{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:28:38Z","timestamp":1791332918517,"version":"4.3.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012320","name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012320","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Neuroradiol"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backround<\/jats:title>\n                    <jats:p>The use of flow diverting stents in the treatment of intracranial aneurysms is associated with a\u00a0risk of neurological morbidity due to their thrombogenicity. To reduce this risk different surface modifications have been developed. The Derivo\u00a02 Embolization Device (Acandis, Pforzheim, Germany) has proven to be a\u00a0safe and effective flow diverter. To overcome the risk of thrombo-embolism, the device was modified by adding an anti-thrombogenic fibrin-heparin coating. We aimed to assess the safety and effectiveness of the Derivo\u00a02 heal Embolization Device.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective multicenter data from nine German neurovascular centers between February 2022 until December 2023 were used. Patients treated with the Derivo\u00a02 heal Embolization Device for unruptured or ruptured intracranial aneurysms were included. Peri- and postprocedural adverse events, clinical outcomes, and angiographic follow-up results were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>84\u00a0patients (73.8% female; mean age\u00a058.7 years) with 89\u00a0aneurysms (mean size 9.8\u202fmm) were included. 87.6% were located in the anterior circulation. Most of them were sidewall aneurysms (88.8%). 96\u00a0flow diverters were used. 99.0% were successfully implanted. An in-stent balloon angioplasty was performed in 6.0% of the cases. An additional coiling was performed in 28.6%. Technical difficulties were present in 12.0% of the cases. Thrombotic events occurred in 4.8% with no neurological sequelae. Mortality and morbidity were 0 and 1.2% respectively. Adequate aneurysm occlusion was achieved in 80.7% with a\u00a0mean follow-up time of 6.6\u00a0months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Derivo\u00a02 heal Embolization Device showed a\u00a0satisfying aneurysm occlusion and safety with a\u00a0low rate of neurological morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00062-024-01446-8","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T06:33:07Z","timestamp":1724394787000},"page":"25-34","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The DERIVO\u00a02 Heal Embolization Device in the Treatment of Ruptured and Unruptured Intracranial Aneurysms: a\u00a0Retrospective Multicenter Study"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3799-6194","authenticated-orcid":false,"given":"Roland","family":"Schwab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kabbasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Goertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Kaschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Loehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauke","family":"Wensing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Bester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Simgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Kemmling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Wendl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erelle","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Thormann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Behme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Nordmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"1446_CR1","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1161\/STROKEAHA.112.678151","volume":"44","author":"W Brinjikji","year":"2013","unstructured":"Brinjikji\u00a0W, Murad\u00a0MH, Lanzino\u00a0G, Cloft\u00a0HJ, Kallmes\u00a0DF. Endovascular Treatment of Intracranial Aneurysms With Flow Diverters: A\u00a0Meta-Analysis. Stroke. 2013;44:442\u20137. https:\/\/doi.org\/10.1161\/STROKEAHA.112.678151.","journal-title":"Stroke"},{"key":"1446_CR2","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1177\/1971400915621321","volume":"29","author":"X Lv","year":"2016","unstructured":"Lv\u00a0X, Yang\u00a0H, Liu\u00a0P, Li\u00a0Y. Flow-diverter devices in the treatment of intracranial aneurysms: A\u00a0meta-analysis and systematic review. Neuroradiol\u00a0J. 2016;29:66\u201371. https:\/\/doi.org\/10.1177\/1971400915621321.","journal-title":"Neuroradiol J"},{"key":"1446_CR3","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.wneu.2018.04.009","volume":"115","author":"Y Yan","year":"2018","unstructured":"Yan\u00a0Y, Zhu\u00a0D, Tang\u00a0H, Huang\u00a0Q. Safety and Efficacy of Flow Diverter Treatment for Aneurysm in Small Cerebral Vessels: A\u00a0Systematic Review and Meta-Analysis. World Neurosurg. 2018;115:54\u201364. https:\/\/doi.org\/10.1016\/j.wneu.2018.04.009.","journal-title":"World Neurosurg"},{"key":"1446_CR4","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1227\/01.neu.0000430297.17961.f1","volume":"73","author":"I Arrese","year":"2013","unstructured":"Arrese\u00a0I, Sarabia\u00a0R, Pintado\u00a0R, Delgado-Rodriguez\u00a0M. Flow-Diverter Devices for Intracranial Aneurysms: Systematic Review and Meta-analysis. Neurosurgery. 2013;73:193\u2013200. https:\/\/doi.org\/10.1227\/01.neu.0000430297.17961.f1.","journal-title":"Neurosurgery"},{"key":"1446_CR5","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1007\/s00270-022-03153-8","volume":"45","author":"V Hellstern","year":"2022","unstructured":"Hellstern\u00a0V, Aguilar\u00a0PM, Henkes\u00a0E, Donauer\u00a0E, Wendl\u00a0C, B\u00e4zner\u00a0H, et\u00a0al. Use of a\u00a0p64 MW Flow Diverter with Hydrophilic Polymer Coating (HPC) and Prasugrel Single Antiplatelet Therapy for the Treatment of Unruptured Anterior Circulation Aneurysms: Safety Data and Short-term Occlusion Rates. Cardiovasc Intervent Radiol. 2022;45:1364\u201374. https:\/\/doi.org\/10.1007\/s00270-022-03153-8.","journal-title":"Cardiovasc Intervent Radiol"},{"key":"1446_CR6","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1136\/neurintsurg-2020-015978","volume":"12","author":"MH Mohammaden","year":"2020","unstructured":"Mohammaden\u00a0MH, English\u00a0SW, Stapleton\u00a0CJ, Khedr\u00a0E, Shoyb\u00a0A, Hegazy\u00a0A, et\u00a0al. Safety and efficacy of ticagrelor as single antiplatelet therapy in prevention of thromboembolic complications associated with the Pipeline Embolization Device (PED): multicenter experience. J\u00a0Neurointerventional Surg. 2020;12:1113\u20136. https:\/\/doi.org\/10.1136\/neurintsurg-2020-015978.","journal-title":"J Neurointerventional Surg"},{"key":"1446_CR7","doi-asserted-by":"publisher","DOI":"10.1177\/15910199231207550","volume-title":"Flow diverter surface modifications for aneurysm treatment: A\u00a0review of the mechanisms and data behind existing technologies. Interv Neuroradiol","author":"TG White","year":"2023","unstructured":"White\u00a0TG, Santhumayor\u00a0BA, Turpin\u00a0J, Shah\u00a0K, Toscano\u00a0D, Teron\u00a0I, et\u00a0al. Flow diverter surface modifications for aneurysm treatment: A\u00a0review of the mechanisms and data behind existing technologies. Interv Neuroradiol. 2023. https:\/\/doi.org\/10.1177\/15910199231207550. 15910199231207550."},{"key":"1446_CR8","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.933428","author":"Z Riedelov\u00e1-Reicheltov\u00e1","year":"2016","unstructured":"Riedelov\u00e1-Reicheltov\u00e1\u00a0Z, Brynda\u00a0E, Riedel\u00a0T. Fibrin Nanostructures for Biomedical Applications. Physiol Res. 2016; https:\/\/doi.org\/10.33549\/physiolres.933428.","journal-title":"Physiol Res"},{"key":"1446_CR9","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s00270-021-03007-9","volume":"45","author":"R M\u00fchl-Benninghaus","year":"2022","unstructured":"M\u00fchl-Benninghaus\u00a0R, Fries\u00a0F, Kie\u00dfling\u00a0M, Tomori\u00a0T, Krajewski\u00a0S, Simgen\u00a0A, et\u00a0al. Vascular Response on a\u00a0Novel Fibrin-Based Coated Flow Diverter. Cardiovasc Intervent Radiol. 2022;45:236\u201343. https:\/\/doi.org\/10.1007\/s00270-021-03007-9.","journal-title":"Cardiovasc Intervent Radiol"},{"key":"1446_CR10","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1161\/STROKEAHA.119.025407","volume":"50","author":"FP Trivelato","year":"2019","unstructured":"Trivelato\u00a0FP, Abud\u00a0DG, Ulh\u00f4a\u00a0AC, Waihrich\u00a0ES, Abud\u00a0TG, Castro\u00a0ALH, et\u00a0al. Derivo Embolization Device for the Treatment of Intracranial Aneurysms: A\u00a0Multicenter Study of 183 Aneurysms. Stroke. 2019;50:2351\u20138. https:\/\/doi.org\/10.1161\/STROKEAHA.119.025407.","journal-title":"Stroke"},{"key":"1446_CR11","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1136\/neurintsurg-2020-016303","volume":"13","author":"CA Taschner","year":"2021","unstructured":"Taschner\u00a0CA, Stracke\u00a0CP, Dorn\u00a0F, Kadziolka\u00a0KB, Kreiser\u00a0K, Solymosi\u00a0L, et\u00a0al. Derivo embolization device in the treatment of unruptured intracranial aneurysms: a\u00a0prospective multicenter study. J\u00a0Neurointerventional Surg. 2021;13:541\u20136. https:\/\/doi.org\/10.1136\/neurintsurg-2020-016303.","journal-title":"J Neurointerventional Surg"},{"key":"1446_CR12","unstructured":"van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJA, van Gijn J. Interobserver agreement for the assessment of handicap in stroke patients. https:\/\/www.ahajournals.org\/doi\/10.1161\/01.STR.19.5.604"},{"key":"1446_CR13","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1161\/01.STR.20.7.864","volume":"20","author":"T Brott","year":"1989","unstructured":"Brott\u00a0T, Adams\u00a0HP, Olinger\u00a0CP, Marler\u00a0JR, Barsan\u00a0WG, Biller\u00a0J, et\u00a0al. Measurements of acute cerebral infarction: a\u00a0clinical examination scale. Stroke. 1989;20:864\u201370. https:\/\/doi.org\/10.1161\/01.STR.20.7.864.","journal-title":"Stroke"},{"key":"1446_CR14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1177\/159101991001600204","volume":"16","author":"CJ O\u2019Kelly","year":"2010","unstructured":"O\u2019Kelly\u00a0CJ, Krings\u00a0T, Fiorella\u00a0D, Marotta\u00a0TR. A\u00a0Novel Grading Scale for the Angiographic Assessment of Intracranial Aneurysms Treated Using Flow Diverting Stents. Interv Neuroradiol. 2010;16:133\u20137.\u00a0https:\/\/journals.sagepub.com\/doi\/10.1177\/159101991001600204","journal-title":"Interv Neuroradiol"},{"key":"1446_CR15","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1136\/neurintsurg-2018-013963","volume":"11","author":"B Kraus","year":"2019","unstructured":"Kraus\u00a0B, Goertz\u00a0L, Turowski\u00a0B, Borggrefe\u00a0J, Schlamann\u00a0M, Dorn\u00a0F, et\u00a0al. Safety and efficacy of the Derivo Embolization Device for the treatment of unruptured intracranial aneurysms: a\u00a0multicentric study. J\u00a0Neurointerventional Surg. 2019;11:68\u201373. https:\/\/doi.org\/10.1136\/neurintsurg-2018-013963.","journal-title":"J Neurointerventional Surg"},{"key":"1446_CR16","doi-asserted-by":"publisher","DOI":"10.23736\/S0390-5616.21.05300-5","author":"M Piano","year":"2021","unstructured":"on behalf of the Italian DERIVO\u00ae Registry Group, Piano\u00a0M, Lozupone\u00a0E, Sgoifo\u00a0A, Nuzzi\u00a0NP, Asteggiano\u00a0F, et\u00a0al. Long-term follow-up of the Derivo\u00ae Embolization Device (DED\u00ae) for intracranial aneurysms: the Italian Multicentric Registry. J\u00a0Neurosurg Sci. 2021; https:\/\/doi.org\/10.23736\/S0390-5616.21.05300-5.","journal-title":"J Neurosurg Sci"},{"key":"1446_CR17","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1136\/neurintsurg-2022-018648","volume":"15","author":"G Chagas Louren\u00e7o","year":"2023","unstructured":"Chagas Louren\u00e7o\u00a0G, Dantas\u00a0F. Silva E Carvalho T, Firmino RUR, Quesado Filgueiras Filho M, Tosello RT, et\u00a0al. Endovascular treatment of intracranial aneurysms using the Derivo Embolization Device: a\u00a0multicenter experience. J\u00a0Neurointerventional Surg. 2023;15:776\u201380. https:\/\/doi.org\/10.1136\/neurintsurg-2022-018648.","journal-title":"J Neurointerventional Surg"},{"key":"1446_CR18","doi-asserted-by":"publisher","DOI":"10.1177\/15910199221142643","author":"M Thormann","year":"2022","unstructured":"Thormann\u00a0M, Sillis\u00a0N, Thoma\u00a0T, Altenbernd\u00a0J, Berger\u00a0B, Cioltan\u00a0A, et\u00a0al. The DERIVO\u00ae2 Embolization Device in the treatment of ruptured and unruptured intracranial aneurysms: A\u00a0multicenter analysis. Interv Neuroradiol. 2022; https:\/\/doi.org\/10.1177\/15910199221142643.","journal-title":"Interv Neuroradiol"},{"key":"1446_CR19","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2022-019993","author":"L Meyer","year":"2023","unstructured":"Meyer\u00a0L, Stracke\u00a0CP, Bester\u00a0M, Kallmes\u00a0KM, Zele\u0148\u00e1k\u00a0K, Rouchaud\u00a0A, et\u00a0al. Predictors of aneurysm occlusion after treatment with flow diverters: a\u00a0systematic literature review. J\u00a0Neurointerventional Surg. 2023; https:\/\/doi.org\/10.1136\/jnis-2022-019993.","journal-title":"J Neurointerventional Surg"},{"key":"1446_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-023-01346-3","author":"S Hohenstatt","year":"2023","unstructured":"Hohenstatt\u00a0S, Ulfert\u00a0C, Herweh\u00a0C, Hilgenfeld\u00a0T, Schmitt\u00a0N, Sch\u00f6nenberger\u00a0S, et\u00a0al. Long-term Follow-up After Aneurysm Treatment with the Flow Redirection Endoluminal Device (FRED) Flow Diverter. Clin Neuroradiol. 2023; https:\/\/doi.org\/10.1007\/s00062-023-01346-3.","journal-title":"Clin Neuroradiol"},{"key":"1446_CR21","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1136\/neurintsurg-2021-017809","volume":"14","author":"A Bonafe","year":"2022","unstructured":"Bonafe\u00a0A, Perez\u00a0MA, Henkes\u00a0H, Lylyk\u00a0P, Bleise\u00a0C, Gascou\u00a0G, et\u00a0al. Diversion-p64: results from an international, prospective, multicenter, single-arm post-market study to assess the safety and effectiveness of the p64 flow modulation device. J\u00a0Neurointerventional Surg. 2022;14:898\u2013903. https:\/\/doi.org\/10.1136\/neurintsurg-2021-017809.","journal-title":"J Neurointerventional Surg"},{"key":"1446_CR22","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s00062-017-0591-y","volume":"28","author":"M Aguilar P\u00e9rez","year":"2018","unstructured":"Aguilar P\u00e9rez\u00a0M, Bhogal\u00a0P, Henkes\u00a0E, Ganslandt\u00a0O, B\u00e4zner\u00a0H, Henkes\u00a0H. In-stent Stenosis after p64 Flow Diverter Treatment. Clin Neuroradiol. 2018;28:563\u20138. https:\/\/doi.org\/10.1007\/s00062-017-0591-y.","journal-title":"Clin Neuroradiol"},{"key":"1446_CR23","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.jcin.2011.05.025","volume":"4","author":"T Inoue","year":"2011","unstructured":"Inoue\u00a0T, Croce\u00a0K, Morooka\u00a0T, Sakuma\u00a0M, Node\u00a0K, Simon\u00a0DI. Vascular Inflammation and Repair. JACC Cardiovasc Interv. 2011;4:1057\u201366. https:\/\/doi.org\/10.1016\/j.jcin.2011.05.025.","journal-title":"JACC Cardiovasc Interv"},{"key":"1446_CR24","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1136\/jcp.2005.025742","volume":"59","author":"AK Mitra","year":"2006","unstructured":"Mitra\u00a0AK. In stent restenosis: bane of the stent era. J\u00a0Clin Pathol. 2006;59:232\u20139. https:\/\/doi.org\/10.1136\/jcp.2005.025742.","journal-title":"J Clin Pathol"},{"key":"1446_CR25","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0735-1097(99)00486-6","volume":"35","author":"PH Grewe","year":"2000","unstructured":"Grewe\u00a0PH, Deneke\u00a0T, Machraoui\u00a0A, Barmeyer\u00a0J, M\u00fcller\u00a0K\u2011M. Acute and chronic tissue response to coronary stent implantation: pathologic findings in human specimen. J\u00a0Am Coll Cardiol. 2000;35:157\u201363. https:\/\/doi.org\/10.1016\/S0735-1097(99)00486-6.","journal-title":"J Am Coll Cardiol"},{"key":"1446_CR26","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3174\/ajnr.A5955","volume":"40","author":"K Ravindran","year":"2019","unstructured":"Ravindran\u00a0K, Salem\u00a0MM, Alturki\u00a0AY, Thomas\u00a0AJ, Ogilvy\u00a0CS, Moore\u00a0JM. Endothelialization following Flow Diversion for Intracranial Aneurysms: A\u00a0Systematic Review. Ajnr Am J Neuroradiol. 2019;40:295\u2013301. https:\/\/doi.org\/10.3174\/ajnr.A5955.","journal-title":"Ajnr Am J Neuroradiol"},{"key":"1446_CR27","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1136\/neurintsurg-2017-013739","volume":"10","author":"MT Bender","year":"2018","unstructured":"Bender\u00a0MT, Jiang\u00a0B, Campos\u00a0JK, Lin\u00a0L\u2011M, Beaty\u00a0N, Vo\u00a0CD, et\u00a0al. Single-stage flow diversion with adjunctive coiling for cerebral aneurysm: outcomes and technical considerations in 72\u00a0cases. J\u00a0Neurointerventional Surg. 2018;10:843\u201350. https:\/\/doi.org\/10.1136\/neurintsurg-2017-013739.","journal-title":"J Neurointerventional Surg"},{"key":"1446_CR28","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3174\/ajnr.A7834","volume":"44","author":"DF Vollherbst","year":"2023","unstructured":"Vollherbst\u00a0DF, L\u00fccking\u00a0H, DuPlessis\u00a0J, Sonnberger\u00a0M, Maurer\u00a0C, Kocer\u00a0N, et\u00a0al. The FRESH Study: Treatment of Intracranial Aneurysms with the New FRED X Flow Diverter with Antithrombotic Surface Treatment Technology\u2014First Multicenter Experience in 161 Patients. Am J Neuroradiol. 2023;44:474\u201380. https:\/\/doi.org\/10.3174\/ajnr.A7834.","journal-title":"Am J Neuroradiol"},{"key":"1446_CR29","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-021182","author":"L De Villiers","year":"2024","unstructured":"De Villiers\u00a0L, Carraro\u00a0DNV, Domitrovic\u00a0L, Dhillon\u00a0PS, Vanguard Study\u00a0RH. Initial experience with the new fourth generation Pipeline Vantage Flow Diverter (PVFD): 6\u2011month results, technical and clinical considerations. J\u00a0Neurointerventional Surg. 2024; https:\/\/doi.org\/10.1136\/jnis-2023-021182.","journal-title":"J Neurointerventional Surg"},{"key":"1446_CR30","doi-asserted-by":"publisher","DOI":"10.1177\/15910199231220964","author":"M Ernst","year":"2023","unstructured":"Ernst\u00a0M, Jamous\u00a0A, Bartl\u00a0M, Riedel\u00a0C, Holtmannsp\u00f6tter\u00a0M, Voit-H\u00f6hne\u00a0H, et\u00a0al. Multicenter study of the safety and effectiveness of intracranial aneurysm treatment with the p64MW-HPC flow modulation device. Interv Neuroradiol. 2023; https:\/\/doi.org\/10.1177\/15910199231220964.","journal-title":"Interv Neuroradiol"},{"key":"1446_CR31","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1177\/1591019920939845","volume":"27","author":"A Petrov","year":"2021","unstructured":"Petrov\u00a0A, Rentsenkhuu\u00a0G, Nota\u00a0B, Ganzorig\u00a0E, Regzengombo\u00a0B, Jagusch\u00a0S, et\u00a0al. Initial experience with the novel p64MW HPC flow diverter from a\u00a0cohort study in unruptured anterior circulation aneurysms under dual antiplatelet medication. Interv Neuroradiol. 2021;27:42\u201350. https:\/\/doi.org\/10.1177\/1591019920939845.","journal-title":"Interv Neuroradiol"},{"key":"1446_CR32","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s00062-023-01314-x","volume":"33","author":"S Sciacca","year":"2023","unstructured":"Sciacca\u00a0S, Bassiouny\u00a0A, Mansoor\u00a0N, Minett\u00a0T, Balasundaram\u00a0P, Siddiqui\u00a0J, et\u00a0al. Early Outcomes of the Pipeline Vantage Flow Diverter: A\u00a0Multicentre Study. Clin Neuroradiol. 2023;33:887\u201396. https:\/\/doi.org\/10.1007\/s00062-023-01314-x.","journal-title":"Clin Neuroradiol"},{"key":"1446_CR33","doi-asserted-by":"publisher","DOI":"10.1136\/jnis-2023-021103","author":"L Guimaraens","year":"2024","unstructured":"Guimaraens\u00a0L, Salda\u00f1a\u00a0J, Vivas\u00a0E, Cifuentes\u00a0S, Balaguer\u00a0E, Mon\u00a0D, et\u00a0al. Flow diverter stents for endovascular treatment of aneurysms: a\u00a0comparative study of efficacy and safety between FREDX and FRED. J\u00a0Neurointerventional Surg. 2024; https:\/\/doi.org\/10.1136\/jnis-2023-021103.","journal-title":"J Neurointerventional Surg"},{"key":"1446_CR34","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1136\/neurintsurg-2018-014363","volume":"11","author":"NW Manning","year":"2019","unstructured":"Manning\u00a0NW, Cheung\u00a0A, Phillips\u00a0TJ, Wenderoth\u00a0JD. Pipeline shield with single antiplatelet therapy in aneurysmal subarachnoid haemorrhage: multicentre experience. J\u00a0Neurointerventional Surg. 2019;11:694\u20138. https:\/\/doi.org\/10.1136\/neurintsurg-2018-014363.","journal-title":"J Neurointerventional Surg"},{"key":"1446_CR35","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1136\/neurintsurg-2022-018969","volume":"15","author":"L Pierot","year":"2023","unstructured":"Pierot\u00a0L, Lamin\u00a0S, Barreau\u00a0X, Berlis\u00a0A, Ciceri\u00a0E, Cohen\u00a0JE, et\u00a0al. Coating (Coating to Optimize Aneurysm Treatment in the New Flow Diverter Generation) study. The first randomized controlled trial evaluating a\u00a0coated flow diverter (p64 MW HPC): study design. J\u00a0Neurointerventional Surg. 2023;15:684\u20138. https:\/\/doi.org\/10.1136\/neurintsurg-2022-018969.","journal-title":"J Neurointerventional Surg"},{"key":"1446_CR36","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1093\/neuros\/nyaa208","volume":"87","author":"J Caroff","year":"2020","unstructured":"Caroff\u00a0J, King\u00a0RM, Ughi\u00a0GJ, Marosfoi\u00a0M, Langan\u00a0ET, Raskett\u00a0C, et\u00a0al. Longitudinal Monitoring of Flow-Diverting Stent Tissue Coverage After Implant in a\u00a0Bifurcation Model Using Neurovascular High-Frequency Optical Coherence Tomography. Neurosurgery. 2020;87:1311\u20139. https:\/\/doi.org\/10.1093\/neuros\/nyaa208.","journal-title":"Neurosurgery"},{"key":"1446_CR37","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1177\/15910199211003432","volume":"27","author":"A Monteiro","year":"2021","unstructured":"Monteiro\u00a0A, Lopes\u00a0DK, Aghaebrahim\u00a0A, Hanel\u00a0R. Optical coherence tomography for elucidation of flow-diversion phenomena: The concept of endothelized mural thrombus behind reversible in-stent stenosis in flow-diverters. Interv Neuroradiol. 2021;27:774\u201380. https:\/\/doi.org\/10.1177\/15910199211003432.","journal-title":"Interv Neuroradiol"},{"key":"1446_CR38","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.neuroscience.2021.06.008","volume":"474","author":"V Anagnostakou","year":"2021","unstructured":"Anagnostakou\u00a0V, Ughi\u00a0GJ, Puri\u00a0AS, Gounis\u00a0MJ. Optical Coherence Tomography for Neurovascular Disorders. Neuroscience. 2021;474:134\u201344. https:\/\/doi.org\/10.1016\/j.neuroscience.2021.06.008.","journal-title":"Neuroscience"},{"key":"1446_CR39","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.1038\/s41467-020-17702-7","volume":"11","author":"GJ Ughi","year":"2020","unstructured":"Ughi\u00a0GJ, Marosfoi\u00a0MG, King\u00a0RM, Caroff\u00a0J, Peterson\u00a0LM, Duncan\u00a0BH, et\u00a0al. A\u00a0neurovascular high-frequency optical coherence tomography system enables in situ cerebrovascular volumetric microscopy. Nat Commun. 2020;11:3851. https:\/\/doi.org\/10.1038\/s41467-020-17702-7.","journal-title":"Nat Commun"},{"key":"1446_CR40","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1148\/radiol.13120099","volume":"267","author":"T Becske","year":"2013","unstructured":"Becske\u00a0T, Kallmes\u00a0DF, Saatci\u00a0I, McDougall\u00a0CG, Szikora\u00a0I, Lanzino\u00a0G, et\u00a0al. Pipeline for Uncoilable or Failed Aneurysms: Results from a\u00a0Multicenter Clinical Trial. Radiology. 2013;267:858\u201368. https:\/\/doi.org\/10.1148\/radiol.13120099.","journal-title":"Radiology"},{"key":"1446_CR41","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3171\/2015.6.JNS15311","volume":"127","author":"T Becske","year":"2017","unstructured":"Becske\u00a0T, Potts\u00a0MB, Shapiro\u00a0M, Kallmes\u00a0DF, Brinjikji\u00a0W, Saatci\u00a0I, et\u00a0al. Pipeline for uncoilable or failed aneurysms: 3\u2011year follow-up results. J\u00a0Neurosurg. 2017;127:81\u20138. https:\/\/doi.org\/10.3171\/2015.6.JNS15311.","journal-title":"J Neurosurg"},{"key":"1446_CR42","first-page":"A47","volume":"15","author":"H Nordmeyer","year":"2023","unstructured":"Nordmeyer\u00a0H, Schwab\u00a0R. Behme D P078\/182 The derivo 2 heal embolization device in the treatment of ruptured and unruptured intracranial aneurysms: a\u00a0retrospective multicenter analysis. J\u00a0NeuroIntervent Surg. 2023;15:A47.\u00a0https:\/\/jnis.bmj.com\/content\/15\/Suppl_2\/A47.2","journal-title":"J NeuroIntervent Surg"}],"container-title":["Clinical Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-024-01446-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00062-024-01446-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-024-01446-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T15:29:43Z","timestamp":1739806183000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00062-024-01446-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["1446"],"URL":"https:\/\/doi.org\/10.1007\/s00062-024-01446-8","relation":{},"ISSN":["1869-1439","1869-1447"],"issn-type":[{"value":"1869-1439","type":"print"},{"value":"1869-1447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]},"assertion":[{"value":"8 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"D.\u00a0Behme: consultant for Stryker, Acandis, Balt and Phenox; H.\u00a0Nordmeyer: has received honoraria as a speaker and consulting fees from Acandis and speaker honoraria from Rapid Medical, Microvention, InspireMD, Cerenovus; C.\u00a0Kabbasch: consultant for Acandis and proctor for Microvention; R.\u00a0Schwab: consultant for Infinity Neuro, Acandis and Stryker. L.\u00a0Goertz, M.\u00a0Kaschner, D.\u00a0Weiss. C.\u00a0Loehr, H.\u00a0Wensing, M.\u00a0Bester, A.\u00a0Simgen, A.\u00a0Kemmling, C.\u00a0Wendl, E.\u00a0Fuchs, and M.\u00a0Thormann declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}