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Most studies investigated patients with ischemic stroke, but only little is known about its occurrence in patients with intracerebral hemorrhage (ICH). This study aimed to assess the frequency, predictors, and implications of myocardial injury in ICH patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Our retrospective analysis included 322 ICH patients. We defined myocardial injury as an elevation of hs-cTnT above the 99th percentile (i.e. 14\u202fng\/L). Acute myocardial injury was defined as either a\u00a0changing pattern of &gt;\u202f50% within 24\u202fh or an excessive elevation of initial hs-cTnT (&gt;\u202f52\u202fng\/L). 3D brain scans were assessed for ICH visually and quantitatively by a\u00a0deep learning algorithm. Multiple regression models and Voxel-based Lesion-Symptom Mapping (VLSM) were applied.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>63.0% (203\/322) of patients presented with myocardial injury, which was associated with more severe strokes and worse outcomes during the in-hospital phase (<jats:italic>P<\/jats:italic>\u202f&lt;\u20090.01). Acute myocardial injury occurred in 24.5% (79\/322) of patients. The only imaging finding associated with acute myocardial injury was midline shift (69.8% vs. 44.6% for normal or stable hs-cTnT, <jats:italic>P<\/jats:italic>\u202f&lt;\u20090.01), which also independently predicted it (odds ratio 3.29, confidence interval 1.38\u20137.87, <jats:italic>P<\/jats:italic>\u202f&lt;\u20090.01). In contrast, VLSM did not identify any specific brain region significantly associated with acute myocardial injury. Acute myocardial injury did not correlate with preexisting cardiac diseases; however, the frequency of adverse cardiac events was higher in the acute myocardial injury group (11.4% vs.\u00a04.1% in patients with normal and\/or stable patterns of hs-cTnT, <jats:italic>P<\/jats:italic>\u202f&lt;\u20090.05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Myocardial injury occurs frequently in ICH and is linked to poor outcomes. Acute myocardial injury primarily correlates to space-occupying effects of ICH but is less dependent on premorbid cardiac status. Nonetheless, it is associated with a\u00a0higher rate of adverse cardiac events.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00062-025-01498-4","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T16:34:11Z","timestamp":1738254851000},"page":"395-404","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Predictors and Implications of Myocardial Injury in Intracerebral Hemorrhage"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1052-1088","authenticated-orcid":false,"given":"Felix","family":"Hess","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"McGinnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enayatullah","family":"Baki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun","family":"Wiltgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Maegerlein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kirschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Hemmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silke","family":"Wunderlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"M\u00fchlau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"issue":"7","key":"1498_CR1","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1161\/CIRCULATIONAHA.122.059678","volume":"146","author":"Y Sandoval","year":"2022","unstructured":"Sandoval\u00a0Y, Apple\u00a0FS, Mahler\u00a0SA, Body\u00a0R, Collinson\u00a0PO, Jaffe\u00a0AS. 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