{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:39:44Z","timestamp":1785811184998,"version":"3.56.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Freiburg"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Neuroradiol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background and Purpose<\/jats:title>\n                <jats:p>To develop a\u00a0fully automatic algorithm for the magnetic resonance imaging (MRI) identification of patients with spontaneous intracranial hypotension (SIH).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Material and Methods<\/jats:title>\n                <jats:p>A\u00a0support vector machine (SVM) was trained with structured reports of 140\u00a0patients with clinically suspected SIH. Venous sinuses and basal cisterns were segmented on contrast-enhanced T1-weighted MPRAGE (Magnetization Prepared-Rapid Gradient Echo) sequences using a\u00a0convolutional neural network (CNN). For the segmented sinuses and cisterns, 56\u00a0radiomic features were extracted, which served as input data for the SVM. The algorithm was validated with an independent cohort of 34\u00a0patients with proven cerebrospinal fluid (CSF) leaks and 27\u00a0patients who had MPRAGE scans for unrelated reasons.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The venous sinuses and the suprasellar cistern had the best discriminative power to separate SIH and non-SIH patients. On a\u00a0combined score with 2\u00a0points, mean SVM score was 1.41 (\u00b10.60) for the SIH and 0.30 (\u00b10.53) for the non-SIH patients (<jats:italic>p<\/jats:italic>\u202f&lt;\u20090.001). Area under the curve (AUC) was 0.91.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A\u00a0fully automatic algorithm analyzing a\u00a0single MRI sequence separates SIH and non-SIH patients with a\u00a0high diagnostic accuracy. It may help to consider the need of invasive diagnostics and transfer to a\u00a0SIH center.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00062-021-01099-x","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T14:29:56Z","timestamp":1634653796000},"page":"225-230","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Support Vector Machine-based Spontaneous Intracranial Hypotension Detection on Brain MRI"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0686-7361","authenticated-orcid":false,"given":"Philipp G.","family":"Arnold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emre","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Reisert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"L\u00fctzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Dovi-Aku\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Urbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"issue":"19","key":"1099_CR1","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1001\/jama.295.19.2286","volume":"295","author":"WI Schievink","year":"2006","unstructured":"Schievink WI. 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Informed consent was obtained from all individual participants included in the study (consent to participate waived by IRB).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}