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First described in 1990, TS has gained substantial attention during the past 15\u00a0years. However, the disease is still underdiagnosed. Prospective studies on TS are largely lacking, and the condition remains incompletely understood. In addition, significant misconceptions and misunderstandings are evident, contributing to potentially severe underestimation. Here, we review important aspects of TS with a\u00a0focus on pitfalls, misinterpretations, and knowledge gaps considered important during diagnosis and management of the disease.<\/jats:p>","DOI":"10.1007\/s00059-020-04906-2","type":"journal-article","created":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T13:03:10Z","timestamp":1584968590000},"page":"252-266","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Takotsubo syndrome: between evidence, myths, and misunderstandings","Takotsubo-Syndrom: Evidenz, Mythen, Missverst\u00e4ndnisse"],"prefix":"10.1007","volume":"45","author":[{"given":"L. Christian","family":"Napp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Bauersachs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,23]]},"reference":[{"key":"4906_CR1","first-page":"56","volume-title":"Clinical aspect of myocardial injury: from Ischemia to heart failure","author":"H Sato","year":"1990","unstructured":"Sato\u00a0H, Tateishi\u00a0H, Uchida\u00a0T et al (1990) Takotsubo-type cardiomyopathy due to multivessel spasm. In: Kodama\u00a0K, Haze\u00a0K, Hori\u00a0M (eds) Clinical aspect of myocardial injury: from Ischemia to heart failure. 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Unrelated to the present work: Modest honoraria for consultancy, proctoring, lectures and travel support from Abiomed, modest honoraria for consultancy, lectures and travel support and research funding from Cytosorbents, modest honoraria for consultancy and travel support from Bayer, modest lecture honoraria from Abbott, Maquet, Orion and Zoll, and travel support from Biotronik, Boston Scientific, Lilly, Medtronic, Merit Medical, Pfizer, Servier, and Volcano. J.\u00a0Bauersachs: Related to the present work: None. Unrelated to the present work: Honoraria for lectures and\/or consulting: Novartis, BMS, Pfizer, Vifor, Bayer, Servier, Orion, CVRx, MSD, Boehringer Ingelheim, AstraZeneca, Abiomed, Abbott, Medtronic; Research support: Zoll, CVRx, Bayer, Vifor, Abiomed, Medtronic.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this article no studies with human participants or animals were performed by any of the authors. All studies performed were in accordance with the ethical standards indicated in each case.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}