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Two neuroradiologists, blinded for patient diagnosis, randomly evaluated DWI of CRAO patients and controls (a\u00a0collective of stroke and transient ischemic attack [TIA] patients) for restrictions of the retina and optic nerve. We calculated statistical quality criteria and analyzed inter-rater reliability using unweighted Kappa statistics.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>20 CRAO patients (60,6\u202f\u00b1\u200917 years) and 20 controls (60,7\u202f\u00b1\u200917 years) were included in the study. Sensitivity, specificity, positive and negative predictive values for retinal DWI restrictions were 75%\/80%\/79%\/76% (reader\u00a01) and 75%\/100%\/100%\/80% (reader\u00a02), respectively. Unweighted Kappa was \u03ba\u202f=\u20090,70 (95% CI 0,48\u20110,92), indicating \u201csubstantial\u201d interrater reliability. In comparison, sensitivity, specificity, PPV and NPV (positive and negative predictive values) for restrictions of the optic nerve in CRAO were 55%\/70%\/65%\/61% (reader\u00a01) and 25%\/100%\/100%\/57% (reader\u00a02). Inter-rater reliability was \u201cfair\u201d with unweighted Kappa \u03ba\u202f=\u20090,32 (95% CI 0,09\u20110,56).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Retinal diffusion restrictions were present in a\u00a0majority of CRAO patients and detectable with reasonable sensitivity, high specificity and substantial inter-rater reliability. Further studies are necessary to study time dependency of retinal diffusion restrictions, improve image quality and investigate the reliability of retinal DWI to discern CRAO from other causes of acute loss of vision.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00062-020-00955-6","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T22:56:01Z","timestamp":1600296961000},"page":"619-626","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Standard Diffusion-weighted MRI for the Diagnosis of Central Retinal Artery Occlusion"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9798-5325","authenticated-orcid":false,"given":"L. 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N Engl J Med. 2018;379:611\u201322.","journal-title":"N Engl J Med"}],"container-title":["Clinical Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-020-00955-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00062-020-00955-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-020-00955-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T17:27:13Z","timestamp":1632504433000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00062-020-00955-6"}},"subtitle":["A\u00a0Case-Control Study"],"short-title":[],"issued":{"date-parts":[[2020,9,16]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["955"],"URL":"https:\/\/doi.org\/10.1007\/s00062-020-00955-6","relation":{},"ISSN":["1869-1439","1869-1447"],"issn-type":[{"value":"1869-1439","type":"print"},{"value":"1869-1447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,16]]},"assertion":[{"value":"14 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical guidelines"}},{"value":"L.A.\u00a0Danyel, G.\u00a0Bohner, F.\u00a0Connolly and E.\u00a0Siebert declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Study approval was obtained from the local ethics committee (Charit\u00e9, Universit\u00e4tsmedizin Berlin, EA1\/177\/19). Consent to participate: not applicable (retrospective analysis)","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}