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There are no established imaging biomarkers to differentiate ALS-FTD from PSP-FTD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We evaluated the midsagittal midbrain area (MBA) and the midbrain-to-pons-(MB\/P)-ratios in T1 MPRAGE MRI of 36\u00a0PSP cases (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u200914\u00a0PSP-FTD), 77\u00a0ALS cases (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u200910\u00a0ALS-FTD), and 72\u00a0healthy controls (HC).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In ALS, both parameters were indistinguishable from HC. Patients with ALS-FTD had low MBA-values and MB\/P-ratios not significantly different from cases of PSP. While ROC-analyses provided an excellent diagnostic accuracy of both parameters for differentiating PSP from HC (AUC\n                      <jats:sub>MBA<\/jats:sub>\n                      \u202f=\u20090.974) as well as PSP from ALS (AUC\n                      <jats:sub>MBA<\/jats:sub>\n                      \u202f=\u20090.982), midbrain morphometry provided poor diagnostic accuracy for distinguishing ALS-FTD from PSP-FTD (AUC\n                      <jats:sub>MBA<\/jats:sub>\n                      \u202f=\u20090,614).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The MBA and the MB\/P-ratio are morphometric parameters that have proven reliable in atypical Parkinsonian syndromes. Both can distinguish between PSP and ALS in their typical clinical forms. 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