{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:11:30Z","timestamp":1793167890751,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008485","name":"Schweizerische Akademie der Medizinischen Wissenschaften","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008485","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Neuroradiol"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Incomplete reperfusion after mechanical thrombectomy (MT) is associated with a poor outcome. Rescue therapy would potentially benefit some patients with an expanded treatment in cerebral ischemia score (eTICI)\u00a02b50\/2b67 reperfusion but also harbors increased risks. The relative benefits of eTICI\u00a02c\/3 over eTICI\u00a02b50\/67 in clinically important subpopulations were analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Retrospective analysis of our institutional database for all patients with occlusion of the intracranial internal carotid artery (ICA) or the M1\/M2 segment undergoing MT and final reperfusion of \u2265eTICI\u00a02b50 (903\u00a0patients). The heterogeneity in subgroups of different time metrics, age, National Institutes of Health Stroke Scale (NIHSS), number of retrieval attempts, Alberta Stroke Programme Early CT Score (ASPECTS) and site of occlusion using interaction terms (p<jats:sub>i<\/jats:sub>) was analyzed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The presence of eTICI\u00a02c\/3 was associated with better outcomes in most subgroups. Time metrics showed no interaction of eTICI\u00a02c\/3 over eTICI\u00a02b50\/2b67 and clinical outcomes (onset to reperfusion p<jats:sub>i<\/jats:sub>\u202f=\u20090.77, puncture to reperfusion p<jats:sub>i<\/jats:sub>\u202f=\u20090.65, onset to puncture p<jats:sub>i<\/jats:sub>\u202f=\u20090.63). An eTICI\u00a02c\/3 had less consistent association with mRS \u22642 in older patients (&gt;82\u00a0years, p<jats:sub>i<\/jats:sub>\u202f=\u20090.038) and patients with either lower NIHSS (\u22649) or very high NIHSS (&gt;19, p<jats:sub>i<\/jats:sub>\u202f=\u20090.01). Regarding occlusion sites, the beneficial effect of eTICI\u00a02c\/3 was absent for occlusions in the M2 segments (aOR 0.73, 95% confidence interval [CI] 0.33\u20131.59, p<jats:sub>i<\/jats:sub>\u202f=\u20090.018).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Beneficial effect of eTICI\u00a02c\/3 over eTICI\u00a02b50\/2b67 only decreased in older patients, M2-occlusions and patients with either low or very high NIHSS. Improving eTICI\u00a02b50\/2b67 to eTICI\u00a02c\/3 in those subgroups may be more often futile.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00062-021-01131-0","type":"journal-article","created":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T13:02:51Z","timestamp":1641474171000},"page":"817-827","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Heterogeneity of the Relative Benefits of TICI\u00a02c\/3 over TICI\u00a02b50\/2b67"],"prefix":"10.1007","volume":"32","author":[{"given":"Christoph C.","family":"Kurmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Mujanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike I.","family":"Piechowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Dobrocky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Zibold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morin","family":"Beyeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Vynckier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Seiffge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Meinel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Mordasini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gralla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9177-2289","authenticated-orcid":false,"given":"Johannes","family":"Kaesmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"1131_CR1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1136\/neurintsurg-2018-014127","volume":"11","author":"DS Liebeskind","year":"2019","unstructured":"Liebeskind\u00a0DS, Bracard\u00a0S, Guillemin\u00a0F, Jahan\u00a0R, Jovin\u00a0TG, Majoie\u00a0CB, Mitchell\u00a0PJ, van der Lugt\u00a0A, Menon\u00a0BK, San Rom\u00e1n\u00a0L, Campbell\u00a0BC, Muir\u00a0KW, Hill\u00a0MD, Dippel\u00a0DW, Saver\u00a0JL, Demchuk\u00a0AM, D\u00e1valos\u00a0A, White\u00a0P, Brown\u00a0S, Goyal\u00a0M; HERMES Collaborators. eTICI reperfusion: defining success in endovascular stroke therapy. 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M.\u00a0Arnold reports personal fees from Bayer, Bristol-Myers Squibb, Medtronic, Amgen, Daiichi Sankyo, Nestl\u00e9 Health Sciences, Boehringer Ingelheim, and Covidien during the conduct of the study. U.\u00a0Fischer reports grants during the conduct of the study from Medtronic, Stryker, and CSL Behring outside the submitted work. J.\u00a0Gralla is a\u00a0global principal investigator of STAR (Solitaire FR Thrombectomy for Acute Revascularisation), Clinical Event Committee member of the PROMISE study (Prospective, Multicenter, Observational, Single-Arm European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic Stroke; Penumbra), and a\u00a0principal investigator and consultant for the SWIFT DIRECT study (Solitaire With the Intention for Thrombectomy Plus Intravenous tPA Versus DIRECT Solitaire Stent-Retriever Thrombectomy in Acute Anterior Circulation Stroke; Medtronic) and receives Swiss National Science Foundation grants for magnetic resonance imaging in stroke. J.\u00a0Kaesmacher reports grants from the Swiss Academy of Medical Sciences\/Bangerter Foundation, Swiss Stroke Society, and Clinical Trial Unit Bern during the conduct of the study. C.C.\u00a0Kurmann, A.\u00a0Mujanovic, E.I.\u00a0Piechowiak, T.\u00a0Dobrocky, F.\u00a0Zibold, M.\u00a0Beyeler, J.\u00a0Vynckier, D.\u00a0Seiffge and P.\u00a0Mordasini declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Institutional Review Board approval was obtained. Consent to participate: written informed consent was obtained from all subjects (patients) in this study. Consent for publication: not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}