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Intraprocedural blood gas samples (1\u202fml) from within cerebral collateral arteries (ischemic) and matched systemic control samples were obtained according to a\u00a0prespecified protocol in 51\u00a0patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We observed a\u00a0significant reduction in cerebral oxygen partial pressure (\u22124.29%, <jats:italic>p<\/jats:italic><jats:sub>a<\/jats:sub>O<jats:sub>2ischemic<\/jats:sub>\u202f=\u2009185.3\u202fmm\u202fHg vs. <jats:italic>p<\/jats:italic><jats:sub>a<\/jats:sub>O<jats:sub>2systemic<\/jats:sub>\u202f=\u2009193.6\u202fmm\u202fHg; <jats:italic>p<\/jats:italic>\u202f=\u20090.035) and K<jats:sup>+<\/jats:sup> concentrations (\u22125.49%, K<jats:sup>+<\/jats:sup><jats:sub>ischemic<\/jats:sub>\u202f=\u20093.44\u202fmmol\/L vs. K<jats:sup>+<\/jats:sup><jats:sub>systemic<\/jats:sub>\u202f=\u20093.64\u202fmmol\/L; <jats:italic>p<\/jats:italic>\u202f=\u20090.0083). The cerebral Na<jats:sup>+<\/jats:sup>:K<jats:sup>+<\/jats:sup> ratio was significantly increased and negatively correlated with baseline tissue integrity (r\u202f=\u2009\u22120.32, <jats:italic>p<\/jats:italic>\u202f=\u20090.031). Correspondingly, cerebral Na<jats:sup>+<\/jats:sup> concentrations were most strongly correlated with infarct progression after recanalization (r\u202f=\u20090.42, <jats:italic>p<\/jats:italic>\u202f=\u20090.0033). We found more alkaline cerebral pH values (+0.14%, pH<jats:sub>ischemic<\/jats:sub>\u202f=\u20097.38 vs. pH<jats:sub>systemic<\/jats:sub>\u202f=\u20097.37; <jats:italic>p<\/jats:italic>\u202f=\u20090.0019), with a\u00a0time-dependent shift towards more acidotic conditions (r\u202f=\u2009\u22120.36, <jats:italic>p<\/jats:italic>\u202f=\u20090.055).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>These findings suggest that stroke-induced changes in oxygen supply, ion composition and acid-base balance occur and dynamically progress within penumbral areas during human cerebral ischemia and are related to acute tissue damage.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00062-023-01296-w","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T06:02:13Z","timestamp":1686117733000},"page":"973-984","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Distinct Alterations in Oxygenation, Ion Composition and Acid-Base Balance in Cerebral Collaterals During Large-Vessel Occlusion Stroke"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-0119","authenticated-orcid":false,"given":"J\u00f6rn","family":"Feick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1295-2685","authenticated-orcid":false,"given":"Mirko","family":"Pham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1358-0871","authenticated-orcid":false,"given":"Alexander G.","family":"M\u00e4rz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8297-1614","authenticated-orcid":false,"given":"Marius L.","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-2000","authenticated-orcid":false,"given":"Marc","family":"Strinitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-5165","authenticated-orcid":false,"given":"Guido","family":"Stoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4014-7010","authenticated-orcid":false,"given":"Michael K.","family":"Schuhmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0288-5928","authenticated-orcid":false,"given":"Alexander M.","family":"Kollikowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"1296_CR1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0140-6736(21)01341-6","volume":"399","author":"TG Jovin","year":"2022","unstructured":"Jovin\u00a0TG, Nogueira\u00a0RG, Lansberg\u00a0MG, Demchuk\u00a0AM, Martins\u00a0SO, Mocco\u00a0J, Ribo\u00a0M, Jadhav\u00a0AP, Ortega-Gutierrez\u00a0S, Hill\u00a0MD, Lima\u00a0FO, Haussen\u00a0DC, Brown\u00a0S, Goyal\u00a0M, Siddiqui\u00a0AH, Heit\u00a0JJ, Menon\u00a0BK, Kemp\u00a0S, Budzik\u00a0R, Urra\u00a0X, Marks\u00a0MP, Costalat\u00a0V, Liebeskind\u00a0DS, Albers\u00a0GW. 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