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Serum levels of pituitary hormones were correlated with ICP and radiological parameters including pituitary volume, flattening, and optic nerve (ON) and optic nerve sheath (ONS) volume. Group comparisons and partial correlations were used to evaluate associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ICP showed a\u00a0significant positive association with thyroid-stimulating hormone (TSH) levels (r\u202f=\u20090.628,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.016), and a\u00a0significant negative association with growth hormone (GH) (r\u202f=\u2009\u22120.602,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.023). Regarding structural parameters, only the volume of the right ON showed a\u00a0strong positive association within the subgroup with elevated ICP (r\u202f=\u20090.90,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.005). Correlations between ONS volumes and ICP in the normal pressure subgroup narrowly missed statistical significance. TSH was the only hormone showing a\u00a0significant association, with higher TSH levels relating to larger pituitary volume in the normal ICP subgroup (r\u202f=\u20090.88,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u20090.020), but not in the elevated ICP subgroup.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our exploratory findings suggest potential interactions between ICP, endocrine markers, and structural MRI measures. However, due to the limited sample size and variability in endocrine parameters, the results should be interpreted cautiously and considered hypothesis generating rather than clinically directive. Larger studies are needed to determine whether endocrine MRI associations hold true and whether they have diagnostic or clinical relevance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00062-026-01618-8","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T16:00:41Z","timestamp":1769529641000},"page":"585-594","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural MRI Biomarkers of Intracranial Pressure in IIH: Linking Optic Nerve Sheath, Pituitary Morphology, and Hormonal Changes"],"prefix":"10.1007","volume":"36","author":[{"given":"Zeynep","family":"Bendella","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara Daria","family":"Wichtmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Clauberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Fenske","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Fries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Jeub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Minnerop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt-Hendrik","family":"Schievelkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziskus M.","family":"Sch\u00fctzeichel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Wabbels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Schaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Witry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berkan","family":"Koyak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Radbruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Linder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ullrich","family":"W\u00fcllner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Kindler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"issue":"13","key":"1618_CR1","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1212\/WNL.0b013e3182a55f17","volume":"81","author":"DI Friedman","year":"2013","unstructured":"Friedman\u00a0DI, Liu\u00a0GT, Digre\u00a0KB. 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