{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:05:35Z","timestamp":1790064335568,"version":"4.0.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T00:00:00Z","timestamp":1479772800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"National Natural Science Foundation of China (CN)","award":["81300092"],"award-info":[{"award-number":["81300092"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Herz"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s00059-016-4500-y","type":"journal-article","created":{"date-parts":[[2016,11,22]],"date-time":"2016-11-22T12:04:14Z","timestamp":1479816254000},"page":"662-668","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Targeting the hedgehog signaling pathway for cardiac repair and regeneration","Der Hedgehog-Signalweg als Zielpunkt bei kardialer Wiederherstellung und Regeneration"],"prefix":"10.1007","volume":"42","author":[{"given":"Y.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,22]]},"reference":[{"key":"4500_CR1","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1056\/NEJM200106073442303","volume":"344","author":"AP Beltrami","year":"2001","unstructured":"Beltrami AP, Urbanek K, al Kajstura Jet (2001) Evidence that human cardiac myocytes divide after myocardial infarction. N\u00a0Engl J Med 344:1750\u20131757. doi:\n                        10.1056\/NEJM200106073442303","journal-title":"N. Engl. J. Med."},{"key":"4500_CR2","doi-asserted-by":"publisher","first-page":"239rv231","DOI":"10.1126\/scitranslmed.3006681","volume":"6","author":"Z Lin","year":"2014","unstructured":"Lin Z, Pu WT (2014) Strategies for cardiac regeneration and repair. Sci Transl Med 6:239rv231. doi:\n                        10.1126\/scitranslmed.3006681","journal-title":"Sci Transl Med"},{"key":"4500_CR3","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.ydbio.2005.04.029","volume":"283","author":"I Washington Smoak","year":"2005","unstructured":"Washington Smoak I, Byrd NA, Abu-Issa R et al (2005) Sonic hedgehog is required for cardiac outflow tract and neural crest cell developmen. Dev Biol 283:357\u2013372. doi:\n                        10.1016\/j.ydbio.2005.04.029","journal-title":"Dev. Biol."},{"key":"4500_CR4","doi-asserted-by":"publisher","first-page":"3789","DOI":"10.1242\/dev.024083","volume":"135","author":"NA Thomas","year":"2008","unstructured":"Thomas NA, Koudijs M, van Eeden FJ, Joyner AL, Yelon D (2008) Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential. Development 135:3789\u20133799. doi:\n                        10.1242\/dev.024083","journal-title":"Development"},{"key":"4500_CR5","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1016\/j.jacc.2010.11.069","volume":"57","author":"J Roncalli","year":"2011","unstructured":"Roncalli J, Renault MA, Tongers J et al (2011) Sonic hedgehog-induced functional recovery after myocardial infarction is enhanced by AMD3100-mediated progenitor-cell mobilization. J Am Coll Cardiol 57:2444\u20132452","journal-title":"J. Am. Coll. Cardiol."},{"key":"4500_CR6","doi-asserted-by":"publisher","first-page":"e8576","DOI":"10.1371\/journal.pone.0008576","volume":"5","author":"RP Ahmed","year":"2010","unstructured":"Ahmed RP, Haider KH, Shujia J, Afzal MR, Ashraf M (2010) Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS\/netrin-1\/PKC pathway. PLOS ONE 5:e8576. doi:\n                        10.1371\/journal.pone.0008576","journal-title":"PLOS ONE"},{"key":"4500_CR7","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/nm1313","volume":"11","author":"KF Kusano","year":"2005","unstructured":"Kusano KF, Pola R, Murayama T et\u00a0al (2005) Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling. Nat Med 11:1197\u20131204. doi:\n                        10.1038\/nm1313","journal-title":"Nat. Med."},{"key":"4500_CR8","doi-asserted-by":"publisher","first-page":"4997","DOI":"10.1016\/j.ijcard.2013.07.126","volume":"168","author":"T Tang","year":"2013","unstructured":"Tang T, Wu M, Yang J (2013) Transplantation of MSCs transfected with SHH gene ameliorates cardiac dysfunction after chronic myocardial infarction. Int J Cardiol 168:4997\u20134999. doi:\n                        10.1016\/j.ijcard.2013.07.126","journal-title":"Int. J. Cardiol."},{"key":"4500_CR9","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/287795a0","volume":"287","author":"C Nusslein-Volhard","year":"1980","unstructured":"Nusslein-Volhard C, Wieschaus E (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287:795\u2013801","journal-title":"Nature"},{"key":"4500_CR10","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/nrm3598","volume":"14","author":"J Briscoe","year":"2013","unstructured":"Briscoe J, Therond PP (2013) The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol 14:416\u2013429. doi:\n                        10.1038\/nrm3598","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4500_CR11","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.devcel.2013.07.015","volume":"26","author":"BR Myers","year":"2013","unstructured":"Myers BR, Sever N, Chong YC et\u00a0al (2013) Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response. Dev Cell 26:346\u2013357. doi:\n                        10.1016\/j.devcel.2013.07.015","journal-title":"Dev. Cell"},{"key":"4500_CR12","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.jfma.2015.01.005","volume":"114","author":"E Yao","year":"2015","unstructured":"Yao E, Chuang PT (2015) Hedgehog signaling: From basic research to clinical applications. J\u00a0Formos Med Assoc 114:569\u2013576. doi:\n                        10.1016\/j.jfma.2015.01.005","journal-title":"J. Formos. Med. Assoc."},{"key":"4500_CR13","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.semcdb.2014.05.003","volume":"33","author":"F Aberger","year":"2014","unstructured":"Aberger F, Ruiz IAA (2014) Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy. Semin Cell Dev Biol 33:93\u2013104. doi:\n                        10.1016\/j.semcdb.2014.05.003","journal-title":"Semin Cell Dev Biol"},{"key":"4500_CR14","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1242\/dev.00364","volume":"130","author":"RO Karlstrom","year":"2003","unstructured":"Karlstrom RO, Tyurina OV, Kawakami A et\u00a0al (2003) Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development 130:1549\u20131564","journal-title":"Development"},{"key":"4500_CR15","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/35010610","volume":"2","author":"M Murone","year":"2000","unstructured":"Murone M, Luoh SM, Stone D et\u00a0al (2000) Gli regulation by the opposing activities of fused and suppressor of fused. Nat Cell Biol 2:310\u2013312. doi:\n                        10.1038\/35010610","journal-title":"Nat. Cell Biol."},{"key":"4500_CR16","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1517\/17460441.2014.920817","volume":"9","author":"U Banerjee","year":"2014","unstructured":"Banerjee U, Hadden MK (2014) Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies. Expert Opin Drug Discov 9:751\u2013771. doi:\n                        10.1517\/17460441.2014.920817","journal-title":"Expert Opin Drug Discov"},{"key":"4500_CR17","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.bbcan.2015.06.003","volume":"1856","author":"L Magno Di","year":"2015","unstructured":"Di Magno L, Coni S, Di Marcotullio L, Canettieri G (2015) Digging a hole under Hedgehog: downstream inhibition as an emerging anticancer strategy. Biochim Biophys Acta 1856:62\u201372. doi:\n                        10.1016\/j.bbcan.2015.06.003","journal-title":"Biochim. Biophys. Acta"},{"key":"4500_CR18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/cmdc.201300358","volume":"9","author":"MK Hadden","year":"2014","unstructured":"Hadden MK (2014) Hedgehog pathway agonism: therapeutic potential and small-molecule development. ChemMedChem 9:27\u201337. doi:\n                        10.1002\/cmdc.201300358","journal-title":"ChemMedChem"},{"key":"4500_CR19","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1242\/dev.088526","volume":"140","author":"WY Choi","year":"2013","unstructured":"Choi WY, Gemberling M, Wang J et\u00a0al (2013) In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration. Development 140:660\u2013666. doi:\n                        10.1242\/dev.088526","journal-title":"Development"},{"key":"4500_CR20","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/nrm3619","volume":"14","author":"M Xin","year":"2013","unstructured":"Xin M, Olson EN, Bassel-Duby R (2013) Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair. Nat Rev Mol Cell Biol 14:529\u2013541. doi:\n                        10.1038\/nrm3619","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4500_CR21","doi-asserted-by":"publisher","first-page":"989","DOI":"10.3181\/0711-RM-307","volume":"233","author":"MF Bijlsma","year":"2008","unstructured":"Bijlsma MF, Leenders PJ, Janssen BJ, Peppelenbosch MP, Ten Cate H, Spek CA (2008) Endogenous hedgehog expression contributes to myocardial ischemia-reperfusion-induced injury. Exp Biol Med 233:989\u2013996. doi:\n                        10.3181\/0711-RM-307","journal-title":"Exp. Biol. Med."},{"key":"4500_CR22","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1242\/dev.02824","volume":"134","author":"MM Goddeeris","year":"2007","unstructured":"Goddeeris MM, Schwartz R, Klingensmith J, Meyers EN (2007) Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. Development 134:1593\u20131604. doi:\n                        10.1242\/dev.02824","journal-title":"Development"},{"key":"4500_CR23","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.ydbio.2009.03.028;","volume":"330","author":"LA Dyer","year":"2009","unstructured":"Dyer LA, Kirby ML (2009) Sonic hedgehog maintains proliferation in secondary heart field progenitors and is required for normal arterial pole formation. Dev Biol 330:305\u2013317. doi:\n                        10.1016\/j.ydbio.2009.03.028;","journal-title":"Dev. Biol."},{"key":"4500_CR24","doi-asserted-by":"publisher","first-page":"e63075","DOI":"10.1371\/journal.pone.0063075","volume":"8","author":"NR Johnson","year":"2013","unstructured":"Johnson NR, Wang Y (2013) Controlled delivery of sonic hedgehog morphogen and its potential for cardiac repair. PLOS ONE 8:e63075. doi:\n                        10.1371\/journal.pone.0063075","journal-title":"PLOS ONE"},{"key":"4500_CR25","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.bbrc.2015.01.006","volume":"457","author":"Q Xiao","year":"2015","unstructured":"Xiao Q, Yang Y, Qin Y et al (2015) AMP-activated protein kinase-dependent autophagy mediated the protective effect of sonic hedgehog pathway on oxygen glucose deprivation-induced injury of cardiomyocytes. Biochem Biophys Res Commun 457:419\u2013425. doi:\n                        10.1016\/j.bbrc.2015.01.006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"4500_CR26","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1101\/gad.1411406","volume":"20","author":"KJ Lavine","year":"2006","unstructured":"Lavine KJ, White AC, Park C et\u00a0al (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev 20:1651\u20131666. doi:\n                        10.1101\/gad.1411406","journal-title":"Genes Dev"},{"key":"4500_CR27","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.tig.2007.10.007","volume":"24","author":"KJ Lavine","year":"2008","unstructured":"Lavine KJ, Ornitz DM (2008) Fibroblast growth factors and Hedgehogs: at the heart of the epicardial signaling center. Trends Genet 24:33\u201340. doi:\n                        10.1016\/j.tig.2007.10.007","journal-title":"Trends Genet"},{"key":"4500_CR28","first-page":"475","volume":"67","author":"JY Pan","year":"2012","unstructured":"Pan JY, Zhou SH (2012) The hedgehog signaling pathway, a new therapeutic target for treatment of ischemic heart disease. Pharmazie 67:475\u2013481","journal-title":"Pharmazie"},{"key":"4500_CR29","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/B978-0-12-407697-6.00007-6","volume":"303","author":"Y Nakajima","year":"2013","unstructured":"Nakajima Y, Imanaka-Yoshida K (2013) New insights into the developmental mechanisms of coronary vessels and epicardium. Int Rev Cell Mol Biol 303:263\u2013317. doi:\n                        10.1016\/B978-0-12-407697-6.00007-6","journal-title":"Int Rev Cell Mol Biol"},{"key":"4500_CR30","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature14325","volume":"522","author":"J Wang","year":"2015","unstructured":"Wang J, Cao J, Dickson AL, Poss KD (2015) Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling. Nature 522:226\u2013230. doi:\n                        10.1038\/nature14325","journal-title":"Nature"},{"key":"4500_CR31","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1111\/j.1524-475X.2012.00814.x","volume":"20","author":"CL Lien","year":"2012","unstructured":"Lien CL, Harrison MR, Tuan TL, Starnes VA (2012) Heart repair and regeneration: recent insights from zebrafish studies. Wound Repair Regen 20:638\u2013646. doi:\n                        10.1111\/j.1524-475X.2012.00814.x","journal-title":"Wound Repair Regen"},{"key":"4500_CR32","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ydbio.2011.11.004","volume":"361","author":"KS Wong","year":"2012","unstructured":"Wong KS, Rehn K, Palencia-Desai S et al (2012) Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish. Dev Biol 361:377\u2013391. doi:\n                        10.1016\/j.ydbio.2011.11.004","journal-title":"Dev. Biol."},{"key":"4500_CR33","doi-asserted-by":"publisher","first-page":"21022","DOI":"10.1074\/jbc.M502977200","volume":"280","author":"PJ Gianakopoulos","year":"2005","unstructured":"Gianakopoulos PJ, Skerjanc IS (2005) Hedgehog signaling induces cardiomyogenesis in P19 cells. J\u00a0Biol Chem 280:21022\u201321028. doi:\n                        10.1074\/jbc.M502977200","journal-title":"J. Biol. Chem."},{"key":"4500_CR34","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1161\/CIRCRESAHA.112.266015","volume":"111","author":"AR Mackie","year":"2012","unstructured":"Mackie AR, Klyachko E, Thorne T et al (2012) Sonic hedgehog-modified human CD34+ cells preserve cardiac function after acute myocardial infarction. Circ Res 111:312\u2013321. doi:\n                        10.1161\/CIRCRESAHA.112.266015","journal-title":"Circ. Res."},{"key":"4500_CR35","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1258\/ebm.2009.009303","volume":"235","author":"MF Bijlsma","year":"2010","unstructured":"Bijlsma MF, Spek CA (2010) The Hedgehog morphogen in myocardial ischemia-reperfusion injury. Exp Biol Med 235:447\u2013454. doi:\n                        10.1258\/ebm.2009.009303","journal-title":"Exp. Biol. Med."},{"key":"4500_CR36","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1096\/fj.07-8079com","volume":"21","author":"A Agouni","year":"2007","unstructured":"Agouni A, Mostefai HA, Porro C et\u00a0al (2007) Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release. FASEB J 21:2735\u20132741. doi:\n                        10.1096\/fj.07-8079com","journal-title":"FASEB J."},{"key":"4500_CR37","doi-asserted-by":"publisher","first-page":"7983","DOI":"10.1038\/srep07983","volume":"5","author":"L Paulis","year":"2015","unstructured":"Paulis L, Fauconnier J, Cazorla O et\u00a0al (2015) Activation of Sonic hedgehog signaling in ventricular cardiomyocytes exerts cardioprotection against ischemia reperfusion injuries. Sci Rep 5:7983. doi:\n                        10.1038\/srep07983","journal-title":"Sci Rep"},{"key":"4500_CR38","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1093\/eurheartj\/ehr018","volume":"32","author":"J Tongers","year":"2011","unstructured":"Tongers J, Losordo DW, Landmesser U (2011) Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges. Eur Heart J 32:1197\u20131206. doi:\n                        10.1093\/eurheartj\/ehr018","journal-title":"Eur. Heart J."},{"key":"4500_CR39","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2174\/1574888X11308040002","volume":"8","author":"E Przybyt","year":"2013","unstructured":"Przybyt E, Harmsen MC (2013) Mesenchymal stem cells: promising for myocardial regeneration? Curr Stem Cell Res Ther 8:270\u2013277","journal-title":"Curr Stem Cell Res Ther"},{"key":"4500_CR40","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1161\/CIRCRESAHA.111.243147;","volume":"109","author":"AR Williams","year":"2011","unstructured":"Williams AR, Hare JM (2011) Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. Circ Res 109:923\u2013940. doi:\n                        10.1161\/CIRCRESAHA.111.243147;","journal-title":"Circ. Res."},{"key":"4500_CR41","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1038\/nm.3389","volume":"19","author":"D Amakye","year":"2013","unstructured":"Amakye D, Jagani Z, Dorsch M (2013) Unraveling the therapeutic potential of the Hedgehog pathway in cancer. Nat Med 19:1410\u20131422. doi:\n                        10.1038\/nm.3389","journal-title":"Nat. Med."},{"key":"4500_CR42","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/nm.3225","volume":"19","author":"RC Addis","year":"2013","unstructured":"Addis RC, Epstein JA (2013) Induced regeneration \u2013 the progress and promise of direct reprogramming for heart repair. Nat Med 19:829\u2013836. doi:\n                        10.1038\/nm.3225","journal-title":"Nat. Med."},{"key":"4500_CR43","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/nbt.3271","volume":"33","author":"MJ Birket","year":"2015","unstructured":"Birket MJ, Ribeiro MC, Verkerk AO et\u00a0al (2015) Expansion and patterning of cardiovascular progenitors derived from human pluripotent stem cells. Nat Biotechnol 33:970\u2013979. doi:\n                        10.1038\/nbt.3271","journal-title":"Nat. Biotechnol."},{"key":"4500_CR44","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1161\/CIRCRESAHA.114.300522","volume":"114","author":"MN Hirt","year":"2014","unstructured":"Hirt MN, Hansen A, Eschenhagen T (2014) Cardiac tissue engineering: state of the art. Circ Res 114:354\u2013367. doi:\n                        10.1161\/CIRCRESAHA.114.300522","journal-title":"Circ. Res."},{"key":"4500_CR45","first-page":"707","volume":"11","author":"E Smaele De","year":"2010","unstructured":"De Smaele E, Ferretti E, Gulino A (2010) Vismodegib, a small-molecule inhibitor of the hedgehog pathway for the treatment of advanced cancers. Curr Opin Investig Drugs 11:707\u2013718","journal-title":"Curr Opin Investig Drugs"},{"key":"4500_CR46","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/nchembio.1184;","volume":"9","author":"E Petrova","year":"2013","unstructured":"Petrova E, Rios-Esteves J, Ouerfelli O, Glickman JF, Resh MD (2013) Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nat Chem Biol 9:247\u2013249. doi:\n                        10.1038\/nchembio.1184;","journal-title":"Nat. Chem. Biol."},{"key":"4500_CR47","doi-asserted-by":"publisher","first-page":"e68271","DOI":"10.1371\/journal.pone.0068271","volume":"8","author":"S Hwang","year":"2013","unstructured":"Hwang S, Thangapandian S, Lee KW (2013) Molecular dynamics simulations of sonic hedgehog-receptor and inhibitor complexes and their applications for potential anticancer agent discovery. PLOS ONE 8:e68271. doi:\n                        10.1371\/journal.pone.0068271","journal-title":"PLOS ONE"},{"key":"4500_CR48","doi-asserted-by":"publisher","first-page":"9675","DOI":"10.1021\/ja400034k","volume":"135","author":"GI Schaefer","year":"2013","unstructured":"Schaefer GI, Perez JR, Duvall JR, Stanton BZ, Shamji AF, Schreiber SL (2013) Discovery of small-molecule modulators of the Sonic Hedgehog pathway. J Am Chem Soc 135:9675\u20139680. doi:\n                        10.1021\/ja400034k","journal-title":"J. Am. Chem. Soc."},{"key":"4500_CR49","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1002\/jcb.23082;","volume":"112","author":"JS Johnson","year":"2011","unstructured":"Johnson JS, Meliton V, Kim WK et al (2011) Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo. J Cell Biochem 112:1673\u20131684. doi:\n                        10.1002\/jcb.23082;","journal-title":"J. Cell. Biochem."},{"key":"4500_CR50","doi-asserted-by":"publisher","first-page":"9323","DOI":"10.1073\/pnas.0910712107;","volume":"107","author":"J Wang","year":"2010","unstructured":"Wang J, Lu J, Bond MC et\u00a0al (2010) Identification of select glucocorticoids as smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci USA 107:9323\u20139328. doi:\n                        10.1073\/pnas.0910712107;","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"4500_CR51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1475-4924-1-10","volume":"1","author":"M Frank-Kamenetsky","year":"2002","unstructured":"Frank-Kamenetsky M, Zhang XM, Bottega S et al (2002) Small-molecule modulators of Hedgehog signaling: identification and characterization of smoothened agonists and antagonists. J Biol 1:10","journal-title":"J. Biol."},{"key":"4500_CR52","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1038\/nprot.2013.106;","volume":"8","author":"Y Liu","year":"2013","unstructured":"Liu Y, Liu H, Sauvey C, Yao L, Zarnowska ED, Zhang SC (2013) Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nat Protoc 8:1670\u20131679. doi:\n                        10.1038\/nprot.2013.106;","journal-title":"Nat Protoc"},{"key":"4500_CR53","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1124\/mol.112.084590","volume":"83","author":"T Gorojankina","year":"2013","unstructured":"Gorojankina T, Hoch L, Faure H et al (2013) Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of smoothened. Mol Pharmacol 83:1020\u20131029. doi:\n                        10.1124\/mol.112.084590","journal-title":"Mol. Pharmacol."},{"key":"4500_CR54","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1172\/JCI34561","volume":"118","author":"KJ Lavine","year":"2008","unstructured":"Lavine KJ, Kovacs A, Ornitz DM (2008) Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. J\u00a0Clin Invest 118:2404\u20132414. doi:\n                        10.1172\/JCI34561","journal-title":"J. Clin. Invest."},{"key":"4500_CR55","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1172\/JCI39896","volume":"120","author":"K Ueda","year":"2010","unstructured":"Ueda K, Takano H, Niitsuma Y et al (2010) Sonic hedgehog is a critical mediator of erythropoietin-induced cardiac protection in mice. J Clin Invest 120:2016\u20132029. doi:\n                        10.1172\/JCI39896","journal-title":"J. Clin. Invest."}],"container-title":["Herz"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00059-016-4500-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00059-016-4500-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00059-016-4500-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,25]],"date-time":"2017-10-25T10:42:15Z","timestamp":1508928135000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00059-016-4500-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,22]]},"references-count":55,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["4500"],"URL":"https:\/\/doi.org\/10.1007\/s00059-016-4500-y","relation":{},"ISSN":["0340-9937","1615-6692"],"issn-type":[{"value":"0340-9937","type":"print"},{"value":"1615-6692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,22]]}}}