title":"J Am Soc Hypertens"},{"key":"4459_CR26","doi-asserted-by":"crossref","unstructured":"Li SY, Li Q, Shen JJ et al (2006) Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling. J Mol Cell Cardiol 40:283\u2013294","DOI":"10.1016\/j.yjmcc.2005.11.006"},{"key":"4459_CR27","first-page":"616","volume":"16","author":"W Ge","year":"2012","unstructured":"Ge W, Ren J (2012) mTOR-STAT3-notch signalling contributes to ALDH2-induced protection against cardiac contractile dysfunction and autophagy under alcoholism. J Cell Mol Med 16:616\u2013626","journal-title":"J Cell Mol Med"},{"key":"4459_CR28","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0092-8674(95)90311-9","volume":"82","author":"Z Wen","year":"1995","unstructured":"Wen Z, Zhong Z, Darnell JE Jr (1995) Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241\u2013250","journal-title":"Cell"},{"key":"4459_CR29","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1093\/nar\/25.11.2062","volume":"25","author":"Z Wen","year":"1997","unstructured":"Wen Z, Darnell JE Jr (1997) Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3. Nucleic Acids Res 25:2062\u20132067","journal-title":"Nucleic Acids Res"},{"key":"4459_CR30","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s00059-007-3040-x","volume":"32","author":"V Ruppert","year":"2007","unstructured":"Ruppert V, Meyer T (2007) JAK-STAT signaling circuits in myocarditis and dilated cardiomyopathy. Herz 32:474\u2013481","journal-title":"Herz"},{"key":"4459_CR31","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1161\/01.RES.0000134921.50377.61","volume":"95","author":"D Hilfiker-Kleiner","year":"2004","unstructured":"Hilfiker-Kleiner D, Hilfiker A, Fuchs M et al (2004) Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury. Circ Res 95:187\u2013195","journal-title":"Circ Res"},{"key":"4459_CR32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/CIRCULATIONAHA.109.933127","volume":"122","author":"D Hilfiker-Kleiner","year":"2010","unstructured":"Hilfiker-Kleiner D, Shukla P, Klein G et al (2010) Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction. Circulation 122:145\u2013155","journal-title":"Circulation"},{"key":"4459_CR33","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1126\/science.1171721","volume":"324","author":"DJ Gough","year":"2009","unstructured":"Gough DJ, Corlett A, Schlessinger K et al (2009) Mitochondrial STAT3 supports Ras-dependent oncogenic transformation. Science 324:1713\u20131716","journal-title":"Science"},{"key":"4459_CR34","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1126\/science.1164551","volume":"323","author":"J Wegrzyn","year":"2009","unstructured":"Wegrzyn J, Potla R, Chwae YJ et\u00a0al (2009) Function of mitochondrial Stat3 in cellular respiration. Science 323:793\u2013797","journal-title":"Science"},{"key":"4459_CR35","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1161\/CIRCRESAHA.111.255604","volume":"109","author":"G Heusch","year":"2011","unstructured":"Heusch G, Musiolik J, Gedik N et\u00a0al (2011) Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia\/reperfusion. Circ Res 109:1302\u20131308","journal-title":"Circ Res"},{"key":"4459_CR36","doi-asserted-by":"crossref","first-page":"618","DOI":"10.15252\/embj.201592629","volume":"35","author":"E Carbognin","year":"2016","unstructured":"Carbognin E, Betto RM, Soriano ME et\u00a0al (2016) Stat3 promotes mitochondrial transcription and oxidative respiration during maintenance and induction of naive pluripotency. EMBO J 35:618\u2013634","journal-title":"EMBO J"}],"container-title":["Herz"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00059-016-4459-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00059-016-4459-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00059-016-4459-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T02:47:04Z","timestamp":1656816424000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00059-016-4459-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,14]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["4459"],"URL":"https:\/\/doi.org\/10.1007\/s00059-016-4459-8","relation":{},"ISSN":["0340-9937","1615-6692"],"issn-type":[{"value":"0340-9937","type":"print"},{"value":"1615-6692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,14]]}}}