{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:23:00Z","timestamp":1793766180459,"version":"4.6.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100018935","name":"Universit\u00e4tsklinikum Erlangen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100018935","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Neuroradiol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The \u201cno-reflow phenomenon\u201d refers to persisting microvascular failure despite complete macrovascular reperfusion. We investigated whether parametric color coding (PCC) analysis of the DSA-series after successful mechanical thrombectomy could predict microvascular dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed the STAMINA database for patients admitted to a\u00a0single tertiary care center over a\u00a05-year period with MCA-Occlusion (M1 or M2 branch), large penumbra, TICI\u00a03 and infarct volume exceeding 15\u202fml on follow-up CT\u2014presumed to reflect microvascular failure. These 55\u00a0patients were compared to 55\u00a0controls with infarcts &lt;\u202f15\u202fml on follow-up CT. As proof of concept, we included 42\u00a0non-stroke patients undergoing elective treatment of unruptured intracranial aneurysms. Using iFlow-PCC software, we calculated critical flow parameters, including cerebral circulation time (CirT), relative cortical time to peak (rTTP), and microvascular transit time (mTT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Microvascular transit time (mTT) was significantly prolonged in the suspected microvascular failure group (3.22\u202f\u00b1\u20090.85\u202fs) compared to the recanalization control group (2.79\u202f\u00b1\u20090.64\u202fs;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.003) and the non-stroke interventional control group (2.54\u202f\u00b1\u20090.90\u202fs,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.0003). The group with suspected microvascular failure exhibited a\u00a0median modified Rankin Score at 3\u00a0months (mRS\u00a03M:\u00a04, IQR: 3\u20135) and a\u00a0higher number of poor outcomes (mRS 5\u20136;\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u200916) compared to the control group with similar strokes (median mRS\u00a03M:\u00a02, IQR: 1\u20134; mRS 5\u20136:\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u20094).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prolonged microvascular transit time (mTT) can predict microvascular failure after thrombectomy. Angiographic flow analysis, performed directly in the angio-suite allows early identification of patients who may benefit from additional therapy like intra-arterial thrombolysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00062-025-01557-w","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T14:55:11Z","timestamp":1755615311000},"page":"67-75","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Detection of Microvascular Failure After Thrombectomy Directly in the Angio-Suite Using Parametric Color Coding"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7817-4823","authenticated-orcid":false,"given":"Ludwig","family":"Singer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1679-9553","authenticated-orcid":false,"given":"Maximilian","family":"Spr\u00fcgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0370-7880","authenticated-orcid":false,"given":"Jeannette","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"L\u00fccking","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan T.","family":"Gerner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnd","family":"D\u00f6rfler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Engelhorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"1557_CR1","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1056\/NEJMoa1415061","volume":"372","author":"JL Saver","year":"2015","unstructured":"Saver\u00a0JL, Goyal\u00a0M, Bonafe\u00a0A, Diener\u00a0H\u2011C, Levy\u00a0EI, Pereira\u00a0VM, et\u00a0al. Stent-retriever thrombectomy after intravenous t\u2011PA vs. t\u2011PA alone in stroke. N\u00a0Engl J Med. 2015;372:2285\u201395.","journal-title":"N Engl J Med"},{"key":"1557_CR2","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/ijs.12459","volume":"10","author":"JL Saver","year":"2015","unstructured":"Saver\u00a0JL, Goyal\u00a0M, Bonafe\u00a0A, Diener\u00a0H\u2011C, Levy\u00a0EI, Pereira\u00a0VM, et\u00a0al. SolitaireTM with the intention for thrombectomy as primary endovascular treatment for acute Ischemic stroke (SWIFT PRIME) trial: protocol for a\u00a0randomized, controlled, multicenter study comparing the solitaire revascularization device with IV tPA with IV tPA alone in acute Ischemic stroke. Int J Stroke. 2015;10:439\u201348.","journal-title":"Int J Stroke"},{"key":"1557_CR3","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1056\/NEJMoa1503780","volume":"372","author":"TG Jovin","year":"2015","unstructured":"Jovin\u00a0TG, Chamorro\u00a0A, Cobo\u00a0E, de Miquel\u00a0MA, Molina\u00a0CA, Rovira\u00a0A, et\u00a0al. Thrombectomy within 8 hours after symptom onset in Ischemic stroke. N\u00a0Engl J Med. 2015;372:2296\u2013306.","journal-title":"N Engl J Med"},{"key":"1557_CR4","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/S0140-6736(16)00163-X","volume":"387","author":"M Goyal","year":"2016","unstructured":"Goyal\u00a0M, Menon\u00a0BK, van Zwam\u00a0WH, Dippel\u00a0DWJ, Mitchell\u00a0PJ, Demchuk\u00a0AM, et\u00a0al. Endovascular thrombectomy after large-vessel ischaemic stroke: a\u00a0meta-analysis of individual patient data from five randomised trials. Lancet. 2016;387:1723\u201331.","journal-title":"Lancet"},{"key":"1557_CR5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1706442","author":"RG Nogueira","year":"2018","unstructured":"Nogueira\u00a0RG, Jadhav\u00a0AP, Haussen\u00a0DC, Bonafe\u00a0A, Budzik\u00a0RF, Bhuva\u00a0P, et\u00a0al. Thrombectomy 6 to 24 hours after stroke with a\u00a0mismatch between deficit and infarct. N\u00a0Engl J Med. 2018; https:\/\/doi.org\/10.1056\/NEJMoa1706442.","journal-title":"N Engl J Med"},{"key":"1557_CR6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713973","author":"GW Albers","year":"2024","unstructured":"Albers\u00a0GW, Marks\u00a0MP, Kemp\u00a0S, Christensen\u00a0S, Tsai\u00a0JP, Ortega-Gutierrez\u00a0S, et\u00a0al. Thrombectomy for stroke at 6 to 16 hours with selection by perfusion imaging. N\u00a0Engl J Med. 2024; https:\/\/doi.org\/10.1056\/NEJMoa1713973.","journal-title":"N Engl J Med"},{"key":"1557_CR7","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/S0140-6736(22)00537-2","volume":"400","author":"U Fischer","year":"2022","unstructured":"Fischer\u00a0U, Kaesmacher\u00a0J, Strbian\u00a0D, Eker\u00a0O, Cognard\u00a0C, Plattner\u00a0PS, et\u00a0al. Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial. Lancet Lond Engl. 2022;400:104\u201315.","journal-title":"Lancet Lond Engl"},{"key":"1557_CR8","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1016\/S0140-6736(23)02032-9","volume":"402","author":"M Bendszus","year":"2023","unstructured":"Bendszus\u00a0M, Fiehler\u00a0J, Subtil\u00a0F, Bonekamp\u00a0S, Aamodt\u00a0AH, Fuentes\u00a0B, et\u00a0al. Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial. Lancet. 2023;402:1753\u201363.","journal-title":"Lancet"},{"key":"1557_CR9","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.1161\/STROKEAHA.122.039476","volume":"53","author":"F Seker","year":"2022","unstructured":"Seker\u00a0F, Qureshi\u00a0MM, M\u00f6hlenbruch\u00a0MA, Nogueira\u00a0RG, Abdalkader\u00a0M, Ribo\u00a0M, et\u00a0al. Reperfusion without functional independence in late presentation of stroke with large vessel occlusion. Stroke. 2022;53:3594\u2013604.","journal-title":"Stroke"},{"key":"1557_CR10","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.jacc.2018.11.052","volume":"73","author":"A Alawieh","year":"2019","unstructured":"Alawieh\u00a0A, Vargas\u00a0J, Fargen\u00a0KM, Langley\u00a0EF, Starke\u00a0RM, De Leacy\u00a0R, et\u00a0al. Impact of procedure time on outcomes of thrombectomy for stroke. J\u00a0Am Coll Cardiol. 2019;73:879\u201390.","journal-title":"J Am Coll Cardiol"},{"key":"1557_CR11","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1177\/15910199221104624","volume":"29","author":"VM Ringheanu","year":"2023","unstructured":"Ringheanu\u00a0VM, Tekle\u00a0WG, Preston\u00a0L, Sarraj\u00a0A, Hassan\u00a0AE. Higher number of stent-retriever thrombectomy passes significantly increases risk of mass effect, poor functional outcome, and mortality. Interv Neuroradiol. 2023;29:674\u201382.","journal-title":"Interv Neuroradiol"},{"key":"1557_CR12","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1097\/01.WCB.0000078322.96027.78","volume":"23","author":"GJ del Zoppo","year":"2003","unstructured":"del Zoppo\u00a0GJ, Mabuchi\u00a0T. Cerebral microvessel responses to focal ischemia. J\u00a0Cereb Blood Flow Metab. 2003;23:879\u201394.","journal-title":"J Cereb Blood Flow Metab"},{"key":"1557_CR13","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1038\/jcbfm.2012.139","volume":"32","author":"T Dalkara","year":"2012","unstructured":"Dalkara\u00a0T, Arsava\u00a0EM. Can restoring incomplete microcirculatory reperfusion improve stroke outcome after thrombolysis? J\u00a0Cereb Blood Flow Metab. 2012;32:2091\u20139.","journal-title":"J Cereb Blood Flow Metab"},{"key":"1557_CR14","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1177\/17474930231180434","volume":"19","author":"A Mujanovic","year":"2024","unstructured":"Mujanovic\u00a0A, Ng\u00a0F, Meinel\u00a0TR, Dobrocky\u00a0T, Piechowiak\u00a0EI, Kurmann\u00a0CC, et\u00a0al. No-reflow phenomenon in stroke patients: a\u00a0systematic literature review and meta-analysis of clinical data. Int J Stroke. 2024;19:58\u201367.","journal-title":"Int J Stroke"},{"key":"1557_CR15","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00062-013-0208-z","volume":"23","author":"T Struffert","year":"2013","unstructured":"Struffert\u00a0T, Deuerling-Zheng\u00a0Y, Engelhorn\u00a0T, Kloska\u00a0S, G\u00f6litz\u00a0P, Bozzato\u00a0A, et\u00a0al. Monitoring of balloon test occlusion of the internal carotid artery by parametric color coding and perfusion imaging within the angio suite: first results. Clin Neuroradiol. 2013;23:285\u201392.","journal-title":"Clin Neuroradiol"},{"key":"1557_CR16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00062-012-0184-8","volume":"23","author":"P G\u00f6litz","year":"2013","unstructured":"G\u00f6litz\u00a0P, Struffert\u00a0T, L\u00fccking\u00a0H, R\u00f6sch\u00a0J, Knossalla\u00a0F, Ganslandt\u00a0O, et\u00a0al. Parametric color coding of digital subtraction angiography in the evaluation of carotid cavernous fistulas. Clin Neuroradiol. 2013;23:113\u201320.","journal-title":"Clin Neuroradiol"},{"key":"1557_CR17","doi-asserted-by":"publisher","first-page":"919","DOI":"10.3174\/ajnr.A2020","volume":"31","author":"CM Strother","year":"2010","unstructured":"Strother\u00a0CM, Bender\u00a0F, Deuerling-Zheng\u00a0Y, Royalty\u00a0K, Pulfer\u00a0KA, Baumgart\u00a0J, et\u00a0al. Parametric color coding of digital subtraction angiography. Am J Neuroradiol. 2010;31:919\u201324.","journal-title":"Am J Neuroradiol"},{"key":"1557_CR18","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1007\/s00062-017-0616-6","volume":"28","author":"P G\u00f6litz","year":"2018","unstructured":"G\u00f6litz\u00a0P, Hoelter\u00a0P, R\u00f6sch\u00a0J, Roessler\u00a0K, Knossalla\u00a0F, Doerfler\u00a0A. Ultra-early detection of Microcirculatory injury as predictor of developing delayed cerebral Ischemia after aneurysmal subarachnoid hemorrhage. Clin Neuroradiol. 2018;28:501\u20137.","journal-title":"Clin Neuroradiol"},{"key":"1557_CR19","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1001\/jama.2022.1645","volume":"327","author":"A Ren\u00fa","year":"2022","unstructured":"Ren\u00fa\u00a0A, Mill\u00e1n\u00a0M, San Rom\u00e1n\u00a0L, Blasco\u00a0J, Mart\u00ed-F\u00e0bregas\u00a0J, Terce\u00f1o\u00a0M, et\u00a0al. Effect of intra-arterial alteplase vs placebo following successful thrombectomy on functional outcomes in patients with large vessel occlusion acute Ischemic stroke: the CHOICE randomized clinical trial. JAMA. 2022;327:826\u201335.","journal-title":"JAMA"},{"key":"1557_CR20","first-page":"382086","volume":"2015","author":"L Wang","year":"2015","unstructured":"Wang\u00a0L, Cheng\u00a0Z, Gu\u00a0Y, Peng\u00a0D. Short-term effects of verapamil and diltiazem in the treatment of no reflow phenomenon: a\u00a0meta-analysis of randomized controlled trials. Biomed Res Int. 2015;2015:382086.","journal-title":"Biomed Res Int"},{"key":"1557_CR21","doi-asserted-by":"crossref","unstructured":"Wyciszkiewicz A, Pawlak MA. Basal ganglia volumes: MR-derived reference ranges and Lateralization indices for children and young adults. Neuroradiol\u00a0J.27:595\u2013612.","DOI":"10.15274\/NRJ-2014-10073"},{"key":"1557_CR22","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.3390\/jcm11102823","volume":"11","author":"SC Reitz","year":"2022","unstructured":"Reitz\u00a0SC, Gerhard\u00a0E, Breuer\u00a0S, Bohmann\u00a0FO, Pfeilschifter\u00a0W, Berkefeld\u00a0J. Outcome after thrombectomy of acute M1 and carotid\u2011T occlusions with involvement of the corticospinal tract in postinterventional imaging. J\u00a0Clin Med. 2022;11:2823.","journal-title":"J Clin Med"},{"key":"1557_CR23","doi-asserted-by":"crossref","unstructured":"Greitz T. A\u00a0radiologic study of the brain circulation by rapid serial angiography of the carotid artery. Acta Radiol Suppl. 1956; 1\u2013123.","DOI":"10.3109\/00016925609170840"},{"key":"1557_CR24","first-page":"56","volume-title":"Data structures for statistical computing in python. Proc 9th\u00a0python sci conf","author":"W McKinney","year":"2010","unstructured":"McKinney\u00a0W. Data structures for statistical computing in python. Proc 9th\u00a0python sci conf. 2010. pp.\u00a056\u201361."},{"key":"1557_CR25","unstructured":"R Core Team. R: a\u00a0language and environment for statistical ## computing_. R foundation for statistical computing, vienna, austria. 2023. https:\/\/www.R-project.org\/."},{"key":"1557_CR26","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.1136\/neurintsurg-2018-014569","volume":"15","author":"G Turc","year":"2023","unstructured":"Turc\u00a0G, Bhogal\u00a0P, Fischer\u00a0U, Khatri\u00a0P, Lobotesis\u00a0K, Mazighi\u00a0M, et\u00a0al. European stroke organisation (ESO)\u2014European society for minimally invasive neurological therapy (ESMINT) guidelines on mechanical thrombectomy in acute Ischemic stroke. J\u00a0Neurointerventional Surg. 2023;15:e8.","journal-title":"J Neurointerventional Surg"},{"key":"1557_CR27","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1161\/STROKEAHA.114.005603","volume":"45","author":"Z-S Shi","year":"2014","unstructured":"Shi\u00a0Z\u2011S, Liebeskind\u00a0DS, Xiang\u00a0B, Ge\u00a0SG, Feng\u00a0L, Albers\u00a0GW, et\u00a0al. Predictors of functional dependence despite successful revascularization in large-vessel occlusion strokes. Stroke. 2014;45:1977\u201384.","journal-title":"Stroke"},{"key":"1557_CR28","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.jvir.2015.11.053","volume":"27","author":"SA Kennedy","year":"2016","unstructured":"Kennedy\u00a0SA, Baerlocher\u00a0MO, Baerlocher\u00a0F, Socko\u00a0D, Sacks\u00a0D, Nikolic\u00a0B, et\u00a0al. meta-analysis of local endovascular therapy for acute Ischemic stroke. J\u00a0Vasc Interv Radiol. 2016;27:307\u2013321.e2.","journal-title":"J Vasc Interv Radiol"},{"key":"1557_CR29","doi-asserted-by":"publisher","first-page":"e128","DOI":"10.1016\/j.wneu.2021.02.064","volume":"149","author":"Y-H Zhang","year":"2021","unstructured":"Zhang\u00a0Y\u2011H, Shi\u00a0M\u2011C, Wang\u00a0Z\u2011X, Li\u00a0C, Sun\u00a0M\u2011Y, Zhou\u00a0J, et\u00a0al. Factors associated with poor outcomes in patients undergoing endovascular therapy for acute Ischemic stroke due to large-vessel occlusion in acute anterior circulation: a\u00a0retrospective study. World Neurosurg. 2021;149:e128\u2013e34.","journal-title":"World Neurosurg"},{"key":"1557_CR30","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1136\/neurintsurg-2018-014141","volume":"11","author":"KR van Kranendonk","year":"2019","unstructured":"van Kranendonk\u00a0KR, Treurniet\u00a0KM, Boers\u00a0AMM, Berkhemer\u00a0OA, van den Berg\u00a0LA, Chalos\u00a0V, et\u00a0al. Hemorrhagic transformation is associated with poor functional outcome in patients with acute ischemic stroke due to a\u00a0large vessel occlusion. J\u00a0Neurointerventional Surg. 2019;11:464\u20138.","journal-title":"J Neurointerventional Surg"},{"key":"1557_CR31","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1177\/0271678X231208476","volume":"44","author":"Y Zhang","year":"2024","unstructured":"Zhang\u00a0Y, Jiang\u00a0M, Gao\u00a0Y, Zhao\u00a0W, Wu\u00a0C, Li\u00a0C, et\u00a0al. \u201cNo-reflow\u201d phenomenon in acute ischemic stroke. J\u00a0Cereb Blood Flow Metab. 2024;44:19\u201337.","journal-title":"J Cereb Blood Flow Metab"},{"key":"1557_CR32","doi-asserted-by":"publisher","first-page":"e14631","DOI":"10.1111\/cns.14631","volume":"30","author":"M Jia","year":"2024","unstructured":"Jia\u00a0M, Jin\u00a0F, Li\u00a0S, Ren\u00a0C, Ruchi\u00a0M, Ding\u00a0Y, et\u00a0al. No-reflow after stroke reperfusion therapy: an emerging phenomenon to be explored. CNS Neurosci Ther. 2024;30:e14631.","journal-title":"CNS Neurosci Ther"},{"key":"1557_CR33","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1007\/s00415-020-09719-1","volume":"267","author":"MH Sch\u00f6nfeld","year":"2020","unstructured":"Sch\u00f6nfeld\u00a0MH, Kabiri\u00a0R, Kniep\u00a0HC, Meyer\u00a0L, Sedlacik\u00a0J, Ernst\u00a0M, et\u00a0al. Sub-angiographic peripheral emboli in high resolution DWI after endovascular recanalization. J\u00a0Neurol. 2020;267:1401\u20136.","journal-title":"J Neurol"},{"key":"1557_CR34","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.wneu.2017.11.023","volume":"110","author":"T Hashimoto","year":"2018","unstructured":"Hashimoto\u00a0T, Matsumoto\u00a0S, Ando\u00a0M, Chihara\u00a0H, Tsujimoto\u00a0A, Hatano\u00a0T. Cerebral Hyperperfusion syndrome after endovascular reperfusion therapy in a\u00a0patient with acute internal carotid artery and middle cerebral artery occlusions. World Neurosurg. 2018;110:145\u201351.","journal-title":"World Neurosurg"},{"key":"1557_CR35","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1136\/jnis-2022-019566","volume":"15","author":"Y Ji","year":"2023","unstructured":"Ji\u00a0Y, Shi\u00a0B, Yuan\u00a0Q, Wu\u00a0K, Fang\u00a0J, Wang\u00a0H, et\u00a0al. Effect of prolonged microcirculation time after thrombectomy on the outcome of acute stroke. J\u00a0Neurointerventional Surg. 2023;15:1078\u201383.","journal-title":"J Neurointerventional Surg"},{"key":"1557_CR36","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1177\/1747493019851278","volume":"14","author":"B Jiang","year":"2019","unstructured":"Jiang\u00a0B, Ball\u00a0RL, Michel\u00a0P, Li\u00a0Y, Zhu\u00a0G, Ding\u00a0V, et\u00a0al. Factors influencing infarct growth including collateral status assessed using computed tomography in acute stroke patients with large artery occlusion. Int J Stroke. 2019;14:603\u201312.","journal-title":"Int J Stroke"},{"key":"1557_CR37","doi-asserted-by":"publisher","first-page":"B48","DOI":"10.1093\/eurheartjsupp\/suac010","volume":"24","author":"T Peisker","year":"2022","unstructured":"Peisker\u00a0T, Va\u0161ko\u00a0P, Mikulenka\u00a0P, Lauer\u00a0D, Ko\u017enar\u00a0B, Sul\u017eenko\u00a0J, et\u00a0al. Clinical and radiological factors predicting stroke outcome after successful mechanical intervention in anterior circulation. Eur Heart J Suppl. 2022;24:B48\u2013B52.","journal-title":"Eur Heart J Suppl"},{"key":"1557_CR38","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3174\/ajnr.A8103","volume":"45","author":"A Mujanovic","year":"2024","unstructured":"Mujanovic\u00a0A, Kurmann\u00a0CC, Manhart\u00a0M, Piechowiak\u00a0EI, Pilgram-Pastor\u00a0SM, Serrallach\u00a0BL, et\u00a0al. Value of immediate flat panel perfusion imaging after endovascular therapy (AFTERMATH): a\u00a0proof of concept study. AJNR Am J Neuroradiol. 2024;45:163\u201370.","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Clinical Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-025-01557-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00062-025-01557-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-025-01557-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T22:01:08Z","timestamp":1774303268000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00062-025-01557-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["1557"],"URL":"https:\/\/doi.org\/10.1007\/s00062-025-01557-w","relation":{},"ISSN":["1869-1439","1869-1447"],"issn-type":[{"value":"1869-1439","type":"print"},{"value":"1869-1447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"assertion":[{"value":"6 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"L.\u00a0Singer, M.\u00a0Spr\u00fcgel, J.\u00a0Becker, H.\u00a0L\u00fccking, S.T.\u00a0Gerner, S.\u00a0Schwab, A.\u00a0D\u00f6rfler and T.\u00a0Engelhorn declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki, the European Guidelines for Good Clinical Practice, and applicable local legislation (BayKrG Art.\u00a027\u00a0(4)). For the stroke groups, the investigation was part of the Stroke Research Consortium in Northern Bavaria (STAMINA;\n                      \n                      , NCT04357899) and received approval from the local institutional review board of Friedrich-Alexander-University Erlangen\u2013N\u00fcrnberg, Germany (No\u00a062_21B). For the non-stroke control group, given the retrospective design of the study, informed consent and the requirement for formal ethical approval were waived in accordance with federal legislation (Gesundheitsdatennutzungsgesetz Art.\u00a06) and institutional requirements.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}