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Aim of this study was to use a\u00a0novel T1 mapping method to enrich the diagnostic work-up of patients with suspected iNPH.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Using 3T magnetic resonance imaging (MRI) we prospectively evaluated rapid high-resolution T1\u00a0mapping at 0.5\u202fmm resolution and 4\u202fs acquisition time in 15\u00a0patients with suspected iNPH and 8\u00a0age-matched, healthy controls. T1\u00a0mapping in axial sections of the cerebrum, clinical and neuropsychological testing were performed prior to and after cerebrospinal fluid tap test (CSF-TT). T1\u00a0relaxation times were measured in 5\u00a0predefined periventricular regions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All 15\u00a0patients with suspected iNPH showed gait impairment, 13 (86.6%) showed signs of cognitive impairment and 8 (53.3%) patients had urinary incontinence. Gait improvement was noted in 12\u00a0patients (80%) after CSF-TT. T1\u00a0relaxation times in all periventricular regions were elevated in patients with iNPH compared to controls with the most pronounced differences in the anterior (1006\u202f\u00b1\u200993\u202fms vs. 911\u202f\u00b1\u200977\u202fms; <jats:italic>p<\/jats:italic>\u202f=\u20090.023) and posterior horns (983\u202f\u00b1\u2009103\u202fms vs. 893\u202f\u00b1\u200968\u202fms; <jats:italic>p<\/jats:italic>\u202f=\u20090.037) of the lateral ventricles. Montreal cognitive assessment (MoCA) scores at baseline were negatively correlated with T1\u00a0relaxation times (r\u202f&lt;\u2009\u22120.5, <jats:italic>p<\/jats:italic>\u202f&lt;\u20090.02). Higher T1\u00a0relaxation times were significantly correlated with an improvement of the 3\u2011m timed up and go test (r\u202f&gt;\u20090.6 and <jats:italic>p<\/jats:italic>\u202f&lt;\u20090.03) after CSF-TT.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In iNPH-patients, periventricular T1\u00a0relaxation times are increased compared to age-matched controls and predict gait improvement after CSF-TT. T1\u00a0mapping might enrich iNPH work-up and might be useful to indicate permanent shunting.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00062-022-01155-0","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T16:02:35Z","timestamp":1649347355000},"page":"1067-1076","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["High Periventricular T1 Relaxation Times Predict Gait Improvement After Spinal Tap in Patients with Idiopathic Normal Pressure Hydrocephalus"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-8878","authenticated-orcid":false,"given":"Ilko L.","family":"Maier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marielle","family":"Heide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Hofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Dechent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-495X","authenticated-orcid":false,"given":"Ingo","family":"Fiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4912-2917","authenticated-orcid":false,"given":"Christian","family":"von der Brelie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3014-4307","authenticated-orcid":false,"given":"Veit","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8279-884X","authenticated-orcid":false,"given":"Jens","family":"Frahm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9570-1592","authenticated-orcid":false,"given":"Mathias","family":"B\u00e4hr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7465-9655","authenticated-orcid":false,"given":"Jan","family":"Liman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"issue":"3 Suppl","key":"1155_CR1","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1227\/01.neu.0000168185.29659.c5","volume":"57","author":"N Relkin","year":"2005","unstructured":"Relkin N, Marmarou A, Klinge P, Bergsneider M, Black PM. 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I.\u00a0L.\u00a0Maier, M.\u00a0Heide, S.\u00a0Hofer, P.\u00a0Dechent, I.\u00a0Fiss, C.\u00a0von der Brelie, V.\u00a0Rohde, J.\u00a0Frahm, M.\u00a0B\u00e4hr and J.\u00a0Liman declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was carried out in accordance with the code of ethics of the World Medical Association (Declaration of Helsinki) and approved by the ethics committee of the University Medicine G\u00f6ttingen (29\/6\/18). Informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}