{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:04:16Z","timestamp":1792641856938,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Bern"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Neuroradiol"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Double-layer stents show promising results in preventing periinterventional and postinterventional embolic events in elective settings of carotid artery stenting (CAS). We report a\u00a0single-center experience with the CGuard stent in the treatment of acute ischemic stroke (AIS) due to symptomatic internal carotid artery (ICA) stenosis or occlusion with or without intracranial occlusion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We retrospectively analyzed all patients who received a\u00a0CGuard stent in the setting of AIS at our institution. Neuroimaging and clinical data were analyzed with the following primary endpoints: technical feasibility, acute and delayed stent occlusion or thrombosis, distal embolism, symptomatic intracranial hemorrhage (sICH) and functional outcome at 3\u00a0months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In 33\u00a0patients, stenting with the CGuard was performed. Stent deployment was successful in all patients (28\u00a0with tandem occlusions, 5\u00a0with isolated ICA occlusion). Transient acute in-stent thrombus formation occurred in three patients (9%) without early stent occlusion. Delayed, asymptomatic stent occlusion was seen in 1 patient (3%) after 49\u00a0days. Asymptomatic periinterventional distal emboli occurred in 2 patients (6%), 1 patient experienced a\u00a0transient ischemic attack 79\u00a0days after the procedure and 1 patient (3%) developed sICH. Favorable clinical outcome (mRS 0\u20132) at 3\u00a0months was achieved in 12 patients (36%) and the mortality rate was 24%.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The CGuard use in emergencies was technically feasible, the safety has to be confirmed by further multicentric studies.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00062-022-01209-3","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T09:02:53Z","timestamp":1662541373000},"page":"237-244","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Safety and Efficacy of Carotid Artery Stenting with the CGuard Double-layer Stent in Acute Ischemic Stroke"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8749-6066","authenticated-orcid":false,"given":"Tomas","family":"Klail","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kurmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kaesmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Mujanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike I.","family":"Piechowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Dobrocky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Pilgram-Pastor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Scutelnic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam R.","family":"Heldner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Gralla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Mordasini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"1209_CR1","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/S0140-6736(10)60239-5","volume":"375","author":"J Ederle","year":"2010","unstructured":"International Carotid Stenting Study investigators; Ederle\u00a0J, Dobson\u00a0J, Featherstone\u00a0RL, Bonati\u00a0LH, van der Worp\u00a0HB, de Borst\u00a0GJ, Lo\u00a0TH, Gaines\u00a0P, Dorman\u00a0PJ, Macdonald\u00a0S, Lyrer\u00a0PA, Hendriks\u00a0JM, McCollum\u00a0C, Nederkoorn\u00a0PJ, Brown\u00a0MM. 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EuroIntervention. 2016;12:e658\u201370.","journal-title":"EuroIntervention"}],"container-title":["Clinical Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-022-01209-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00062-022-01209-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-022-01209-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T23:11:55Z","timestamp":1679872315000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00062-022-01209-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,7]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["1209"],"URL":"https:\/\/doi.org\/10.1007\/s00062-022-01209-3","relation":{},"ISSN":["1869-1439","1869-1447"],"issn-type":[{"value":"1869-1439","type":"print"},{"value":"1869-1447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,7]]},"assertion":[{"value":"18 May 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"J.\u00a0Kaesmacher reports grants from the Swiss Academy of Medical Sciences\/Bangerter Foundation, Swiss Stroke Society, and Clinical Trials Unit Bern during the conduct of the study. A.\u00a0Scutelnic reports research support from Swiss Heart Foundation, not related to this manuscript. M.R.\u00a0Heldner reports grants from the Swiss National Science Foundation, the Swiss Heart Foundation, the SITEM Support Funds and from the Bangerter Foundation, and Advisory Board participation for Amgen, unrelated to the submitted work. J.\u00a0Gralla is the global co-principal investigator of the SWIFT DIRECT trial (Solitaire With the Intention for Thrombectomy Plus Intravenous tPA Versus DIRECT Solitaire Stent-Retriever Thrombectomy in Acute Anterior Circulation Stroke; Medtronic), therefore consultant Medtronic. He receives Swiss National Science Foundation grants for magnetic resonance imaging in stroke. P.\u00a0Mordasini reports research support from Siemens, Cerenovus, iSchemaview, Medtronic and Stryker, and receipt of honoraria and consultation fees from Medtronic, Cerenovus, Phenox and Microvention payed to the institution. T.\u00a0Klail, C.\u00a0Kurmann, A.\u00a0Mujanovic, E.I.\u00a0Piechowiak, T.\u00a0Dobrocky, S.\u00a0Pilgram-Pastor and A.\u00a0Scutelnic declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the local ethics committee (Kantonale Ethikkommission f\u00fcr die Forschung Bern, Bern Switzerland, amendment access number: 231\/2014).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}