{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:28:25Z","timestamp":1788233305933,"version":"build-2803163510"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Neuroradiol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s00062-025-01595-4","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T15:35:39Z","timestamp":1764171339000},"page":"431-438","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["CT-based Volume Measurement of Brain Calcification Is Related to Clinical Symptoms and Disease Progression in Primary Familial Brain Calcification"],"prefix":"10.1007","volume":"36","author":[{"given":"Birgitta M.G.","family":"Snijders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennard","family":"Pierey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike J.L.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie V.","family":"de Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"van der Star","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noah","family":"Allaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle H.","family":"Emmelot-Vonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim A.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiberdina L.","family":"Koek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"issue":"Pt\u00a011","key":"1595_CR1","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.1093\/brain\/awt255","volume":"136","author":"G Nicolas","year":"2013","unstructured":"Nicolas\u00a0G, Pottier\u00a0C, Charbonnier\u00a0C, et\u00a0al. Phenotypic spectrum of probable and genetically-confirmed idiopathic basal ganglia calcification. Brain. 2013;136(Pt\u00a011):3395\u2013407.","journal-title":"Brain"},{"key":"1595_CR2","doi-asserted-by":"crossref","unstructured":"Chen SY, Ho CJ, Lu YT, et\u00a0al. The Genetics of Primary Familial Brain Calcification: A\u00a0Literature Review. Int J Mol Sci. 2023;24(13).","DOI":"10.3390\/ijms241310886"},{"issue":"1","key":"1595_CR3","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1038\/s41467-024-46354-0","volume":"15","author":"V Chelban","year":"2024","unstructured":"Chelban\u00a0V, Aksnes\u00a0H, Maroofian\u00a0R, et\u00a0al. Biallelic NAA60 variants with impaired n\u2011terminal acetylation capacity cause autosomal recessive primary familial brain calcifications. Nat Commun. 2024;15(1):2269.","journal-title":"Nat Commun"},{"issue":"6","key":"1595_CR4","doi-asserted-by":"publisher","first-page":"3270","DOI":"10.1007\/s00415-023-11650-0","volume":"270","author":"M Carecchio","year":"2023","unstructured":"Carecchio\u00a0M, Mainardi\u00a0M, Bonato\u00a0G. The clinical and genetic spectrum of primary familial brain calcification. J\u00a0Neurol. 2023;270(6):3270\u20137.","journal-title":"J Neurol"},{"issue":"4","key":"1595_CR5","doi-asserted-by":"publisher","first-page":"e200163","DOI":"10.1212\/CPJ.0000000000200163","volume":"13","author":"NMS Goluke","year":"2023","unstructured":"Goluke\u00a0NMS, Meijer\u00a0E, van Maren\u00a0EA, et\u00a0al. Amount and Distribution of Intracranial Calcification in Symptomatic and Asymptomatic Primary Familial Brain Calcification. Neurol Clin Pract. 2023;13(4):e200163.","journal-title":"Neurol Clin Pract"},{"issue":"7","key":"1595_CR6","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1002\/ajmg.b.32336","volume":"168","author":"G Nicolas","year":"2015","unstructured":"Nicolas\u00a0G, Charbonnier\u00a0C, de Lemos\u00a0RR, et\u00a0al. Brain calcification process and phenotypes according to age and sex: Lessons from SLC20A2, PDGFB, and PDGFRB mutation carriers. Am J Med Genet B Neuropsychiatr Genet. 2015;168(7):586\u201394.","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"1595_CR7","doi-asserted-by":"crossref","unstructured":"Mathijssen G, van Valen E, de Jong PA, et\u00a0al. The Association between Intracranial Calcifications and Symptoms in Patients with Primary Familial Brain Calcification. J\u00a0Clin Med. 2024;13(3).","DOI":"10.3390\/jcm13030828"},{"issue":"1","key":"1595_CR8","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13023-024-03039-7","volume":"19","author":"BM Snijders","year":"2024","unstructured":"Snijders\u00a0BM, Mathijssen\u00a0G, Peters\u00a0MJ, et\u00a0al. The effects of etidronate on brain calcifications in Fahr\u2019s disease or syndrome: rationale and design of the randomised, placebo-controlled, double-blind CALCIFADE trial. Orphanet J Rare Dis. 2024;19(1):49.","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"1595_CR9","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3174\/ajnr.A8446","volume":"46","author":"BMG Snijders","year":"2025","unstructured":"Snijders\u00a0BMG, Koek\u00a0HL, Peters\u00a0MJL, et\u00a0al. Inter- and Intrarater Agreement of CT Brain Calcification Scoring in Primary Familial Brain Calcification. AJNR Am J Neuroradiol. 2025;46(1):147\u201352.","journal-title":"AJNR Am J Neuroradiol"},{"issue":"4","key":"1595_CR10","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","volume":"53","author":"ZS Nasreddine","year":"2005","unstructured":"Nasreddine\u00a0ZS, Phillips\u00a0NA, Bedirian\u00a0V, et\u00a0al. The Montreal Cognitive Assessment, MoCA: a\u00a0brief screening tool for mild cognitive impairment. J\u00a0Am Geriatr Soc. 2005;53(4):695\u20139.","journal-title":"J Am Geriatr Soc"},{"key":"1595_CR11","unstructured":"Verhage F. Intelligentie en leeftijd: Onderzoek bij Nederlanders van twaalf tot zevenenzeventig jaar: van Gorcum Assen; 1964."},{"key":"1595_CR12","volume-title":"Klinimetrie bij de ziekte van Parkinson, een praktische handleiding. Klinimetrie bij de ziekte van Parkinson, een praktische handleiding: NPI","author":"E Van Wegen","year":"2005","unstructured":"Van Wegen\u00a0E, Lim-de\u00a0VL, Nieuwboer\u00a0A, et\u00a0al. Klinimetrie bij de ziekte van Parkinson, een praktische handleiding. Klinimetrie bij de ziekte van Parkinson, een praktische handleiding: NPI. Amersfoort. 2005."},{"key":"1595_CR13","unstructured":"Cummings JL, Inventory N. 2009. https:\/\/dementiaresearch.org.au\/wp-content\/uploads\/2016\/01\/NPI.pdf.1."},{"key":"1595_CR14","doi-asserted-by":"crossref","unstructured":"Lin Z, Yang D, Wang L, et\u00a0al. The Genetic and Phenotypic Spectrum of Primary Brain Calcification in a\u00a0Large Cohort from China. Mov Disord. 2025;.","DOI":"10.1002\/mds.30207"},{"issue":"4","key":"1595_CR15","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1002\/humu.23703","volume":"40","author":"XX Guo","year":"2019","unstructured":"Guo\u00a0XX, Zou\u00a0XH, Wang\u00a0C, et\u00a0al. Spectrum of SLC20A2, PDGFRB, PDGFB, and XPR1 mutations in a\u00a0large cohort of patients with primary familial brain calcification. Hum Mutat. 2019;40(4):392\u2013403.","journal-title":"Hum Mutat"},{"key":"1595_CR16","doi-asserted-by":"crossref","unstructured":"Bonato G, Cimino P, Pistonesi F, et\u00a0al. Non-Motor Symptoms in Primary Familial Brain Calcification. J\u00a0Clin Med. 2024;13(13).","DOI":"10.3390\/jcm13133873"},{"issue":"5","key":"1595_CR17","doi-asserted-by":"publisher","first-page":"105550","DOI":"10.1016\/j.jamda.2025.105550","volume":"26","author":"S Cheng","year":"2025","unstructured":"Cheng\u00a0S, Qin\u00a0J, Hou\u00a0C, et\u00a0al. Linking Cognitive Screening Tests in Community-Dwelling Older Adults: Crosswalk between the Montreal Cognitive Assessment-Basic and the Mini-Mental State Examination. J\u00a0Am Med Dir Assoc. 2025;26(5):105550.","journal-title":"J Am Med Dir Assoc"},{"key":"1595_CR18","first-page":"100222","volume":"6","author":"E Lindvall","year":"2024","unstructured":"Lindvall\u00a0E, Abzhandadze\u00a0T, Quinn\u00a0TJ, et\u00a0al. Is the difference real, is the difference relevant: the minimal detectable and clinically important changes in the Montreal Cognitive Assessment. Cereb Circ Cogn Behav. 2024;6:100222.","journal-title":"Cereb Circ Cogn Behav"},{"issue":"7","key":"1595_CR19","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1159\/000518939","volume":"68","author":"DA Jehu","year":"2022","unstructured":"Jehu\u00a0DA, Davis\u00a0JC, Madden\u00a0K, et\u00a0al. Minimal Clinically Important Difference of Executive Function Performance in Older Adults Who Fall: A\u00a0Secondary Analysis of a\u00a0Randomized Controlled Trial. Gerontology. 2022;68(7):771\u20139.","journal-title":"Gerontology"},{"key":"1595_CR20","first-page":"467131","volume":"2014","author":"RA Hauser","year":"2014","unstructured":"Hauser\u00a0RA, Gordon\u00a0MF, Mizuno\u00a0Y, et\u00a0al. Minimal clinically important difference in Parkinson\u2019s disease as assessed in pivotal trials of pramipexole extended release. Parkinsons Dis. 2014;2014:467131.","journal-title":"Parkinsons Dis"},{"issue":"4","key":"1595_CR21","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1002\/mdc3.12632","volume":"5","author":"A Sanchez-Ferro","year":"2018","unstructured":"Sanchez-Ferro\u00a0A, Matarazzo\u00a0M, Martinez-Martin\u00a0P, et\u00a0al. Minimal Clinically Important Difference for UPDRS-III in Daily Practice. Mov Disord Clin Pract. 2018;5(4):448\u201350.","journal-title":"Mov Disord Clin Pract"},{"key":"1595_CR22","doi-asserted-by":"publisher","first-page":"123020","DOI":"10.1016\/j.jns.2024.123020","volume":"460","author":"S Sennfalt","year":"2024","unstructured":"Sennfalt\u00a0S, Gustavsson\u00a0P, Malmgren\u00a0H, et\u00a0al. Novel findings in a\u00a0Swedish primary familial brain calcification cohort. J\u00a0Neurol Sci. 2024;460:123020.","journal-title":"J Neurol Sci"}],"container-title":["Clinical Neuroradiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-025-01595-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00062-025-01595-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00062-025-01595-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:01:18Z","timestamp":1782860478000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00062-025-01595-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["1595"],"URL":"https:\/\/doi.org\/10.1007\/s00062-025-01595-4","relation":{},"ISSN":["1869-1439","1869-1447"],"issn-type":[{"value":"1869-1439","type":"print"},{"value":"1869-1447","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,26]]},"assertion":[{"value":"1 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"B. Snijders, L. Pierey, M. Peters, S. de Lange, S. van der Star, N. Allaerts, M. Emmelot-Vonk, P. de Jong and H. Koek declare that there are no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}