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This study aimed to identify predictors of failed reperfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study 2211 patients from the German Stroke Registry who received EVT for anterior circulation stroke were retrospectively analyzed. Failure of reperfusion was defined as thrombolysis in cerebral infarction (TICI) grades\u00a00\/1\/2a, and sufficient reperfusion as TICI\u00a02b\/3. In 1629 patients with complete datasets, associations between failure of reperfusion and baseline clinical data, comorbidities, location of occlusion, and procedural data were assessed with multiple logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Failure of reperfusion occurred in 371 patients (16.8%) and was associated with the following locations of occlusion: cervical internal carotid artery (ICA, adjusted odds ratio, OR 2.01, 95% confidence interval, CI 1.08\u20133.69), intracranial ICA without carotid T occlusion (adjusted OR 1.79, 95% CI 1.05\u20132.98), and M2 segment (adjusted OR 1.86, 95% CI 1.21\u20132.84). Failed reperfusion was also associated with cervical ICA stenosis (&gt;70% stenosis, adjusted OR 2.90, 95% CI 1.69\u20134.97), stroke of other determined etiology by TOAST (Trial of ORG 10172 in acute stroke treatment) criteria (e.g. nonatherosclerotic vasculopathies, adjusted OR 2.73, 95% CI 1.36\u20135.39), and treatment given outside the usual working hours (adjusted OR 1.41, 95% CI 1.07\u20131.86). Successful reperfusion was associated with higher Alberta stroke program early CT score (ASPECTS) on initial imaging (adjusted OR 0.85, 95% CI 0.79\u20130.92), treatment with the patient under general anesthesia (adjusted OR 0.72, 95% CI 0.54\u20130.96), and concomitant ICA stenting in patients with ICA stenosis (adjusted OR 0.20, 95% CI 0.11\u20130.38).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Several factors are associated with failure of reperfusion, most notably occlusions of the proximal ICA and low ASPECTS on admission. Conversely, stent placement in the proximal ICA was associated with reperfusion success.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00062-020-00880-8","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T10:45:16Z","timestamp":1582022716000},"page":"197-205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Factors Associated with Failure of Reperfusion in Endovascular Therapy for Acute Ischemic Stroke"],"prefix":"10.1007","volume":"31","author":[{"name":"for the GSR investigators","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8358-8089","authenticated-orcid":false,"given":"Fabian","family":"Flottmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Broocks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias Djamsched","family":"Faizy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalie","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Watermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milani","family":"Deb-Chatterji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6tz","family":"Thomalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moriz","family":"Herzberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian H.","family":"Nolte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Fiehler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Leischner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caspar","family":"Brekenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"880_CR1","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","volume":"387","author":"M Goyal","year":"2016","unstructured":"Goyal\u00a0M, Menon\u00a0BK, van Zwam\u00a0WH, Dippel\u00a0DW, Mitchell\u00a0PJ, Demchuk\u00a0AM, et\u00a0al. 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BMC Neurol. 2019;19:65.","journal-title":"BMC Neurol"}],"container-title":["Clinical Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-020-00880-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00062-020-00880-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-020-00880-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T12:09:54Z","timestamp":1615291794000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00062-020-00880-8"}},"subtitle":["A\u00a0Multicenter Analysis"],"short-title":[],"issued":{"date-parts":[[2020,2,17]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["880"],"URL":"https:\/\/doi.org\/10.1007\/s00062-020-00880-8","relation":{},"ISSN":["1869-1439","1869-1447"],"issn-type":[{"value":"1869-1439","type":"print"},{"value":"1869-1447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,17]]},"assertion":[{"value":"16 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"G.\u00a0Thomalla serves as a\u00a0consultant or speaker for Acandis, Bayer Healthcare, Boehringer Ingelheim, BristolMyersSquibb\/Pfizer, Covidien, Glaxo Smith Kline; served as a\u00a0lead investigator of the WAKE-UP study; Principal Investigator of the THRILL study; received grants by the European Union (Grant No. 278276 und 634809) and Deutsche Forschungsgemeinschaft (SFB 936, Projekt C2). C.H.\u00a0Nolte reports consulting and lecture fess from Boehringer Ingelheim, W.L.\u00a0Gore and Associates, Bristol-Myers Squibb, Pfizer, and Sanofi, all outside of the submitted work. J.\u00a0Fiehler served as a\u00a0consultant for Acandis, Boehringer Ingelheim, Codman, Microvention, Sequent, Stryker. Speaker for Bayer Healthcare, Bracco, Covidien\/ev3, Penumbra, Philips, Siemens. Received grants from Bundesministeriums f\u00fcr Wirtschaft und Energie (BMWi), Bundesministerium f\u00fcr Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), European Union (EU), Covidien, Stryker (THRILL study), Microvention (ERASER study). F.\u00a0Flottmann, G.\u00a0Broocks, T.D.\u00a0Faizy, R.\u00a0McDonough, L.\u00a0Watermann, M.\u00a0Deb-Chatterji, M.\u00a0Herzberg, H.\u00a0Leischner and C.\u00a0Brekenfeld declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}