{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:58:32Z","timestamp":1787068712467,"version":"build-2736575974"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100016377","name":"Ministerium f\u00fcr Wirtschaft, Innovation, Digitalisierung und Energie des Landes Nordrhein-Westfalen","doi-asserted-by":"publisher","award":["005-2008-0055"],"award-info":[{"award-number":["005-2008-0055"]}],"id":[{"id":"10.13039\/501100016377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009400","name":"Medizinische Fakult\u00e4t, Heinrich-Heine-Universit\u00e4t D\u00fcsseldorf","doi-asserted-by":"publisher","award":["n\/a"],"award-info":[{"award-number":["n\/a"]}],"id":[{"id":"10.13039\/501100009400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["493659010"],"award-info":[{"award-number":["493659010"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universit\u00e4tsklinikum D\u00fcsseldorf. Anstalt \u00f6ffentlichen Rechts"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Neuroradiol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Modern endovascular techniques enable the treatment of various neurovascular diseases. Given the complexity of these interventions, a\u00a0certification system was introduced to ensure standardized care at specialized treatment centers. We used a\u00a0driving-time-based isochrone approach to identify care gaps in different German Society of Interventional Radiology (DeGIR) certified neurovascular treatment centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>DeGIR-certified neurovascular centers for minimally invasive stroke care (module\u00a0E), neurovascular vessel anomalies (module\u00a0F), and neurovascular therapy (module EF) were geocoded and driving-time-based isochrones were calculated for 30, 60, 90, and 120\u202fmin. The resulting contours were aggregated and combined with the 2025 population estimates from the Global Human Settlement Layer to estimate residents\u2019 access.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The analysis identified gaps in under-60-minute reachability, notably in northeastern Germany and parts of Rhineland-Palatinate, Saarland, and the southwest, with modules EF and F most affected, while module\u00a0E fared better. Within 120\u202fmin, coverage was nearly complete across all modules. On a\u00a0population level, 59.4% of residents lived within 30\u202fmin, 92.81% within 60\u202fmin, and 99.98% within 120\u202fmin of a\u00a0module\u00a0E center. Module\u00a0F reached 45.8%, 84.26%, and 99.73%, respectively, with module EF showing intermediate accessibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The driving-time-based isochrone approach identifies regions where access to specialized neurovascular care is limited\u2014a\u00a0critical issue in emergencies like stroke or aneurysm hemorrhage. Although immediate stroke care is generally more accessible than care for neurovascular anomalies, thrombectomy within an acceptable timeframe is not available to the entire population. These findings can guide strategies to enhance neurovascular care across Germany.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00062-025-01537-0","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:17:55Z","timestamp":1750940275000},"page":"747-753","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Isochrone-based Identification of Gaps in Neurovascular Care in Germany"],"prefix":"10.1007","volume":"35","author":[{"given":"Marius","family":"Vach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rubbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Caspers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven G.","family":"Meuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Pawlitzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Masanneck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"1537_CR1","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.1136\/neurintsurg-2018-014569","volume":"15","author":"G Turc","year":"2023","unstructured":"Turc\u00a0G, Bhogal\u00a0P, Fischer\u00a0U, et\u00a0al. 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Front Neurol. 2022;13:973095. https:\/\/doi.org\/10.3389\/fneur.2022.973095.","journal-title":"Front Neurol"}],"container-title":["Clinical Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-025-01537-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00062-025-01537-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-025-01537-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T11:21:11Z","timestamp":1761304871000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00062-025-01537-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1537"],"URL":"https:\/\/doi.org\/10.1007\/s00062-025-01537-0","relation":{},"ISSN":["1869-1439","1869-1447"],"issn-type":[{"value":"1869-1439","type":"print"},{"value":"1869-1447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]},"assertion":[{"value":"18 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M.\u00a0Vach\n                      reports no conflicts of interest related to this study. His research is funded by the Medical Faculty of the Heinrich-Heine-University Duesseldorf, Germany.\n                      C.\u00a0Rubbert\n                      reports no conflicts of interest related to this study.\n                      J.\u00a0Caspers\n                      reports no conflicts of interest related to this study. He has received honoraria for lecturing and travel expenses from Allergan and Pfizer.\n                      S.G.\u00a0Meuth\n                      reports no conflicts of interest related to this study. He has received honoraria for lecturing and travel expenses for attending meetings from Almirall, Amicus Therapeutics Germany, ArgenX, Bayer Health Care, Biogen, Celgene, Diamed, Genzyme, MedDay Pharmaceuticals, Merck Serono, Novartis, Neuraxpharm, Novo Nordisk, ONO Pharma, Roche, Sanofi-Aventis, Chugai Pharma, QuintilesIMS, and Teva. His research is funded by the German Ministry for Education and Research (BMBF), Bundesinstitut f\u00fcr Risikobewertung (BfR), Deutsche Forschungsgemeinschaft (DFG), Else Kr\u00f6ner Fresenius Foundation, Gemeinsamer Bundesausschuss (G-BA), German Academic Exchange Service, Hertie Foundation, Interdisciplinary Center for Clinical Studies (IZKF) Muenster, German Foundation Neurology, and by Alexion, Almirall, Amicus Therapeutics Germany, Biogen, Diamed, Fresenius Medical Care, Genzyme, HERZ Burgdorf, Merck Serono, Novartis, ONO Pharma, Roche, and Teva, all outside the scope of this study.\n                      M.\u00a0Pawlitzki\n                      reports no conflicts of interest related to this study. He has received honoraria for lecturing and travel expenses for attending meetings from Alexion, ArgenX, Bayer Health Care, Biogen, Hexal, Merck Serono, Neuraxpharm, Novartis, Roche, Sanofi-Aventis, Takeda, and Teva. His research is funded by ArgenX, Biogen, Hexal, and Novartis, all outside the scope of this study.\n                      L.\u00a0Masanneck\n                      reports no conflicts of interest related to this study. He has received honoraria for lecturing, consulting, and travel expenses for attending meetings from Biogen, Merck, Sanofi, argenX, Roche, Alexion, and Novartis, all outside the scope of this work. His research is funded by the German Multiple Sclerosis Foundation (DMSG), B.\u00a0Braun Foundation and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)\u2014493659010.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}