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The diagnosis of DAI on CT is challenging due to the lack of structural abnormalities. Radiomics, a\u00a0method from the field of artificial intelligence (AI) offers the opportunity to extract additional information from imaging data. The purpose of this work was the evaluation of the feasibility of radiomics for an improved diagnosis of DAI in comparison to conventional radiological image assessment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>CT and MR imaging was performed in 42\u00a0patients suspicious of DAI due to the clinical state, and two control groups (<jats:italic>n<\/jats:italic>\u202f=\u200944;42). DAI was diagnosed by experienced neuroradiologists. Radiomics features were extracted using a\u00a0standardized MRI-based atlas of the predilection areas for DAI. Different MRI and CT based models were trained and validated by five-fold cross validation. Diagnostic performance was compared to the reading of two experienced radiologists and further validated in an external test dataset.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The MRI and CT models showed significant differences in radiomics features between patients with DAI and controls. The developed MRI based random forest classifier yielded an accuracy of 80\u201390%. The best performing CT model yielded an accuracy of 88% in the training data and 70% in the external test data. The results were comparable to conventional image analysis which achieved an accuracy of 70\u201381% for CT-based diagnosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>MRI- and CT-based radiomics analysis is feasible for the assessment of DAI. The radiomics classifier achieved equivalent performance rates as visual radiological image diagnosis. Especially a\u00a0radiomics based CT classifier can be of clinical value as a\u00a0screening and AI-based decision support tool for patients with TBI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00062-025-01507-6","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T05:47:22Z","timestamp":1741326442000},"page":"521-532","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of CT and MRI Radiomics for an Early Assessment of Diffuse Axonal Injury in Patients with Traumatic Brain Injury Compared to Conventional Radiological Diagnosis"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4150-7265","authenticated-orcid":false,"given":"Anna-Katharina","family":"Mei\u00dfner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Gutsche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenhard","family":"Pennig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Nelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Budzejko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Hamisch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schlamann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Goldbrunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Grau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Lohmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,7]]},"reference":[{"issue":"2","key":"1507_CR1","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1016\/S2468-2667(16)30017-2","volume":"1","author":"M Majdan","year":"2016","unstructured":"Majdan\u00a0M, Plancikova\u00a0D, Brazinova\u00a0A, Rusnak\u00a0M, Nieboer\u00a0D, Feigin\u00a0V, et\u00a0al. 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A.-K.\u00a0Mei\u00dfner, R.\u00a0Gutsche, L.\u00a0Pennig, C.\u00a0Nelles, E.\u00a0Budzejko, C.\u00a0Hamisch, M.\u00a0Kocher, M.\u00a0Schlamann, R.\u00a0Goldbrunner and S.\u00a0Grau declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The present study was conducted according to the guidelines of the Declaration of Helsinki, and the retrospective analysis of data was approved by the Ethics Committees of the University Hospital Cologne, Germany (approval number 21-1344). As the reported work is a\u00a0retrospective study design informed consent has been waived by the approval committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}