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It occurs after trauma, myocardial infarction, percutaneous coronary intervention, cardiac surgery, intracardiac ablation, and implantation of cardiac implantable electronic device (CIED). In this study we assessed the incidence of PCIS after CIED implantation and its possible risk factors.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Material and methods<\/jats:title>\n<jats:p>All patients who received CIED implantation at Heidelberg University Hospital between 2000 and 2014 were evaluated (<jats:italic>n<\/jats:italic>\u202f=\u20094989 patients). Clinical data including age, sex, underlying cardiac disease, type of implanted CIED, location of electrode implantation, clinical symptoms, time of symptom onset of PCIS, therapy, and outcome were extracted and analyzed.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>We identified 19\u00a0cases of PCIS in 4989 patients, yielding an incidence of 0.38%. The age of patients with PCIS ranged from 39 to 86\u00a0years. Dilated cardiomyopathy (DCM) as underlying cardiac disease and right atrial (RA) lead implantation had a\u00a0significant association with occurrence of PCIS (<jats:italic>p<\/jats:italic>\u202f=\u20090.045 in DCM and <jats:italic>p<\/jats:italic>\u202f&lt;\u20090.001 in RA lead implantation). Dyspnea, chest pain, dry cough, and fever were the most frequently reported symptoms in patients with PCIS. Pericardial and pleura effusion as well as elevated C\u2011reactive protein (CRP), increased erythrocyte sedimentation rate (ESR), and leukocytosis were the most common findings.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>To the best of our knowledge, this is the largest cohort evaluating the incidence of PCIS after CIED implantation. The data show that PCIS is a\u00a0rare complication after CIED implantation and occurs more frequently in patients with DCM and those with RA lead implantation. Although rare and mostly benign, PCIS can lead to potentially lethal complications and physicians must be aware of its symptoms.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00059-020-04910-6","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T17:02:52Z","timestamp":1584118972000},"page":"696-702","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Postcardiac injury syndrome after cardiac implantable electronic device implantation","Syndrom infolge Herzsch\u00e4digung nach Implantation eines kardialen implantierbaren elektronischen Systems"],"prefix":"10.1007","volume":"45","author":[{"given":"Kevin","family":"Filbey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-0527","authenticated-orcid":false,"given":"Farbod","family":"Sedaghat-Hamedani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elham","family":"Kayvanpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Xynogalos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Meder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Zitron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"issue":"2","key":"4910_CR1","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1016\/j.ijcard.2012.09.052","volume":"168","author":"M Imazio","year":"2013","unstructured":"Imazio\u00a0M, Hoit\u00a0BD (2013) Post-cardiac injury syndromes. 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This retrospective study was performed after approval of the institutional ethics committee of the University of Heidelberg and in accordance with national ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}