{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:52:17Z","timestamp":1781869937974,"version":"3.54.5"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008967","name":"Philipps-Universit\u00e4t Marburg","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008967","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Neuroradiol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the feasibility and safety of microcatheter aspiration thrombectomy (MAT) using a\u00a00.025\u2033 microcatheter (PX-SLIM\u2122) for distal vessel occlusions (DVOs) in acute ischemic stroke (AIS) with disabling deficits, and to explore outcome differences between patients with and without intravenous thrombolysis (IVT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicenter study included 21\u00a0highly selected AIS patients (July 2022\u2013June 2024) with angiographically confirmed DVOs in the M3\u2013M4, A3\u2013A4, or P3\u2013P4 segments. All had an Alberta Stroke Program Early CT Score (ASPECTS) of\u00a010 and disabling deficits and underwent MAT using the PX-SLIM\u2122 microcatheter. Outcomes included clinical scores\u2014National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS)\u2014angiographic reperfusion using the modified Thrombolysis in Cerebral Infarction (mTICI; success \u2265\u202f2b), and procedural safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>14\u00a0patients (66.7%) received IVT\u202f+\u2009MAT and 7\u00a0(33.3%) MAT alone. Successful reperfusion (mTICI \u2265\u202f2b) was achieved in all 21\u00a0patients (100%). Median NIHSS improved from 3\u00a0at admission to 1\u00a0at discharge and 0\u00a0at 3\u00a0months. At discharge, 90.5% had an mRS of\u00a01 and 9.5% an mRS of\u00a02; at 3\u00a0months, 85.7% achieved mRS\u00a00 and 14.3% mRS 1.\u00a0No hemorrhage, dissection, distal embolization, or AIS recurrence occurred; transient vasospasm was observed in 38% without clinical impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MAT using the PX-SLIM\u2122 microcatheter appears to be a\u00a0technically feasible approach with an acceptable safety profile in this small, highly selected cohort. The encouraging results are exploratory, and larger prospective studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00062-026-01692-y","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:11:39Z","timestamp":1781867499000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microcatheter Aspiration Thrombectomy with a\u00a00.025\u2033 Microcatheter for Distal Vessel Occlusions in Acute Ischemic Stroke with Disabling Deficits"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4233-8048","authenticated-orcid":false,"given":"Mohammad","family":"Almohammad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hekers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mete","family":"Dadak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Khanafer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Gurschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayan Alhaj","family":"Moustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakarya","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Timmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole J.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Aburub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Kemmling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"1692_CR1","doi-asserted-by":"publisher","unstructured":"Jeong EO, Kwon HJ, Jeong H, Lee HJ, Kim KH, Koh HS. 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Informed consent was waived due to the completely anonymized nature of the data collection and analysis.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}