{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T18:54:16Z","timestamp":1777748056178,"version":"3.51.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Neuroradiol"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s00062-020-00962-7","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T13:03:51Z","timestamp":1601557431000},"page":"581-588","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Imaging Neurovascular Uncoupling in Acute Migraine with Aura with Susceptibility Weighted Imaging"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6019-0147","authenticated-orcid":false,"given":"Frauke","family":"Kellner-Weldon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Jossen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipe S.","family":"Breiding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenz","family":"Grunder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schankin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Scutelnic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphaela","family":"Muri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Pastore-Wapp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Wiest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan","family":"El-Koussy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"962_CR1","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neuroimage.2007.11.046","volume":"40","author":"J Sedlacik","year":"2008","unstructured":"Sedlacik J, Helm K, Rauscher A, Stadler J, Mentzel HJ, Reichenbach JR. Investigations on the effect of caffeine on cerebral venous vessel contrast by using susceptibility-weighted imaging (SWI) at 1.5, 3 and 7 T. Neuroimage. 2008;40:11\u20138.","journal-title":"Neuroimage"},{"key":"962_CR2","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1002\/mrm.20198","volume":"52","author":"EM Haacke","year":"2004","unstructured":"Haacke EM, Xu Y, Cheng YC, Reichenbach JR. Susceptibility weighted imaging (SWI). Magn Reson Med. 2004;52:612\u20138.","journal-title":"Magn Reson Med"},{"key":"962_CR3","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1177\/0333102413491027","volume":"33","author":"EM Fedak","year":"2013","unstructured":"Fedak EM, Zumberge NA, Heyer GL. The diagnostic role for susceptibility-weighted MRI during sporadic hemiplegic migraine. Cephalalgia. 2013;33:1258\u201363.","journal-title":"Cephalalgia"},{"key":"962_CR4","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.3174\/ajnr.A5693","volume":"39","author":"KM Cobb-Pitstick","year":"2018","unstructured":"Cobb-Pitstick KM, Munjal N, Safier R, Cummings DD, Zuccoli G. Time Course of Cerebral Perfusion Changes in Children with Migraine with Aura Mimicking Stroke. AJNR Am J Neuroradiol. 2018;39:1751\u20135.","journal-title":"AJNR Am J Neuroradiol"},{"key":"962_CR5","doi-asserted-by":"publisher","first-page":"e2577","DOI":"10.1212\/WNL.0000000000009493","volume":"94","author":"N Slavova","year":"2020","unstructured":"Slavova N, Denier N, El-Koussy M, Wiest R, Kellner-Weldon F, Fischer U, Schankin CJ. The index vein pointing to the origin of the migraine aura symptom: A case series. Neurology. 2020;94:e2577\u201380.","journal-title":"Neurology"},{"issue":"20","key":"962_CR6","doi-asserted-by":"publisher","first-page":"30108","DOI":"10.1016\/j.ejpn.2020.05.008","volume":"3798","author":"F Kellner-Weldon","year":"2020","unstructured":"Kellner-Weldon F, Lehmann VF, Breiding PS, Grunder L, Muri R, Pastore-Wapp M, Bigi S, Wiest R, El-Koussy M, Slavova N. Findings in susceptibility weighted imaging in pediatric patients with migraine with aura. Eur J Paediatr Neurol. 2020:S1090-3798(20)30108-2. https:\/\/doi.org\/10.1016\/j.ejpn.2020.05.008. Epub ahead of print.","journal-title":"Eur J Paediatr Neurol"},{"key":"962_CR7","doi-asserted-by":"publisher","unstructured":"The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33:629\u2013808. https:\/\/doi.org\/10.1177\/0333102413485658.","DOI":"10.1177\/0333102413485658"},{"key":"962_CR8","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1097\/00004728-200011000-00023","volume":"24","author":"JR Reichenbach","year":"2000","unstructured":"Reichenbach JR, Barth M, Haacke EM, Klarh\u00f6fer M, Kaiser WA, Moser E. High-resolution MR venography at 3.0 Tesla. J Comput Assist Tomogr. 2000;24:949-57.","journal-title":"J Comput Assist Tomogr"},{"key":"962_CR9","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1161\/01.STR.25.5.974","volume":"25","author":"L Friberg","year":"1994","unstructured":"Friberg L, Olesen J, Lassen NA, Olsen TS, Karle A. Cerebral oxygen extraction, oxygen consumption, and regional cerebral blood flow during the aura phase of migraine. Stroke. 1994;25:974\u20139.","journal-title":"Stroke"},{"key":"962_CR10","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1212\/WNL.50.6.1736","volume":"50","author":"EM Bednarczyk","year":"1998","unstructured":"Bednarczyk EM, Remler B, Weikart C, Nelson AD, Reed RC. Global cerebral blood flow, blood volume, and oxygen metabolism in patients with migraine headache. Neurology. 1998;50:1736\u201340.","journal-title":"Neurology"},{"key":"962_CR11","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1152\/jn.1944.7.6.359","volume":"7","author":"A Le\u00e3o","year":"1944","unstructured":"Le\u00e3o A. Spreading depression of activity in the cerebral cortex. J. Neurophysiol. 1944, 7, 359\u2013390.","journal-title":"J. Neurophysiol."},{"key":"962_CR12","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1152\/classicessays.00031.2005","volume":"94","author":"GG Somjen","year":"2005","unstructured":"Somjen GG. Aristides Le\u00e3o\u2019s discovery of cortical spreading depression. J\u00a0Neurophysiol. 2005;94:2\u20134.","journal-title":"J\u00a0Neurophysiol"},{"key":"962_CR13","doi-asserted-by":"publisher","first-page":"4687","DOI":"10.1073\/pnas.071582498","volume":"98","author":"N Hadjikhani","year":"2001","unstructured":"Hadjikhani N, Sanchez Del Rio M, Wu O, Schwartz D, Bakker D, Fischl B, Kwong KK, Cutrer FM, Rosen BR, Tootell RB, Sorensen AG, Moskowitz MA. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci U S A. 2001;98:4687\u201392.","journal-title":"Proc Natl Acad Sci U S A."},{"key":"962_CR14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2463\/mrms.10.49","volume":"10","author":"Y Shimoda","year":"2011","unstructured":"Shimoda Y, Kudo K, Kuroda S, Zaitsu Y, Fujima N, Terae S, Sasaki M, Houkin K. Susceptibility-weighted imaging and magnetic resonance angiography during migraine attack: a case report. Magn Reson Med Sci. 2011;10:49\u201352.","journal-title":"Magn Reson Med Sci"},{"key":"962_CR15","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s10140-012-1051-2","volume":"19","author":"C Miller","year":"2012","unstructured":"Miller C, Goldberg MF. Susceptibility-weighted imaging and computed tomography perfusion abnormalities in diagnosis of classic migraine. Emerg Radiol. 2012;19:565\u20139.","journal-title":"Emerg Radiol"},{"key":"962_CR16","doi-asserted-by":"publisher","first-page":"E5","DOI":"10.3174\/ajnr.A1973","volume":"32","author":"E Karaarslan","year":"2011","unstructured":"Karaarslan E, Ulus S, K\u00fcrt\u00fcnc\u00fc M. Susceptibility-weighted imaging in migraine with aura. AJNR Am J Neuroradiol. 2011;32:E5\u20137.","journal-title":"AJNR Am J Neuroradiol"},{"key":"962_CR17","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1093\/brain\/awp338","volume":"133","author":"JC Chang","year":"2010","unstructured":"Chang JC, Shook LL, Biag J, Nguyen EN, Toga AW, Charles AC, Brennan KC. Biphasic direct current shift, haemoglobin desaturation and neurovascular uncoupling in cortical spreading depression. Brain. 2010;133:996\u20131012.","journal-title":"Brain."},{"key":"962_CR18","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1159\/000492503","volume":"51","author":"AM Slatculescu","year":"2018","unstructured":"Slatculescu AM, Chen Y. Synergism between Female Gender and High Levels of Daily Stress Associated with Migraine Headaches in Ontario, Canada. Neuroepidemiology. 2018;51:183\u20139.","journal-title":"Canada. Neuroepidemiology."},{"key":"962_CR19","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1089\/jwh.2018.7274","volume":"27","author":"RA Schroeder","year":"2018","unstructured":"Schroeder RA, Brandes J, Buse DC, Calhoun A, Eikermann-Haerter K, Golden K, Halker R, Kempner J, Maleki N, Moriarty M, Pavlovic J, Shapiro RE, Starling A, Young WB, Nebel RA. Sex and Gender Differences in Migraine-Evaluating Knowledge Gaps. J Womens Health (Larchmt). 2018;27:965\u201373.","journal-title":"J Womens Health (Larchmt)"},{"key":"962_CR20","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/head.12741","volume":"56","author":"J Genizi","year":"2016","unstructured":"Genizi J, Khourieh Matar A, Zelnik N, Schertz M, Srugo I. Frequency of pediatric migraine with aura in a clinic-based sample. Headache. 2016;56:113\u20137.","journal-title":"Headache"},{"key":"962_CR21","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1002\/ana.22329","volume":"69","author":"X Zhang","year":"2011","unstructured":"Zhang X, Levy D, Kainz V, Noseda R, Jakubowski M, Burstein R. Activation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol. 2011;69:855\u201365.","journal-title":"Ann Neurol."},{"key":"962_CR22","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1111\/j.1468-2982.2005.00955.x","volume":"25","author":"MK Eriksen","year":"2005","unstructured":"Eriksen MK, Thomsen LL, Olesen J. The Visual Aura Rating Scale (VARS) for migraine aura diagnosis. Cephalalgia. 2005;25:801\u201310.","journal-title":"Cephalalgia"},{"key":"962_CR23","first-page":"51","volume":"20","author":"WE Randolph","year":"2014","unstructured":"Randolph WE. The clinical features of migraine with and without aura. J\u00a0Cataract Refract Surg. 2014;20:51\u201360.","journal-title":"J\u00a0Cataract Refract Surg."},{"key":"962_CR24","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1136\/jnnp.2006.093484","volume":"78","author":"IP Martins","year":"2007","unstructured":"Martins IP. Crossed aphasia during migraine aura: transcallosal spreading depression? J Neurol Neurosurg Psychiatry. 2007;78:544\u20135.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"962_CR25","first-page":"207","volume":"29","author":"I Petrusic","year":"2014","unstructured":"Petrusic I, Zidverc-Trajkovic J. Cortical spreading depression: origins and paths as inferred from the sequence of events during migraine aura. Funct Neurol. 2014;29:207\u201312.","journal-title":"Funct Neurol"},{"key":"962_CR26","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1212\/WNL.0b013e3181e042e4","volume":"74","author":"G Kapinos","year":"2010","unstructured":"Kapinos G, Fischbein NJ, Zaharchuk G, Venkatasubramanian C. Migraine-like headache with visual deficit and perfusion abnormality on MRI. Neurology. 2010;74:1743\u20135.","journal-title":"Neurology"},{"key":"962_CR27","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1016\/j.ejrad.2014.05.001","volume":"83","author":"RK Verma","year":"2014","unstructured":"Verma RK, Hsieh K, Gratz PP, Schankath AC, Mordasini P, Zubler C, Kellner-Weldon F, Jung S, Schroth G, Gralla J, El-Koussy M. Leptomeningeal collateralization in acute ischemic stroke: impact on prominent cortical veins in susceptibility-weighted imaging. Eur J Radiol. 2014;83:1448\u201354.","journal-title":"Eur J Radiol"},{"key":"962_CR28","doi-asserted-by":"publisher","first-page":"e0233992","DOI":"10.1371\/journal.pone.0233992","volume":"15","author":"PS Breiding","year":"2020","unstructured":"Breiding PS, Kellner-Weldon F, Grunder L, Scutelnic A, Fischer U, Meinel TR, Slavova N, Gralla J, El-Koussy M, Denier N. Quantification of cerebral veins in patients with acute migraine with aura: A fully automated quantification algorithm using susceptibility-weighted imaging. PLoS One. 2020;15:e0233992.","journal-title":"PLoS One."}],"container-title":["Clinical Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-020-00962-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00062-020-00962-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-020-00962-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T01:08:59Z","timestamp":1633050539000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00062-020-00962-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["962"],"URL":"https:\/\/doi.org\/10.1007\/s00062-020-00962-7","relation":{},"ISSN":["1869-1439","1869-1447"],"issn-type":[{"value":"1869-1439","type":"print"},{"value":"1869-1447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,1]]},"assertion":[{"value":"12 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical guidelines"}},{"value":"F.\u00a0Kellner-Weldon, M.\u00a0Jossen, P.S.\u00a0Breiding, L.\u00a0Grunder, C.\u00a0Schankin, A.\u00a0Scutelnic, U.\u00a0Fischer, R.\u00a0Muri, M.\u00a0Pastore-Wapp and M.\u00a0El-Koussy declare that they have no competing interests. R.\u00a0Wiest: unrelated: grants\/grants pending: Swiss National Foundation, Swiss Heart Foundation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional local ethics committee, Bern, Switzerland Project ID: PB_2018-00128 and\/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}